Effects of a soluble dietary fibre NUTRIOSE® on colonic fermentation and excretion rates in rats

The resistant dextrin NUTRIOSE®, developed from starch, is expected to act as a prebiotic. The aim of this study was to determine the effects of NUTRIOSE® on cecal parameters, short-chain fatty acid (SCFA) concentrations, and fecal excretion in rats. In an initial experiment, twenty-four male Fischer F344 rats were randomly assigned to one of the following four treatments for 14 days: G0 (control diet), G2.5 (control diet + 2.5% of dextrin), G5 (control diet + 5% of dextrin), and G10 (control diet + 10% of dextrin). After 14 days, total cecal weight, cecal content, and cecal wall weight were significantly increased in G5 and G10 compared to G0. At the same time, cecal pH was significantly lower in G10 compared to G0. Total SCFA concentration was significantly higher in G10 than in G5, G2.5, and G0, and significantly higher in G5 than in G0. Acetate, butyrate, and propionate concentrations were significantly increased in G5 and G10 compared to the controls. In a second trial based on a similar design, eighteen male Fischer F344 rats were treated with a control diet supplemented with 5% of dextrin or 5% of fructo-oligosaccharide. The results obtained with NUTRIOSE® were similar to those obtained with the fructo-oligosaccharide. In a third experiment, two groups of 5 Fischer F344 rats were orally treated with 100 and 1,000 mg/kg NUTRIOSE®, respectively, and from 18% to 25% of the dextrin was excreted in the feces. The results of these three studies show that the consumption of NUTRIOSE®, by its effects on total cecal weight, cecal content, cecal wall weight, pH, and SCFA production, could induce healthy benefits since these effects are reported to be prebiotic effects

Recent trends in climate variability at the local scale using 40 years of observations: the case of the Paris region of France

International audienceFor several years, global warming has been unequivocal, leading to climate change at global, regional and local scales. A good understanding of climate characteristics and local variability is important for adaptation and response. Indeed, the contribution of local processes and their understanding in the context of warming are still very little studied and poorly represented in climate models. Improving the knowledge of surface–atmosphere feedback effects at local scales is therefore important for future projections. Using observed data in the Paris region from 1979 to 2017, this study characterizes the changes observed over the last 40 years for six climatic parameters (e.g. mean, maximum and minimum air temperature at 2 m, 2 m relative and specific humidities and precipitation) at the annual and seasonal scales and in summer, regardless of large-scale circulation, with an attribution of which part of the change is linked to large-scale circulation or thermodynamic. The results show that some trends differ from the ones observed at the regional or global scale. Indeed, in the Paris region, the maximum temperature increases faster than does the minimum temperature. The most significant trends are observed in spring and in summer, with a strong increase in temperature and a very strong decrease in relative humidity, while specific humidity and precipitation show no significant trends. The summer trends can be explained more precisely using large-scale circulation, especially regarding the evolution of the precipitation and specific humidity. The analysis indicates the important role of surface–atmosphere feedback in local variability and that this feedback is amplified or inhibited in a context of global warming, especially in an urban environment