Bent crystal spectrometer for both frequency and wavenumber resolved x-ray scattering at a seeded free-electron laser

We present a cylindrically curved GaAs x-ray spectrometer with energy resolution $\Delta E/E = 1.1\cdot 10^{-4}$ and wave-number resolution of $\Delta k/k = 3\cdot 10^{-3}$, allowing plasmon scattering at the resolution limits of the Linac Coherent Light Source (LCLS) x-ray free-electron laser. It spans scattering wavenumbers of 3.6 to $5.2/$\AA\ in 100 separate bins, with only 0.34\% wavenumber blurring. The dispersion of 0.418~eV/$13.5\,\mu$m agrees with predictions within 1.3\%. The reflection homogeneity over the entire wavenumber range was measured and used to normalize the amplitude of scattering spectra. The proposed spectrometer is superior to a mosaic HAPG spectrometer when the energy resolution needs to be comparable to the LCLS seeded bandwidth of 1~eV and a significant range of wavenumbers must be covered in one exposure

Multibarrier tunneling

We study the tunneling through an arbitrary number of finite rectangular opaque barriers and generalize earlier results by showing that the total tunneling phase time depends neither on the barrier thickness nor on the inter-barrier separation. We also predict two novel peculiar features of the system considered, namely the independence of the transit time (for non resonant tunneling) and the resonant frequency on the number of barriers crossed, which can be directly tested in photonic experiments. A thorough analysis of the role played by inter-barrier multiple reflections and a physical interpretation of the results obtained is reported, showing that multibarrier tunneling is a highly non-local phenomenon.Comment: RevTex, 7 pages, 1 eps figur

Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo

This work was funded by grants from the Biotechnology and Biological Sciences Research Council Experimental Research on Aging Initiative, Research Into Aging, The Sir Jules Thorne Research Trust, and The Hayward Foundation and Dermatrust

On a universal photonic tunnelling time

We consider photonic tunnelling through evanescent regions and obtain general analytic expressions for the transit (phase) time $\tau$ (in the opaque barrier limit) in order to study the recently proposed ``universality'' property according to which $\tau$ is given by the reciprocal of the photon frequency. We consider different physical phenomena (corresponding to performed experiments) and show that such a property is only an approximation. In particular we find that the ``correction'' factor is a constant term for total internal reflection and quarter-wave photonic bandgap, while it is frequency-dependent in the case of undersized waveguide and distributed Bragg reflector. The comparison of our predictions with the experimental results shows quite a good agreement with observations and reveals the range of applicability of the approximated ``universality'' property.Comment: RevTeX, 8 pages, 4 figures, 1 table; subsection added with a new experiment analyzed, some other minor change

Aspects of Two-Photon Physics at Linear e+e- Colliders

We discuss various reactions at future e+e- and gamma-gamma colliders involving real (beamstrahlung or backscattered laser) or quasi--real (bremsstrahlung) photons in the initial state and hadrons in the final state. The production of two central jets with large pT is described in some detail; we give distributions for the rapidity and pT of the jets as well as the di--jet invariant mass, and discuss the relative importance of various initial state configurations and the uncertainties in our predictions. We also present results for `mono--jet' production where one jet goes down a beam pipe, for the production of charm, bottom and top quarks, and for single production of W and Z bosons. Where appropriate, the two--photon processes are compared with annihilation reactions leading to similar final states. We also argue that the behaviour of the total inelastic gamma-gamma cross section at high energies will probably have little impact on the severity of background problems caused by soft and semi--hard (`minijet') two--photon reactions. We find very large differences in cross sections for all two--photon processes between existing designs for future e+e- colliders, due to the different beamstrahlung spectra; in particular, both designs with >1 events per bunch crossing exist.Comment: 51 pages, 13 figures(not included

Thermopower of a 2D electron gas in suspended AlGaAs/GaAs heterostructures

We present thermopower measurements on a high electron mobility two-dimensional electron gas (2DEG) in a thin suspended membrane.We show that the small dimension of the membrane substantially reduces the thermal conductivity compared to bulk material so that it is possible to establish a strong thermal gradient along the 2DEG even at a distance of few micrometers. We find that the zero-field thermopower is significantly affected by the micro patterning. In contrast to 2DEGs incorporated in a bulk material, the diffusion contribution to the thermopower stays dominant up to a temperature of 7 K until the phonon-drag becomes strong and governs the run of the thermopower. We also find that the coupling between electrons and phonons in the phonon-drag regime is due to screened deformation potentials, in contrast to piezoelectric coupling found with bulk phonons.Comment: 7 page

Possibility of the tunneling time determination

We show that it is impossible to determine the time a tunneling particle spends under the barrier. However, it is possible to determine the asymptotic time, i.e., the time the particle spends in a large area including the barrier. We propose a model of time measurements. The model provides a procedure for calculation of the asymptotic tunneling and reflection times. The model also demonstrates the impossibility of determination of the time the tunneling particle spends under the barrier. Examples for delta-form and rectangular barrier illustrate the obtained results.Comment: 8 figure

Chaste: an open source C++ library for computational physiology and biology

Chaste - Cancer, Heart And Soft Tissue Environment - is an open source C++ library for the computational simulation of mathematical models developed for physiology and biology. Code development has been driven by two initial applications: cardiac electrophysiology and cancer development. A large number of cardiac electrophysiology studies have been enabled and performed, including high performance computational investigations of defibrillation on realistic human cardiac geometries. New models for the initiation and growth of tumours have been developed. In particular, cell-based simulations have provided novel insight into the role of stem cells in the colorectal crypt. Chaste is constantly evolving and is now being applied to a far wider range of problems. The code provides modules for handling common scientific computing components, such as meshes and solvers for ordinary and partial differential equations (ODEs/PDEs). Re-use of these components avoids the need for researchers to "re-invent the wheel" with each new project, accelerating the rate of progress in new applications. Chaste is developed using industrially-derived techniques, in particular test-driven development, to ensure code quality, re-use and reliability. In this article we provide examples that illustrate the types of problems Chaste can be used to solve, which can be run on a desktop computer. We highlight some scientific studies that have used or are using Chaste, and the insights they have provided. The source code, both for specific releases and the development version, is available to download under an open source Berkeley Software Distribution (BSD) licence at http://www.cs.ox.ac.uk/chaste, together with details of a mailing list and links to documentation and tutorials

Multi-wavelength analysis of high energy electrons in solar flares: a case study of August 20, 2002 flare

A multi-wavelength spatial and temporal analysis of solar high energy electrons is conducted using the August 20, 2002 flare of an unusually flat (gamma=1.8) hard X-ray spectrum. The flare is studied using RHESSI, Halpha, radio, TRACE, and MDI observations with advanced methods and techniques never previously applied in the solar flare context. A new method to account for X-ray Compton backscattering in the photosphere (photospheric albedo) has been used to deduce the primary X-ray flare spectra. The mean electron flux distribution has been analysed using both forward fitting and model independent inversion methods of spectral analysis. We show that the contribution of the photospheric albedo to the photon spectrum modifies the calculated mean electron flux distribution, mainly at energies below 100 keV. The positions of the Halpha emission and hard X-ray sources with respect to the current-free extrapolation of the MDI photospheric magnetic field and the characteristics of the radio emission provide evidence of the closed geometry of the magnetic field structure and the flare process in low altitude magnetic loops. In agreement with the predictions of some solar flare models, the hard X-ray sources are located on the external edges of the Halpha emission and show chromospheric plasma heated by the non-thermal electrons. The fast changes of Halpha intensities are located not only inside the hard X-ray sources, as expected if they are the signatures of the chromospheric response to the electron bombardment, but also away from them.Comment: 26 pages, 9 figures, accepted to Solar Physic