Contextual Process Digitalization

This open access book presents an overview and step-by-step explanation of process management. It starts with the individual participants’ perspectives on their work in a process and its structuring and harmonization, and then moves on to its specification in a model and how it is embedded in the organizational and IT environment of the company. Lastly, the book examines the joint processing of instances in the resulting socio-technical systems. A corresponding illustration, which expands with the overview, enables readers to gain a comprehensive understanding of business process management. The book presents various facets of business process management from the perspective of the participants, and introduces a selection of models that have proved useful in practice. The design of such models supports the transition from a more-or-less unstructured or unsatisfactory way of working to a structured process that corresponds to the ideas of the company and its customers. The book is intended for professionals in industry as well as students in the field of business information systems who are looking for guidelines on how to discover, create and implement real-world processes

Behavior-Centered Digital-Twin Design for Dynamic Cyber-Physical System Development

Digital Twins are digital models of Cyber-Physical Systems to enable not only continuous monitoring but also active functional improvement of networked services, physical products, machines and devices. This capacity is of utmost importance when recognizing and exploring business opportunities in terms of organizational and technology innovations, as well as enriching the scope of system-relevant applications. Before being operated in their target ecosystems, such as smart cities, Cyber-Physical Systems can be validated and be run as Digital Twin through executable behavior models. The development of these models captures both, the horizontal, and the vertical integration of CPS components, thus allowing to consider specific system qualities, such as pollution effects of traffic. This article investigates methodological and technological aspects of developing and operating Digital Twins along system transformation processes. We consider integration depth and breadth, connectivity, organizational intelligence, validation, and implementation variability in the context of human-centered modeling and development. The approach enriches the understanding of digital twins towards digital representation of Cyber-Physical Systems allowing for dynamic allocation of physical and digital parts according to operational conditions. An exemplary case study in traffic management demonstrates the feasibility and practicability of the communication-centered approach

Contextual Process Digitalization

This open access book presents an overview and step-by-step explanation of process management. It starts with the individual participants’ perspectives on their work in a process and its structuring and harmonization, and then moves on to its specification in a model and how it is embedded in the organizational and IT environment of the company. Lastly, the book examines the joint processing of instances in the resulting socio-technical systems. A corresponding illustration, which expands with the overview, enables readers to gain a comprehensive understanding of business process management. The book presents various facets of business process management from the perspective of the participants, and introduces a selection of models that have proved useful in practice. The design of such models supports the transition from a more-or-less unstructured or unsatisfactory way of working to a structured process that corresponds to the ideas of the company and its customers. The book is intended for professionals in industry as well as students in the field of business information systems who are looking for guidelines on how to discover, create and implement real-world processes

Subject-Oriented Business Process Management

Activities performed in organizations are coordinated via communication between the people involved. The sentences used to communicate are naturally structured by subject, verb, and object. The subject describes the actor, the verb the action and the object what is affected by the action. Subject-oriented Business Process Management (S-BPM) as presented in this book is based on this simple structure which enables process-oriented thinking and process modeling. S-BPM puts the subject of a process at the center of attention and thus deals with business processes and their organizational environment from a new perspective, meeting organizational requirements in a much better way than traditional approaches. Subjects represent agents of an action in a process, which can be either technical or human (e.g. a thread in an IT system or a clerk). A process structures the actions of each subject and coordinates the required communication among the subjects. S-BPM provides a coherent procedural framework to model and analyze business processes: its focus is the cooperation of all stakeholders involved in the strategic, tactical, and operational issues, sharing their knowledge in a networked structure. The authors illustrate how each modeling activity through the whole development lifecycle can be supported through the use of appropriate software tools. The presentation style focuses on professionals in industry, and on students specializing in process management or organizational modeling. Each chapter begins with a summary of key findings and is full of examples, hints, and possible pitfalls. An interpreter model, a toolbox, and a glossary summarizing the main terms complete the book. The web site www.i2pm.net provides additional software tools and further material

Subject-Oriented Business Process Management

Information Systems Applications (incl.Internet); Business Information Systems; Computer Appl. in Administrative Data Processing; Management of Computing and Information System

Subject-Oriented Business Process Management

Information Systems Applications (incl.Internet); Business Information Systems; Computer Appl. in Administrative Data Processing; Management of Computing and Information System

Subject-Oriented Modeling by Construction and Restriction

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Report of first recurrent glioma patients examined with PET-MRI prior to re-irradiation

Background and purpose The advantage of combined PET-MRI over sequential PET and MRI is the high spatial conformity and the absence of time delay between the examinations. The benefit of this technique for planning of re-irradiation (re-RT) treatment is unkown yet. Imaging data from a phase 1 trial of re-RT for recurrent glioma was analysed to assess whether planning target volumes and treatment margins in glioma re-RT can be adjusted by PET-MRI with rater independent PET based biological tumour volumes (BTVs). Patients and methods Combined PET-MRI with the tracer O-(2-F-18-fluoroethyl)-1-tyrosine (F-18-FET) prior to re-RT was performed in recurrent glioma patients in a phase I trial. GTVs including all regions suspicious of tumour on contrast enhanced MRI were delineated by three experienced radiation oncologists and included into MRI based consensus GTVs (mRGTVs). BTVs were semiautomatically delineated with a fixed threshold of 1.6 x background activity. Corresponding BTVs and mRGTVs were fused into union volume RET-NARGIVs. The Sorensen Dice coefficient and the conformity index were used to assess the geometric overlap of the BTVs with the mRGTVs. A recurrence pattern analysis was performed based on the original planning target volumes (PTVs = GTV + 10 mm margin or 5 mm in one case) and the RET-NARGTVs with margins of 10, 8, 5 and 3 mm. Results Seven recurrent glioma patients, who received PET-MRI prior to re-RT, were included into the present planning study. At the time of re-RT, patients were in median 54 years old and had a median Karnofsky Performance Status (KPS) score of 80. Median post-recurrence survival after the beginning of re-RT was 13 months. Concomitant bevacizumab therapy was applied in six patients and one patient received chemoradiation with temozolomide. Median GTV volumes of the three radiation oncologists were 35.0, 37.5 and 40.5 cubic centimeters (cc) and median (MR)GTV volume 41.8 cc. Median BTV volume was 36.6 cc and median (PET-MR)GTV volume 59.3 cc. The median Sorensen-Dice coefficient for the comparison between (MR)GTV and BTV was 0.61 and the median conformity index 0.44. Recurrence pattern analysis revealed two central, two in-field and one distant recurrence within both, the original PTV, as well as the (PER-MR)GTV with a reduced margin of 3 mm. Conclusion PET-MRI provides radiation treatment planning imaging with high spatial and timely conformity for high-grade glioma patients treated with re-RT with potential advancements for target volume delineation. Prospective randomised trials are warranted to further investigate the treatment benefits of PET-MRI based re-RT planning

MRI-based contrast clearance analysis shows high differentiation accuracy between radiation-induced reactions and progressive disease after cranial radiotherapy

BACKGROUND: Pseudoprogression (PsP) or radiation necrosis (RN) may frequently occur after cranial radiotherapy and show a similar imaging pattern compared with progressive disease (PD). We aimed to evaluate the diagnostic accuracy of magnetic resonance imaging-based contrast clearance analysis (CCA) in this clinical setting. PATIENTS AND METHODS: Patients with equivocal imaging findings after cranial radiotherapy were consecutively included into this monocentric prospective study. CCA was carried out by software-based automated subtraction of imaging features in late versus early T1-weighted sequences after contrast agent application. Two experienced neuroradiologists evaluated CCA with respect to PsP/RN and PD being blinded for histological findings. The radiological assessment was compared with the histopathological results, and its accuracy was calculated statistically. RESULTS: A total of 33 patients were included; 16 (48.5%) were treated because of a primary brain tumor (BT), and 17 (51.1%) because of a secondary BT. In one patient, CCA was technically infeasible. The accuracy of CCA in predicting the histological result was 0.84 [95% confidence interval (CI) 0.67-0.95; one-sided P = 0.051; n = 32]. Sensitivity and specificity of CCA were 0.93 (95% CI 0.66-1.00) and 0.78 (95% CI 0.52-0.94), respectively. The accuracy in patients with secondary BTs was 0.94 (95% CI 0.71-1.00) and nonsignificantly higher compared with patients with primary BT with an accuracy of 0.73 (95% CI 0.45-0.92), P = 0.16. CONCLUSIONS: In this study, CCA was a highly accurate, easy, and helpful method for distinguishing PsP or RN from PD after cranial radiotherapy, especially in patients with secondary tumors after radiosurgical treatment