43 research outputs found
Photography practicum: learning the basics of managing a fine art photography studio
https://scholarworks.moreheadstate.edu/student_scholarship_posters/1071/thumbnail.jp
SB46-20/21: Resolution Establishing the ASUM Legislative Priorities
SB46-20/21: Resolution Establishing the ASUM Legislative Priorities. This resolution passed on a 19Y-1N-0A vote during the December 3, 2020 meeting of the Associated Students of the University of Montana (ASUM)
Winning Strategies: Best Practices in Home-Ownership Promotion
The NeighborWorks Campaign for Home Ownership 2002, in creating a framework for expanding NeighborWorks organizations' work with first-time homeowners, has also had the positive outcome of pooling the collective talent and creativity within the network of those organizations. The Campaign has given dedicated people who are the wellspring of local organizations' talent a chance to come together, share their wisdom and be inspired by their colleagues' ideas.These Winning Strategies are a natural response to the enthusiasm and collective thought expressed through the Campaign. Documenting these strategies as case studies has been an important piece of the Campaign's work, in part because these written reports can disperse accounts of successful models to distant locales and a range of audiences. The objectives in publishing the Winning Strategies have been:1. To describe and record in a straightforward way NeighborWorks organizations' innovative approaches to helping families overcome barriers to home ownership;2. To illustrate how NeighborWorks organizations are implementing the comprehensive approach to home ownership called Full Cycle Lending, itself formalized under the aegis of the Campaign; and3. To offer NeighborWorks organizations and others interested in home-ownership promotion a way to learn from and perhaps replicate existing work in the field
Engaging the next generation in Appalachian studies: building community and expanding outreach through technology and diversity of programming
https://scholarworks.moreheadstate.edu/student_scholarship_posters/1089/thumbnail.jp
Patterns of postmeal insulin secretion in individuals with sulfonylurea- treated KCNJ11 neonatal diabetes show predominance of non- KATP- channel pathways
Insulin secretion in sulfonylurea-treated KCNJ11 permanent neonatal diabetes mellitus (PNDM) is thought to be mediated predominantly through amplifying non-KATP-channel pathways such as incretins. Affected individuals report symptoms of postprandial hypoglycemia after eating protein/fat-rich foods. We aimed to assess the physiological response to carbohydrate and protein/fat in people with sulfonylurea-treated KCNJ11 PNDM.This article is freely available via Open Access. Click on the Publisher URL to access the full-text via the publisher's site
The HNF4A R76W mutation causes atypical dominant Fanconi syndrome in addition to a β cell phenotype
types: JOURNAL ARTICLEMutation specific effects in monogenic disorders are rare. We describe atypical Fanconi syndrome caused by a specific heterozygous mutation in HNF4A. Heterozygous HNF4A mutations cause a beta cell phenotype of neonatal hyperinsulinism with macrosomia and young onset diabetes. Autosomal dominant idiopathic Fanconi syndrome (a renal proximal tubulopathy) is described but no genetic cause has been defined.This article presents independent research supported by the National Institute for Health Research (NIHR) Exeter Clinical Research Facility. The research is funded by a Wellcome Trust Senior Investigator Award, (grant number 098395/Z/12/Z).Wellcome Trus
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Long-term follow-up of glycemic and neurological outcomes in an international series of patients with sulfonylurea-treated ABCC8 permanent neonatal diabetes
This is the author accepted manuscript. The final version is available from the American Diabetes Association via the DOI in this record OBJECTIVE ABCC8 mutations cause neonatal diabetes mellitus that can be transient (TNDM) or, less commonly, permanent (PNDM); ∼90% of individuals can be treated with oral sulfonylureas instead of insulin. Previous studies suggested that people with ABCC8-PNDM require lower sulfonylurea doses and have milder neurological features than those with KCNJ11-PNDM. However, these studies were short-term and included combinations of ABCC8-PNDM and ABCC8-TNDM. We aimed to assess the long-term glycemic and neurological outcomes in sulfonylurea-treated ABCC8-PNDM.
RESEARCH DESIGN AND METHODS We studied all 24 individuals with ABCC8-PNDM diagnosed in the U.K., Italy, France, and U.S. known to transfer from insulin to sulfonylureas before May 2010. Data on glycemic control, sulfonylurea dose, adverse effects including hypoglycemia, and neurological features were analyzed using nonparametric statistical methods.
RESULTS Long-term data were obtained for 21 of 24 individuals (median follow-up 10.0 [range 4.1–13.2] years). Eighteen of 21 remained on sulfonylureas without insulin at the most recent follow-up. Glycemic control improved on sulfonylureas (presulfonylurea vs. 1-year posttransfer HbA1c 7.2% vs. 5.7%, P = 0.0004) and remained excellent long-term (1-year vs. 10-year HbA1c 5.7% vs. 6.5%, P = 0.04), n = 16. Relatively high doses were used (1-year vs. 10-year dose 0.37 vs. 0.25 mg/kg/day glyburide, P = 0.50) without any severe hypoglycemia. Neurological features were reported in 13 of 21 individuals; these improved following sulfonylurea transfer in 7 of 13. The most common features were learning difficulties (52%), developmental delay (48%), and attention deficit hyperactivity disorder (38%).
CONCLUSIONS Sulfonylurea treatment of ABCC8-PNDM results in excellent long-term glycemic control. Overt neurological features frequently occur and may improve with sulfonylureas, supporting early, rapid genetic testing to guide appropriate treatment and neurodevelopmental assessment.Wellcome Trus
Screening for neonatal diabetes at day 5 of life using dried blood spot glucose measurement.
The majority of infants with neonatal diabetes mellitus present with severe ketoacidosis at a median of 6 weeks. The treatment is very challenging and can result in severe neurological sequelae or death. The genetic defects that cause neonatal diabetes are present from birth. We aimed to assess if neonatal diabetes could be diagnosed earlier by measuring glucose in a dried blood spot collected on day 5 of life.This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.Published