Development and flight tests of a Kalman filter for navigation during terminal area and landing operations

A Kalman filter for aircraft terminal area and landing navigation was implemented and flight tested in the NASA Ames STOLAND avionics computer onboard a Twin Otter aircraft. This system combines navaid measurements from TACAN, MODILS, air data, radar altimeter sensors along with measurements from strap-down accelerometer and attitude angle sensors. The flight test results demonstrate that the Kalman filter provides improved estimates of the aircraft position and velocity as compared with estimates from the more standard complementary filter. The onboard computer implementation requirements to achieve this improved performance are discussed

An epigenetic hypothesis for ovarian cancer prevention by oral contraceptive pill use

Background: Ovarian cancer is the second most common gynecological cancer type after uterine cancers. In 2020, according to worldwide statistics, there were more than 313,000 new cases of ovarian cancer. Most concerning with ovarian cancer is the poor overall survival, with only 30% of patients surviving for longer than 5 years after diagnosis. The reason for this poor outcome includes late diagnosis due to non-specific symptoms and a lack of any highly effective biomarkers of the early stages of ovarian carcinogenesis. However, it is important to note that some modifiable lifestyle factors can be preventative [pregnancy, breastfeeding and combined oral contraceptives pill (COCP) use]. Results: There is now increasing data reporting the role of epigenetic changes, which are detectable in ovarian cancer tumors, suggesting the possibility that epigenetics may also play a key role in the mechanism of long-term effective prevention of ovarian cancer. To our knowledge, there is a lack of high-quality data on the molecular mechanisms of ovarian cancer prevention, although several hypotheses have been proposed. Conclusions: This review focusses on the evidence for a proposed novel hypothesis—that COCPs act as a chemoprevention through the impact on the epigenome of the cells of origin of ovarian cancer—fallopian tubes epithelium

Abstract Interpretation of Stateful Networks

Modern networks achieve robustness and scalability by maintaining states on their nodes. These nodes are referred to as middleboxes and are essential for network functionality. However, the presence of middleboxes drastically complicates the task of network verification. Previous work showed that the problem is undecidable in general and EXPSPACE-complete when abstracting away the order of packet arrival. We describe a new algorithm for conservatively checking isolation properties of stateful networks. The asymptotic complexity of the algorithm is polynomial in the size of the network, albeit being exponential in the maximal number of queries of the local state that a middlebox can do, which is often small. Our algorithm is sound, i.e., it can never miss a violation of safety but may fail to verify some properties. The algorithm performs on-the fly abstract interpretation by (1) abstracting away the order of packet processing and the number of times each packet arrives, (2) abstracting away correlations between states of different middleboxes and channel contents, and (3) representing middlebox states by their effect on each packet separately, rather than taking into account the entire state space. We show that the abstractions do not lose precision when middleboxes may reset in any state. This is encouraging since many real middleboxes reset, e.g., after some session timeout is reached or due to hardware failure

Controlled Phenylhydrazine-Induced Reticulocytosis in the Rat

Author Institution: Department of Physiology, Ohio State University, College of Medicine, Columbus, Ohio 43210The pattern of development of phenylhydrazine-induced rat reticulocytosis was studied over a period of nine days. Intraperitoneal injections of phenylhydrazine (4 mg/100 gm) every other day caused a fall in hematocrit which leveled off at 60% of normal by the fifth day. Increased erythropoiesis was indicated by a three-fold increase in the number of circulating reituclocytes after the first three injections. The immediate response was the release of stored mature reticulocytes from the bone marrow. As the anemia progressed, more and more young reticulocytes appeared until 70 to 85% of the red cells in the peripheral circulation were reticulocytes and 20% of these were juvenile forms

Radion Potential and Brane Dynamics

We examine the cosmology of the Randall-Sundrum model in a dynamic setting where scalar fields are present in the bulk as well as the branes. This generates a mechanism similar to that of Goldberger-Wise for radion stabilization and the recovery of late-cosmology features in the branes. Due to the induced radion dynamics, the inflating branes roll towards the minimum of the radion potential, thereby exiting inflation and reheating the Universe. In the slow roll part of the potential, the 'TeV' branes have maximum inflation rate and energy as their coupling to the radion and bulk modes have minimum suppresion. Hence, when rolling down the steep end of the potential towards the stable point, the radion field (which appears as the inflaton of the effective 4D theory in the branes) decays very fast, reheats the Universe .This process results decayin a decrease of brane's canonical vacuum energy $\Lambda_4$. However, at the minimum of the potential $\Lambda_4$ is small but not neccessarily zero and the fine-tuning issue remains .Density perturbation constraints introduce an upper bound when the radion stabilizies. Due to the large radion mass and strong suppression to the bulk modes, moduli problems and bulk reheating do not occur. The reheat temperature and a sufficient number of e-folding constraints for the brane-universe are also satisfied. The model therefore recovers the radiation dominated FRW universe.Comment: 16 pages, 3 figures,extraneous sentences removed, 2 footnotes added, some typos correcte

Chandra X-ray Observation of a Mature Cloud-Shock Interaction in the Bright Eastern Knot Region of Puppis A

We present Chandra X-ray images and spectra of the most prominent cloud-shock interaction region in the Puppis A supernova remnant. The Bright Eastern Knot (BEK) has two main morphological components: (1) a bright compact knot that lies directly behind the apex of an indentation in the eastern X-ray boundary and (2) lying 1' westward behind the shock, a curved vertical structure (bar) that is separated from a smaller bright cloud (cap) by faint diffuse emission. Based on hardness images and spectra, we identify the bar and cap as a single shocked interstellar cloud. Its morphology strongly resembles the ``voided sphere'' structures seen at late times in Klein et al.'s experimental simulations of cloud-shock interactions, when the crushing of the cloud by shear instabilities is well underway. We infer an interaction time of roughly 3 cloud-crushing timescales, which translates to 2000-4000 years, based on the X-ray temperature, physical size, and estimated expansion of the shocked cloud. This is the first X-ray identified example of a cloud-shock interaction in this advanced phase. Closer to the shock front, the X-ray emission of the compact knot in the eastern part of the BEK region implies a recent interaction with relatively denser gas, some of which lies in front of the remnant. The complex spatial relationship of the X-ray emission of the compact knot to optical [O III] emission suggests that there are multiple cloud interactions occurring along the line of sight.Comment: 22 pages LaTeX with multiple figures, to appear in Ap

Method and apparatus for spur-reduced digital sinusoid synthesis

A technique for reducing the spurious signal content in digital sinusoid synthesis is presented. Spur reduction is accomplished through dithering both amplitude and phase values prior to word-length reduction. The analytical approach developed for analog quantization is used to produce new bounds on spur performance in these dithered systems. Amplitude dithering allows output word-length reduction without introducing additional spurs. Effects of periodic dither similar to that produced by a pseudo-noise (PN) generator are analyzed. This phase dithering method provides a spur reduction of 6(M + 1) dB per phase bit when the dither consists of M uniform variates. While the spur reduction is at the expense of an increase in system noise, the noise power can be made white, making the power spectral density small. This technique permits the use of a smaller number of phase bits addressing sinusoid look-up tables, resulting in an exponential decrease in system complexity. Amplitude dithering allows the use of less complicated multipliers and narrower data paths in purely digital applications, as well as the use of coarse-resolution, highly-linear digital-to-analog converters (DAC's) to obtain spur performance limited by the DAC linearity rather than its resolution

LOWER LIMB PERFORMANCE IN ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTED INDIVIDUALS

This experiment examined lower limb performance in individuals with previous history of anterior cruciate ligament rupture and reconstruction. 10 volunteers took part in the study. Lower limb performance was assessed with maximal effort countermovement, drop and rebound jumps on a force sledge apparatus. The subjects’ contra-lateral, uninjured leg was used as an internal control. No significant differences were observed in any of the measured variables, in any of the jumping procedures between the involved and uninvolved leg. This suggests that current reconstructive practices and post-surgery rehabilitation techniques may have the ability to restore ACL deficient legs to a similar level of performance to an uninvolved control leg in dynamic, non-fatiguing, maximal effort jumping activity