Multiparticle Schrodinger operators with point interactions in the plane

We study a system of N bosons in the plane interacting with delta function potentials. After a coupling constant renormalization we show that the Hamiltonian defines a self-adjoint operator and obtain a lower bound for the energy. The same results hold if one includes a regular inter-particle potential.Comment: 17 pages, Late

La violence sociale comme actant du processus de subjectivation révolutionnaire. Comment la question de la violence socialise les jeunes révolutionnaires ?

National audienc

Autour du centenaire d’Octobre 1917. Réflexions sur la transmission mémorielle, l’engagement politique et la fabrique du sujet communiste révolutionnaire à Lutte ouvrière

Le concept de mémoire historique se révèle particulièrement fécond pour la sociologie de l’engagement. Envisagé du point de vue de sa transmission et du champ d’interactions dans lequel il s’inscrit, il permet d’interroger concrètement les mécanismes d’alignement entre la mémoire historique et les vécus individuels. Dans le processus de recrutement de l’organisation trotskyste Lutte ouvrière (présenté comme une étude de cas) les mécanismes de transmission mémorielle font apparaître, avant même l’acte formel d’engagement, comment se construit le sujet communiste révolutionnaire au contact des dispositifs militants.The concept of historical memory appears to be particularly useful to the sociology of commitment. From the perspective of transmission and the system of interactions it is based on, it allows us to question the way individual experiences are brought into line with the historical memory. Through the process of recruitment of the French Trotskyist organization « Lutte ouvrière » (considered as a case study), the concrete ways of the transmission of memory reveals, way before the formal commitment, how the revolutionary communist subject is produced.Los trabajos históricos acerca de la memoria son indispensables para la sociología del compromiso. El concepto de memoria histórica, considerado por su sistema de transmisión y el campo de interrelaciones que atraviesa, permite preguntarse como las experiencias de los individuos les alinean concretamente con la memoria histórica. Dentro del proceso de enrolamiento de la organización francesa trotskista “Lutte ouvrière” (presentado como un ejemplo), los mecanismos de transmisión de la memoria muestran, antes del acto formal de compromiso, cómo se constituye el súbdito comunista revolucionar

Se sentir politiquement engagé : Le rôle des émotions dans la subjectivation politique des recrues de Lutte ouvrière

La sociologie du militantisme fait généralement du passage à l’acte la première étape du devenir militant. On gagnerait pourtant à déplacer le regard : comment en vient-on à se sentir politiquement engagé avant même toute institutionnalisation de l’engagement ? Cet article s’appuie sur une observation participante des dispositifs de recrutement de l’organisation trotskyste Lutte ouvrière (LO) et sur une douzaine de récits de vie avec des individus en situation de recrutement, qui ont vocation à être reconduits dans les prochaines années pour mesurer l’évolution du processus d’engagement politique des jeunes recrues. Ces dernières ne peuvent espérer être intégrées comme « révolutionnaires professionnels » avant plusieurs années. Les émotions sont l’instrument de leur transformation subjective et deviennent dès lors une voie essentielle pour pouvoir construire une analyse phénoménologique de l’engagement politique, irréductible à l’adhésion militante.Taking action and joining an activist organization has often been introduced as the foremost questions to be answered by sociology of activist commitment. And yet far too little attention has been paid to commitment outside the institutional frame: long before joining any organization, how do we come to feel politically committed? This paper is based on a participant observation of the recruitment methods of a French Trotskyist organization, as well as a dozen of life stories with young recruits of this organization. Recruits are indeed to undergo several trials before being granted full “professional revolutionary” membership. Emotions actively contribute to spawning the recruits’ political subjectivity through their experience of the recruitment methods. The study of emotions from a phenomenological perspective may thus throw into relief certain features of political commitment that might otherwise be missed

La violence sociale comme actant du processus de subjectivation révolutionnaire. Comment la question de la violence socialise les jeunes révolutionnaires ?

National audienc

Updated report of a phase II randomized trial of transoral surgical resection followed by low-dose or standard postoperative therapy in resectable p16+ locally advanced oropharynx cancer: A trial of the ECOG-ACRIN cancer research group (E3311).

Research Funding: U10CA180820, U10CA180794, UG1CA189953, UG1CA232760, UG1CA233184, UG1CA233196, UG1CA233247, UG1CA233329, UG1CA233331, UG1CA233337, U10CA180863, Canadian Cancer Society #704970 Background:Definitive or postoperative chemoradiation (CRT) is highly curative for human papillomavirus-associated (HPV+) oropharynx cancer (OPC) but induces significant toxicity. As a potential deintensification strategy, we studied primary transoral surgery (TOS) and, in intermediate pathologic risk patients, reduced dose postoperative RT (PORT).Methods:E3311 is a phase II trial with randomization to reduced- or standard-dose PORT for resected stage III-IVa (AJCC7) intermediate pathologic risk HPV+ OPC, stratified by smoking history. Primary endpoints have been reported; we now present updated 3-year PFS and patient-reported outcomes (PRO), including head and neck-cancer specific quality of life (FACT-H&N) and swallowing perception and performance (MDADI).Results:Of 519 enrolled patients, 495 underwent TOS. The primary oncologic endpoint was 2-year PFS for 50 Gy (Arm B) or 60Gy (Arm C). Among 360 eligible and treated patients (ETP), Arm A (observation, N = 38) enrolled 11%, Arms B (N = 100) or C (N = 109) randomized 58%, and Arm D (66Gy + weekly cisplatin, N = 113) enrolled 31%. With 35.1 months median follow-up, 3-year PFS Kaplan-Meier estimate is 96.9% (90% CI [91.9%, 100%]) for Arm A; 94.9% (90% CI [91.3%, 98.6%]) for Arm B; 93.5% (90% CI [89.4%, 97.9%]) for Arm C; and 90.7% (90% CI [86.2%, 95.4%]) for Arm D. Recurrences and death without recurrence were 4 and 1 in Arm B, and 5 and one in Arm C. Smokers ( \u3e 10 pack-years) did not have worse 3-year PFS in Arms B or C. Treatment arm distribution and outcome for ineligible patients who started adjuvant therapy mirrored the 360 ETP. A comparison combining arms B/C versus arm D in the proportion of patients stable/improved in FACT-H&N total score, from baseline to 6 months post-treatment as a pre-specified endpoint, was 56% vs. 38% (p value = 0.011, one-sided Fisher’s exact test); however, underlying differences in treatment and risk may be confounding. An exploratory comparison between Arms B and C revealed improvement in FACT H&N (63% in Arm B vs. 49% in Arm C had a stable/improved score, p-value = 0.056).Conclusions:Primary TOS and reduced PORT retained outstanding oncologic outcome at 35 months follow up, with favorable QOL and functional outcomes, in intermediate risk HPV+ OPC. Clinical trial information: NCT 01898494

Enhancing the Membranolytic Activity of Chenopodium quinoa Saponins by Fast Microwave Hydrolysis

peer reviewedSaponins are plant secondary metabolites. There are associated with defensive roles due to their cytotoxicity and are active against microorganisms. Saponins are frequently targeted to develop efficient drugs. Plant biomass containing saponins deserves sustained interest to develop high-added value applications. A key issue when considering the use of saponins for human healthcare is their toxicity that must be modulated before envisaging any biomedical application. This can only go through understanding the saponin-membrane interactions. Quinoa is abundantly consumed worldwide, but the quinoa husk is discarded due to its astringent taste associated with its saponin content. Here, we focus on the saponins of the quinoa husk extract (QE). We qualitatively and quantitively characterized the QE saponins using mass spectrometry. They are bidesmosidic molecules, with two oligosaccharidic chains appended on the aglycone with two different linkages; a glycosidic bond and an ester function. The latter can be hydrolyzed to prepare monodesmosidic molecules. The microwave-assisted hydrolysis reaction was optimized to produce monodesmosidic saponins. The membranolytic activity of the saponins was assayed based on their hemolytic activity that was shown to be drastically increased upon hydrolysis. In silico investigations confirmed that the monodesmosidic saponins interact preferentially with a model phospholipid bilayer, explaining the measured increased hemolytic activity