Galen and his treatise on grief

Throughout his career, Fika Janse van Rensburg has rightly insisted on the importance of the socio-historical context in interpreting early Christian literature. Although New Testament scholars have given careful attention to many aspects of this context, they have generally neglected writings by physicians. This neglect includes the numerous works of the philosopher-physician Galen (129-ca. 216 or 217 CE), who was one of the Roman Empire’s most prolific writers. As a corrective, this article focuses on Galen, with attention given to his life and to a recently discovered treatise on distress or grief (lype¯), known as De indolentia [Avoiding Distress or On Freedom from Distress]. Galen discusses grief from both a physiological and philosophical perspective, and his treatment of this emotion and common human experience provides an important context for the statements about lype¯ found in the New Testament and other early Christian documents

Growth and structure of prismatic boron nitride nanorods

Prismatic boron nitride nanorods have been grown on single crystal silicon substrates by mechanical ball-milling followed by annealing at 1300 &deg;C. Growth takes place by rapid surface diffusion of BN molecules, and follows heterogeneous nucleation at catalytic particles of an Fe/Si alloy. Lattice imaging transmission electron microscopy studies reveal a central axial row of rather small truncated pyramidal nanovoids on each nanorod, surrounded by three basal planar BN domains which, with successive deposition of epitaxial layers adapt to the void geometry by crystallographic faceting. The bulk strain in the nanorods is taken up by the presence of what appear to be simple nanostacking faults in the external, near-surface domains which, like the nanovoids are regularly repetitive along the nanorod length. Growth terminates with a clear cuneiform tip for each nanorod. Lateral nanorod dimensions are essentially determined by the size of the catalytic particle, which remains as a foundation essentially responsible for base growth. Growth, structure, and dominating facets are shown to be consistent with a system which seeks lowest bulk and surface energies according to the well-known thermodynamics of the capillarity of solids.<br /

A practical method of reverse engineering and automatic path programming for robotic surface finishing

A method of robotic surface finishing is discussed. The method is question incorporates COTS (commercial of the shelf) technology

Nano-scale behavior of irradiated nano-structured alloys

Future fast neutron fusion and fission nuclear systems will be subjected to levels of radiation damage from fast neutrons which is significantly higher than the current generation of nuclear power stations. This will require innovative materials solutions to allow long term mechanical stability of reactors. One proposed class of materials are nanostructured alloys where the large number of interfaces allow for recombination defects and reduce the degree of radiation hardening seen. However their response under irradiation has not thoroughly been studied. In this work, two irradiated nanostructured alloys have been studied W-5%Re in both a nanostructured and annealed variant and a novel Hf-Ti-Ta-V-Zr high entropy alloy. I will outline the benefits nanostructured materials offer under irradiation and some of the problems and challenges in measuring their mechanical properties after irradiation and relating this to the nano-structure using XRD, TEM, HR-EBSD and atom probe tomography. Rolled tungsten 5 wt% rhenium sheet was studied in two microstructural variants: (a) as received with a high dislocation density (mean value of 1.4×1014lines/m2), measured using HR-EBSD, and pancake shaped grains with a thickness of≈200nm and (b) annealed at 1400oC for 24 hours to produce equiaxed grains with average grain size of ≈90 µm and low dislocation density (with a mean value of 4.8×1013 lines/m2). Both materials were ion implanted with 2MeV W+ ions at 300oC to damage levels from 0.07, to 33 displacements per atom (dpa). Nanoindentation was used to measure the change in hardness after implantations. Irradiation induced hardening saturated in the as-received material at an increase of 0.4dpa from the unimplanted hardness of 8GPa at 0.4dpa. In the annealed material saturation does not occur by 13dpa and the hardness change of 1.3GPa from the unimplanted hardness of 6.2GPa was over four times higher. At 33dpa both material types showed a further increase in hardening. In these samples Atom probe tomography showed clustering of Re in ≈4nm precipitates with a rhenium concentration of ≈11%. In both cases the number density and volume fraction are similar at ≈3100 x1000/µm3 and volume fraction of ≈13%. These differences in radiation response are likely to be due to the high damage sink density in the as-received microstructure in the form of dislocation networks, as even in the as-received material the average grain size is too large to provide sufficient sinks. Initially this provides a large sink network for radiation damage resulting in less hardening in the rolled material. However at 33dpa the formation of rhenium clusters occurs at similar levels in both material conditions. These dominate the hardening mechanisms and result in secondary hardening at high damage levels. The difficulties in extracting hardness values from 200nm deep ion implanted layers will be discussed, with reference to minimizing the influence of the substrate material and how changes in pile up effects in irradiated materials can change mechanical responses, and proposed methods to minimize these. High entropy alloys have been proposed as potential nuclear materials as high configurational entropy may provide resistance to radiation damage. We have produced a novel high entropy alloy (Hf-Ti-Ta-V-Zr) in which is single phase on casting but two high entropy phases (one bcc and one hcp) are produced during heat treatment. This material then has a nano-lamella structure with an average lamella thickness of 200nm. Samples of the as cast single phase material, the dual phase high entropy alloy and single crystal vanadium were ion irradiated with V+ ions at 300oC to a dose of 5e14 ions/cm2. In the vanadium control samples the hardness as measured using CSM-nanoindentation was seen to increase from 2GPa in the unimplanted condition to 3.5GPa in the ion irradiated condition. The high entropy alloy in both the as cast and heat treated condition showed no increase in hardness after irradiation, demonstrating the intrinsic resistance to radiation damage of HEA’s. These studies show the ability of nanostructured alloys to have improved irradiation hardening resistance over conventional alloys. However challenges still remain in the production of large scale engineering components in such materials

Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model

peer-reviewedThe aim of this study was to investigate if dietary administration of γ-aminobutyric acid (GABA)-producing Lactobacillus brevis DPC 6108 and pure GABA exert protective effects against the development of diabetes in streptozotocin (STZ)-induced diabetic Sprague Dawley rats. In a first experiment, healthy rats were divided in 3 groups (n=10/group) receiving placebo, 2.6 mg/kg body weight (bw) pure GABA or L. brevis DPC 6108 (~109microorganisms). In a second experiment, rats (n=15/group) were randomised to five groups and four of these received an injection of STZ to induce type 1 diabetes. Diabetic and non-diabetic controls received placebo [4% (w/v) yeast extract in dH2O], while the other three diabetic groups received one of the following dietary supplements: 2.6 mg/kg bw GABA (low GABA), 200 mg/kg bw GABA (high GABA) or ~109 L. brevis DPC 6108. L. brevis DPC 6108 supplementation was associated with increased serum insulin levels (P0.05), compared with non-diabetic controls while all other diabetic groups displayed reduced diversity (P<0.05). L. brevis DPC 6108 attenuated hyperglycaemia induced by diabetes but additional studies are needed to understand the mechanisms involved in this reduction.The authors and their work were supported by the APC Microbiome Institute. The APC Microbiome Institute is funded by Science Foundation Ireland (SFI). This publication has emanated from research supported by a research grant from Science Foundation Ireland (SFI) under Grant Number SFI/12/RC/2273

Budget Perspectives 2013. RESEARCH SERIES NUMBER 28 September 2012

The annual Budget Perspectives Conference provides a forum for discussing key public policy issues of both immediate and longer term concern. In the context of the current fiscal and economic crisis, research insights are needed at both the macro and micro level. The former are central to understanding and managing the significant reductions in the budget deficit needed to put Ireland's public finances on a sustainable footing. The latter are essential because a successful budgetary adjustment requires restructuring of both public expenditure and taxation. This in turn requires that policy adjustments take full account of both efficiency and equity issue and are seen to do so. The research papers presented at this year's annual Budget Perspectives Conference continue in this tradition, providing an opportunity for policymakers, social partners and researchers to engage with some of the major current issues

Influence of Chaperone-Like Activity of Caseinomacropeptide on the Gelation Behaviour of Whey Proteins at pH 6.4 and 7.2

The effect of caseinomacropeptide (CMP) on the heat-induced denaturation and gelation of whey proteins (2.5–10%, w/v) at pH 6.4 and 7.2, at a whey protein:CMP ratio of 1:0.9 (w/w), was investigated using differential scanning calorimetry (DSC), oscillatory rheology (90 °C for 20 min) and confocal microscopy. Greater frequency-dependence in the presence of CMP suggested that the repulsive interactions between CMP and the whey proteins affected the network generated by the non-heated whey protein samples. At pH 6.4 or 7.2, CMP increased the temperature of denaturation of β-lactoglobulin by up to 3 °C and increased the gelation temperature by up to 7 °C. The inclusion of CMP strongly affected the structure of the heat-induced whey protein gels, resulting in a finer stranded structure at pH 6.4 and 7.2. The presence of CMP combined with a lower heating rate (2 °C/min) prevented the formation of a solid gel of whey proteins after heating for 20 min at 90 °C and at pH 7.2. These results show the potential of CMP for control of whey protein denaturation and gelation

Perspectives and experiences with COVID-19 vaccines in people with MS

Background: People with MS may have unique perspectives on COVID-19 vaccines due to their condition and/or medications. Objective: Assess perspectives and experiences with COVID-19 vaccination, and quantify variables impacting COVID-19 vaccine willingness in people with MS. Methods: A survey captured demographics, MS characteristics, and COVID-19 infection and exposures data; opinions on COVID-19 vaccine safety, side effects, and efficacy; and experiences following vaccination. Chi-square tests and a logistic regression model were used to denote between-group differences and variables predicting vaccine willingness, respectively. Results: Most (87.8%) of the 237 participants were willing to receive the vaccine. Fifteen percent held or delayed a DMT dose for vaccination. MS symptoms worsened in a minority (7.6% first/only dose; 14.7% second dose), and most side effects were mild (80.0%; 55.3%). Those not planning to receive the vaccine were primarily concerned with long-term safety (70.4%). Medical comorbidities (adjusted odds ratio [aOR]=5.222; p=0.04) and following infection prevention precautions (aOR=6.330; p=0.008) were associated with vaccine willingness. Conclusion: Most individuals with MS surveyed plan to receive the COVID-19 vaccine. People with MS experience similar side effects to the general population, and few experience transient MS symptom worsening. These results can inform conversations on vaccination between providers and people with MS

A Framework to Manage the Complex Organisation of Collaborating: Its Application to Autonomous Systems

In this paper we present an analysis of the complexities of large group collaboration and its application to develop detailed requirements for collaboration schema for Autonomous Systems (AS). These requirements flow from our development of a framework for collaboration that provides a basis for designing, supporting and managing complex collaborative systems that can be applied and tested in various real world settings. We present the concepts of "collaborative flow" and "working as one" as descriptive expressions of what good collaborative teamwork can be in such scenarios. The paper considers the application of the framework within different scenarios and discuses the utility of the framework in modelling and supporting collaboration in complex organisational structures