Biomarkers of inflammatory arthritis and proteomics

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Research into display sharing techniques for distributed computing environments

The X-based Display Sharing solution for distributed computing environments is described. The Display Sharing prototype includes the base functionality for telecast and display copy requirements. Since the prototype implementation is modular and the system design provided flexibility for the Mission Control Center Upgrade (MCCU) operational consideration, the prototype implementation can be the baseline for a production Display Sharing implementation. To facilitate the process the following discussions are presented: Theory of operation; System of architecture; Using the prototype; Software description; Research tools; Prototype evaluation; and Outstanding issues. The prototype is based on the concept of a dedicated central host performing the majority of the Display Sharing processing, allowing minimal impact on each individual workstation. Each workstation participating in Display Sharing hosts programs to facilitate the user's access to Display Sharing as host machine

Exploring the Nuances of 'Wickedness' in Information Systems Development

Information Systems Development (ISD) practice is an inherently challenging undertaking, as exemplified by the high rate of ISD project failures. The scale of the challenge is often heightened in distributed environments where ISD practitioners can face considerable complexity, uncertainty, and contention. The concept of -˜wickedness’ epitomizes such challenges. However, ISD literature has yet to fully explore the nuances of wickedness found in ISD practices within distributed environments. To address this gap, we use a theoretical framework to analyze case study findings from an interdisciplinary connected health project. In particular, we break open the social aspects of wickedness and explore their impact on shared understanding and shared commitment in ISD projects. The paper highlights the implications that these nuances have for group decision-making in distributed ISD project teams

Self-regulation and retirement: how regulatory focus affects pre-retirement anxiety and affect

Contemporary retirement research endeavours to identify the complex antecedents and consequences of retirement decisions and retirement planning. However, few research studies have examined how retirement decisions and planning behaviours have been implemented, nor has there been any significant research investigating the impact of the complex interactions that occur between individual traits and matching or non-matching strategic preferences on retirement outcomes. This research programme addresses these shortcomings by applying the theories of regulatory focus and regulatory fit (Higgins, 1997,2000) to a model designed to examine the relationship between individual chronic motivational orientations and the means of pursuing retirement preparation strategies and their influence on pre-retirement anxiety and affect. In three studies a set of approach and avoidance strategies are elicited and tested as moderators of the relationship between an individual’s chronic regulatory orientation, measured by general regulatory focus measure strength (GRFMS) and their pre-retirement anxiety (measured by the Social Components of Retirement Anxiety SCRAS) and positive and negative affect(measured by the PANA Schedule). Overall, the three studies support the application and adaptation of the regulatory focus and regulatory fit approach to a greater understanding of the interaction between motivational orientation and means of pursuing retirement preparation goals. Results indicate that it is possible to differentiate retirement preparation strategies into distinguishable groups of approach and avoidance strategies. Results also demonstrate that a “fit” versus a “non-fit” between chronic orientation and the type of strategies pursued can improve outcomes for those approaching retirement. Results from Study 3 shows that regulatory orientation coupled with the type of strategies chosen explained significant variance in pre-retirement anxiety and positive and negative affect. Specifically, the type of strategies chosen significantly moderated the relationship between regulatory orientation and both preretirement anxiety and negative affect. The moderation effect on the relationship between regulatory orientation and positive affect was not statistically significant. One unexpected result indicated that for chronic prevention orientated individuals a match might in fact exacerbate their negative reactions rather than decrease them. Results from this research helps to further explain the consequences of planning behaviours by demonstrating that a fit between individual differences and specific means of goal pursuit, as proposed by regulatory fit theory, does impact on outcomes such as anxiety and affect. The implications of these results, for research in retirement, self-regulation and questionnaire development, are suggested

A Typology for Organizational ICT Practice

This paper sets out a typology for organizational ICT practice in order to derive a more holistic perspective of sociomateriality and its constituent elements (i.e. humans, objects, and practice). Seminal literature by Parsons and Bourdieu is combined with sociomateriality literature in order to offer insights into the factors that need to be investigated when conducting research into organizational ICT practice. The outlined typology is evaluated through an empirical case study of a connected health ICT project to show how the dimensions of the typology come together and contribute to a better understanding

Exploring the Nuances of \u27Wickedness\u27 in Information Systems Development

Information Systems Development (ISD) practice is an inherently challenging undertaking, as exemplified by the high rate of ISD project failures. The scale of the challenge is often heightened in distributed environments where ISD practitioners can face considerable complexity, uncertainty, and contention. The concept of -˜wickedness’ epitomizes such challenges. However, ISD literature has yet to fully explore the nuances of wickedness found in ISD practices within distributed environments. To address this gap, we use a theoretical framework to analyze case study findings from an interdisciplinary connected health project. In particular, we break open the social aspects of wickedness and explore their impact on shared understanding and shared commitment in ISD projects. The paper highlights the implications that these nuances have for group decision-making in distributed ISD project teams

TOWARDS A FRAMEWORK FOR SHARED UNDERSTANDING AND SHARED COMMITMENT IN AGILE DISTRIBUTED ISD PROJECT TEAMS

Agile distributed Information Systems Development (ISD) is an innately social process in which distributed team members must continuously interact to develop new IT solutions. Existing literature suggests that shared understanding and shared commitment are essential for the effective functioning of agile distributed ISD project teams; however, the factors that shape the emergence of these two phenomena remain elusive. In this paper, we seek to develop a framework for investigating the interplay of factors that shape shared understanding and shared commitment during agile distributed ISD project team interactions. We draw on in-depth case study findings from an agile distributed ISD project called the “CHP project” which involved team members from diverse backgrounds such as academia, healthcare, and industry. The study reveals that shared understanding and shared commitment in agile distributed project teams are shaped by the dynamic interplay between macro-level (contextual) and micro-level (localised) factors. In particular, we find that diverse macro-level structures, identities, and cultures interplay with the micro-level vision, approach, and means of the project to impact shared understanding and shared commitment. Empirical findings also suggest that the absence of shared understanding and shared commitment can sometimes be constructive as conflict allows team members to air differences of opinio

Blended Stakeholder Participation for Responsible Information Systems Research

Researchers often conduct information systems (IS) research under the assumption that technology use leads to positive outcomes for different stakeholders. However, many IS studies demonstrate limited evidence of having engaged with the stakeholders that they claim benefit and speak on behalf of. Therefore, we can unsurprisingly find many examples in which technology use failed to make the world a better place or, worse still, contributed towards unintended negative outcomes. Given these concerns, calls have recently emerged for responsible research and innovation (RRI) studies in IS to understand how different stakeholder groups can have a voice in complex socio-technical issues. In this paper, we take steps towards addressing this call by presenting case study findings from a responsible IS research project that combined “blended” face-to-face and online participatory techniques. The case study relates to a large-scale consultation in a 24-month European project that involved 30 countries. The project engaged over 1,500 stakeholders in co-creating future research agendas for the European Union. We discuss case study findings using Stilgoe, Owen, and Macnaghten’s (2013) framework and reflect on lessons learned for responsible IS research going forward

Distributed ISD Team Leadership and the Paradox of Cohesion and Conflict

Distributed ISD projects are often typified by deep-seated differences between team members from diverse organizational and professional backgrounds. Consequently, literature suggests that cohesion is crucial for aligning the efforts of a distributed ISD team; however, a competing body of literature also asserts that conflict is essential for capitalizing on diverse knowledge flows. Team leaders can therefore face a conundrum around how to balance the paradoxical need for both cohesion and conflict. In this paper, we develop a theoretical framework to analyze case study findings from the ‘CDSS project’, a distributed ISD project undertaken in an Intensive Care Unit (ICU). We find evidence that distributed ISD leaders must adopt a ‘paradox mindset’, one which embraces both cohesion and conflict. Based on these findings, we also put forward the concept of ‘leadership intelligence’ which describes the simultaneous enactment of a diverse set of leadership styles for balancing constructive cohesion and conflict

ΦCrAss001 represents the most abundant bacteriophage family in the human gut and infects Bacteroides intestinalis

peer-reviewedCrAssphages are an extensive and ubiquitous family of tailed bacteriophages, predicted to infect bacteria of the order Bacteroidales. Despite being found in ~50% of individuals and representing up to 90% of human gut viromes, members of this viral family have never been isolated in culture and remain understudied. Here, we report the isolation of a CrAssphage (ΦCrAss001) from human faecal material. This bacteriophage infects the human gut symbiont Bacteroides intestinalis, confirming previous in silico predictions of the likely host. DNA sequencing demonstrates that the bacteriophage genome is circular, 102 kb in size, and has unusual structural traits. In addition, electron microscopy confirms that ΦcrAss001 has a podovirus-like morphology. Despite the absence of obvious lysogeny genes, ΦcrAss001 replicates in a way that does not disrupt proliferation of the host bacterium, and is able to maintain itself in continuous host culture during several weeks