2,861 research outputs found
The Ethics of International Criminal ‘Lawfare’
Despite the expansive employment of the term to refer to appeals to law in ongoing conflict as a tool of war, this article demonstrates how ‘lawfare’ has taken on negative meaning without ethical justification. We argue that the co-opting of the term as a means of condemnation is unfair and potentially detrimental, and a more exacting definition and narrower use of the term are needed to avoid obfuscating potentially purposeful recourses to international law. In looking at how international criminal lawfare has manifested with referrals to the International Criminal Court (ICC), it becomes clear that problems of negative perceptions lie not with lawfare itself, but with the intentional perverting or obstructing of law by parties interested in the outcome of a conflict. Tackling these negative perceptions also lays the groundwork for a necessary future argument for the international community’s moral responsibility to promote safeguards to ensure that the international criminal legal system is itself just
Creativity and the computer nerd: an exploration of attitudes
This study arises from our concern that many of our best art and design students are failing to make the most of the opportunities provided by IT because of their fear or dislike of computers. This not only deprives them of useful skills, but, even more importantly, deprives many IT based developments of their input. In this paper we investigate the relationship between attitudes to creativity and to computers among students. We quickly discard an approach based on theories of personality types as philosophically and educationally problematic. An approach based on the self-concept of artists and designers, in relation to their own creativity and to their feelings about computers, offers more hope of progress. This means that we do not try to define the attributes of "creative people". Rather, we ask what creativity means to students of art and design and relate these responses to their attitudes to computers. Self-concept depends on how the subjects see themselves within society and culture, and is liable to change as culture changes. One major instrument of cultural change at the present time is the growth of IT itself. We then describe a first attempt at using a psychological method - Kelly's Repertory Grids - to investigate the self-concept of artists and designers. It is hoped to continue with this approach in further studies over the next few years
Conformal symmetry in non-local field theories
We have shown that a particular class of non-local free field theory has
conformal symmetry in arbitrary dimensions. Using the local field theory
counterpart of this class, we have found the Noether currents and Ward
identities of the translation, rotation and scale symmetries. The operator
product expansion of the energy-momentum tensor with quasi-primary fields is
also investigated.Comment: 15 pages, V2 (Some references added) V3(published version
Investigating the poor outcomes of BRAF - mutant advanced colorectal cancer: Analysis from 2530 patients in randomised clinical trials
Background: To improve strategies for the treatment of BRAF-mutant advanced colorectal cancer (aCRC) patients we examined individual data from patients treated with chemotherapy alone in three randomised trials to identify points on the treatment pathway where outcomes differ from BRAF wild-types. Patients and Methods: 2530 aCRC patients were assessed from three randomised trials. End-points were progression free survival (PFS), response rate (RR), disease control rate (DCR), post-progression survival (P-PS) and overall survival (OS). Treatments included first-line oxaliplatin/fluorouracil (OxFU), and second-line irinotecan. Clinicians were unaware of BRAF-status Results 231 patients (9.1%) had BRAF-mutant tumours. BRAF-mutation conferred significantly worse survival independent of associated clinicopathological factors known to be prognostic. Compared with wild-type, BRAF-mutant patients treated with first-line OxFU had similar DCR (59.2% vs 72%; adjusted OR=0.76,p=0.24) and PFS (5.7 vs 6.3 months; adjusted HR=1.14, p=0.26). Following progression on first-line chemotherapy, BRAF-mutant patients had a markedly shorter P-PS (4.2 vs 9.2 months, adjusted HR=1.69,p6 months; OS=24.0 months), however 36.5% progressed rapidly through first-line chemotherapy and thereafter, with OS=4.7 months. Conclusions BRAF-mutant aCRC confers a markedly worse prognosis independent of associated clinicopathological features. Chemotherapy provides meaningful improvements in outcome throughout treatment lines. Post-progression survival is markedly worse and vigilance is required to ensure appropriate delivery of treatment after first-line progression
Principles of crystal growth of intermetallic and oxide compounds from molten solutions
We present a tutorial on the principles of crystal growth of intermetallic
and oxide compounds from molten solutions, with an emphasis on the fundamental
principles governing the underlying phase equilibria and phase diagrams of
multicomponent systems.Comment: 43 pages, 24 figures; Philosophical Magazine, 201
Reticular formation responses to magnetic brain stimulation of primary motor cortex
Transcranial magnetic stimulation (TMS) of cerebral cortex is a popular technique for the non-invasive investigation of motor function. TMS is often assumed to influence spinal circuits solely via the corticospinal tract. We were interested in possible trans-synaptic effects of cortical TMS on the ponto-medullary reticular formation in the brainstem, which is the source of the reticulospinal tract and could also generate spinal motor output. We recorded from 210 single units in the reticular formation of three anaesthetized macaque monkeys whilst TMS was performed over primary motor cortex. Short latency responses were observed consistent with activation of a cortico-reticular pathway. However, we also demonstrated surprisingly powerful responses at longer latency, which often appeared at lower threshold than the earlier effects. These late responses seemed to be generated partly as a consequence of the sound click made by coil discharge, and changed little with coil location. This novel finding has implications for the design of future studies using TMS, as well as suggesting a means of non-invasively probing an otherwise inaccessible important motor centre
Mathematizing Darwin
Ernst Mayr called the first part of the evolutionary synthesis the ‘Fisherian synthesis’ on account of the dominant role played by R.A. Fisher in forging a mathematical theory of natural selection together with J.B.S. Haldane and Sewall Wright in the decade 1922–1932. It is here argued that Fisher’s contribution relied on a close reading of Darwin’s work to a much greater extent than did the contributions of Haldane and Wright, that it was synthetic in contrast to their analytic approach and that it was greatly influenced by his friendship with the Darwin family, particularly with Charles’s son Leonard
Dynamical system analysis and forecasting of deformation produced by an earthquake fault
We present a method of constructing low-dimensional nonlinear models
describing the main dynamical features of a discrete 2D cellular fault zone,
with many degrees of freedom, embedded in a 3D elastic solid. A given fault
system is characterized by a set of parameters that describe the dynamics,
rheology, property disorder, and fault geometry. Depending on the location in
the system parameter space we show that the coarse dynamics of the fault can be
confined to an attractor whose dimension is significantly smaller than the
space in which the dynamics takes place. Our strategy of system reduction is to
search for a few coherent structures that dominate the dynamics and to capture
the interaction between these coherent structures. The identification of the
basic interacting structures is obtained by applying the Proper Orthogonal
Decomposition (POD) to the surface deformations fields that accompany
strike-slip faulting accumulated over equal time intervals. We use a
feed-forward artificial neural network (ANN) architecture for the
identification of the system dynamics projected onto the subspace (model space)
spanned by the most energetic coherent structures. The ANN is trained using a
standard back-propagation algorithm to predict (map) the values of the observed
model state at a future time given the observed model state at the present
time. This ANN provides an approximate, large scale, dynamical model for the
fault.Comment: 30 pages, 12 figure
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