Research Opportunities in Nutrition and Metabolism in Space

The objectives of the Life Sciences Research Office (LSRO) study on nutrient requirements for meeting metabolic needs in manned space flights are as follows: review extant knowledge on the subject; identify significant gaps in knowledge; formulate suggestions for possible research; and produce a documented report of the foregoing items that can be used for program planning. In accordance with NASA's request for this study, the report focuses on issues of nutrition and metabolism that relate primarily to the contemplated United States Space Station, secondarily to the Shuttle Program as an orbital test bed for operational studies, and incidentally to scenarios for future long-term space flights. Members of the LSRO ad hoc Working Group on Nutrition and Metabolism were provided with pertinent articles and summaries on the subject. At the meeting of the Working Group, presentations were made by NASA Headquarters program staff on past experiences relative to space-flight nutrition and metabolism, as well as scenarios for future flights. The discussions of the ad hoc Working Group focused on the following: (1) metabolic needs related to work and exercise; (2) nutrients required to meet such needs; (3) food types, management, and records; and (4) nutritional amelioration or prevention of space-related physiological and behavioral changes

Propulsion Risk Reduction Activities for Non-Toxic Cryogenic Propulsion

The Propulsion and Cryogenics Advanced Development (PCAD) Project s primary objective is to develop propulsion system technologies for non-toxic or "green" propellants. The PCAD project focuses on the development of non-toxic propulsion technologies needed to provide necessary data and relevant experience to support informed decisions on implementation of non-toxic propellants for space missions. Implementation of non-toxic propellants in high performance propulsion systems offers NASA an opportunity to consider other options than current hypergolic propellants. The PCAD Project is emphasizing technology efforts in reaction control system (RCS) thruster designs, ascent main engines (AME), and descent main engines (DME). PCAD has a series of tasks and contracts to conduct risk reduction and/or retirement activities to demonstrate that non-toxic cryogenic propellants can be a feasible option for space missions. Work has focused on 1) reducing the risk of liquid oxygen/liquid methane ignition, demonstrating the key enabling technologies, and validating performance levels for reaction control engines for use on descent and ascent stages; 2) demonstrating the key enabling technologies and validating performance levels for liquid oxygen/liquid methane ascent engines; and 3) demonstrating the key enabling technologies and validating performance levels for deep throttling liquid oxygen/liquid hydrogen descent engines. The progress of these risk reduction and/or retirement activities will be presented

Far-Term Exploration of Advanced Single-Aisle Subsonic Transport Aircraft Concepts

Far-term single-aisle class aircraft concepts for potential entry-into-service of 2045 were investigated using an Interactive Reconfigurable Matrix of Alternatives (IRMA) approach. The configurations identified through this design space exploration were then distilled into three advanced aircraft concepts best characterizing the prominent features identified through the IRMA exploration. These three aircraft concepts were then configured and sized for a 150-passenger capacity and a 3,500 nautical mile design mission. Mission block fuel burn was estimated and compared to a far-term conventional configuration baseline concept and a 2005 l. These comparisons suggest considerable potential improvements in fuel efficiency from the investigated advanced concepts

USCID fourth international conference

Presented at the Role of irrigation and drainage in a sustainable future: USCID fourth international conference on irrigation and drainage on October 3-6, 2007 in Sacramento, California.Includes bibliographical references.While rice is produced in some parts of the world in an upland, rainfed culture, almost all US-produced rice is grown with flood irrigation. In the dry-seeding system commonly used in the midsouthern US, the crop is usually flooded at approximately the V-4 (early tillering) growth stage and a continuous flood is maintained until after heading. The total amount of water used in rice production is quite large, and soil, fertilizers, and pesticides can be carried in the runoff from agricultural fields. Flood depth affects most aspects of flooded rice production, and remote monitoring of the flood depth could be quite valuable to many producers. The objective of this research is to develop and test a system for monitoring water depths in rice fields and alerting the producer so that less labor and energy is required to efficiently manage flood-irrigated rice. A prototype monitoring station was designed to measure water depth in a flooded rice field and transmit the information over a wireless link. A similar sensor and circuit performed satisfactorily in a raingage in 2006. In 2007, prototype monitoring stations will be installed in production rice fields. Concurrently with sensor durability testing, tests will be conducted to determine the limits of the wireless communication system. With daily reports of the water status in each paddy, field visits can be reduced. Over-pumping should be minimized by allowing better scheduling of field visits to stop the pump, and future systems should work with automatic pump control systems to stop the pump before runoff occurs

Analysis of Turbofan Design Options for an Advanced Single-Aisle Transport Aircraft

The desire for higher engine efficiency has resulted in the evolution of aircraft gas turbine engines from turbojets, to low bypass ratio, first generation turbofans, to today's high bypass ratio turbofans. It is possible that future designs will continue this trend, leading to very-high or ultra-high bypass ratio (UHB) engines. Although increased bypass ratio has clear benefits in terms of propulsion system metrics such as specific fuel consumption, these benefits may not translate into aircraft system level benefits due to integration penalties. In this study, the design trade space for advanced turbofan engines applied to a single-aisle transport (737/A320 class aircraft) is explored. The benefits of increased bypass ratio and associated enabling technologies such as geared fan drive are found to depend on the primary metrics of interest. For example, bypass ratios at which fuel consumption is minimized may not require geared fan technology. However, geared fan drive does enable higher bypass ratio designs which result in lower noise. Regardless of the engine architecture chosen, the results of this study indicate the potential for the advanced aircraft to realize substantial improvements in fuel efficiency, emissions, and noise compared to the current vehicles in this size class

Real-Time Coral Stress Observations Before, During, and After Beach Nourishment Dredging Offshore SE Florida

Beach nourishment in Southeast Florida involves dredging sand source borrow areas located between offshore reefs. From May 2005 to February 2006 Broward County, FL. nourished 10.9 km of beach with 1.5 ×106 m3 of sand. As part of a program to monitor potential reef community impacts, a visual stress index was developed from laboratory experiments and histological analyses for three stony coral species (Montastrea cavernosa, Solenastrea bournoni, and Siderastrea siderea). Scoring involved healthy = 0; moderately stressed = 1 (polyp swelling, increased mucus); markedly stressed = 2 (coloration changes, increased mucus secretion, tissue thinning); and severely stressed = 3 (severe swelling/thinning tissue erosion/necrosis). Colonies were scored weekly at sites adjacent to borrow areas and control sites pre-, during, and post-dredging. Permit conditions were established which would suspend dredging based on mean stress index values above 1.5 at 50% of monitored sites adjacent to borrow areas. This condition was never met. However, three hurricanes, passing the region during dredging, contributed to an elevated mean stress level above 1.0. Post-dredging observations documented recovery to pre-dredging stress levels. This program was effectively used to monitor stress on a sensitive marine habitat adjacent to sediment dredging activities

Engine Concept Study for an Advanced Single-Aisle Transport

The desire for higher engine efficiency has resulted in the evolution of aircraft gas turbine engines from turbojets, to low bypass ratio, first generation turbofans, to today's high bypass ratio turbofans. Although increased bypass ratio has clear benefits in terms of propulsion system metrics such as specific fuel consumption, these benefits may not translate into aircraft system level benefits due to integration penalties. In this study, the design trade space for advanced turbofan engines applied to a single aisle transport (737/A320 class aircraft) is explored. The benefits of increased bypass ratio and associated enabling technologies such as geared fan drive are found to depend on the primary metrics of interest. For example, bypass ratios at which mission fuel consumption is minimized may not require geared fan technology. However, geared fan drive does enable higher bypass ratio designs which result in lower noise. The results of this study indicate the potential for the advanced aircraft to realize substantial improvements in fuel efficiency, emissions, and noise compared to the current vehicles in this size class

Refined Exploration of Turbofan Design Options for an Advanced Single-Aisle Transport

A comprehensive exploration of the turbofan engine design space for an advanced technology single-aisle transport (737/A320 class aircraft) was conducted previously by the authors and is documented in a prior report. Through the course of that study and in a subsequent evaluation of the approach and results, a number of enhancements to the engine design ground rules and assumptions were identified. A follow-on effort was initiated to investigate the impacts of these changes on the original study results. The fundamental conclusions of the prior study were found to still be valid with the revised engine designs. The most significant impact of the design changes was a reduction in the aircraft weight and block fuel penalties incurred with low fan pressure ratio, ultra-high bypass ratio designs. This enables lower noise levels to be pursued (through lower fan pressure ratio) with minor negative impacts on aircraft weight and fuel efficiency. Regardless of the engine design selected, the results of this study indicate the potential for the advanced aircraft to realize substantial improvements in fuel efficiency, emissions, and noise compared to the current vehicles in this size class

ETV6 germline mutations cause HDAC3/NCOR2 mislocalization and upregulation of interferon response genes

ETV6 is an ETS family transcription factor that plays a key role in hematopoiesis and megakaryocyte development. Our group and others have identified germline mutations in ETV6 resulting in autosomal dominant thrombocytopenia and predisposition to malignancy; however, molecular mechanisms defining the role of ETV6 in megakaryocyte development have not been well established. Using a combination of molecular, biochemical, and sequencing approaches in patient-derived PBMCs, we demonstrate abnormal cytoplasmic localization of ETV6 and the HDAC3/NCOR2 repressor complex that led to overexpression of HDAC3-regulated interferon response genes. This transcriptional dysregulation was also reflected in patient-derived platelet transcripts and drove aberrant proplatelet formation in megakaryocytes. Our results suggest that aberrant transcription may predispose patients with ETV6 mutations to bone marrow inflammation, dysplasia, and megakaryocyte dysfunction