Addressing present pitfalls in 3D printing for tissue engineering to enhance future potential

Additive manufacturing in tissue engineering has significantly advanced in acceptance and use to address complex problems. However, there are still limitations to the technologies used and potential challenges that need to be addressed by the community. In this manuscript, we describe how the field can be advanced not only through the development of new materials and techniques but also through the standardization of characterization, which in turn may impact the translation potential of the field as it matures. Furthermore, we discuss how education and outreach could be modified to ensure end-users have a better grasp on the benefits and limitations of 3D printing to aid in their career development

RQF publication quality measures: methodoligical issues

The Research Quality Framework uses Thomson-ISI citation benchmarks as its main set of objective measures of research quality. The Thomson-ISI measures rely on identifying a core set of journals in which the major publications for a discipline are to be found. The core for a discipline is determined by applying a nontransparent process that is partly based on Bradford&rsquo;s Law (1934). Yet Bradford was not seeking measures about quality of publications or journals. How valid then is it to base measures of publication quality on Bradford&rsquo;s Law? We explore this by returning to Bradford&rsquo;s Law and subsequent related research asking &lsquo;what is Bradford&rsquo;s Law really about?&rsquo; We go further, and ask &lsquo;does Bradford&rsquo;s Law apply in Information Systems?&rsquo; We use data from John Lamp&rsquo;s internationally respected Index of Information Systems Journals to explore the latter question. We have found that Information Systems may have a core of journals only a subset of which is also in the list of Thomson-ISI journals. There remain many unanswered questions about the RQF metrics based on Thomson-ISI and their applicability to information systems.<br /

RQF Publication Quality Measures: Methodological Issues

The Research Quality Framework uses Thomson-ISI citation benchmarks as its main set of objective measures of research quality. The Thomson-ISI measures rely on identifying a core set of journals in which the major publications for a discipline are to be found. The core for a discipline is determined by applying a nontransparent process that is partly based on Bradford’s Law (1934). Yet Bradford was not seeking measures about quality of publications or journals. How valid then is it to base measures of publication quality on Bradford’s Law? We explore this by returning to Bradford’s Law and subsequent related research asking ‘what is Bradford’s Law really about?’ We go further, and ask ‘does Bradford’s Law apply in Information Systems?’ We use data from John Lamp’s internationally respected Index of Information Systems Journals to explore the latter question. We have found that Information Systems may have a core of journals only a subset of which is also in the list of Thomson-ISI journals. There remain many unanswered questions about the RQF metrics based on Thomson-ISI and their applicability to information systems

Making Activated Carbon by Wet Pressurized Pyrolysis

A wet pressurized pyrolysis (wet carbonization) process has been invented as a means of producing activated carbon from a wide variety of inedible biomass consisting principally of plant wastes. The principal intended use of this activated carbon is room-temperature adsorption of pollutant gases from cooled incinerator exhaust streams. Activated carbon is highly porous and has a large surface area. The surface area depends strongly on the raw material and the production process. Coconut shells and bituminous coal are the primary raw materials that, until now, were converted into activated carbon of commercially acceptable quality by use of traditional production processes that involve activation by use of steam or carbon dioxide. In the wet pressurized pyrolysis process, the plant material is subjected to high pressure and temperature in an aqueous medium in the absence of oxygen for a specified amount of time to break carbon-oxygen bonds in the organic material and modify the structure of the material to obtain large surface area. Plant materials that have been used in demonstrations of the process include inedible parts of wheat, rice, potato, soybean, and tomato plants. The raw plant material is ground and mixed with a specified proportion of water. The mixture is placed in a stirred autoclave, wherein it is pyrolized at a temperature between 450 and 590 F (approximately between 230 and 310 C) and a pressure between 1 and 1.4 kpsi (approximately between 7 and 10 MPa) for a time between 5 minutes and 1 hour. The solid fraction remaining after wet carbonization is dried, then activated at a temperature of 500 F (260 C) in nitrogen gas. The activated carbon thus produced is comparable to commercial activated carbon. It can be used to adsorb oxides of sulfur, oxides of nitrogen, and trace amounts of hydrocarbons, any or all of which can be present in flue gas. Alternatively, the dried solid fraction can be used, even without the activation treatment, to absorb oxides of nitrogen

Therapy of pancreatic cancer via an EphA2 receptor-targeted delivery of gemcitabine.

First line treatment for pancreatic cancer consists of surgical resection, if possible, and a subsequent course of chemotherapy using the nucleoside analogue gemcitabine. In some patients, an active transport mechanism allows gemcitabine to enter efficiently into the tumor cells, resulting in a significant clinical benefit. However, in most patients, low expression of gemcitabine transporters limits the efficacy of the drug to marginal levels, and patients need frequent administration of the drug at high doses, significantly increasing systemic drug toxicity. In this article we focus on a novel targeted delivery approach for gemcitabine consisting of conjugating the drug with an EphA2 targeting agent. We show that the EphA2 receptor is highly expressed in pancreatic cancers, and accordingly, the drug-conjugate is more effective than gemcitabine alone in targeting pancreatic tumors. Our preliminary observations suggest that this approach may provide a general benefit to pancreatic cancer patients and offers a comprehensive strategy for enhancing delivery of diverse therapeutic agents to a wide range of cancers overexpressing EphA2, thereby potentially reducing toxicity while enhancing therapeutic efficacy

Ozone depletion and chlorine loading potentials

The recognition of the roles of chlorine and bromine compounds in ozone depletion has led to the regulation or their source gases. Some source gases are expected to be more damaging to the ozone layer than others, so that scientific guidance regarding their relative impacts is needed for regulatory purposes. Parameters used for this purpose include the steady-state and time-dependent chlorine loading potential (CLP) and the ozone depletion potential (ODP). Chlorine loading potentials depend upon the estimated value and accuracy of atmospheric lifetimes and are subject to significant (approximately 20-50 percent) uncertainties for many gases. Ozone depletion potentials depend on the same factors, as well as the evaluation of the release of reactive chlorine and bromine from each source gas and corresponding ozone destruction within the stratosphere

Trash to Supply Gas (TtSG) Project Overview

Technologies that reduce logistical needs are a key to long term space missions. Currently, trash and waste generated during a mission is carried during the entire roundtrip mission or stored inside a logistic module which is de-orbited into Earth's atmosphere for destruction. The goal of the Trash to Supply Gas (TtSG) project is to develop space technology alternatives for converting trash and other waste materials from human spaceflight into high-value products that might include propellants or power system fuels in addition to life support oxygen and water. In addition to producing a useful product from waste, TtSG will decrease the volume needed to store waste on long term space missions. This paper presents an overview of the TtSG technologies and future plans for the project

Ground State and Excitations of Disordered Boson Systems

After an introduction to the dirty bosons problem, we present a gaussian theory for the ground state and excitations. This approach is physically equivalent to the Bogoliubov approximation. We find that ODLRO can be destroyed with sufficient disorder. The density of states and localization of the elementary excitations are discussed. (To appear in JLTP Proceedings of the Conference on Condensed Bose Systems at the University of Minnesota, 1993.)Comment: 13 pages. (postscript file because of the figures inserted in the text.

Recruitment, growth and mortality of an Antarctic hexactinellid sponge, Anoxycalyx joubini.

Polar ecosystems are sensitive to climate forcing, and we often lack baselines to evaluate changes. Here we report a nearly 50-year study in which a sudden shift in the population dynamics of an ecologically important, structure-forming hexactinellid sponge, Anoxycalyx joubini was observed. This is the largest Antarctic sponge, with individuals growing over two meters tall. In order to investigate life history characteristics of Antarctic marine invertebrates, artificial substrata were deployed at a number of sites in the southern portion of the Ross Sea between 1967 and 1975. Over a 22-year period, no growth or settlement was recorded for A. joubini on these substrata; however, in 2004 and 2010, A. joubini was observed to have settled and grown to large sizes on some but not all artificial substrata. This single settlement and growth event correlates with a region-wide shift in phytoplankton productivity driven by the calving of a massive iceberg. We also report almost complete mortality of large sponges followed over 40 years. Given our warming global climate, similar system-wide changes are expected in the future