841 research outputs found
MAO-A and the EEG Recognition Memory Signal in Left Parietal Cortex
A key part of episodic memory, or memory for the events of our lives, is recognition memory. Recognition memory is the ability to remember previously encountered stimuli. Studies have linked recognition memory to the old/new effect, an EEG indicator of stimulus familiarity. Monoamine oxidase A (MAO-A) is an enzyme that catalyzes monoamines, leading to the depletion of norepinephrine, epinephrine, serotonin, and dopamine. MAO-A is more efficiently transcribed in individuals with a 4 repeating sequence variation (4R) of the MAO-A gene leading to less monoamine availability. As many of these monoamines have been linked to episodic memory, we hypothesized that individuals homozygous for the 4R MAO-A polymorphism would show differences in mean EEG signal amplitudes during recognition memory. EEG data was recorded as participants viewed both new words and words that had been previously presented. Our results show that mean peak amplitudes over the left parietal cortex 500-800 ms post-stimulus presentation for hits were greater than those for correct rejections, indicating the old/new effect. Critically, our results revealed an interaction between mean hit and correct rejection amplitude over the left parietal cortex and MAO-A group. Individuals homozygous for the 4R variation (the High MAO-A group) do not show an old/new effect due to increased correct rejection amplitudes. These results suggest that less monoamine availability leads to new stimuli being identified as old by the left parietal cortex
The reward value of infant facial cuteness tracks within-subject changes in women’s salivary testosterone
“Baby schema” refers to infant characteristics, such as facial cues, that
positively influence cuteness perceptions and trigger caregiving and protective
behaviors in adults. Current models of hormonal regulation of parenting
behaviors address how hormones may modulate protective behaviors and
nurturance, but not how hormones may modulate responses to infant
cuteness. To explore this issue, we investigated possible relationships
between the reward value of infant facial cuteness and within-woman changes
in testosterone, estradiol, and progesterone levels. Multilevel modeling of
these data showed that infant cuteness was more rewarding when women’s
salivary testosterone levels were high. Moreover, this within-woman effect of
testosterone was independent of the possible effects of estradiol and
progesterone and was not simply a consequence of changes in women’s
cuteness perceptions. These results suggest that testosterone may modulate
differential responses to infant facial cuteness, potentially revealing a new
route through which testosterone shapes selective allocation of parental
resources
Women’s facial attractiveness is related to their body mass index, but not their salivary cortisol
Objectives: Although many theories of human facial attractiveness propose positive correlations between facial attractiveness and measures of actual health, evidence for such correlations is somewhat mixed. Here we sought to replicate a recent study reporting that women’s facial attractiveness is independently related to both their adiposity and cortisol.
Methods: Ninety-six women provided saliva samples, which were analyzed for cortisol level, and their height and weight, which were used to calculate their body mass index (BMI). A digital face image of each woman was also taken under standardized photographic conditions and rated for attractiveness.
Results: There was a significant negative correlation between women’s facial attractiveness and BMI. By contrast, salivary cortisol and facial attractiveness were not significantly correlated.
Conclusions: Our results suggest that the types of health information reflected in women's faces include qualities that are indexed by BMI, but do not necessarily include qualities that are indexed by cortisol
Testing the utility of a data-driven approach for assessing BMI from face images
Several lines of evidence suggest that facial cues of adiposity may be important for human social interaction. However, tests for quantifiable cues of body mass index (BMI) in the face have examined only a small number of facial proportions and these proportions were found to have relatively low predictive power. Here we employed a data-driven approach in which statistical models were built using principal components (PCs) derived from objectively defined shape and color characteristics in face images. The predictive power of these models was then compared with models based on previously studied facial proportions (perimeter-to-area ratio, width-to-height ratio, and cheek-to-jaw width). Models based on 2D shape-only PCs, color-only PCs, and 2D shape and color PCs combined each performed significantly and substantially better than models based on one or more of the previously studied facial proportions. A non-linear PC model considering both 2D shape and color PCs was the best predictor of BMI. These results highlight the utility of a “bottom-up”, data-driven approach for assessing BMI from face images
General sexual desire, but not desire for uncommitted sexual relationships, tracks changes in women's hormonal status
Several recent longitudinal studies have investigated the hormonal correlates of both young adult women's general sexual desire and, more specifically, their desire for uncommitted sexual relationships. Findings across these studies have been mixed, potentially because each study tested only small samples of women (Ns = 43, 33, and 14). Here we report results from a much larger (N = 375) longitudinal study of hormonal correlates of young adult women's general sexual desire and their desire for uncommitted sexual relationships. Our analyses suggest that within-woman changes in general sexual desire are negatively related to progesterone, but are not related to testosterone or cortisol. We observed some positive relationships for estradiol, but these were generally only significant for solitary sexual desire. By contrast with our results for general sexual desire, analyses showed no evidence that changes in women’s desire for uncommitted sexual relationships are related to their hormonal status. Together, these results suggest that changes in hormonal status contribute to changes in women's general sexual desire, but do not influence women's desire for uncommitted sexual relationships
Are physiological and behavioral immune responses negatively correlated? Evidence from hormone-linked differences in men's face preferences
Behaviors that minimize exposure to sources of pathogens can carry opportunity costs. Consequently, how individuals resolve the tradeoff between the benefits and costs of behavioral immune responses should be sensitive to the extent to which they are vulnerable to infectious diseases. However, although it is a strong prediction of this functional flexibility principle, there is little compelling evidence that individuals with stronger physiological immune responses show weaker behavioral immune responses. Here we show that men with the combination of high testosterone and low cortisol levels, a hormonal profile recently found to be associated with particularly strong physiological immune responses, show weaker preferences for color cues associated with carotenoid pigmentation. Since carotenoid cues are thought to index vulnerability to infectious illnesses, our results are consistent with the functional flexibility principle's prediction that individuals with stronger physiological immune responses show weaker behavioral immune responses
Mate choice, mate preference, and biological markets : the relationship between partner choice and health preference is modulated by women's own attractiveness
Although much of the research on human mate preference assumes that mate preference and partner choice will be related to some extent, evidence for correlations between mate preference and mate choice is mixed. Inspired by biological market theories of mate choice, which propose that individuals with greater market value will be better placed to translate their preference into choice, we investigated whether participants' own attractiveness modulated the relationship between their preference and choice. Multilevel modeling showed that experimentally assessed preferences for healthy-looking other-sex faces predicted third-party ratings of partner's facial health better among women whose faces were rated as more attractive by third parties. This pattern of results was not seen for men. These results suggest that the relationship between mate preference and mate choice may be more complex than was assumed in previous research, at least among women. Our results also highlight the utility of biological market theories for understanding the links between mate preference and partner choice
Facial coloration tracks changes in women’s estradiol
Red facial coloration is an important social cue in many primate species, including humans. In such species, the vasodilatory effects ofestradiolmay cause red facial coloration to change systematically during females’ ovarian cycle. Although increased red facial coloration during estrus has been observed in female mandrills (Mandrillus sphinx) and rhesus macaques (Macaca mulatta), evidence linking primate facial color changes directly to changes in measured estradiol is lacking. Addressing this issue, we used alongitudinal designto demonstrate that red facial coloration tracks within-subject changes in women's estradiol, but not within-subject changes in women'sprogesteroneor estradiol-to-progesterone ratio. Moreover, the relationship between estradiol and facial redness was observed in two independent samples of women (N=50 andN=65). Our results suggest that changes in facial coloration may provide cues of women's fertility and present the first evidence for a direct link between estradiol and female facial redness in a primate species
A short-term multicenter analysis of radiolucent lines in a single uncemented rotating platform implant for total knee arthroplasty
BACKGROUND: Uncemented total knee arthroplasty is increasing as a potential solution for aseptic loosening via biologic fixation and to increase operative efficiency. However, postoperative radiolucent lines (RLLs) remain a concern for some clinicians. We report on a multicenter analysis of these RLLs over a 2-year period to identify their incidence, progression, and clinical significance.
MATERIAL AND METHODS: Institutional review board approval was obtained for this retrospective, multicenter case series. A total of 312 patients treated with a single cruciate-retaining, fully porous coated femoral and tibial component design were included in the study. All patients were evaluated clinically and radiographically in the early postoperative period and at final follow-up (average 2.0 years). Average age of the study group was 58.2 years, and average body mass index was 30.7. Of the total, 66% were male, and 34% were female. Two independent surgeons evaluated the radiographs at the initial postoperative visit and at the most recent follow-up for RLLs. Knee Society Scores and range of motion (ROM) were collected at each visit.
RESULTS: We identified RLLs in 25% of patients. All RLLs were less than 1 mm in size and located at the periphery of the tibial implant. None of the RLLs were progressive. At the final follow-up, compared with early postoperative imaging, no new RLLs were identified. Average ROM in flexion was 124 degrees, and the average Knee Society Scores at the most recent clinical follow-up was 96.
CONCLUSION: RLLs are commonly seen following cementless TKA, most commonly underneath the tibial tray. Based on this data set, there does not appear to be progression of these RLLs with time, and they do not appear to have an effect on ROM or clinical outcome at 2 years
http://wrap.warwick.ac.uk Original citation
Previous research suggests that people who score higher on measures of pathogen disgust demonstrate (1) stronger preferences for healthy individuals when assessing their facial attractiveness and (2) stronger negative attitudes about obese individuals. The relationship between pathogen disgust and attractiveness judgments of faces differing in cues of weight has yet to be investigated, however. Here we found that men's, but not women's, pathogen disgust was positively correlated with their preference for facial cues of lower weight. Moreover, this effect of pathogen disgust was independent of the possible effects of moral and sexual disgust. These data implicate pathogen disgust in individual differences in preferences for facial cues of weight, at least among men, and suggest that the sex-specific effects of pathogen disgust on preferences for facial cues of weight may be different to those previously reported for general negative attitudes about obese individuals
- …