2,591 research outputs found

    Alien Registration- Fisher, Anna G. (Island Falls, Aroostook County)

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    https://digitalmaine.com/alien_docs/34882/thumbnail.jp

    Poly(ADP-Ribose) Polymerase 1 Accelerates Single-Strand Break Repair in Concert with Poly(ADP-Ribose) Glycohydrolase

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    Single-strand breaks are the commonest lesions arising in cells, and defects in their repair are implicated in neurodegenerative disease. One of the earliest events during single-strand break repair (SSBR) is the rapid synthesis of poly(ADP-ribose) (PAR) by poly(ADP-ribose) polymerase (PARP), followed by its rapid degradation by poly(ADP-ribose) glycohydrolase (PARG). While the synthesis of poly(ADP-ribose) is important for rapid rates of chromosomal SSBR, the relative importance of poly(ADP-ribose) polymerase 1 (PARP-1) and PARP-2 and of the subsequent degradation of PAR by PARG is unclear. Here we have quantified SSBR rates in human A549 cells depleted of PARP-1, PARP-2, and PARG, both separately and in combination. We report that whereas PARP-1 is critical for rapid global rates of SSBR in human A549 cells, depletion of PARP-2 has only a minor impact, even in the presence of depleted levels of PARP-1. Moreover, we identify PARG as a novel and critical component of SSBR that accelerates this process in concert with PARP-1

    The effect of changing financial incentives on repartnering

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    This paper examines how a reduction in the financial resources available to lone parents affects repartnering. We exploit an Australian natural experiment that reduced the financial resources available to a subset of separating parents. Using biweekly administrative data capturing separations occurring among low and middle income couples, we show that the policy reform significantly increased the repartnering hazard for affected separating mothers, especially those with low labour force attachment. Reconciliation with the woman's prior partner drives this result. Complementary analysis of an annual panel survey demonstrates that repartnering impacts are also present over the five years post-separation and that the impact on repartnering hazards is increasing in the extent of financial loss and the urgency of the impact. Together, these results demonstrate that one way that lone mothers respond to a reduction in financial resources available at the time of relationship breakdown is by repartnering more quickly

    The Play in the System

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    What does artistic resistance look like in the twenty-first century, when disruption and dissent have been co-opted and commodified in ways that reinforce dominant systems? In The Play in the System Anna Watkins Fisher locates the possibility for resistance in artists who embrace parasitism—tactics of complicity that effect subversion from within hegemonic structures. Fisher tracks the ways in which artists on the margins—from hacker collectives like Ubermorgen to feminist writers and performers like Chris Kraus—have willfully abandoned the radical scripts of opposition and refusal long identified with anticapitalism and feminism. Space for resistance is found instead in the mutually, if unevenly, exploitative relations between dominant hosts giving only as much as required to appear generous and parasitical actors taking only as much as they can get away with. The irreverent and often troubling works that result raise necessary and difficult questions about the conditions for resistance and critique under neoliberalism today

    Case Study: Caregiver Perception of Pediatric Multidisciplinary Feeding Outpatient Clinic

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    This study explores the perception of satisfaction of caregivers who attended a feeding clinic at a large pediatric hospital in the midwest. The clinic is designed for a multidisciplinary team to meet with the child and the caregiver. Thirty-five participants were involved in the study. Results indicated that most participants were satisfied with the clinic experience. However, there were areas of care not covered by the members of the feeding team, which indicates a need. It is suggested that this need could be filled by occupational therapists

    Casimir interactions in Ising strips with boundary fields: exact results

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    An exact statistical mechanical derivation is given of the critical Casimir forces for Ising strips with arbitrary surface fields applied to edges. Our results show that the strength as well as the sign of the force can be controled by varying the temperature or the fields. An interpretation of the results is given in terms of a linked cluster expansion. This suggests a systematic approach for deriving the critical Casimir force which can be used in more general models.Comment: 10 pages, 4 figure

    Third Age Men's Experience of Fashion and Clothing: An Interpretative Phenomenological Analysis

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    This paper is set within the context of the current shift in focus around aging from an objective to a subjective stance, placing the emphasis on individuality (Bennett and Hodkinson; Powell and Gilbert) and resulting in the emergence and development of cultural gerontology. Human biographies have the potential to be interpreted through the relationships between personal and structural factors, and individual and collective experiences. Fashion and clothes, as communicators and mediators between self and society (Entwistle; Craik) can therefore be seen as key factors in understanding aging identities. Contemporary research on fashion and aging concentrates mainly on older women (Twigg). Whilst this research has told us much about how aging women experience fashion, it excludes the parallel considerations of aging men. This paper addresses this gap by presenting research that investigates how older men negotiate their aging bodies through the media of clothing and fashion. Data were collected via in-depth, semi-structured interviews with fve older men and were analyzed using Interpretative Phenomenological Analysis (IPA). The fndings reveal the experience of fashion and clothing of fve older men who, during their lives, have actively engaged with fashion, considered in the contexts of time, space, and “others” (Kaiser)

    Distribution of ions near a charged selective surface in critical binary solvents

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    Near-critical binary mixtures containing ionic solutes near a charged wall preferentially adsorbing one component of the solvent are studied. Within the Landau-Ginzburg approach extended to include electrostatic interactions and the chemical preference of ions for one component of the solvent, we obtain a simple form for the leading-order correction to the Debye-Huckel theory result for the charge density profile. Our result shows that critical adsorption influences significantly distribution of ions near the wall. This effect may have important implications for the screening of electrostatic interactions between charged surfaces immersed in binary near-critical solvents.Comment: 24 pages, 3 figure

    Supported accommodation evaluation framework (SAEF) guide

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    High hopes for the NDIS are that people with disability will be able to live as independently as they choose, with the housing of their choice, and with the paid support that suits their preferences and life goals. Research conducted by the Social Policy Research Centre for the NSW government about disability housing support that is like the NDIS found that most people did achieve some positive outcomes. Least change was evident in people’s interpersonal relationships and employment, and some people did not live in housing that met their needs.&nbsp
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