How European cardiologists perceive the role of calcium antagonists in follow-up after myocardial infarction

About one hundred European cardiologists discussed the role of calcium antagonists in the follow-up management of myocardial infarction, β-blockers are the treatment of choice. Where these are contra-indicated or otherwise unsuitable, many clinicians would use a non-dihydropyridine calcium antagonist alone or in combination with an ACE inhibitor. There is broad agreement that calcium antagonists should not be used in patients with concomitant left ventricular failure. Cholesterol estimation in post-infarction patients is essentia

Gaussian excitations model for glass-former dynamics and thermodynamics

We describe a model for the thermodynamics and dynamics of glass-forming liquids in terms of excitations from an ideal glass state to a Gaussian manifold of configurationally excited states. The quantitative fit of this three parameter model to the experimental data on excess entropy and heat capacity shows that ``fragile'' behavior, indicated by a sharply rising excess heat capacity as the glass transition is approached from above, occurs in anticipation of a first-order transition -- usually hidden below the glass transition -- to a ``strong'' liquid state of low excess entropy. The dynamic model relates relaxation to a hierarchical sequence of excitation events each involving the probability of accumulating sufficient kinetic energy on a separate excitable unit. Super-Arrhenius behavior of the relaxation rates, and the known correlation of kinetic with thermodynamic fragility, both follow from the way the rugged landscape induces fluctuations in the partitioning of energy between vibrational and configurational manifolds. A relation is derived in which the configurational heat capacity, rather than the configurational entropy of the Adam Gibbs equation, controls the temperature dependence of the relaxation times, and this gives a comparable account of the experimental observations.Comment: 21 pp., 17 fig

The Spectral Energy Distributions of White Dwarfs in 47 Tucanae: The Distance to the Cluster

We present a new distance determination to the Galactic globular cluster 47 Tucanae by fitting the spectral energy distributions of its white dwarfs to pure hydrogen atmosphere white dwarf models. Our photometric dataset is obtained from a 121 orbit Hubble Space Telescope program using the Wide Field Camera 3 UVIS/IR channels, capturing F390W, F606W, F110W, and F160W images. These images cover more than 60 square arcmins and extend over a radial range of 5-13.7 arcmin (6.5-17.9 pc) within the globular cluster. Using a likelihood analysis, we obtain a best fitting unreddened distance modulus of (m - M)o=13.36+/-0.02+/-0.06 corresponding to a distance of 4.70+/-0.04+/-0.13 kpc, where the first error is random and the second is systematic. We also search the white dwarf photometry for infrared excess in the F160W filter, indicative of debris disks or low mass companions, and find no convincing cases within our sample.Comment: Accepted to The Astronomical Journal, 13 Figures, 2 Tables. Figures 3 and 6 are figure sets, each composed of 59 subfigures (to appear in the electronic journal). This is a Companion paper to the article ID: submit/037561

Soft Interaction Between Dissolved Dendrimers: Theory and Experiment

Using small-angle neutron scattering and liquid integral equation theory, we relate the structure factor of flexible dendrimers of 4th generation to their average shape. The shape is measured as a radial density profile of monomers belonging to a single dendrimer. From that, we derive an effective interaction of Gaussian form between pairs of dendrimers and compute the structure factor using the hypernetted chain approximation. Excellent agreement with the corresponding experimental results is obtained, without the use of adjustable parameters. The present analysis thus strongly supports the previous finding that flexible dendrimers of low generation present fluctuating structures akin to star polymers.Comment: 20 pages, 4 figures, submitted to Macromolecules on July 24, 200

HAT-P-16b: A 4 Mj Planet Transiting A Bright Star On An Eccentric Orbit

We report the discovery of HAT-P-16b, a transiting extrasolar planet orbiting the V = 10.8 mag F8 dwarf GSC 2792-01700, with a period P = 2.775960 +- 0.000003 d, transit epoch Tc = 2455027.59293 +- 0.00031 (BJD), and transit duration 0.1276 +- 0.0013 d. The host star has a mass of 1.22 +- 0.04 Msun, radius of 1.24 +- 0.05 Rsun, effective temperature 6158 +-80 K, and metallicity [Fe/H] = +0.17 +- 0.08. The planetary companion has a mass of 4.193 +- 0.094 MJ, and radius of 1.289 +- 0.066 RJ yielding a mean density of 2.42 +- 0.35 g/cm3. Comparing these observed characteristics with recent theoretical models, we find that HAT-P-16b is consistent with a 1 Gyr H/He-dominated gas giant planet. HAT-P-16b resides in a sparsely populated region of the mass{radius diagram and has a non-zero eccentricity of e = 0.036 with a significance of 10 sigma.Comment: Submitted to Ap

Spin-orbit Scattering and the Kondo Effect

The effects of spin-orbit scattering of conduction electrons in the Kondo regime are investigated theoretically. It is shown that due to time-reversal symmetry, spin-orbit scattering does not suppress the Kondo effect, even though it breaks spin-rotational symmetry, in full agreement with experiment. An orbital magnetic field, which breaks time-reversal symmetry, leads to an effective Zeeman splitting, which can be probed in transport measurements. It is shown that, similar to weak-localization, this effect has anomalous magnetic field and temperature dependence.Comment: 10 pages, RevTex, one postscript figure available on request from [email protected]

Ferroelectric and Dipolar Glass Phases of Non-Crystalline Systems

In a recent letter [Phys. Rev. Lett. {\bf 75}, 2360 (1996)] we briefly discussed the existence and nature of ferroelectric order in positionally disordered dipolar materials. Here we report further results and give a complete description of our work. Simulations of randomly frozen and dynamically disordered dipolar soft spheres are used to study ferroelectric ordering in non-crystalline systems. We also give a physical interpretation of the simulation results in terms of short- and long-range interactions. Cases where the dipole moment has 1, 2, and 3 components (Ising, XY and XYZ models, respectively) are considered. It is found that the Ising model displays ferroelectric phases in frozen amorphous systems, while the XY and XYZ models form dipolar glass phases at low temperatures. In the dynamically disordered model the equations of motion are decoupled such that particle translation is completely independent of the dipolar forces. These systems spontaneously develop long-range ferroelectric order at nonzero temperature despite the absence of any fined-tuned short-range spatial correlations favoring dipolar order. Furthermore, since this is a nonequilibrium model we find that the paraelectric to ferroelectric transition depends on the particle mass. For the XY and XYZ models, the critical temperatures extrapolate to zero as the mass of the particle becomes infinite, whereas, for the Ising model the critical temperature is almost independent of mass and coincides with the ferroelectric transition found for the randomly frozen system at the same density. Thus in the infinite mass limit the results of the frozen amorphous systems are recovered.Comment: 25 pages (LATEX, no macros). 11 POSTSCRIPT figures enclosed. Submitted to Phisical Review E. Contact: [email protected]

Phase behavior and material properties of hollow nanoparticles

Effective pair potentials for hollow nanoparticles like the ones made from carbon (fullerenes) or metal dichalcogenides (inorganic fullerenes) consist of a hard core repulsion and a deep, but short-ranged, van der Waals attraction. We investigate them for single- and multi-walled nanoparticles and show that in both cases, in the limit of large radii the interaction range scales inversely with the radius, $R$, while the well depth scales linearly with $R$. We predict the values of the radius $R$ and the wall thickness $h$ at which the gas-liquid coexistence disappears from the phase diagram. We also discuss unusual material properties of the solid, which include a large heat of sublimation and a small surface energy.Comment: Revtex, 13 pages with 8 Postscript files included, submitted to Phys. Rev.

Communication: theoretical prediction of free-energy landscapes for complex self-assembly.

We present a technique for calculating free-energy profiles for the nucleation of multicomponent structures that contain as many species as building blocks. We find that a key factor is the topology of the graph describing the connectivity of the target assembly. By considering the designed interactions separately from weaker, incidental interactions, our approach yields predictions for the equilibrium yield and nucleation barriers. These predictions are in good agreement with corresponding Monte Carlo simulations. We show that a few fundamental properties of the connectivity graph determine the most prominent features of the assembly thermodynamics. Surprisingly, we find that polydispersity in the strengths of the designed interactions stabilizes intermediate structures and can be used to sculpt the free-energy landscape for self-assembly. Finally, we demonstrate that weak incidental interactions can preclude assembly at equilibrium due to the combinatorial possibilities for incorrect association.W.M.J. acknowledges support from the Gates Cambridge Trust and the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1143678. D.F. acknowledges European Research Council Advanced Grant No. 227758 and Engineering and Physical Sciences Research Council Programme Grant No. EP/I001352/1. Research carried out in part at the Center for Functional Nanomaterials, Brookhaven National Laboratory, which is supported by the U.S. Department of Energy, Office of Basic Energy Sciences, under Contract No. DE-AC02-98CH10886.This is the accepted manuscript. Copyright (2015) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in The Journal of Chemical Physics 142, 021101 (2015) and may be found at http://doi.org/10.1063/1.490567