12 research outputs found
Ligonių, kuriems atlikta aortokoronarinių jungčių suformavimo operacija (AKJO), reabilitacijos efektyvumas
Phosphorus pentoxide supported on silica gel and alumina (P2O5/SiO2, P2O5/Al2O3) as useful catalysts in organic synthesis
1,4-Dihydroxyanthraquinone-copper(II) nanoparticles immobilized on silica gel: a highly efficient, copper scavenger and recyclable heterogeneous nanocatalyst for a click approach to the three-component synthesis of 1,2,3-triazole derivatives in water
Base and Catalyst-Free Preparation of Silyl Ethers in the Choline Chloride/Urea Deep Eutectic Solvent (DES)
H3PMo12O40 Heteropolyacid: A Versatile and Efficient Bifunctional Catalyst for the Oxidation and Esterification Reactions
Angiotensin-converting enzyme gene variants are associated with both cortisol secretion and late-life depression
Highly stable chromium(III) terephthalate metal organic framework (MIL-101) encapsulated 12-tungstophosphoric heteropolyacid as a water-tolerant solid catalyst for hydrolysis and esterification
The renin-angiotensin system: a possible new target for depression
Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin-angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways related to neurodevelopment and regulation of the stress response. Studies of drugs targeting the renin-angiotensin system have yielded promising results. Here, we review the potential beneficial effects of angiotensin blockers in depression and their mechanisms of action. Drugs blocking the angiotensin system have efficacy in several animal models of depression. While no randomised clinical trials were found, case reports and observational studies showed that angiotensin-converting enzyme inhibitors or angiotensin receptor blockers had positive effects on depression, whereas other antihypertensive agents did not. Drugs targeting the renin-angiotensin system act on inflammatory pathways implicated in depression. Both preclinical and clinical data suggest that these drugs possess antidepressant properties. In light of these results, angiotensin system-blocking agents offer new horizons in mood disorder treatment