A middleware approach to achieving fault-tolerance of Kahn process networks on networks-on-chips.

Kahn process networks (KPNs) is a distributed model of computation used for describing systems where streams of data are transformed by processes executing in sequence or parallel. Autonomous processes communicate through unbounded FIFO channels in absence of a global scheduler. In this work, we propose a task-aware middleware concept that allows adaptivity in KPN implemented over a Network on Chip (NoC). We also list our ideas on the development of a simulation platform as an initial step towards creating fault tolerance strategies for KPNs applications running on NoCs. In doing that, we extend our SACRE (Self-Adaptive Component Run Time Environment) framework by integrating it with an open source NoC simulator, Noxim. We evaluate the overhead that the middleware brings to the the total execution time and to the total amount of data transferred in the NoC. With this work, we also provide a methodology that can help in identifying the requirements and implementing fault tolerance and adaptivity support on real platforms

Avaliação da tolerância de acesso do gênero Paspalum ao sombreamento.

Editado por Ana Rita de Araújo Nogueira, Simone Cristina Meo Niciura

Seasonality of soil water exchange in the soybean growing season in southern Brazil

The processes of water transfer in the soil-plant-atmosphere system are strongly affected by soil use and management. Differences in the dynamics of soil water transfer between no-tillage (NT) and conventional tillage (CT) practices during a soybean (Glycine max) growing season in southern Brazil were assessed in this study. All the water balance components were analyzed during the soybean growing season (2009/2010). Rainfall, runoff, soil water storage and hydro-physical soil properties were analyzed under two tillage systems. The land-atmosphere water vapor exchanges, obtained from eddy covariance stations, were analyzed with regard to the soybean agroecosystem. Characterizations of soil water storage were also formulated in the 2006/2007 and 2008/2009 soybean growing seasons under the NT system. During the periods without rain, the soil water content under NT was greater than under CT. The soil superficial layer, more porous under NT, contributed to less runoff during rainy events. Moreover, under NT conditions the water supply was always high, between 0.2 - 0.5 m. The total evapotranspiration in the soybean agroecosystem growing season was 410.8 mm

Driving calmodulin protein towards conformational shift by changing ionization states of select residues

Proteins are complex systems made up of many conformational sub-states which are mainly determined by the folded structure. External factors such as solvent type, temperature, pH and ionic strength play a very important role in the conformations sampled by proteins. Here we study the conformational multiplicity of calmodulin (CaM) which is a protein that plays an important role in calcium signaling pathways in the eukaryotic cells. CaM can bind to a variety of other proteins or small organic compounds, and mediates different physiological processes by activating various enzymes. Binding of calcium ions and proteins or small organic molecules to CaM induces large conformational changes that are distinct to each interacting partner. In particular, we discuss the effect of pH variation on the conformations of CaM. By using the pKa values of the charged residues as a basis to assign protonation states, the conformational changes induced in CaM by reducing the pH are studied by molecular dynamics simulations. Our current view suggests that at high pH, barrier crossing to the compact form is prevented by repulsive electrostatic interactions between the two lobes. At reduced pH, not only is barrier crossing facilitated by protonation of residues, but also conformations which are on average more compact are attained. The latter are in accordance with the fluorescence resonance energy transfer experiment results of other workers. The key events leading to the conformational change from the open to the compact conformation are (i) formation of a salt bridge between the N-lobe and the linker, stabilizing their relative motions, (ii) bending of the C-lobe towards the N-lobe, leading to a lowering of the interaction energy between the two-lobes, (iii) formation of a hydrophobic patch between the two lobes, further stabilizing the bent conformation by reducing the entropic cost of the compact form, (iv) sharing of a Ca+2 ion between the two lobes

Análise do Fluxo de Co2 sobre uma Cultura de Soja

Análise do fluxo de CO2 sobre uma cultura de soj

Changes in the biochemical and immunological components of serum and colostrum of overweight and obese mothers

Abstract\ud \ud Background\ud Obesity in pregnancy is associated with systemic inflammation, immunological changes and adverse maternal-fetal outcomes. Information on the association between maternal obesity and breast milk composition is scarce. This study describes changes and relationships between biochemical and immunological parameters of colostrum and serum of overweight and obese women.\ud \ud \ud Methods\ud Colostrum and blood samples were collected from 25 normal weight, 24 overweight and 19 obese women for determination of glucose, total protein, triglycerides, cholesterol, immunoglobulins, complement proteins (C3 and C4), fat and calorie content and C-reactive protein (CRP).\ud \ud \ud Results\ud Glucose was higher in colostrum of obese women (p = .002). In normal weight and obese women, total protein content was higher in colostrum than in serum (p = .001). Serum triglycerides (p = .008) and cholesterol (p = .010) concentrations were significantly higher in overweight and obese women than in their normal weight counterparts, but in colostrum their concentrations were similar across the three groups. Secretory IgA (sIgA) in colostrum and IgA in serum concentrations were significantly higher (p = .001) in overweight and obese mothers, whereas IgG and IgM concentrations did not vary among the groups (p = .825). Serum C3 (p = .001) and C4 (p = .040) concentrations were higher in obese women. No differences in colostrum complement proteins were detected among the groups. Calorie content (p = .003) and fat (p = .005) concentrations in colostrum and serum CRP (p = .002) were higher in obese women.\ud \ud \ud Conclusions\ud The results corroborate the hypothesis that colostrum of overweight and obese women undergoes biochemical and immunological changes that affect its composition, namely increasing glucose concentrations, calorie content, fat and sIgA concentrations.Fundação de Amparo a Pesquisa de São Paulo (FAPESP-No 2012-17843-8; No 2012-16662-0)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq-No 308702/2013-1; No 475238/2013-3

Implications of the three-dimensional chromatin organization for genome evolution in a fungal plant pathogen

The spatial organization of eukaryotic genomes is linked to their biological functions, although it is not clear how this impacts the overall evolution of a genome. Here, we uncover the three-dimensional (3D) genome organization of the phytopathogen Verticillium dahliae, known to possess distinct genomic regions, designated adaptive genomic regions (AGRs), enriched in transposable elements and genes that mediate host infection. Short-range DNA interactions form clear topologically associating domains (TADs) with gene-rich boundaries that show reduced levels of gene expression and reduced genomic variation. Intriguingly, TADs are less clearly insulated in AGRs than in the core genome. At a global scale, the genome contains bipartite long-range interactions, particularly enriched for AGRs and more generally containing segmental duplications. Notably, the patterns observed for V. dahliae are also present in other Verticillium species. Thus, our analysis links 3D genome organization to evolutionary features conserved throughout the Verticillium genus

Produção de forragem de populações de azevém anual em diferentes ambientes do Rio Grande do Sul.

O azevém anual (Lolium multiflorum Lam.) é uma das forrageiras mais utilizadas no RS durante o período frio do ano, seja na sobressemeadura em campos naturais, ou na formação de pastagens cultivadas. Porém, existem poucas cultivares registradas no Brasil. Assim, o objetivo do trabalho foi avaliar, em diferentes ambientes, algumas populações de azevém anual, visando a seleção de genótipos que apresentem um elevado potencial produtivo e o futuro lançamento de cultivares. Foram avaliadas sete populações, sendo comparadas com uma população comercial e com o cultivar LE-284. O experimento foi implantado em cinco diferentes regiões fisiográficas do RS e as variáveis analisadas foram produção de MS Total e produção de MS de Folhas, sendo procedida uma análise estatística conjunta para locais. A análise estatística indicou como significativa a interação local x população tanto para MS Total quanto para MS Folhas. A produção de MS Total não diferiu muito entre as populações na maioria dos locais. Porém, em alguns deles, a população Vacaria e o cultivar LE-284 apresentaram-se com produções inferiores. Por outro lado, as populações Trovão e Sarandi foram as melhores em Augusto Pestana e Eldorado do Sul, respectivamente. Quanto a produção de MS Folhas, a população comercial Comum-RS figurou entre as menos produtivas em todos os locais, exceto em São Gabriel, em função da sua maior precocidade reprodutiva