TOWERS: T-One with Enhanced Robustness and Speed: TOWERS

A new T1 mapping method is proposed that is accurate, rapid and robust to motion. Considering these features, the method is dubbed “T-One with Enhanced Robustness and Speed (TOWERS)”

Age related diffusion and tractography changes in typically developing pediatric cervical and thoracic spinal cord

Background and objective: Diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) are two techniques that can measure white matter integrity of the spinal cord. Recently, DTI indices have been shown to change with age. The purpose of this study is (a) to evaluate the maturational states of the entire pediatric spinal cord using DTI and DTT indices including fractional anisotropy (FA), mean diffusivity (MD), mean length of white matter fiber tracts and tract density and (b) to analyze the DTI and DTT parameters along the entire spinal cord as a function of spinal cord levels and age. Method: A total of 23 typically developing (TD) pediatric subjects ranging in age from 6 to 16 years old (11.94 ± 3.26 (mean ± standard deviation), 13 females and 10 males) were recruited, and scanned using 3.0 T MR scanner. Reduced FOV diffusion tensor images were acquired axially in the same anatomical location prescribed for the T2-weighted images to cover the entire spinal cord (C1-mid L1 levels). To mitigate motion induced artifacts, diffusion directional images were aligned with the reference image (b0) using a rigid body registration algorithm performed by in-house software developed in Matlab (MathWorks, Natick, Massachusetts). Diffusion tensor maps (FA and MD) and streamline deterministic tractography were then generated from the motion corrected DTI dataset. DTI and DTT parameters were calculated by using ROIs drawn to encapsulate the whole cord along the entire spinal cord by an independent board certified neuroradiologist. These indices then were compared between two age groups (age group A = 6–11 years (n = 11) and age group B = 12–16 years (n = 12)) based on similar standards and age definitions used for reporting spinal cord injury in the pediatric population. Standard least squared linear regression based on a restricted maximum likelihood (REML) method was used to evaluate the relationship between age and DTI and DTT parameters. Results: An increase in FA (group A = 0.42 ± 0.097, group B = 0.49 ± 0.116), white matter tract density (group A = 368.01 ± 236.88, group B = 440.13 ± 245.24) and mean length of fiber tracts (group A = 48.16 ± 20.48 mm, group B = 60.28 ± 23.87 mm) and a decrease in MD (group A = 1.06 ± 0.23 × 10−3 mm2/s, group B = 0.82 ± 0.24 × 10−3 mm2/s) were observed with age along the entire spinal cord. Statistically significant increases have been shown in FA (p = 0.004, R2 = 0.57), tract density (p = 0.0004, R2 = 0.58), mean length of fiber tracts (p \u3c 0.001, R2 = 0.5) and a significant decrease has been shown in MD (p = 0.002, R2 = 0.59) between group A and group B. Also, it has been shown DTI and DTT parameters vary along the spinal cord as a function of intervertebral disk and mid-vertebral body level. Conclusion: This study provides an initial understanding of age related changes of DTI values as well as DTT metrics of the spinal cord. The results show significant differences in DTI and DTT parameters which may result from decreasing water content, myelination of fiber tracts, and the thickening diameter of fiber tracts during the maturation process. Consequently, when quantitative DTI and DTT of the spinal cord is undertaken in the pediatric population an age and level matched normative dataset should be used to accurately interpret the quantitative results. © 201

Oxide‐Based Solid‐State Batteries: A Perspective on Composite Cathode Architecture

The garnet-type phase Li$_7$La$_3$Zr$_2$O$_{12}$ (LLZO) attracts significant attention as an oxide solid electrolyte to enable safe and robust solid-state batteries (SSBs) with potentially high energy density. However, while significant progress has been made in demonstrating compatibility with Li metal, integrating LLZO into composite cathodes remains a challenge. The current perspective focuses on the critical issues that need to be addressed to achieve the ultimate goal of an all-solid-state LLZO-based battery that delivers safety, durability, and pack-level performance characteristics that are unobtainable with state-of-the-art Li-ion batteries. This perspective complements existing reviews of solid/solid interfaces with more emphasis on understanding numerous homo- and heteroionic interfaces in a pure oxide-based SSB and the various phenomena that accompany the evolution of the chemical, electrochemical, structural, morphological, and mechanical properties of those interfaces during processing and operation. Finally, the insights gained from a comprehensive literature survey of LLZO–cathode interfaces are used to guide efforts for the development of LLZO-based SSBs

Improving T2*-weighted human cortico-spinal acquisitions with a dedicated algorithm for region-wise shimming

Cortico-spinal fMRI acquisitions aim to investigate direct interactions between brain and spinal cord, e.g. during motor output or pain processing, by covering both regions in a single measurement. Due to their large distance and location in the body, a dynamic shim update of constant and linear shim terms is required when using echo-planar imaging (EPI) to achieve reasonable image quality in both target regions. A previously presented approach with region-wise shim settings is based on a standard single-region shim algorithm and suffers from (i) non-optimal shim settings because it combines linear and second-order shim terms optimized for different volumes, and (ii) significant user interactions making it rather cumbersome, time consuming, and error-prone. Here, a dedicated (“CoSpi”) shim algorithm for cortico-spinal fMRI is presented that performs joint optimization of static second-order shim terms and one set of linear and constant shim terms for each region in a single run and with minimal user interaction. Field map and T2*-weighted EPI measurements were performed on a clinical 3 T whole-body MR system in water phantoms and five healthy volunteers using the conventional region-wise and CoSpi shim settings as well as “gold standard” shim settings optimized for one of the target regions only. With CoSpi shim settings, (i) overall field inhomogeneity was reduced by about 65% / 75% (brain / spinal cord volume) compared to the conventional region-wise approach and in vivo was within 5% of the values obtained with the single-volume shim settings, (ii) geometric distortions derived from voxel displacement maps were reduced on average by about 35% / 70%, (iii) the temporal SNR determined from an EPI time series that may reflect the impact of through-slice dephasing, was increased by about 17% / 10%, and (iv) the variation of the mean field between slices, a measure targeting the predisposition to insufficient fat saturation and GRAPPA-related ghosting artifacts, was reduced by about 90% / 45%. Thus, the presented algorithm not only speeds up and simplifies the shim procedure considerably, but also provides a better field homogeneity and image quality, which both could help to significantly improve the applicability of cortico-spinal fMRI

Separate amygdala subregions signal surprise and predictiveness during associative fear learning in humans

It has recently been suggested that learning signals in the amygdala might be best characterized by attentional theories of associative learning [such as Pearce-Hall (PH)] and more recent hybrid variants that combine Rescorla-Wagner and PH learning models. In these models, unsigned prediction errors (PEs) determine the associability of a cue, which is used in turn to control learning of outcome expectations dynamically and reflects a function of the reliability of prior outcome predictions. Here, we employed an aversive Pavlovian reversal-learning task to investigate computational signals derived from such a hybrid model. Unlike previous accounts, our paradigm allowed for the separate assessment of associability at the time of cue presentation and PEs at the time of outcome. We combined this approach with high-resolution functional magnetic resonance imaging to understand how different subregions of the human amygdala contribute to associative learning. Signal changes in the corticomedial amygdala and in the midbrain represented unsigned PEs at the time of outcome showing increased responses irrespective of whether a shock was unexpectedly administered or omitted. In contrast, activity in basolateral amygdala regions correlated negatively with associability at the time of cue presentation. Thus, whereas the corticomedial amygdala and the midbrain reflected immediate surprise, the basolateral amygdala represented predictiveness and displayed increased responses when outcome predictions became more reliable. These results extend previous findings on PH-like mechanisms in the amygdala and provide unique insights into human amygdala circuits during associative learning

Microstructural and mechanical characterization of Na1+xHf2Si2.3P0.7O10.85+0.5x and Na1+xZr2P3-xSixO12 NASICON-type solid electrolytes

NASICON-type solid electrolytes are promising materials for novel solid-state-batteries aiming toward high energy densities. Na1+xHf2Si2.3P0.7O10.85+0.5x with varying sodium content as well as Sc- or Mg-doped and undoped Na1+xZr2P3-xSixO12 were synthesized by solution-assisted solid-state reaction. Microstructural and mechanical characteristics as well as conductivities were investigated. The electrochemical and microstructural properties of all studied materials appear to be highly affected by the sodium content glassy phase and secondary phase formation as well as bloating. The mechanical properties of the specimens depend mainly on microstructural characteristics. Our findings indicate improved mechanical behavior is achieved when bloating and secondary phase formation are inhibited. However, possible influences of glassy phase content on the material properties need to be further investigated