The Sensitivity of Auditory-Motor Representations to Subtle Changes in Auditory Feedback While Singing

Singing requires accurate control of the fundamental frequency (F0) of the voice. This study examined trained singers’ and untrained singers’ (nonsingers’) sensitivity to subtle manipulations in auditory feedback and the subsequent effect on the mapping between F0 feedback and vocal control. Participants produced the consonant-vowel /ta/ while receiving auditory feedback that was shifted up and down in frequency. Results showed that singers and nonsingers compensated to a similar degree when presented with frequency-altered feedback (FAF); however, singers’ F0 values were consistently closer to the intended pitch target. Moreover, singers initiated their compensatory responses when auditory feedback was shifted up or down 6 cents or more, compared to nonsingers who began compensating when feedback was shifted up 26 cents and down 22 cents. Additionally, examination of the first 50 ms of vocalization indicated that participants commenced subsequent vocal utterances, during FAF, near the F0 value on previous shift trials. Interestingly, nonsingers commenced F0 productions below the pitch target and increased their F0 until they matched the note. Thus, singers and nonsingers rely on an internal model to regulate voice F0, but singers’ models appear to be more sensitive in response to subtle discrepancies in auditory feedback

A PC parallel port button box provides millisecond response time accuracy under Linux

For psychologists, it is sometimes necessary to measure people's reaction times to the nearest millisecond. This article describes how to use the PC parallel port to receive signals from a button box to achieve millisecond response time accuracy. The workings of the parallel port, the corresponding port addresses, and a simple Linux program for controlling the port are described. A test of the speed and reliability of button box signal detection is reported. If the reader is moderately familiar with Linux, this article should provide sufficient instruction for him or her to build and test his or her own parallel port button box. This article also describes how the parallel port could be used to control an external apparatus

Good Learning and Implicit Model Enumeration

MathSBML is an open-source, freely-downloadable Mathematica package that facilitates working with Systems Biology Markup Language (SBML) models. SBML is a toolneutral,computer-readable format for representing models of biochemical reaction networks, applicable to metabolic networks, cell-signaling pathways, genomic regulatory networks, and other modeling problems in systems biology that is widely supported by the systems biology community. SBML is based on XML, a standard medium for representing and transporting data that is widely supported on the internet as well as in computational biology and bioinformatics. Because SBML is tool-independent, it enables model transportability, reuse, publication and survival. In addition to MathSBML, a number of other tools that support SBML model examination and manipulation are provided on the sbml.org website, including libSBML, a C/C++ library for reading SBML models; an SBML Toolbox for MatLab; file conversion programs; an SBML model validator and visualizer; and SBML specifications and schemas. MathSBML enables SBML file import to and export from Mathematica as well as providing an API for model manipulation and simulation

THE HELIUM PURIFICATION SYSTEM FOR THE PROPOSED PEBBLE BED REACTOR EXPERIMENT

A helium coolant side-stream purification system consisting of parallel sections for radioactive and nonradioactive decontamination was designed for the proposed Pebble Bed Reactor Experiment. Primary equipment components are two gas coolers, gas heater, charcoal delay trap, CuO oxidizer, molecular sieve adsorber, and full flow filter. The charcoal delay trap is sized to provide a hold-up of 30 min for Kr isotopes. 6 hr hold-up for Xe isotopes, and 99.9% retention of iodine isotopes resulting in "decontamination factors" varying from 1 for Kr/sup 85/ to 556 for I/sup 131/. Nonradioactive decontamination will result in a steady state concentration of CO/sub 2/ in the coolant of 20.8 ppm or less. Total cost of the system excluding auxiliary equipment and containment is estimated to be .690. (auth

“Whatdunit?” Developmental changes in children\u27s syntactically based sentence interpretation abilities and sensitivity to word order

Aim 1 of this study was to examine the developmental changes in typically developing English-speaking children’s syntactically-based sentence interpretation abilities and sensitivity to word order. Aim 2 was to determine the psychometric standing of the novel sentence interpretation task developed for this study, as we wish to use it later with children with Specific Language Impairment (SLI). Children listened to semantically implausible sentences in which noun animacy and the natural affordance between the nouns were removed, thus controlling for event probability. Using this novel “whatdunit?” agent selection task, 256 children 7-11 years listened to two structures with canonical word order and two with non-canonical word order. After each sentence, children selected as quickly as possible the picture of the noun they believed was “doing the action.” Children interpreted sentences with canonical word order with greater accuracy and speed than those with non-canonical word order. Older children (AgeM = 10:8) were more accurate and faster than younger children (AgeM = 8:1) across all sentence forms. Both older and younger children demonstrated similar error patterns across sentence type. The “whatdunit?” task also proved to have strong validity and reliability, making it suitable for studies with children with SLI

First Results from the KMOS Lens-Amplified Spectroscopic Survey (KLASS): Kinematics of Lensed Galaxies at Cosmic Noon

We present the first results of the KMOS Lens-Amplified Spectroscopic Survey (KLASS), a new ESO Very Large Telescope (VLT) large program, doing multi-object integral field spectroscopy of galaxies gravitationally lensed behind seven galaxy clusters selected from the HST Grism Lens-Amplified Survey from Space (GLASS). Using the power of the cluster magnification we are able to reveal the kinematic structure of 25 galaxies at $0.7 \lesssim z \lesssim 2.3$, in four cluster fields, with stellar masses $8 \lesssim \log{(M_\star/M_\odot)} \lesssim 11$. This sample includes 5 sources at $z>1$ with lower stellar masses than in any previous kinematic IFU surveys. Our sample displays a diversity in kinematic structure over this mass and redshift range. The majority of our kinematically resolved sample is rotationally supported, but with a lower ratio of rotational velocity to velocity dispersion than in the local universe, indicating the fraction of dynamically hot disks changes with cosmic time. We find no galaxies with stellar mass $<3 \times 10^9 M_\odot$ in our sample display regular ordered rotation. Using the enhanced spatial resolution from lensing, we resolve a lower number of dispersion dominated systems compared to field surveys, competitive with findings from surveys using adaptive optics. We find that the KMOS IFUs recover emission line flux from HST grism-selected objects more faithfully than slit spectrographs. With artificial slits we estimate slit spectrographs miss on average 60% of the total flux of emission lines, which decreases rapidly if the emission line is spatially offset from the continuum.Comment: Accepted for publication in Ap

Armed and accurate: engineering cytotoxic T cells for eradication of leukemia

Translational medicine depends on a rapid and efficient exchange of results between the bench and the bedside. A recent example from the field of cancer immunotherapy highlights the essential nature of this exchange. Methods have been developed to convert a patient's cytotoxic T cells into efficient and specific killers of cancer cells in patients with leukemia. By using recombinant DNA techniques, a lentiviral vector was constructed to express chimeric antigen receptors in cytotoxic T cells from patients with advanced chronic lymphocytic leukemia. The purpose of the chimeric receptors was to direct the cytotoxic T cell activity against cells causing the cancer. The effect of infusing the engineered T cells back into the cancer patients was tested in a Phase I trial at the University of Pennsylvania, and the initial results were described in two articles from the research team of Dr. Carl June. The remarkable success of this trial should energize further applications of biotechnology in the development of new cancer immunotherapies

Overall Assessment of Actinide Partitioning and Transmutation for Waste Management Purposes

A program to establish the technical feasibility and incentives for partitioning (i.e., recovering) actinides from fuel cycle wastes and then transmuting them in power reactors to shorter-lived or stable nuclides has recently been concluded at the Oak Ridge National Laboratory. The feasibility was established by experimentally investigating the reduction that can be practicably achieved in the actinide content of the wastes sent to a geologic repository, and the incentives for implementing this concept were defined by determining the incremental costs, risks, and benefits. Eight US Department of Energy laboratories and three private companies participated in the program over its 3-year duration. A reference fuel cycle was chosen based on a self-generated plutonium recycle PWR, and chemical flowsheets based on solvent extraction and ion-exchange techniques were generated that have the potential to reduce actinides in fuel fabrication and reprocessing plant wastes to less than 0.25% of those in the spent fuel. Waste treatment facilities utilizing these flowsheets were designed conceptually, and their costs were estimated. Finally, the short-term (contemporary) risks from fuel cycle operations and long-term (future) risks from deep geologic disposal of the wastes were estimated for cases with and without partitioning and transmutation. It was concluded that, while both actinide partitioning from wastes and transmutation in power reactors appear to be feasible using currently identified and studied technology, implementation of this concept cannot be justified because of the small long-term benefits and substantially increased costs of the concept