Demonstration of Converter Control Interactions in MMC-HVDC Systems

Although the control of modular multi-level converters (MMCs) in high-voltage direct-current (HVDC) networks has become a mature subject these days, the potential for adverse interactions between different converter controls remains an under-researched challenge attracting the attention from both academia and industry. Even for point-to-point HVDC links (i.e., simple HVDC systems), converter control interactions may result in the shifting of system operating voltages, increased power losses, and unintended power imbalances at converter stations. To bridge this research gap, the risk of multiple cross-over of control characteristics of MMCs is assessed in this paper through mathematical analysis, computational simulation, and experimental validation. Specifically, the following point-to-point HVDC link configurations are examined: (1) one MMC station equipped with a current versus voltage droop control and the other station equipped with a constant power control; and (2) one MMC station equipped with a power versus voltage droop control and the other station equipped with a constant current control. Design guidelines for droop coefficients are provided to prevent adverse control interactions. A 60-kW MMC test-rig is used to experimentally verify the impact of multiple crossing of control characteristics of the DC system configurations, with results verified through software simulation in MATLAB/Simulink using an open access toolbox. Results show that in operating conditions of 650 V and 50 A (DC voltage and DC current), drifts of 7.7% in the DC voltage and of 10% in the DC current occur due to adverse control interactions under the current versus voltage droop and power control scheme. Similarly, drifts of 7.7% both in the DC voltage and power occur under the power versus voltage droop and current control scheme.This work was supported by the EU FP7 program, through the project “BEyond State of the art Technologies for re-Powering AC corridors and multi-Terminal HVDC Systems” (BEST-PATHS), grant agreement 612748. The simulation toolbox can be downloaded from the project website at www.bestpaths-project.eu (accessed on 10 December 2021)

Early retreat of the Alaska Peninsula Glacier Complex and the implications for coastal migrations of First Americans

The debate over a coastal migration route for the First Americans revolves around two major points: seafaring technology, and a viable landscape and resource base. Three lake cores from Sanak Island in the western Gulf of Alaska yield the first radiocarbon ages from the continental shelf of the Northeast Pacific and record deglaciation nearly 17 ka BP (thousands of calendar years ago), much earlier than previous estimates based on extrapolated data from other sites outside the coastal corridor in the Gulf of Alaska. Pollen data suggest an arid, terrestrial ecosystem by 16.3 ka BP. Therefore glaciers would not have hindered the movement of humans along the southern edge of the Bering Land Bridge for two millennia before the first well-recognized “New World” archaeological sites were inhabited.Keywords: First Americans, Deglaciation, Coastal migratio

Inference of hidden structures in complex physical systems by multi-scale clustering

We survey the application of a relatively new branch of statistical physics--"community detection"-- to data mining. In particular, we focus on the diagnosis of materials and automated image segmentation. Community detection describes the quest of partitioning a complex system involving many elements into optimally decoupled subsets or communities of such elements. We review a multiresolution variant which is used to ascertain structures at different spatial and temporal scales. Significant patterns are obtained by examining the correlations between different independent solvers. Similar to other combinatorial optimization problems in the NP complexity class, community detection exhibits several phases. Typically, illuminating orders are revealed by choosing parameters that lead to extremal information theory correlations.Comment: 25 pages, 16 Figures; a review of earlier work

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Extrinsic Fluorescent Dyes as Tools for Protein Characterization

Noncovalent, extrinsic fluorescent dyes are applied in various fields of protein analysis, e.g. to characterize folding intermediates, measure surface hydrophobicity, and detect aggregation or fibrillation. The main underlying mechanisms, which explain the fluorescence properties of many extrinsic dyes, are solvent relaxation processes and (twisted) intramolecular charge transfer reactions, which are affected by the environment and by interactions of the dyes with proteins. In recent time, the use of extrinsic fluorescent dyes such as ANS, Bis-ANS, Nile Red, Thioflavin T and others has increased, because of their versatility, sensitivity and suitability for high-throughput screening. The intention of this review is to give an overview of available extrinsic dyes, explain their spectral properties, and show illustrative examples of their various applications in protein characterization

C5a Enhances Dysregulated Inflammatory and Angiogenic Responses to Malaria In Vitro: Potential Implications for Placental Malaria

Placental malaria (PM) is a leading cause of maternal and infant mortality. Although the accumulation of parasitized erythrocytes (PEs) and monocytes within the placenta is thought to contribute to the pathophysiology of PM, the molecular mechanisms underlying PM remain unclear. Based on the hypothesis that excessive complement activation may contribute to PM, in particular generation of the potent inflammatory peptide C5a, we investigated the role of C5a in the pathogenesis of PM in vitro and in vivo.Using primary human monocytes, the interaction between C5a and malaria in vitro was assessed. CSA- and CD36-binding PEs induced activation of C5 in the presence of human serum. Plasmodium falciparum GPI (pfGPI) enhanced C5a receptor expression (CD88) on monocytes, and the co-incubation of monocytes with C5a and pfGPI resulted in the synergistic induction of cytokines (IL-6, TNF, IL-1beta, and IL-10), chemokines (IL-8, MCP-1, MIP1alpha, MIP1beta) and the anti-angiogenic factor sFlt-1 in a time and dose-dependent manner. This dysregulated response was abrogated by C5a receptor blockade. To assess the potential role of C5a in PM, C5a plasma levels were measured in malaria-exposed primigravid women in western Kenya. Compared to pregnant women without malaria, C5a levels were significantly elevated in women with PM.These results suggest that C5a may contribute to the pathogenesis of PM by inducing dysregulated inflammatory and angiogenic responses that impair placental function