2,259 research outputs found
Very Red and Extremely Red Galaxies in the Fields of z ~ 1.5 Radio-Loud Quasars
We previously identified an excess of mostly red galaxies around 31 RLQs at
z=1-2. These fields have an ERO (extremely red object, R-K>6) density 2.7 times
higher than the field. Assuming the EROs are passively evolved galaxies at the
quasar redshifts, they have characteristic luminosities of only ~L^*. We also
present new observations of four z~1.54 RLQ fields: (1) Wide-field J & Ks data
confirm an Abell richness ~2 excess within 140" of Q0835+580 but an excess only
within 50" of Q1126+101. (2) In 3 fields we present deep narrow-band redshifted
H-alpha observations. We detect five candidate galaxies at the quasar
redshifts, a surface density 2.5x higher than the field. (3) SCUBA sub-mm
observations of 3 fields detect 2 quasars and 2 galaxies with SEDs best fit as
highly reddened galaxies at the quasar z. (4) H-band adaptive optics (AO)
imaging is used to estimate redshifts for 2 red, bulge-dominated galaxies using
the Kormendy relation. Both have structural redshifts foreground to the quasar,
but these are not confirmed by photometric redshifts, possibly because their
optical photometry is corrupted by scattered light from the AO guidestar. (5)
We use quantitative SED fits to constrain the photometric redshifts z_ph for
some galaxies. Most galaxies near Q0835+580 are consistent with being at its
redshift, including a candidate very old passively evolving galaxy. Many very &
extremely red objects have z_ph z_q, and dust reddening is required to fit most
of them, including many objects whose fits also require relatively old stellar
populations. Large reddenings of E(B-V)~0.6 are required to fit four J-K
selected EROs, though all but one of them have best-fit z_ph>z_q. These objects
may represent a population of dusty high-z galaxies underrepresented in
optically selected samples. (Abridged)Comment: Missing object 1126.424 added to Table 4; title changed to save
people the apparent trouble of reading the abstract. 38 pages, 16 figures, 2
in color; all-PostScript figure version available from
http://astro.princeton.edu/~pathall/tp3.ps.g
Plans for the LIGO-TAMA Joint Search for Gravitational Wave Bursts
We describe the plans for a joint search for unmodelled gravitational wave
bursts being carried out by the LIGO and TAMA collaborations using data
collected during February-April 2003. We take a conservative approach to
detection, requiring candidate gravitational wave bursts to be seen in
coincidence by all four interferometers. We focus on some of the complications
of performing this coincidence analysis, in particular the effects of the
different alignments and noise spectra of the interferometers.Comment: Proceedings of the 8th Gravitational Wave Data Analysis Workshop,
Milwaukee, WI, USA. 10 pages, 3 figures, documentclass ``iopart'
Bayesian detection of unmodeled bursts of gravitational waves
The data analysis problem of coherently searching for unmodeled
gravitational-wave bursts in the data generated by a global network of
gravitational-wave observatories has been at the center of research for almost
two decades. As data from these detectors is starting to be analyzed, a renewed
interest in this problem has been sparked. A Bayesian approach to the problem
of coherently searching for gravitational wave bursts with a network of
ground-based interferometers is here presented. We demonstrate how to
systematically incorporate prior information on the burst signal and its source
into the analysis. This information may range from the very minimal, such as
best-guess durations, bandwidths, or polarization content, to complete prior
knowledge of the signal waveforms and the distribution of sources through
spacetime. We show that this comprehensive Bayesian formulation contains
several previously proposed detection statistics as special limiting cases, and
demonstrate that it outperforms them.Comment: 18 pages, 3 figures, revisions based on referee comment
An excess power statistic for detection of burst sources of gravitational radiation
We examine the properties of an excess power method to detect gravitational
waves in interferometric detector data. This method is designed to detect
short-duration (< 0.5 s) burst signals of unknown waveform, such as those from
supernovae or black hole mergers. If only the bursts' duration and frequency
band are known, the method is an optimal detection strategy in both Bayesian
and frequentist senses. It consists of summing the data power over the known
time interval and frequency band of the burst. If the detector noise is
stationary and Gaussian, this sum is distributed as a chi-squared (non-central
chi-squared) deviate in the absence (presence) of a signal. One can use these
distributions to compute frequentist detection thresholds for the measured
power. We derive the method from Bayesian analyses and show how to compute
Bayesian thresholds. More generically, when only upper and/or lower bounds on
the bursts duration and frequency band are known, one must search for excess
power in all concordant durations and bands. Two search schemes are presented
and their computational efficiencies are compared. We find that given
reasonable constraints on the effective duration and bandwidth of signals, the
excess power search can be performed on a single workstation. Furthermore, the
method can be almost as efficient as matched filtering when a large template
bank is required. Finally, we derive generalizations of the method to a network
of several interferometers under the assumption of Gaussian noise.Comment: 22 pages, 6 figure
GLA-modified RNA treatment lowers GB3 levels in iPSC-derived cardiomyocytes from Fabry-affected individuals
Recent studies in non-human model systems have shown therapeutic potential of nucleoside-modified messenger RNA (modRNA) treatments for lysosomal storage diseases. Here, we assessed the efficacy of a modRNA treatment to restore the expression of the galactosidase alpha (GLA), which codes for α-Galactosidase A (α-GAL) enzyme, in a human cardiac model generated from induced pluripotent stem cells (iPSCs) derived from two individuals with Fabry disease. Consistent with the clinical phenotype, cardiomyocytes from iPSCs derived from Fabry-affected individuals showed accumulation of the glycosphingolipid Globotriaosylceramide (GB3), which is an α-galactosidase substrate. Furthermore, the Fabry cardiomyocytes displayed significant upregulation of lysosomal-associated proteins. Upon GLA modRNA treatment, a subset of lysosomal proteins were partially restored to wild-type levels, implying the rescue of the molecular phenotype associated with the Fabry genotype. Importantly, a significant reduction of GB3 levels was observed in GLA modRNA-treated cardiomyocytes, demonstrating that α-GAL enzymatic activity was restored. Together, our results validate the utility of iPSC-derived cardiomyocytes from affected individuals as a model to study disease processes in Fabry disease and the therapeutic potential of GLA modRNA treatment to reduce GB3 accumulation in the heart.</p
The Center for Integrated Molecular Brain Imaging (Cimbi) database
AbstractWe here describe a multimodality neuroimaging containing data from healthy volunteers and patients, acquired within the Lundbeck Foundation Center for Integrated Molecular Brain Imaging (Cimbi) in Copenhagen, Denmark. The data is of particular relevance for neurobiological research questions related to the serotonergic transmitter system with its normative data on the serotonergic subtype receptors 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4 and the 5-HT transporter (5-HTT), but can easily serve other purposes.The Cimbi database and Cimbi biobank were formally established in 2008 with the purpose to store the wealth of Cimbi-acquired data in a highly structured and standardized manner in accordance with the regulations issued by the Danish Data Protection Agency as well as to provide a quality-controlled resource for future hypothesis-generating and hypothesis-driven studies.The Cimbi database currently comprises a total of 1100 PET and 1000 structural and functional MRI scans and it holds a multitude of additional data, such as genetic and biochemical data, and scores from 17 self-reported questionnaires and from 11 neuropsychological paper/computer tests. The database associated Cimbi biobank currently contains blood and in some instances saliva samples from about 500 healthy volunteers and 300 patients with e.g., major depression, dementia, substance abuse, obesity, and impulsive aggression. Data continue to be added to the Cimbi database and biobank
Upper limits on the strength of periodic gravitational waves from PSR J1939+2134
The first science run of the LIGO and GEO gravitational wave detectors
presented the opportunity to test methods of searching for gravitational waves
from known pulsars. Here we present new direct upper limits on the strength of
waves from the pulsar PSR J1939+2134 using two independent analysis methods,
one in the frequency domain using frequentist statistics and one in the time
domain using Bayesian inference. Both methods show that the strain amplitude at
Earth from this pulsar is less than a few times .Comment: 7 pages, 1 figure, to appear in the Proceedings of the 5th Edoardo
Amaldi Conference on Gravitational Waves, Tirrenia, Pisa, Italy, 6-11 July
200
mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria
The urea cycle enzyme argininosuccinate lyase (ASL) enables the clearance of neurotoxic ammonia and the biosynthesis of arginine. Patients with ASL deficiency present with argininosuccinic aciduria, an inherited metabolic disease with hyperammonemia and a systemic phenotype coinciding with neurocognitive impairment and chronic liver disease. Here, we describe the dysregulation of glutathione biosynthesis and upstream cysteine utilization in ASL-deficient patients and mice using targeted metabolomics and in vivo positron emission tomography (PET) imaging using ( S)-4-(3-18F-fluoropropyl)-l-glutamate ([18F]FSPG). Up-regulation of cysteine metabolism contrasted with glutathione depletion and down-regulated antioxidant pathways. To assess hepatic glutathione dysregulation and liver disease, we present [18F]FSPG PET as a noninvasive diagnostic tool to monitor therapeutic response in argininosuccinic aciduria. Human hASL mRNA encapsulated in lipid nanoparticles improved glutathione metabolism and chronic liver disease. In addition, hASL mRNA therapy corrected and rescued the neonatal and adult Asl-deficient mouse phenotypes, respectively, enhancing ureagenesis. These findings provide mechanistic insights in liver glutathione metabolism and support clinical translation of mRNA therapy for argininosuccinic aciduria. </p
Improving the sensitivity to gravitational-wave sources by modifying the input-output optics of advanced interferometers
We study frequency dependent (FD) input-output schemes for signal-recycling
interferometers, the baseline design of Advanced LIGO and the current
configuration of GEO 600. Complementary to a recent proposal by Harms et al. to
use FD input squeezing and ordinary homodyne detection, we explore a scheme
which uses ordinary squeezed vacuum, but FD readout. Both schemes, which are
sub-optimal among all possible input-output schemes, provide a global noise
suppression by the power squeeze factor, while being realizable by using
detuned Fabry-Perot cavities as input/output filters. At high frequencies, the
two schemes are shown to be equivalent, while at low frequencies our scheme
gives better performance than that of Harms et al., and is nearly fully
optimal. We then study the sensitivity improvement achievable by these schemes
in Advanced LIGO era (with 30-m filter cavities and current estimates of
filter-mirror losses and thermal noise), for neutron star binary inspirals, and
for narrowband GW sources such as low-mass X-ray binaries and known radio
pulsars. Optical losses are shown to be a major obstacle for the actual
implementation of these techniques in Advanced LIGO. On time scales of
third-generation interferometers, like EURO/LIGO-III (~2012), with
kilometer-scale filter cavities, a signal-recycling interferometer with the FD
readout scheme explored in this paper can have performances comparable to
existing proposals. [abridged]Comment: Figs. 9 and 12 corrected; Appendix added for narrowband data analysi
Quantum state preparation and macroscopic entanglement in gravitational-wave detectors
Long-baseline laser-interferometer gravitational-wave detectors are operating
at a factor of 10 (in amplitude) above the standard quantum limit (SQL) within
a broad frequency band. Such a low classical noise budget has already allowed
the creation of a controlled 2.7 kg macroscopic oscillator with an effective
eigenfrequency of 150 Hz and an occupation number of 200. This result, along
with the prospect for further improvements, heralds the new possibility of
experimentally probing macroscopic quantum mechanics (MQM) - quantum mechanical
behavior of objects in the realm of everyday experience - using
gravitational-wave detectors. In this paper, we provide the mathematical
foundation for the first step of a MQM experiment: the preparation of a
macroscopic test mass into a nearly minimum-Heisenberg-limited Gaussian quantum
state, which is possible if the interferometer's classical noise beats the SQL
in a broad frequency band. Our formalism, based on Wiener filtering, allows a
straightforward conversion from the classical noise budget of a laser
interferometer, in terms of noise spectra, into the strategy for quantum state
preparation, and the quality of the prepared state. Using this formalism, we
consider how Gaussian entanglement can be built among two macroscopic test
masses, and the performance of the planned Advanced LIGO interferometers in
quantum-state preparation
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