1,546 research outputs found
Predictors of programme adherence and weight loss in women in an obesity programme using meal replacements
Objective: To explore predictors of programme adherence and weight loss in patients participating in a weight management programme using meal replacements (MR).Design: One hundred and fifty healthy obese women, age 48.5 years (s.d. = 8.3); weight, 97.6 kg (13.4); body mass index (BMI) 36.5 (3.7), participated in a longitudinal study with a 16-week acute weight loss phase (Phase 1) followed by 1 year of a trial of weight-loss maintenance (Phase 2). Energy intake during Phase 1 totaled 900 kcal (3.7 MJ) a day from a diet including two MR. Energy intake during Phase 2 consisted of either MR or a low-fat diet with a calculated energy deficit of 600 kcal/day (2.5 MJ).Methods: Weight, height and waist circumference were measured and body composition assessed by air plethysmography (Bodpod). Glucose and insulin were measured by standard immunoassays and insulin sensitivity assessed by homeostatic model assessment.Results: At the end of 16 weeks, 114 subjects (76%) completed Phase 1 and achieved a mean weight loss of 8.95 kg (3.38). Adherence to Phase 1 was predicted by weight loss over the first 2 weeks (p < 0.001). Weight loss during Phase 1 was predicted by initial weight and initial systolic blood pressure. Adherence to Phase 2 was not predicted by physiological measures. Weight loss maintenance in Phase 2 (not gaining more than 3% of the weight at start of phase 2) was predicted by cholesterol and triglyceride measured at the start of Phase 2 but otherwise was not predicted by the physiological measures. Initial insulin sensitivity did not predict weight loss in either phase.Conclusion: Participants whose weight loss over the first 2 weeks falls in the bottom third may need additional intervention if they are to continue in this type of programme. A battery of physiological measures at entry to a MR weight loss and maintenance programme explains only a very small proportion of the variation in weight loss
Scots pine litter decomposition along drainage succession and soil nutrient gradients in peatland forests, and the effects of inter-annual weather variation
Peer reviewe
The impact of cooperative learning on student attitudes and achievement
It is essential for teachers to know how and when to structure students\u27 learning goals competitively, individualistically, or cooperatively. Each goal structure has its place. Goal structures determine the way in which students will interact with each other and how the teacher will achieve an instructional goal. It is important for students to learn which behaviors are expected in each situation. By using all three goal structures students learn how to collaboratively work with others, compete for fun and enjoyment, and work on their own. Johnson and Johnson ( 1987) stated that no aspect of teaching is more important than the appropriate use of goal structures. Teachers have no choice but to choose a goal structure for each lesson they teach
Rimonabant improves cardiometabolic risk factors in overweight/obese patients with poorly controlled type 2 diabetes (HbA(1c)>= 8%) on monotherapy with metformin or sulfonylureas
peer reviewe
Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates
BB/H012494/1/ Biotechnology and Biological Sciences Research Counci
Fluctuating-friction molecular motors
We show that the correlated stochastic fluctuation of the friction
coefficient can give rise to long-range directional motion of a particle
undergoing Brownian random walk in a constant periodic energy potential
landscape. The occurrence of this motion requires the presence of two
additional independent bodies interacting with the particle via friction and
via the energy potential, respectively, which can move relative to each other.
Such three-body system generalizes the classical Brownian ratchet mechanism,
which requires only two interacting bodies. In particular, we describe a simple
two-level model of fluctuating-friction molecular motor that can be solved
analytically. In our previous work [M.K., L.M and D.P. 2000 J. Nonlinear Opt.
Phys. Mater. vol. 9, 157] this model has been first applied to understanding
the fundamental mechanism of the photoinduced reorientation of dye-doped liquid
crystals. Applications of the same idea to other fields such as molecular
biology and nanotechnology can however be envisioned. As an example, in this
paper we work out a model of the actomyosin system based on the
fluctuating-friction mechanism.Comment: to be published in J. Physics Condensed Matter
(http://www.iop.org/Journals/JPhysCM
Do Abstinence-Plus Interventions Reduce Sexual Risk Behavior among Youth?
The authors discuss the policy questions arising from a new study on "abstinence-plus" interventions for reducing HIV risk behavior among youth in high-income countries
Cooperative Transport of Brownian Particles
We consider the collective motion of finite-sized, overdamped Brownian
particles (e.g., motor proteins) in a periodic potential. Simulations of our
model have revealed a number of novel cooperative transport phenomena,
including (i) the reversal of direction of the net current as the particle
density is increased and (ii) a very strong and complex dependence of the
average velocity on both the size and the average distance of the particles.Comment: 4 pages, 5 figure
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