YOUTH AT RISK - POLICY CONSIDERATIONS

Agricultural and Food Policy,

Digital co-regulation: designing a supranational legal framework for the platform economy

This paper examines digital data-driven platforms and their impact on contemporary regulatory paradigms. While these phenomena are increasingly proclaimed as paradigm altering in many respects, they remain relatively little understood, including in their regulatory dimension. Lawmakers around the globe including the European Commission are currently trying to make sense of these evolutions and determine how to regulate digital platforms. In its 2016 Communication on Online Platforms, the European Commission proposed various options for regulating the platform economy, including self-regulatory and co-regulatory models. The Commission’s assumption that self-regulation or co-regulation can replace top-down legislative intervention in the platform economy forms the background of this paper, which examines these three options to determine their respective suitability. We shall conclude that as command-and-control regulation as well as self-regulation raise significant problems in their application to the platform economy, co-regulation emerges as the most adequate option if certain conditions are complied with

Advancing subsidy reforms: towards a viable policy package

Executive Summary: World subsidies may total some $800 billion, of which perhaps two-thirds occur in the developed economies of the OECD. Reforming subsidy regimes that damage the prospects for sustainable development is immensely complex. Simply calling for subsidy removal is unlikely to succeed. The complexity arises from the fact that subsidies are manifestations of rent-seeking, which, in turn is part of a wider category of unproductive activity in economic systems. Rentseeking involves redirecting economic resources to special interest groups rather than using resources productively. Interest groups then use those resources to reinforce their privleged positions. Subsidy reform will inevitably conflict with those special interests. The idea that subsidy reform is a ‘win-win’ policy is therefore misleading – there will always be losers, even if they are undeserving losers. In many cases, the most harmful subsidies will be those that are least easy to remove. Subsidy reform is therefore about dissipating rents, has to be part of a wider programme of macroeconomic and political reform. Subsidies are often linked to corruption, thus emphasising the difficulty of securing the political changes that are needed. Moreover, instituting democratic reform is not sufficient either: democratic societies have even larger subsidy regimes than less democratic societies. Political change has to be combined with economic reform. Some have advocated ‘sudden shocks’ whereby dramatic events are seized as an opportunity to institute reform. There is some evidence to suggest that if a crisis does occur, it may be best to implement subsidy reform along with other transitional measures in one large package. An alternative is to let the almost inevitable growth of subsidies produce economic bankruptcy, and then institute reform. But many societies have proved surprisingly resilient whilst sustaining extensive subsidy regimes, and the costs of waiting may not be acceptable anyway. In the absence of crisis, a gradual approach is best. Policies need to be pre-announced and gradual subsidy reduction needs to be combined with careful public awareness campaigns and efforts at political transparency and accountability. Bilateral and multilateral lenders have a strong role to play, even though reforming subsidies as part of a conditionality package is still controversial. Reform almost inevitably involves privatisation since exposure to market forces is essential for rent dissipation. Nonetheless, reform is complex and its success if difficult to guarantee: for example, privatisation may simply shift rents from the public to the private sector. Subsidy regimes seem peculiarly resilient to change

Treating hepatic steatosis and fibrosis by modulating mitochondrial pyruvate metabolism

A hepatic comorbidity of metabolic syndrome, known as nonalcoholic fatty liver disease (NAFLD), is increasing in prevalence in conjunction with the pandemics of obesity and diabetes. The spectrum of NAFLD ranges from simple hepatic fat accumulation to a more severe disease termed nonalcoholic steatohepatitis (NASH), involving inflammation, hepatocyte death, and fibrosis. Importantly, NASH is linked to a much higher risk of cirrhosis, liver failure, and hepatocellular carcinoma, as well as an increased risk for nonhepatic malignancies and cardiovascular disease. Interest in the understanding of the disease processes and search for treatments for the spectrum of NAFLD-NASH has increased exponentially, but there are no approved pharmacologic therapies. In this review, we discuss the existing literature supporting insulin-sensitizing thiazolidinedione compounds as potential drug candidates for the treatment of NASH. In addition, we put these results into new context by summarizing recent studies suggesting these compounds alter mitochondrial metabolism by binding and inhibiting the mitochondrial pyruvate carrier. Keywords: Nonalcoholic Steatohepatitis, Mitochondria, Pyruvate, Thiazolidinedion

Isolation & Characterization of Bacteria in the Built Environment: Measuring The Effect of Pharmaceuticals on Growth

This work reports the isolation and characterization of bacteria from the built environment at Gettysburg College in Gettysburg, PA. Surfaces of a water fountain on campus were swabbed and serially streaked to isolate multiple bacteria on R2A agar. Following multiple rounds of growth, the unknown microbial candidates were narrowed to two visibly­distinct organisms. Morphological characterization and phylogenetic identification based on 16S rDNA sequencing revealed that the isolates were Chryseobactierum hispalense and Microbacterium maritypicum. We report synergistic biofilm formation between Chryseobactierum hispalense and Microbacterium maritypicum. The contamination of drinking water with varying levels of personal care products and pharmaceuticals (PCPPs) is well documented. Additionally, these environmental pollutants and their derivatives affect aquatic life, as illustrated with effect of the antidepressant fluoxetine on mudsnails. To determine if previously reported contaminants affect freshwater bacteria, we assessed both planktonic growth and biofilm formation following exposure to nalidixic acid (non­fluorinated quinolone antibiotic), diphenhydramine (over­the­counter drug Benadryl), and fluoxetine (Prozac)

Phase Coherence and Andreev Reflection in Topological Insulator Devices

Topological insulators (TIs) have attracted immense interest because they host helical surface states. Protected by time-reversal symmetry, they are robust to non-magnetic disorder. When superconductivity is induced in these helical states, they are predicted to emulate p-wave pairing symmetry, with Majorana states bound to vortices. Majorana bound states possess non-Abelian exchange statistics which can be probed through interferometry. Here, we take a significant step towards Majorana interferometry by observing pronounced Fabry-Perot oscillations in a TI sandwiched between a superconducting and normal lead. For energies below the superconducting gap, we observe a doubling in the frequency of the oscillations, arising from the additional phase accumulated from Andreev reflection. When a magnetic field is applied perpendicular to the TI surface, a number of very sharp and gate-tunable conductance peaks appear at or near zero energy, which has consequences for interpreting spectroscopic probes of Majorana fermions. Our results demonstrate that TIs are a promising platform for exploring phase-coherent transport in a solid-state system.Comment: 9 pages, 7 figure