449 research outputs found
What is the evidence for the performance of generic preference-based measures? A systematic overview of reviews
OBJECTIVE: To assess the evidence on the validity and responsiveness of five commonly used preference-based instruments, the EQ-5D, SF-6D, HUI3, 15D and AQoL, by undertaking a review of reviews.
METHODS: Four databases were investigated using a strategy refined through a highly sensitive filter for systematic reviews. References were screened and a search for grey literature was performed. Identified citations were scrutinized against pre-defined eligibility criteria and data were extracted using a customized extraction template. Evidence on known group validity, convergent validity and responsiveness was extracted and reviewed by narrative synthesis. Quality of the included reviews was assessed using a modified version of the AMSTAR checklist.
RESULTS: Thirty reviews were included, sixteen of which were of excellent or good quality. The body of evidence, covering more than 180 studies, was heavily skewed towards EQ-5D, with significantly fewer studies investigating HUI3 and SF-6D, and very few the 15D and AQoL. There was also lack of head-to-head comparisons between GPBMs and the tests reported by the reviews were often weak. Where there was evidence, EQ-5D, SF-6D, HUI3, 15D and AQoL seemed generally valid and responsive instruments, although not for all conditions. Evidence was not consistently reported across reviews.
CONCLUSIONS: Although generally valid, EQ-5D, SF-6D and HUI3 suffer from some problems and perform inconsistently in some populations. The lack of head-to-head comparisons and the poor reporting impedes the comparative assessment of the performance of GPBMs. This highlights the need for large comparative studies designed to test instruments' performance
Selecting bolt-on dimensions for the EQ-5D: examining their contribution to health-related quality of life
Background: Generic preference-based measures may miss dimensions important for the health-related quality of life (HRQOL) of patients. When this happens, a possible solution is to add bolt-ons. Finch et al. (Finch AP, Brazier JE, Mukuria C, Bjorner JB. An exploratory study on using principal component analysis and confirmatory factor analysis to identify bolt-on dimensions: the EQ-5D case study. Value Health 2017;10:1362–75) have recently shown that bolt-ons can be systematically identified using factor analysis. Nevertheless, because for each bolt-on option a complete re-evaluation may be required, methods to select between them are needed. Objectives: To investigate the possibility of selecting bolt-ons using their ability to predict differences in HRQOL. It tests six factors (energy/vitality, satisfaction, relationships, hearing, vision, and speech), and 37 items loading on them, using the EuroQol five-dimensional questionnaire as a case study. Methods: Data were obtained from the Multi-Instrument Comparison study, an online survey on health and well-being measures carried out in six countries. Two tests were performed. In the first test, linear regressions were fitted to determine whether different bolt-ons helped explain variations in HRQOL as measured by the Health visual analogue scale. The upper anchor (100) of this scale represents excellent physical, mental, and social health, and the lower anchor (0) represents death. Bolt-on relevance was judged comparing the strength, direction, and statistical significance of unadjusted β coefficients. In the second test, linear regressions were fitted to further investigate whether different factors and items helped explain the negative effect of six chronic conditions on HRQOL. A reduction in the coefficients for the chronic condition dummies meant that the factor or item detected the effect. Results: Energy/vitality, relationships, and satisfaction reported substantially larger coefficients than did speech, vision, and hearing. Also, items loading on energy/vitality, relationships, and satisfaction generally presented larger coefficients than did those loading on speech, vision, and hearing. The second test did not detect consistent decrements in the coefficients for chronic conditions when testing factors, but it generally did detect consistent decrements when testing items. Conclusions: The first test appeared useful for bolt-on selection. Further research is needed before using the second test
Recommended from our members
Abstracts of computer programs and data libraries pertaining to photon production data
Abstracts, or descriptions, of computer programs and data libraries pertaining to Photon Production Data (Measurements, Evaluations and Calculations) maintained in the collections of the Radiation Safety Information Computational Center, Oak Ridge, Tennessee USA and at the OECD/NEA Data Bank, Paris, are collected in this document
Assembly and characterisation of a unique onion diversity set identifies resistance to Fusarium basal rot and improved seedling vigour
Conserving biodiversity is critical for safeguarding future crop production. Onion (Allium cepa L.) is a globally important crop with a very large (16 Gb per 1C) genome which has not been sequenced. While onions are self-fertile, they suffer from severe inbreeding depression and as such are highly heterozygous as a result of out-crossing. Bulb formation is driven by daylength, and accessions are adapted to the local photoperiod. Onion seed is often directly sown in the field, and hence seedling establishment is a critical trait for production. Furthermore, onion yield losses regularly occur worldwide due to Fusarium basal rot caused by Fusarium oxysporum f. sp. cepae. A globally relevant onion diversity set, consisting of 10 half-sib families for each of 95 accessions, was assembled and genotyping carried out using 892 SNP markers. A moderate level of heterozygosity (30–35%) was observed, reflecting the outbreeding nature of the crop. Using inferred phylogenies, population structure and principal component analyses, most accessions grouped according to local daylength. A high level of intra-accession diversity was observed, but this was less than inter-accession diversity. Accessions with strong basal rot resistance and increased seedling vigour were identified along with associated markers, confirming the utility of the diversity set for discovering beneficial traits. The onion diversity set and associated trait data therefore provide a valuable resource for future germplasm selection and onion breeding
Recommendations to encourage participation of individuals from diverse backgrounds in psychiatric genetic studies
We present innovative research practices in psychiatric genetic studies to ensure representation of individuals from diverse ancestry, sex assigned at birth, gender identity, age, body shape and size, and socioeconomic backgrounds. Due to histories of inappropriate and harmful practices against marginalized groups in both psychiatry and genetics, people of certain identities may be hesitant to participate in research studies. Yet their participation is essential to ensure diverse representation, as it is incorrect to assume that the same genetic and environmental factors influence the risk for various psychiatric disorders across all demographic groups. We present approaches developed as part of the Eating Disorders Genetics Initiative (EDGI), a study that required tailored approaches to recruit diverse populations across many countries. Considerations include research priorities and design, recruitment and study branding, transparency, and community investment and ownership. Ensuring representation in participants is costly and funders need to provide adequate support to achieve diversity in recruitment in prime awards, not just as supplemental afterthoughts. The need for diverse samples in genetic studies is critical to minimize the risk of perpetuating health disparities in psychiatry and other health research. Although the EDGI strategies were designed specifically to attract and enroll individuals with eating disorders, our approach is broadly applicable across psychiatry and other fields
Azimuthal anisotropy and correlations in p+p, d+Au and Au+Au collisions at 200 GeV
We present the first measurement of directed flow () at RHIC. is
found to be consistent with zero at pseudorapidities from -1.2 to 1.2,
then rises to the level of a couple of percent over the range . The latter observation is similar to data from NA49 if the SPS rapidities
are shifted by the difference in beam rapidity between RHIC and SPS.
Back-to-back jets emitted out-of-plane are found to be suppressed more if
compared to those emitted in-plane, which is consistent with {\it jet
quenching}. Using the scalar product method, we systematically compared
azimuthal correlations from p+p, d+Au and Au+Au collisions. Flow and non-flow
from these three different collision systems are discussed.Comment: Quark Matter 2004 proceeding, 4 pages, 3 figure
Azimuthal anisotropy: the higher harmonics
We report the first observations of the fourth harmonic (v_4) in the
azimuthal distribution of particles at RHIC. The measurement was done taking
advantage of the large elliptic flow generated at RHIC. The integrated v_4 is
about a factor of 10 smaller than v_2. For the sixth (v_6) and eighth (v_8)
harmonics upper limits on the magnitudes are reported.Comment: 4 pages, 6 figures, contribution to the Quark Matter 2004 proceeding
Strange Resonance Production in p+p and Au+Au Collisions at RHIC Energies
Resonance yields and spectra from elementary p+p and Au+Au collisions at
200 GeV from the STAR experiment at RHIC are presented
and discussed in terms of chemical and thermal freeze-out conditions. Thermal
models do not adequately describe the yields of the resonance production in
central Au+Au collisions. The approach to include elastic hadronic interactions
between chemical freeze-out and thermal freeze-out suggests a time of 5 fm/c.Comment: 4 pages, 7 figures, proceedings of the Quark Matter 2004, in Oakland,
California, to be published in Journal of Physics G: Nuclear and Particle
Physic
Identified particles at large transverse momenta in STAR in Au+Au collisions @ sqrt(s_NN) = 200 GeV
We report measurements of the ratios of identified hadrons (pi,K,p,Lambda) in
Au+Au collisions at sqrt(s_NN) = 200 GeV as a function of both collision
centrality and transverse momentum (p_T). Ratios of anti-baryon to baryon
yields are independent of p_T within 2<p_T <6 GeV/c indicating that, for such a
range, our measurements are inconsistent with theoretical pQCD calculations
predicting a decrease due to a stronger contribution from valence quark
scattering. For both strange and non-strange species, a strong baryon
enhancement relative to meson yields is observed as a function of collision
centrality in this intermediate p_T region, leading to p/pi and Lambda/K ratios
greater than unity. The nuclear modification factor, R_cp (central relative to
peripheral collisions), is used to illustrate the interplay between jet
quenching and hadron production. The physics implications of these measurements
are discussed with reference to different theoretical models.Comment: 5 pages, 4 figures. Proceedings of Quark Matter 2004 Conference, Jan
2004, Oakland, USA. Submitted to Journal of Physics
High- electron distributions in d+Au and p+p collisions at RHIC
We present preliminary measurements of electron and positron spectra in d+Au
and p+p collisions at GeV for GeV/c.
These measurements were carried out using the STAR Time Projection Chamber
(TPC) and the Barrel Electromagnetic calorimeter (EMC). Overall hadron
rejection factors in the range of have been achieved. In this work we
describe the measurement technique used to discriminate electrons from hadrons
and compare the results for single electron spectra with Pythia based pQCD
calculations for electrons from heavy-quark semi-leptonic decays.Comment: Quark Matter 2004 conference proceeding
- …