Modulation of the glyoxalase system in the aging model Podospora anserina : effects on growth and lifespan

The eukaryotic glyoxalase system consists of two enzymatic components, glyoxalase I (lactoylglutathionelyase) and glyoxalase II (hydroxyacylglutathione hydrolase). These enzymes are dedicated to the removal of toxic alpha-oxoaldehydes like methylglyoxal (MG). MG is formed as a by-product of glycolysis and MG toxicity results from its damaging capability leading to modifications of proteins, lipids and nucleic acids. An efficient removal of MG appears to be essential to ensure cellular functionality and viability. Here we study the effects of the genetic modulation of genes encoding the components of the glyoxalase system in the filamentous ascomycete and aging model Podospora anserina. Overexpression of PaGlo1 leads to a lifespan reduction on glucose rich medium, probably due to depletion of reduced glutathione. Deletion of PaGlo1 leads to hypersensitivity against MG added to the growth medium. A beneficial effect on lifespan is observed when both PaGlo1 and PaGlo2 are overexpressed and the corresponding strains are grown on media containing increased glucose concentrations. Notably, the double mutant has a ‘healthy’ phenotype without physiological impairments. Moreover, PaGlo1/PaGlo2_OEx strains are not long-lived on media containing standard glucose concentrations suggesting a tight correlation between the efficiency and capacity to remove MG within the cell, the level of available glucose and lifespan. Overall, our results identify the up-regulation of both components of the glyoxalase system as an effective intervention to increase lifespan in P. anserina. Key words: Podospora anserina, aging, lifespan, glycation, glucose, methylglyoxal, advanced glycation end product

Does current noise arise from the competition between conductive and insulating phase at the trap-filling transition in organic semiconductors?

The relative current noise power spectral density S = S(I)(f)/I(2) observed in organic semiconductors exhibits a maximum at the trap filling transition between the ohmic and the space-charge-limited-current regime. The electrostatic conditions determining the crossover from ohmic to space-charge-limited transport at the trap filling transition are here discussed. These arguments shed light on the need to adopt a percolative fluctuations model to account for the competition between insulating and conductive phases as the voltage increases

Latina Titans: A Journey of Inspiration

This qualitative research examined the journey of renowned female leadership in higher education. Two top level Latina administrators of universities were interviewed extensively to discover their journey to leadership. The theoretical framework used was Latina critical race theory, feminist theory, and counter-storytelling. Themes that surfaced were strong supportive mother, fervent faith, humble beginnings, mentors, intelligence, and challenges not obstacles. These guiding themes serve as a path for Latinas who aspire to higher educational leadership positions

Latina Titans: A Journey of Inspiration

This qualitative research examined the journey of renowned female leadership in higher education. Two top level Latina administrators of universities were interviewed extensively to discover their journey to leadership. The theoretical framework used was Latina critical race theory, feminist theory, and counter-storytelling. Themes that surfaced were strong supportive mother, fervent faith, humble beginnings, mentors, intelligence, and challenges not obstacles. These guiding themes serve as a path for Latinas who aspire to higher educational leadership positions

Latina School Leadership: Breaking the Mold and Rising to the Top

For this qualitative research study, interviews with two Latina school leaders revealed their journeys to leadership. The theoretical framework used was Latina critical race theory, feminist theory, and counter storytelling. Identified themes were strong supportive mother, fervent faith, humble beginnings, mentors, intelligent, and challenges not obstacles. These guiding themes serve as a path for Latinas who aspire to public school leadership positions

Exopolysaccharides enriched in rare suggars: bacterial sources, production and applications

Mini ReviewMicrobial extracellular polysaccharides (EPS), produced by a wide range of bacteria, are high molecular weight biopolymers, presenting an extreme diversity in terms of chemical structure and composition. They may be used in many applications, depending on their chemical and physical properties. A rather unexplored aspect is the presence of rare sugars in the composition of some EPS. Rare sugars, such as rhamnose or fucose, may provide EPS with additional biological properties compared to those composed of more common sugar monomers. This review gives a brief overview of these specific EPS and their producing bacteria. Cultivation conditions are summarized, demonstrating their impact on the EPS composition, together with downstream processing. Finally, their use in different areas, including cosmetics, food products, pharmaceuticals, and biomedical applications, are discussedinfo:eu-repo/semantics/publishedVersio

Gini Method Application: Indoor Radon Survey in Kpong, Ghana

In this study, the indoor radon concentrations map, starting from a sparse measurements survey, was realized with the Gini index method. This method was applied on a real dataset coming from indoor radon measurements carried out in Kpong, Ghana. The Gini coefficient variogram is shown to be a good estimator of the inhomogeneity degree of radon concentration because it allows for better constraining of the critical distance below which the radon geological source can be considered as uniform. The indoor radon measurements were performed in 96 dwellings in Kpong, Ghana. The data showed that 84% of the residences monitored had radon levels below 100 Bqm¯³, versus 16% having levels above the World Health Organization's (WHO) suggested reference range (100 Bqm¯³). The survey indicated that the average indoor radon concentration (IRC) was 55 ± 36 Bqm¯³. The concentrations range from 4–176 Bqm¯³. The mean value 55 Bqm¯³ is 38% higher than the world's average IRC of 40 Bqm¯³ (UNSCEAR, 1993)

Perianal Paget Disease: Different Entities With the Same Name

Extramammary Paget disease (EMPD) is a rare form of cancer that involves skin areas rich in apocrine glands. The common sites of occurrence include the vulva, perianal region, perineum, and axilla. Perianal Paget disease (PPD) is a subset of EMPD, which arises in the perianal skin. The disease commonly presents with a thickened plaque-like lesion with erythema or white scaly appearance. It is generally classified into two categories based on the origin of the tumor cells: (1) primary PPD if the tumor arises from intraepidermal cells and (2) secondary PPD if cancer originates from the underlying colorectal or urinary tract neoplasm. Due to its rarity, only a few sporadic case reports have been published in the literature, and treatment methods are yet to be standardized. In light of this, we report two PPD cases with different etiopathogenesis and staging: one involved only the perianal skin without regional or metastatic disease, and was not accompanied by visceral adenocarcinomas although there was a previous history of sigmoid adenocarcinoma; the other was probably secondary to an anal canal tumor spreading with disseminated disease involving the perianal and perineum area with bilateral inguinal, pelvic lymph node, and liver metastasis. The treatment plans and the outcomes of both cases were necessarily different from each other.info:eu-repo/semantics/publishedVersio

Tamarind (Tamarindus indica linn.) and Sweet Sorghum (Sorghum bicolor L.Moench): their Potential Utilization in Phytotherapy

The use of botanical extracts and essential oil in skin care has been increasing due to greater demand on the part of consumers to use natural ingredients. Tamarind and Sweet Sorghum really have   big potentials  for reaching the public and showcasing its benefits , thus this study could encourage growers to raise more Tamarind and Sweet Sorghum in their areas not only as  food but as a raw material in the production of natural products which are for health and wellness. Both Tamarind and Sweet Sorghum possess skin healing effect which may be attributed to their biologically active components. Tamarind  possess to have bioflavonoids and alkaloids which occur in its leaves, pulp and bark. The bark contains  tannin which are recommended for treatments of inflammation, ulceration and skin disease. Tamarind has  Tartaric acid that makes it possible for tamarind to works wonders on oily skin with pimples and on sun-damaged.  Sweet Sorghum on the other hand contains emulsion, a substance that can give a moisturizing effect on the skin. the majestic phytochemistry of Tamarind and Sweet Sorghum encouraged the researcher  to produce and test  the acceptability, efficacy and safety of different skin care products that are commonly needed by the community. The Tamarind Leaves soap was proven to be highly acceptable in terms of its color, odor, texture, hardness and overall appearance. Both the Tamarind soap and the Sweet Sorghum soap were safe and free from insoluble soap and fatty acid soap. The percent reduction of acne in using Tamarind soap, Sweet Sorghum and Commercial soap have similar effect on the tenth and twelve days of use. The initial means of the treatments ranges from 10.00 pustule to 2.00 pustule. After 12 days of treatment the mean decrease is zero or equivalent to 100% decrease in the number of acne. The result of this study maybe explained with the result on antibacterial property test ( against Staphylococcus A.) of Tamarind soap and Sweet Sorghum Soap. Tamarind soap with 8% extract was found to be most effective in reduction of pimples. The Tamarind shower gel and Sweet Sorghum shower gels were effective against Staphylococcus Aurous. Tamarind Bark Ointment was an effective anti – inflammatory agent particularly on swelling and redness as well as for wound healing. Tamarind scrub salt, shower gel  and liniment  were also highly acceptable and found to be safe and effective. Result on the acceptability of Sweet Sorghum natural products are comparable to the acceptability of Tamarind natural products.  The development of technology for the Production of Natural  Products from Tamarind and Sweet Sorghum is timely, considering the growing consciousness of consumers on safe, organic and healthy natural products. Likewise, this product diversification scheme can promote multi-uses and competitive of the Tamarind and Sweet Sorghum