Boundary regularity for manifold constrained p(x)-harmonic maps

We prove partial and full boundary regularity for manifold constrained (Formula presented.) -harmonic maps

Exploring the cellular basis of human disease through a large-scale mapping of deleterious genes to cell types

Table S5. Disease–cell-type association P values computed using the GSC method. (XLS 686 kb

Effects of the electron-phonon coupling near and within the insulating Mott phase

The role of the electron-phonon interaction in the Holstein-Hubbard model is investigated in the metallic phase close to the Mott transition and in the insulating Mott phase. The model is studied by means of a variational slave boson technique. At half-filling, mean-field static quantities are in good agreement with the results obtained by numerical techniques. By taking into account gaussian fluctuations, an analytic expression of the spectral density is derived in the Mott insulating phase showing that an increase of the electron-phonon coupling leads to a sensitive reduction of the Mott gap through a reduced effective repulsion. The relation of the results with recent experimental observations in strongly correlated systems is discussed.Comment: 4 pages, 4 figure

Spin polarization of electrons with Rashba double-refraction

We demonstrate how the Rashba spin-orbit coupling in semiconductor heterostructures can produce and control a spin-polarized current without ferromagnetic leads. Key idea is to use spin-double refraction of an electronic beam with a nonzero incidence angle. A region where the spin-orbit coupling is present separates the source and the drain without spin-orbit coupling. We show how the transmission and the beam spin-polarization critically depend on the incidence angle. The transmission halves when the incidence angle is greater than a limit angle and a significant spin-polarization appears. Increasing the spin-orbit coupling one can obtain the modulation of the intensity and of the spin-polarization of the output electronic current when the input current is unpolarized. Our analysis shows the possibility to realize a spin-field-effect transistor based on the propagation of only one mode with the region with spin-orbit coupling. Where the original Datta and Das device [Appl.Phys.Lett. {\bf 56}, 665 (1990)] use the spin-precession that originates from the interference between two modes with orthogonal spin.Comment: 12 pages with 7 figure

Animal rennets as sources of dairy lactic acid bacteria

The microbial composition of artisan and industrial animal rennet pastes was studied by using both culture-dependent and -independent approaches. Pyrosequencing targeting the 16S rRNA gene allowed to identify 361 operational taxonomic units (OTUs) to the genus/species level. Among lactic acid bacteria (LAB), Streptococcus thermophilus and some lactobacilli, mainly Lactobacillus crispatus and Lactobacillus reuteri, were the most abundant species, with differences among the samples. Twelve groups of microorganisms were targeted by viable plate counts revealing a dominance of mesophilic cocci. All rennets were able to acidify ultrahigh-temperature-processed (UHT) milk as shown by pH and total titratable acidity (TTA). Presumptive LAB isolated at the highest dilutions of acidified milks were phenotypically characterized, grouped, differentiated at the strain level by randomly amplified polymorphic DNA (RAPD)-PCR analysis, and subjected to 16S rRNA gene sequencing. Only 18 strains were clearly identified at the species level, as Enterococcus casseliflavus, Enterococcus faecium, Enterococcus faecalis, Enterococcus lactis, Lactobacillus delbrueckii, and Streptococcus thermophilus, while the other strains, all belonging to the genus Enterococcus, could not be allotted into any previously described species. The phylogenetic analysis showed that these strains might represent different unknown species. All strains were evaluated for their dairy technological performances. All isolates produced diacetyl, and 10 of them produced a rapid pH drop in milk, but only 3 isolates were also autolytic. This work showed that animal rennet pastes can be sources of LAB, mainly enterococci, that might contribute to the microbial diversity associated with dairy productions

A 10-3 drift velocity monitoring chamber

The MEG-II experiment searches for the lepton flavor violating decay: mu in electron and gamma. The reconstruction of the positron trajectory uses a cylindrical drift chamber operated with a mixture of He and iC4H10 gas. It is important to provide a stable performance of the detector in terms of its electron transport parameters, avalanche multiplication, composition and purity of the gas mixture. In order to have a continuous monitoring of the quality of gas, we plan to install a small drift chamber, with a simple geometry that allows to measure very precisely the electron drift velocity in a prompt way. This monitoring chamber will be supplied with gas coming from the inlet and the outlet of the detector to determine if gas contaminations originate inside the main chamber or in the gas supply system. The chamber is a small box with cathode walls, that define a highly uniform electric field inside two adjacent drift cells. Along the axis separating the two drift cells, four staggered sense wires alternated with five guard wires collect the drifting electrons. The trigger is provided by two 90Sr weak calibration radioactive sources placed on top of a two thin scintillator tiles telescope. The whole system is designed to give a prompt response (within a minute) about drift velocity variations at the 0.001 level

Milk protein digestion and the gut microbiome influence gastrointestinal discomfort after cow milk consumption in healthy subjects

Many healthy people suffer from milk-related gastrointestinal discomfort (GID) despite not being lactose intolerant; the mechanisms underpinning such condition are unknown. This study aimed to explore milk protein digestion and related physiological responses (primary outcome), gut microbiome and gut permeability in 19 lactose-tolerant healthy nonhabitual milk consumers [NHMCs] reporting GID after consuming cow milk compared to 20 habitual milk consumers [HMCs] without GID. NHMCs and HMCs participated in a milk-load (250 mL) test, underwent blood sample collection at 6 time points over 6 h after milk consumption and collected urine samples and GID self-reports over 24 h. We measured the concentrations of 31 milk-derived bioactive peptides (BAPs), 20 amino acids, 4 hormones, 5 endocannabinoid system mediators, glucose and the dipeptidyl peptidase-IV (DPPIV) activity in blood and indoxyl sulfate in urine samples. Subjects also participated in a gut permeability test and delivered feces sample for gut microbiome analysis. Results showed that, compared to HMCs, milk consumption in NHMCs, along with GID, elicited a slower and lower increase in circulating BAPs, lower responses of ghrelin, insulin, and anandamide, a higher glucose response and serum DPPIV activity. The gut permeability of the two groups was similar, while the habitual diet, which was lower in dairy products and higher in the dietary-fibre-to-protein ratio in NHMCs, possibly shaped the gut microbiome; NHMCs exhibited lower abundance of Bifidobacteria, higher abundance of Prevotella and lower abundance of protease-coding genes, which may have reduced protein digestion, as evidenced by lower urinary excretion of indoxyl sulfate. In conclusion, the findings showed that a less efficient digestion of milk proteins, supported by a lower proteolytic capability of the gut microbiome, may explain GID in healthy people after milk consumption

CMS Monte Carlo production in the WLCG computing Grid

Monte Carlo production in CMS has received a major boost in performance and scale since the past CHEP06 conference. The production system has been re-engineered in order to incorporate the experience gained in running the previous system and to integrate production with the new CMS event data model, data management system and data processing framework. The system is interfaced to the two major computing Grids used by CMS, the LHC Computing Grid (LCG) and the Open Science Grid (OSG). Operational experience and integration aspects of the new CMS Monte Carlo production system is presented together with an analysis of production statistics. The new system automatically handles job submission, resource monitoring, job queuing, job distribution according to the available resources, data merging, registration of data into the data bookkeeping, data location, data transfer and placement systems. Compared to the previous production system automation, reliability and performance have been considerably improved. A more efficient use of computing resources and a better handling of the inherent Grid unreliability have resulted in an increase of production scale by about an order of magnitude, capable of running in parallel at the order of ten thousand jobs and yielding more than two million events per day

AC 114: a cluster with a soft X-ray tail

We present Chandra observations of the galaxy cluster AC114, which shows a strongly irregular morphology, with signs of multiple merging activity. We report the discovery of a soft X-ray filament originating close to the core of the cluster. We confirm that X-ray emission is associated with two of three mass concentrations identified in previous gravitational lensing studies of this object. These two mass concentrations are located at opposite ends of the soft filament, evidence for interaction between them. In the northern part, the cluster shows two sharp discontinuities, both in surface brightness and in temperature, evincing another, more recent merger event which took place in, or close, to the cluster core. In spite of the merger activity, a combined mass and lensing analysis shows remarkably good agreement between lensing and X-ray masses. We therefore advocate for the robustness of the X-ray mass estimates, and conclude that the assumption of hydrostatic equilibrium can yield accurate mass estimates even in clusters as dynamically active as AC 114, once the gas density distribution is properly mapped.Comment: 11 pages; to appear in ApJ 10 August 2004 issu