Kinematic and dynamic simulation of the functioning of torsionally flexible metal coupling

The article presents the process of visualization and the accuracy of performance of the prototype of bidirectional torsionally flexible metal coupling using Autodesk® Inventor® Professional 2009. Selected figures from the simulations are presented and discussed on the basis of a virtual model of the coupling

Nonlinear dynamics of a two-stage gear system with consideration given to the torsional stiffness of the countershaft

In the article presented and discussed are research results obtained during computer simulation conduced on dynamic model of a two-stage gear system. The investigation attempted to identify the impact of torsional stiffness of the countershaft on nonlinear gear stage behavior. Analysis of the results showed significant influence of the investigated constructional parameter on dynamic state of analyzed gear. First of all, lack of nonlinear gear behavior for adopted range of change in mesh torsional stiffness was observed

Molecular genetics of PKU in Poland and potential impact of mutations on BH4 responsiveness

Tetrahydrobiopterin (BH4) has been recently approved as a treatment of patients with phenylketonuria. However, as a confirmation of BH4-responsiveness, it might require a very expensive trial treatment with BH4 or prolonged BH4-loading procedures. The selection of patients eligible for BH4-therapy by means of genotyping of the PAH gene mutations may be recommended as a complementary approach. A population-wide genotyping study was carried out in 1286 Polish phenyloketonuria-patients. The aim was to estimate the BH4 demand and to cover prospectively the treatment by a National Health Fund. A total of 95 types of mutations were identified. Genetic variants corresponding with probable BH4-responsiveness were found in 28.2% of cases. However, patients with mild or classical phenylketonuria who require continuous treatment accounted for 11.4% of the studied population only. Analysis of the published data shows similar percentage of the "BH4-responsive" variants of a PAH gene in patients from other countries of Eastern Europe. Therefore, it can be concluded, that the proportion of phenylketonuria-patients who could benefit from the use of BH4 reaches approximately 10% in the entire region

4C Mortality Score correlates with in-hospital functional outcome after COVID-19-associated ischaemic stroke

Aim of the study. The 4C Mortality Score was created to predict mortality in hospitalised patients with COVID-19 and has to date been evaluated only in respiratory system disorders. The aim of this study was to investigate its application in patients with COVID-19-associated acute ischaemic stroke (AIS).Clinical rationale for study. COVID-19 is a risk factor for AIS. COVID-19-associated AIS results in higher mortality and worse functional outcome. Predictors of functional outcome in COVID-19-associated AIS are required.Materials and methods. This was a retrospective observational study of patients with AIS hospitalised in seven neurological wards in Małopolska Voivodship (Poland) between August and December 2020. We gathered data concerning the patients’ age, sex, presence of cardiovascular risk factors, type of treatment received, and the presence of stroke-associated infections (including pneumonia, urinary tract infection and infection of unknown source). We calculated 4C Mortality Score at stroke onset, and investigated whether there was a correlation with neurological deficit measured using the National Health Institute Stroke Scale (NIHSS) and functional outcome assessed using the modified Rankin Scale (mRS) at discharge.Results. The study included 52 patients with COVID-19-associated AIS. The 4C Mortality Score at stroke onset correlated with mRS (rs = 0.565, p < 0.01) at discharge. There was also a statistically significant difference in the mean 4C Mortality Score between patients who died and patients who survived the stroke (13.08 ± 2.71 vs. 9.85 ± 3.47, p = 0.04).Conclusions and clinical implications. 4C Mortality Score predicts functional outcome at discharge in COVID-19-associated AIS patients

Monte Carlo fitting of data from muon catalyzed fusion experiments in solid hydrogen Dopasowanie metodą Monte Carlo danych z eksperymentów katalizy mionowej w zestalonym wodorze /

Tyt. z nagłówka.Bibliografia s.20.Dostępny również w formie drukowanej.ABSTRACT: Applying the classical chi-square fitting procedure for multiparameter systems is in some cases extremely difficult due to the lack of an analytical expression for the theoretical functions describing the system. This paper presents an analysis procedure for experimental data using theoretical functions generated by Monte Carlo method, each corresponding to definite values of the minimization parameters. It was applied for the E742 experiment (TRIUMF, Vancouver, Canada) data analysis with the aim to analyze data from Muon Catalyzed Fusion experiments (extraction muonic atom scattering parameters and parameters of pd fusion in pdµ molecule). STRESZCZENIE: Zastosowanie klasycznej procedury fitowania przy użyciu estymatora chi-kwadrat jest w pewnych przypadkach bardzo trudne z powodu braku analitycznych wyrażeń na teoretyczne funkcje opisujące system. W pracy zaprezentowano procedurę analizy danych eksperymentalnych przy użyciu teoretycznych funkcji generowanych metodą Monte Carlo, odpowiadających zdefiniowanym wartościom szukanych parametrów. Analiza została zastosowana dla eksperymentu E742 (TRIUMF, Vancouver, Kanada) w celu opisu danych pochodzących z syntezy jądrowej katalizowanej mionami (uzyskanie parametrów opisujących rozpraszanie atomów mionowych i parametrów syntezy pd w molekule pdµ). KEYWORDS: data fitting, Monte Carlo simulation, chi-square estimator, gradient calculation, diffusion simulation, muonic atoms and molecules. SŁOWA KLUCZOWE: dopasowywanie danych, symulacja Monte Carlo, estymator chi-kwadrat, obliczenia gradientu, symulacja dyfuzji, atomy i molekuły mionowe

Experimental and numerical analysis of cylindrical straw drying

The paper presents experimental and numerical results of the heat and mass transfer in a cylindrical bale of straw. The experimental measurements were made in a specialized stand of straw driers. Flue gasses, comes from straw combustion in the biomass boiler, are used as a drying medium. There were made measurements of humidity and temperature inside the cylindrical straw bale during the drying process. The results were used to prepare the drying rate curve. Moreover, data were used to validate the numerical model of straw drying. The numerical model was performed to depict the heat and mass transfer inside the straw bale. Furthermore, the model was used to optimize the drying process. The paper presents result of experimental and numerical drying rates of cylindrical straw bale and heat and mass transfer in its interior. As a result of the work numerical model was obtained. It satisfactorily describes the mechanisms inside the drying straw bale

Computer finite element analysis of stress derived from particular units of torsionally flexible metal coupling

In this article the results of Finite Element Analysis (FEA) results of stresses derived from chosen units of torsionally flexible metal coupling are presented. As model and simulation tool for particular component loads is used the Autodesk Inventor Professional 2009 program

The investigation of the impact of basic operational parameters on the dynamics of water jacket in a biomass boiler using numerical and experimental methods

Biomass boiler application, despite its many advantages, is dependent upon many technical aspects, which require tests and optimization. Because of practical constraints, one of the most problematic areas of research is the analysis of phenomena occurring inside the water jacket of the boiler during the combustion process. The issue referred to above is significant due to its direct impact on the heating up of the operating medium for current power of the device and the total efficiency. The paper presents the analytical possibilities of the operating medium in a biomass boiler water jacket. The experimental works conducted as a part of the study were performed using an actual device – EKOPAL RM 40 straw boiler. They were aimed at defining the values of significant boundary conditions. Resistance thermometers and K-type thermocouples connected to a data acquisition system were placed in selected points of the water jacket and the combustion chambers to allow the monitoring of the conditions of the water heating process during biomass combustion. A measurement of inlet water mass flow rate was performed. To develop a numerical model of heat transfer into the water jacket, ANSYS CFX software was applied. The results of the experiments and simulations were compared and discussed. The paper describes the methodology and instruments used to perform the experimental studies, as well as some optimization solutions developed based on the results of the numeric alanalysis