Effect of Fe content on atomic and electronic structure of complex oxides Sr Ti,Fe O3 delta

Two series of SrTi1 xFexO3 amp; 948; STFO powders with different Fe content produced by two different methods, solid state reaction or modified Pechini synthesis, have been investigated by soft X ray absorption spectroscopy. The O1s K , Fe2p L2,3 and Ti2p L2,3 absorption spectra of STFO powders were analyzed. Partial substitution of Ti by Fe atoms in SrTiO3 were found to cause asymmetric distortion of TiO6 octahedrons which may violate the cubic symmetry of STFO. It was established that the distortion of TiO6 octahedrons increases with increasing Fe content. The joint analysis of the STFO spectra along with the reference compounds points to the presence mainly of Fe3 states in octahedral environment at small concentration of Fe atoms along with essentially smaller content of Fe4 states in octahedral environment where the latter contribution increases with increasing Fe content. Also a presence of Fe3 states in tetrahedral environment with Fe content higher than 50 is traced. A certain amount of Fe2 ions in an octahedral environment was also found in the STFO compound prepared by spray pyrolysis with Fe content higher than 75 . The O1s K absorption spectra point to increase in oxygen vacancy concentration with increasing Fe content. The lowest degree of structure distortions was traced in STFO35. Hence, the STFO35 compound seems to be mostly appropriate for technical application

Physical constraints of cultural evolution of dialects in killer whales

Data collection was supported by a variety of organizations, including the Russian Fund for the Fundamental Research (Grant No. 15-04-05540), the Rufford Small Grants Fund, Whale and Dolphin Conservation, the Fundação para a Ciência e a Tecnologia (Grant No. SFRH/BD/30303/2006), Russell Trust Award of the University of St. Andrews, the Office of Naval Research, the Icelandic Research Fund (i. Rannsóknasjóður), the National Geographic Society Science and Exploration Europe (Grant No. GEFNE65-12), Vancouver Aquarium Marine Science Centre, the Canadian Ministry of Fisheries and Oceans, and the North Gulf Oceanic Society.Odontocete sounds are produced by two pairs of phonic lips situated in soft nares below the blowhole; the right pair is larger and is more likely to produce clicks, while the left pair is more likely to produce whistles. This has important implications for the cultural evolution of delphinid sounds: the greater the physical constraints, the greater the probability of random convergence. In this paper the authors examine the call structure of eight killer whale populations to identify structural constraints and to determine if they are consistent among all populations. Constraints were especially pronounced in two-voiced calls. In the calls of all eight populations, the lower component of two-voiced (biphonic) calls was typically centered below 4 kHz, while the upper component was typically above that value. The lower component of two-voiced calls had a narrower frequency range than single-voiced calls in all populations. This may be because some single-voiced calls are homologous to the lower component, while others are homologous to the higher component of two-voiced calls. Physical constraints on the call structure reduce the possible variation and increase the probability of random convergence, producing similar calls in different populations.PostprintPeer reviewe

Возрастные аспекты эпидемиологии бронхиальной астмы у детей Новосибирска

An epidemiological survey on the ISAAC protocol involved 7,168 schoolchildren, 3,584 aged 13— 14 and 3,584 aged 7—8. Medical histories reported wheeze and rale in 25.6% of cases, and 10.4% in the 12 months preceding the survey. 2% had wheezes more than 4 times a year. The junior group revealed a spectacularly higher occurrence of nocturnal wheezes. Exercise-induced wheezes were much more frequent in the 13— 14 age group. Bronchial asthma had been diagnosed prior to the survey in 1.6% and 3.3% of cases in the 7—8 and 13— 14 age groups, respectively, to reveal BA morbidity drastically understated by the health service, especially with junior children.По данным эпидемиологического обследования по программе “ISAAC” 7168 детей (3584 учащихся в возрасте 13— 14 лет и 3584 школьников в возрасте 7—8 лет) распространенность затрудненного хрипящего дыхания, хрипов в грудной клетке составляет в анамнезе 25,6%, в течение 12 месяцев, предшествующих обследованию, — 10,4%. Частые рецидивы (более 4 раз в год) отмечены у 2% обследованных. У младших школьников ночные симптомы встречались достоверно чаще. Бронхоспазм физической нагрузки с большей частотой зафиксирован у восьмиклассников. До обследования диагноз бронхиальной астмы стоял у 1,6% первоклассников, 3,3% — восьмиклассников, что свидетельствуете гиподиагностике бронхиальной астмы, особенно у младших школьников

Severe food allergy to cow's milk proteins

The purpose of the study is to present a clinical case of severe/extremely severe nutritional anaphylaxis on cow's milk proteins in a child with concomitant atopic bronchial asthma, paying attention to the issues of timely diagnosis and emergency medical care during anaphylaxis.Цель исследования - представить клинический случай пищевой анафилаксии на белки коровьего молока тяжелой/крайне тяжелой степени тяжести у ребенка с атопической бронхиальной астмой, уделяя внимание вопросам своевременной диагностики и оказания неотложной медицинской помощи во время анафилаксии

Lipoprotein(a) concentration and the blood content of INFγ-producing T-helpers 17 (Th17/1) in males with premature coronary artery disease

Aim. To analyze the relationship of blood lipid profile parameters, including the level of lipoprotein(a) (Lp(a)), and the content of circulating CD4+ T-lymphocytes with premature coronary artery disease (CAD).Material and methods. This retrospective cross-sectional study included 76 men aged 40 to 79 years. Patients were divided into following groups: main group — patients with CAD (58 [54;64] years, n=56) onset before the age of 55; control group — patients (62 [57;66] years, n=20) without CAD and obstructive CAD and peripheral arterial disease. Statins were taken by 51 (91%) and 9 (45%) patients in the main and control groups, respectively. In serum and plasma samples, lipid spectrum parameters and Lp(a) concentration were determined. Cellular phenotyping was performed by direct immunofluorescence in a culture of mononuclear leukocytes isolated from blood. To determine cytokines, cells were in vitro activated with inhibitor of intracellular transport of secretory proteins. Cell fluorescence was determined using flow cytometry.Results. Patients of both groups were comparable in age, body mass index, prevalence of hypertension and diabetes. Blood Lp(a) concentrations were higher in the CAD group than in the control group (49 [10;102] mg/dL vs 12 [4,3;32] mg/ dL, p<0,05). The content of INFγ-producing T-helpers 17 (Th17/1) was also higher in the CAD group (19 [15;24] vs 13 [11;22], % of Th17, p=0,05). Logistic regression revealed that elevated Lp(a) levels (≥30 mg/dL) and relative amounts of Th17/1 (>14% of Th17) independently of each other, atherogenic lipoprotein cholesterol levels, classical risk factors, and statin use were associated with premature CAD in the general group of patients with odds ratio (OR) of 4,6 (95% confidence interval (CI), 1,1-20,2) and 10,9 (2,1-56,7), p<0,05, respectively. The combination of Lp(a) >30 mg/dl and Th17/1 over 14% significantly increased the risk of premature CAD (OR, 28,0, 95% CI, 4,31-181,75, p=0,0005).Conclusion. We have shown for the first time that an increased Lp(a) concentration with an increased Th17/1 content is associated with the premature CAD in men

Currency as the most important vector of development directions of educational work in the higher education

The article are considers the questions of the organization of curatorship at the Dental faculty, the main directions of curatorial work and forms of interaction between the curators and students.В статье рассмотрены вопросы организации кураторства на стоматологическом факультете, рассмотрены основные направления кураторской работы и формы взаимодействия кураторов со студентами

Volunteering as the direction of the educational work at the university

This article is dedicated to the direction of this educational work at the university as a volunteer, in the article the basic directions and summed up the results of volunteering students of dental faculty UGMU.Данная статья посвящена такому направлению воспитательной работы в вузе как волонтерство, также в статье представлены основные направления и подведены некоторые итоги волонтерской деятельности студентов стоматологического факультета УГМУ

Improving the quality of the educational process, taking into account the need for the development of communicative culture of students of faculty of dentistry

Тhe article describes the instruments, mechanisms and role of the Dean in improving the quality of the educational process, taking into account the need for the development of communicative culture of students of Faculty of Dentistry.В статье рассмотрены инструменты и механизмы, а также роль деканата в повышении качества учебно-воспитательного процесса с учетом потребности в развитии коммуникативной культуры студентов стоматологического факультета УГМУ

Expression of the NUP153 and YWHAB genes from their canonical promoters and alternative promoters of the LINE-1 retrotransposon in the placenta of the first trimester of pregnancy

The placenta has a unique hypomethylated genome. Due to this feature of the placenta, there is a potential possibility of using regulatory elements derived from retroviruses and retrotransposons, which are suppressed by DNA methylation in the adult body. In addition, there is an abnormal increase in the level of methylation of the LINE-1 retrotransposon in the chorionic trophoblast in spontaneous abortions with both normal karyotype and aneuploidy on different chromosomes, which may be associated with impaired gene transcription using LINE-1 regulatory elements. To date, 988 genes that can be expressed from alternative LINE-1 promoters have been identified. Using the STRING tool, genes (NUP153 and YWHAB) were selected, the products of which have significant functional relationships with proteins highly expressed in the placenta and involved in trophoblast differentiation. This study aimed to analyze the expression of the NUP153 and YWHAB genes, highly active in the placenta, from canonical and alternative LINE-1 promoters in the germinal part of the placenta of spontaneous and induced abortions. Gene expression analysis was performed using real-time PCR in chorionic villi and extraembryonic mesoderm of induced abortions (n = 10), adult lymphocytes (n = 10), spontaneous abortions with normal karyotype (n = 10), and with the most frequent aneuploidies in the first trimester of pregnancy (trisomy 16 (n = 8) and monosomy X (n = 6)). The LINE-1 methylation index was assessed in the chorionic villi of spontaneous abortions using targeted bisulfite massive parallel sequencing. The level of expression of both genes from canonical promoters was higher in blood lymphocytes than in placental tissues (p < 0.05). However, the expression level of the NUP153 gene from the alternative LINE-1 promoter was 17 times higher in chorionic villi and 23 times higher in extraembryonic mesoderm than in lymphocytes (p < 0.05). The expression level of NUP153 and YWHAB from canonical promoters was higher in the group of spontaneous abortions with monosomy X compared to all other groups (p < 0.05). The LINE-1 methylation index negatively correlated with the level of gene expression from both canonical (NUP153 – R = –0.59, YWHAB – R = –0.52, p < 0.05) and alternative LINE-1 promoters (NUP153 – R = –0.46, YWHAB – R = –0.66, p < 0.05). Thus, the observed increase in the LINE-1 methylation index in the placenta of spontaneous abortions is associated with the level of expression of the NUP153 and YWHAB genes not only from alternative but also from canonical promoters, which can subsequently lead to negative consequences for normal embryogenesis