Diagnóstico estratégico da produção de carne de cabrito da raça serrana

Este trabalho pretende realizar um diagnóstico estratégico do setor de carnes de cabrito Serrana. Os dados baseiam-se numa amostra de 70 criadores da região Norte de Trás-os-Montes. Os resultados do estudo revelam algumas debilidades estruturais no setor, como a reduzida escolaridade dos produtores, a ancianidade, o abandono da atividade, o baixo preço ao produtor ou mesmo as oscilações da procura. Efetivamente, de acordo com os indivíduos da nossa amostra, se agruparmos o envelhecimento dos produtores à diminuição do efetivo e ao abandono da atividade, a fragilidade do setor é enorme. Acresce alguma carência de visão e inovação, por parte dos agentes, nos diferentes elos do sistema de comercialização. Nenhum criador vende a carne através da internet, a retalho ou pré-embalada, não retendo para si o valor acrescentado da transformação. Assim, o escoamento do produto é praticamente assegurado pela qualidade da carne, que se tem apresentado como uma potencialidade irrefutável.This paper intends to perform a strategic diagnostic of the meat sector of Serrana goat kid. The data is based on a sample of 70 breeders, members of the Association for the Serrana goats (ANCRAS), from the Northern region of Trás-os-Montes. The study findings reveal some structural weaknesses in the sector, such as low schooling of farmers, old age, cessation of goat farming activity, low producer prices or demand fluctuations. Indeed, according to our sample goat breeders, if we add the “goat breeders aging” with “herd goat decrease” and “abandonment of the goat farming activity”, the sector’s fragility is huge. Moreover, there are some lack of vision and innovation, by the actors in different links of the marketing chain. No one of the farmers sells the meat over the internet, retail or prepacked, so do not appropriate themselves of the added value of processing. Indeed, the product marketing is essentially based on meat quality, which has been presented as the sector main strength.Este trabalho foi financiado por: Projeto OPEN2PRESERVE - Modelo de gestión sostenible para la preservación de paisajes abiertos de montaña (SOE2/P5/E0804). Os autores agradecem à Fundação para a Ciência e a Tecnologia (FCT, Portugal) e ao FEDER no âmbito do programa PT2020 pelo apoio financeiro ao CIMO (UID/AGR/00690/2013).info:eu-repo/semantics/publishedVersio

Increased homocysteine plasma levels in breast cancer patients of a Mexican population

Aim: Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. Materials and Methods: The tHcy plasma levels were measured using high-performance liquid chromatography with a fluorescence detector in 89 female controls and 261 BC patients. Results: The observed plasma tHcy levels were significantly higher among the BC patients (11.1019 ± 5.9161 µmol/l) compared to the controls (9.1046 ± 1.3213 µmol/l) (p = 0.002), and these differences were evident when stratified by age (≥ 50 years old), menopause status, overweight and obesity, miscarriages, node metastases, progression, subtype classification (luminal, Her2 and triple negative) and nonresponse to chemotherapy. Conclusions: The tHcy plasma levels could be a good marker for the progression and chemosensitivity of BC in the analyzed sample from a Mexican population. Key Words: plasma levels, homocysteine, HPLC, breast cancer, Mexican population

Virtual molecular medicine in developing countries: The Mexican initiative

[No abstract available

Current topics in Fabry disease [Aspectos de actualidad en enfermedad de Fabry]

Fabry disease is a lysosomal storage disease due to deficiency of the enzyme acid α-Galactosidase, which hydrolysis of globotriaosylceramide, causing its accumulation in cells and body tissues. Most males with classic phenotype have angiokeratoma, acroparesthesias, hypohidrosis and cornea verticilata childhood-onset, and have a marked decrease in life span, death occurs between the fourth and fifth decade of life secondary to renal, cardiovascular and cerebrovascular complications. Carriers female have a wide spectrum of disease severity, from asymptomatic to the presentation of characteristic symptoms as men. Currently, the treatment is enzyme replacement therapy. The aim of this paper is to present a current perspective and advances in Fabry disease

Terminal deletion of the short arm of chromosome 3

Deletion of the short arm of chromosome number 3, has been proposed as a distinctive syndrome, all cases are (de novo) deletions and the band 3p26 was systematically involved. The comparative study of the 21 reviewed cases (including one reported here) allows to conclude that there is no consistent association to delineate a typical clinical syndrome

Terminal deletion of the short arm of chromosome 3

Deletion of the short arm of chromosome number 3, has been proposed as a distinctive syndrome, all cases are (de novo) deletions and the band 3p26 was systematically involved. The comparative study of the 21 reviewed cases (including one reported here) allows to conclude that there is no consistent association to delineate a typical clinical syndrome

The Ohdo blepharophimosis syndrome in a Mexican boy

The clinical picture of a 16-month-old Mexican boy (hypotonia, psychomotor retardation, blepharophimosis, small and widely spaced teeth, hypoplastic scrotum) was compatible with the diagnosis of Ohdo blepharophimosis syndrome (OBS). Comparison with six previously described patients confirms that the OBS is mainly characterized by psychomotor and mental retardation, blepharophimosis, dental hypoplasia, deafness, and hypoplastic scrotum. The advanced age of this boy's father suggests a possible autosomal dominant mutation in the syndrome

The Ohdo blepharophimosis syndrome in a Mexican boy

The clinical picture of a 16-month-old Mexican boy (hypotonia, psychomotor retardation, blepharophimosis, small and widely spaced teeth, hypoplastic scrotum) was compatible with the diagnosis of Ohdo blepharophimosis syndrome (OBS). Comparison with six previously described patients confirms that the OBS is mainly characterized by psychomotor and mental retardation, blepharophimosis, dental hypoplasia, deafness, and hypoplastic scrotum. The advanced age of this boy's father suggests a possible autosomal dominant mutation in the syndrome

[Current genetic issues and phenotypic variants in Kallmann syndrome]. [Síndrome de Kallmann. Aspectos genéticos y variantes fenotópicas.]

Kallmann syndrome is characterized by hypogonadotropic hypogonadism and anosmia/hyposmia. The hypogonadotropic hypogonadism is due to deficiency of gonadotropin-releasing hormone, caused by a defect in the migration of neurons synthesizing gonadotropin-releasing hormone, and anosmia/hyposmia is related to the absence or hypoplasia of the olfactory bulb and tracts. Some patients may have other associated abnormalities such as renal agenesis, cleft palate, dental agenesis, synkinesis, shortening of metacarpal, sensory neural hearing loss and seizures. The aim of this paper is to present an updated review of the clinical and molecular basis, highlighting the relevance of knowledge of phenotypic variants in Kallmann syndrome

[Current genetic issues and phenotypic variants in Kallmann syndrome]. [Síndrome de Kallmann. Aspectos genéticos y variantes fenotípicas.]

Kallmann syndrome is characterized by hypogonadotropic hypogonadism and anosmia/hyposmia. The hypogonadotropic hypogonadism is due to deficiency of gonadotropin-releasing hormone, caused by a defect in the migration of neurons synthesizing gonadotropin-releasing hormone, and anosmia/hyposmia is related to the absence or hypoplasia of the olfactory bulb and tracts. Some patients may have other associated abnormalities such as renal agenesis, cleft palate, dental agenesis, synkinesis, shortening of metacarpal, sensory neural hearing loss and seizures. The aim of this paper is to present an updated review of the clinical and molecular basis, highlighting the relevance of knowledge of phenotypic variants in Kallmann syndrome