Adaptive system and method for signal generation Patent

Adaptive signal generating system and logic circuits for satellite television system

Defects in Heavy-Fermion Materials: Unveiling Strong Correlations in Real Space

Complexity in materials often arises from competing interactions at the atomic length scale. One such example are the strongly correlated heavy-fermion materials where the competition between Kondo screening and antiferromagnetic ordering is believed to be the origin of their puzzling non-Fermi-liquid properties. Insight into such complex physical behavior in strongly correlated electron systems can be gained by impurity doping. Here, we develop a microscopic theoretical framework to demonstrate that defects implanted in heavy-fermion materials provide an opportunity for unveiling competing interactions and their correlations in real space. Defect-induced perturbations in the electronic and magnetic correlations possess characteristically different spatial patterns that can be visualized via their spectroscopic signatures in the local density of states or non-local spin susceptibility. These real space patterns provide insight into the complex electronic structure of heavy-fermion materials, the light or heavy character of the perturbed states, and the hybridization between them. The strongly correlated nature of these materials also manifests itself in highly non-linear quantum interference effects between defects that can drive the system through a first-order phase transition to a novel inhomogeneous ground state.Comment: 11 pages, 7 figure

Hidden Order Transition in URu2Si2 and the Emergence of a Coherent Kondo Lattice

Using a large-N approach, we demonstrate that the differential conductance and quasi-particle interference pattern measured in recent scanning tunneling spectroscopy experiments (A.R. Schmidt et al. Nature 465, 570 (2010); P. Aynajian et al., PNAS 107, 10383 (2010)) in URu2Si2 are consistent with the emergence of a coherent Kondo lattice below its hidden order transition (HOT). Its formation is driven by a significant increase in the quasi-particle lifetime, which could arise from the emergence of a yet unknown order parameter at the HOT.Comment: 5 pages, 3 figure

How Kondo Holes Create Intense Nanoscale Heavy-Fermion Hybridization Disorder

Replacing a magnetic atom by a spinless atom in a heavy fermion compound generates a quantum state often referred to as a 'Kondo-hole'. No experimental imaging has been achieved of the atomic-scale electronic structure of a Kondo-hole, or of their destructive impact (Lawrence JM, et al. (1996) Kondo hole behavior in Ce0. 97La0. 03Pd3. Phys Rev B 53:12559-12562; Bauer ED, et al. (2011) Electronic inhomogeneity in a Kondo lattice. Proc Natl Acad Sci. 108:6857-6861) on the hybridization process between conduction and localized electrons which generates the heavy fermion state. Here we report visualization of the electronic structure at Kondo-holes created by substituting spinless Thorium atoms for magnetic Uranium atoms in the heavy-fermion system URu2Si2. At each Thorium atom, an electronic bound state is observed. Moreover, surrounding each Thorium atom we find the unusual modulations of hybridization strength recently predicted to occur at Kondo-holes (Figgins J, Morr DK (2011) Defects in heavy-fermion materials: unveiling strong correlations in real space. Phys Rev Lett 107:066401). Then, by introducing the 'hybridization gapmap' technique to heavy fermion studies, we discover intense nanoscale heterogeneity of hybridization due to a combination of the randomness of Kondo-hole sites and the long-range nature of the hybridization oscillations. These observations provide direct insight into both the microscopic processes of heavy-fermion forming hybridization and the macroscopic effects of Kondo-hole doping.Comment: Main Article + Figures, Supporting Information + Figures; PNAS 201

Potent antiviral activity against HSV-1 and SARS-CoV-2 by antimicrobial peptoids

Viral infections, such as those caused by Herpes Simplex Virus-1 (HSV-1) and SARS-CoV-2, affect millions of people each year. However, there are few antiviral drugs that can effectively treat these infections. The standard approach in the development of antiviral drugs involves the identification of a unique viral target, followed by the design of an agent that addresses that target. Antimicrobial peptides (AMPs) represent a novel source of potential antiviral drugs. AMPs have been shown to inactivate numerous different enveloped viruses through the disruption of their viral envelopes. However, the clinical development of AMPs as antimicrobial therapeutics has been hampered by a number of factors, especially their enzymatically labile structure as peptides. We have examined the antiviral potential of peptoid mimics of AMPs (sequence-specific N-substituted glycine oligomers). These peptoids have the distinct advantage of being insensitive to proteases, and also exhibit increased bioavailability and stability. Our results demonstrate that several peptoids exhibit potent in vitro antiviral activity against both HSV-1 and SARS-CoV-2 when incubated prior to infection. In other words, they have a direct effect on the viral structure, which appears to render the viral particles non-infective. Visualization by cryo-EM shows viral envelope disruption similar to what has been observed with AMP activity against other viruses. Furthermore, we observed no cytotoxicity against primary cultures of oral epithelial cells. These results suggest a common or biomimetic mechanism, possibly due to the differences between the phospholipid head group makeup of viral envelopes and host cell membranes, thus underscoring the potential of this class of molecules as safe and effective broad-spectrum antiviral agents. We discuss how and why differing molecular features between 10 peptoid candidates may affect both antiviral activity and selectivity

Mammals collected in Alaska

p. 215-230 ; 24 cm.Includes bibliographical references

Birds collected in Alaska

p. 231-247 ; 24 cm.Includes bibliographical references

Intermediate Phenotypes Identify Divergent Pathways to Alzheimer's Disease

Background: Recent genetic studies have identified a growing number of loci with suggestive evidence of association with susceptibility to Alzheimer's disease (AD). However, little is known of the role of these candidate genes in influencing intermediate phenotypes associated with a diagnosis of AD, including cognitive decline or AD neuropathologic burden. Methods/Principal Findings: Thirty-two single nucleotide polymorphisms (SNPs) previously implicated in AD susceptibility were genotyped in 414 subjects with both annual clinical evaluation and completed brain autopsies from the Religious Orders Study and the Rush Memory and Aging Project. Regression analyses evaluated the relation of SNP genotypes to continuous measures of AD neuropathology and cognitive function proximate to death. A SNP in the zinc finger protein 224 gene (ZNF224, rs3746319) was associated with both global AD neuropathology (p = 0.009) and global cognition (p = 0.002); whereas, a SNP at the phosphoenolpyruvate carboxykinase locus (PCK1, rs8192708) was selectively associated with global cognition (p = 3.57×10−4). The association of ZNF224 with cognitive impairment was mediated by neurofibrillary tangles, whereas PCK1 largely influenced cognition independent of AD pathology, as well as Lewy bodies and infarcts. Conclusions/Significance: The findings support the association of several loci with AD, and suggest how intermediate phenotypes can enhance analysis of susceptibility loci in this complex genetic disorder

A new pika from Colorado. Bulletin of the AMNH ; v. 31, article 9.

p. 103-104 ; 24 cm