Evaluation of the risk of CAEV (caprine arthritis encephalitis virus) transmission via assisted reproduction techniques

Caprine Arthritis-Encephalitis Virus (CAEV) has been identified in the tissues of male and female genital tract, in the semen, in uterine and vaginal secretions, and in embryo flushing medias. So a health risk is associated with artificial insemination (AI), In vitro fecundation (IVF) and embryo transfer (ET). However, it has been demonstrated that sperm fraction, oocytes free of granulosa cells, embryo with intact zona pellicida and after ten washing, take off from naturally infected goats are free of CAEV. So with the respect of definite process, IA, IVF and ET are associated with low level CAEV transmission risk and TE can be use as preventive health measureLe virus de l’arthrite encéphalite caprine (CAEV) a été identifié dans les tissus de l’appareil génital mâle et femelle, dans la semence, dans les sécrétions utérines et vaginales et dans le liquide de lavage utérin lors de récoltes d’embryons. Un risque sanitaire lors d’inséminations artificielles (IA), de fécondations in vitro (FIV) et de transfert embryonnaire (TE) existe. Cependant, il a été démontré que la fraction spermatique de la semence, l’ovocyte dépourvu des cellules de la granulosa, l’embryon à zone pellucide intacte et lavé dix fois, prélevés chez des animaux naturellement infectés, étaient indemnes de CAEV. Ainsi en respectant des procédures précises, l’IA, la FIV et le TE présentent un risque négligeable de transmission du CAEV et il est démontré que le TE est utilisable comme technique de prophylaxie sanitair

The selection process of students in medicine and in veterinary medicine in the medical and veterinary medical school in USA

Fieni Francis. Les modalités de recrutement et de formation des étudiants en médecine et des étudiants en médecine vétérinaire aux États-Unis d’Amérique. In: Bulletin de l'Académie Vétérinaire de France tome 172 n°1, 2019. pp. 34-36

The New Boundaries of 3D-Printed Clay Bricks Design: Printability of Complex Internal Geometries

[EN] The building construction sector is undergoing one of the most profound transformations towards the digital transition of production. In recent decades, the advent of a novel technology for the 3D printing of clay opened up new sustainable possibilities in construction. Some architectural applications of 3D-printed clay bricks with simple internal configurations are being developed around the world. On the other hand, the full potential of 3D-printed bricks for building production is still unknown. Scientific studies about the design and printability of 3D-printed bricks exploiting complex internal geometries are completely missing in the related literature. This paper explores the new boundaries of 3D-printed clay bricks realized with a sustainable extrusion-based 3D clay printing process by proposing a novel conception, design, and analysis. In particular, the proposed methodological approach includes: (i) conception and design; (ii) parametric modeling; (iii) simulation of printability; and (iv) prototyping. The new design and conception aim to fully exploit the potential of 3D printing to realize complex internal geometry in a 3D-printed brick. To this aim, the research investigates the printability of internal configuration generated by using geometries with well-known remarkable mechanical properties, such as periodic minimal surfaces. In conclusion, the results are validated by a wide prototyping campaign.This research and APC was funded by Fondi Casa delle Tecnologie Emergenti MateraSangiorgio, V.; Parisi, F.; Fieni, F.; Parisi, N. (2022). The New Boundaries of 3D-Printed Clay Bricks Design: Printability of Complex Internal Geometries. Sustainability. 14(2). https://doi.org/10.3390/su1402059814

Mitochondrial Ca2+ Uniporter and CaMKII in heart

The influx of cytosolic Ca2+ into mitochondria is mediated primarily by the mitochondrial calcium uniporter (MCU), a small-conductance, Ca2+-selective channel-. MCU modulates intracellular Ca2+ transients and regulates ATP production and cell death. Recently, Joiner et al. reported that MCU is regulated by mitochondrial CaMKII, and this regulation determines stress response in heart. They reported a very large current putatively mediated by MCU that was about two orders of magnitude greater than the MCU current (IMCU) that we previously measured in heart mitochondria. Also, the current traces presented by Joiner et al. showed unusually high fluctuations incompatible with the low single-channel conductance of MCU. Here we performed patch-clamp recordings from mouse heart mitochondria under the exact conditions used by Joiner et al. We confirmed that IMCU in cardiomyocytes is very small and showed that it is not directly regulated by CaMKII. Thus the currents presented by Joiner et al. do not correspond to MCU, and there is no direct electrophysiological evidence that CaMKII regulates MCU

Power Budgeting of Big Data Applications in Container-based Clusters

[Abstract] Energy consumption is currently highly regarded on computing systems for many reasons, such as improving the environmental impact and reducing operational costs considering the rising price of energy. Previous works have analysed how to improve energy efficiency from the entire infrastructure down to individual computing instances (e.g., virtual machines). However, the research is more scarce when it comes to controlling energy consumption, specially in real time and at the software level. This paper presents a platform that manages a power budget to cap the energy consumed from users to applications and down to individual instances. Using containers as virtualization technology, the energy limitation is implemented thanks to the platform's ability to monitor container energy consumption and dynamically adjust its CPU resources via vertical scaling as required. Representative Big Data applications have been deployed on the platform to prove the feasibility of this approach for energy control, showing that it is possible to distribute and enforce a power budget among users and applications.Ministerio de Ciencia e Innovación de España; TIN2016-75845-PMinisterio de Ciencia e Innovación de España; PID2019-104184RB-I00Consolidation Program of Competitive Reference Groups; ED431C 2017/04Xunta de Galicia e fondos FEDER; ED431G 2019/0

SELFWATTS: On-the-fly Selection of Performance Events to Optimize Software-defined Power Meters

International audienceFine-grained power monitoring of software-defined infrastructures is unavoidable to maximize the power usage efficiency of data centers. However, the design of the underlying power models that estimate the power consumption of the monitored software components keeps being a long and fragile process that remains tightly coupled to the host machine and prevents a wider adoption by the industry beyond the rich literature on this topic. To overcome these limitations, this paper introduces SELFWATTS: a lightweight power monitoring system that explores and selects the relevant performance events to automatically optimize the power models to the underlying architecture. Unlike state-of-the-art techniques, SELFWATTS does not require any a priori training phase or specific hardware to configure the power models and can be deployed on a wide range of machines, including heterogeneous environments

PLAZA CAIRASCO Y GABINETE LITERARIO [Material gráfico]

FOTO DE LA PLAZA DE CAIRASCO. LAS PALMASCopia digital. Madrid : Ministerio de Educación, Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 201

Hyperechoic amniotic membranes in patients with preterm premature rupture of membranes (p-PROM) and pregnancy outcome

Objectives The early identification of women with preterm premature rupture of membranes (p-PROM) who are at higher risk of imminent delivery remains challenging. The aim of our study was to evaluate if an increased echogenicity of the amniotic membranes may represent a sonographic marker of impending delivery in women with p-PROM. Methods This was a prospective study including women with singleton pregnancies and diagnosis of p-PROM between 22 and 37 gestational weeks. A sonographic examination was performed within 24h from the hospital admission and the appearance of the amniotic membranes close to the internal os was specifically evaluated. The membranes were defined as hyperechoic when their echogenicity was similar to that of the fetal bones or normoechoic in the other cases. The primary aim of the study was to compare the admission to spontaneous onset of labor interval and the pregnancy outcome between the cases of p-PROM with and without hyperechoic membranes. Results Overall, 45 women fulfilled the inclusion criteria with similar characteristics at admission. In women with hyperechoic membranes, the admission to spontaneous onset of labor interval was significantly shorter (11.5 [5.3-25.0] vs. 3.0 [1.5-9.0] p=0.04) compared to women with normo-echoic membranes. At binomial logistic regression after adjustment for GA at hospital admission, the presence of hyperechoic membranes was found as the only independent predictor of spontaneous onset of labor≤72h (aOR: 6.1; 95% CI: 1.0-36.9) Conclusions The presence of hyperechoic membranes is associated with a 6-fold higher incidence of spontaneous onset of labor within 72h independently from the gestational age at p-PROM