A High-Resolution Resistive Probe for Nonlinear Analysis of Two-Phase Flows

Two-phase flow dynamics are highly complex, due to the strong coupling of various independent mechanisms and as demonstrated by the existence of a variety of flow patterns. The adoption of appropriate tools for nonlinear time series analysis tools may lead to a deeper insight in this complexity but requires high quality time series. This study describes a procedure appositely assessed in order to realise an impedance void fraction sensor of resistive type characterised by high-spatial and -temporal resolution. These characteristics have been accomplished through an appropriate geometrical design of the probe electrodes, aiming at obtaining a thin measurement volume so to improve the probe spatial resolution, and through the electronic assessment of the data acquisition system, improving its temporal resolution. A new calibration procedure has been also defined, based on an estimation of void fraction through a code for automatic extraction of bubble contours and the correction of image distortions

A Low Cost Ultrasound-based Localisation System

This paper presents a low-cost localisation system based on ultrasonic sensing and time of flight measurements. A compact ultrasound emitter has been designed to generate omnidirectional train of ultrasound pulses which are then picked up by several fixed receivers measuring the time difference of arrival. A least squares approach is used to analytically obtain a first estimate of the emitter position, which is then refined through steepest descent optimisation. All processing is done via a standard Arduino platform, proving the low computational demands of the method. Localisation results are validated against a state-of-the-art Optitrack motion capture system. It is shown that the system can cover a 4.3x3.1m arena with a mean error localisation error of 1.57cm and an average standard deviation of 1.39cm throughout the arena

Widening use of dexamethasone implant for the treatment of macular edema

Sustained-release intravitreal 0.7 mg dexamethasone (DEX) implant is approved in Europe for the treatment of macular edema related to diabetic retinopathy, branch retinal vein occlusion, central retinal vein occlusion, and non-infectious uveitis. The implant is formulated in a biodegradable copolymer to release the active ingredient within the vitreous chamber for up to 6 months after an intravitreal injection, allowing a prolonged interval of efficacy between injections with a good safety profile. Various other ocular pathologies with inflammatory etio­pathogeneses associated with macular edema have been treated by DEX implant, including neovascular age-related macular degeneration, Irvine–Gass syndrome, vasoproliferative retinal tumors, retinal telangiectasia, Coats’ disease, radiation maculopathy, retinitis pigmentosa, and macular edema secondary to scleral buckling and pars plana vitrectomy. We undertook a review to provide a comprehensive collection of all of the diseases that benefit from the use of the sustained-release DEX implant, alone or in combination with concomitant therapies. A MEDLINE search revealed lack of randomized controlled trials related to these indications. Therefore we included and analyzed all available studies (retrospective and prospective, com­parative and non-comparative, randomized and nonrandomized, single center and multicenter, and case report). There are reports in the literature of the use of DEX implant across a range of macular edema-related pathologies, with their clinical experience supporting the use of DEX implant on a case-by-case basis with the aim of improving patient outcomes in many macular pathologies. As many of the reported macular pathologies are difficult to treat, a new treat­ment option that has a beneficial influence on the clinical course of the disease may be useful in clinical practice

Appearance of quasiperiodicity within a period doubling route to chaos of a swaying thermal plume

The birth, evolution and disappearance of quasiperiodic dynamics in buoyancy-driven flow arising from an enclosed horizontal cylinder are analysed here, by numerical means, in the limit of the 2D approximation. The governing equations are solved on orthogonal Cartesian grids, giving special treatment to the internal, non-aligned boundaries. Thanks to the adoption of a high level of re finement of the Rayleigh number range, quasiperiodicity was observed to emerge from a periodic limit cycle (P1), and to turn into its omologous orbit with doubled period (P2), eventually evolving into a classical period-doubling route to chaos, for further increases of the Rayleigh number. The present study gives a deeper insight to what appears to be an imperfect period doubling bifurcation through a quasiperiodic T2-torus. The approach used is based on the classical tools for time series analysis. The distribution of the power spectral densities is used to search for and characterise the existence of relations between the frequencies of the P1, T2 and P2 dynamics. The topology of the orbits, as well as their evolution within the quasiperiodic window, are analysed with the aid of phase space representation and Poincar è maps

Heat transfer along the route to chaos of a swaying thermal plume

Detailed analyses have been recently reported on the low order dynamics of a thermal plume arising from a horizontal cylindrical heat source concentric: to an air-\ufb01lled isothermally cooled square enclosure, together with those of the related \ufb02ow structures, in the limit of the 2D approximation. In particular. within the range of O < Ra < 3 RaL-T, With Ram corresponding to the loss of stability of the stationary buoyant plume, the entire evolution from a periodic limit cycle (P1) to the birth of chaos through a period\ubbdoubling cascade has been fullyexplored. With this respect, special attention has been given to the window of quasiperiodic dynamics onto a T;-torus that is observed to separate the monoperiodic dynamics from the biperiodic dynamics onto a P1 and a Pg-liniit cycle, respectively. The results of these analyses hint at the bimodal nature of the overall dynamics. in general, and of the subharmonic cascade, in particular, which are still under investigation. Although relevant on a dynamical perspective, a with a main re\ufb02ection on the laminar-turbulent transition, the observed oscillations appear to be characterised by comparable amplitudes and to be determined by similar evolutions of the \ufb02ow pattern evolutions, so that their role on the overall heat transfer rate is expected to be marginal. Vi/'ithin this frame, the present study aims at reporting the in\ufb02uence played by the observed dynamics of the thermal plume and of the [low structures on the global heat transferrate. In particular, the aim is the assessment of the correlation between the Rayleigh number and the average Nusselt number on the cylinder surface, as well as the effect on the latter of the observed series of bifurcations

Alternative Translations of a Single RNA Message: An Identity Switch of (2S,3R)-4,4,4-Trifluorovaline between Valine and Isoleucine Codons

Changed in translation: Bacterial expression hosts can be engineered so that a single RNA message can be read in different ways depending on the relative rates of competing aminoacylation reactions. The (2S,3R)-4,4,4-trifluorovaline can be assigned either to isoleucine or to valine codons according to whether the bacterial host overexpresses the isoleucyl- or the valyl-tRNA synthetase (IleRS and ValRS, respectively; see scheme)

Twin reversed arterial perfusion sequence: current treatment options

Twin reversed arterial perfusion (TRAP) sequence is a specific and severe complication of monochorionic multiple pregnancy, characterized by vascular anastomosis and partial or complete lack of cardiac development in one twin. Despite its rarity, interest in the international literature is rising, and we aimed to review its pathogenesis, prenatal diagnostic features and treatment options. Due to the parasitic hemodynamic dependence of the acardiac twin on the pump twin, the management of these pregnancies aims to maximize the pump twin’s chances of survival. If treatment is needed, the best timing of intervention is still debated, although the latest studies encourage intervention in the first trimester of pregnancy. As for the technique of choice to interrupt the vascular supply to the acardiac twin, ultrasound-guided laser coagulation and radiofrequency ablation of the intrafetal vessels are usually the preferred approaches

Bifurcations of Natural Convection Flows from an Enclosed Cylindrical Heat Source

A numerical analysis of transitional natural convection from a confined thermal source is presented. The system considered is an air-filled, square-sectioned 2D enclosure containing a horizontal heated cylinder. The resulting flow is investigated with respect to the variation of the Rayleigh number, for three values of the aspect ratio A. The first bifurcation of the low-Ra fixed-point solution is tracked for each A-value. Chaotic flow features are detailed for the case A = 2.5. The supercritical behaviour of the system is investigated using nonlinear analysis tools and phase-space representations, and the effect of the flow on heat transfer is discussed