10 research outputs found
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): study protocol for a randomized controlled trial
- Author
- \ucdsola A.
- Abreu M.
- Acerbi P.
- Albuquerque R.
- Aldrighi J.
- Alencastro A.
- Almeida M.
- Almeida P.
- Almeida S.
- Alves J.
- Amaro A.
- Amato M.
- Amato P.
- Amorim D.
- Amorim F.
- Andrade A.
- Andrade I.
- Andrade L.
- Andrade L.
- Andrade W.
- Apoena P.
- Ara\ufajo M.
- Ara\ufajo M.
- Araujo A.
- Araujo J.
- Arduini R.
- Assef M.
- Azevedo L.
- Azevedo L.
- Backes F.
- Bainy M.
- Barbosa P.
- Barra W.
- Barros D.
- Baruzzi C.
- Bastos A.
- Bastos R.
- Batista R.
- Becker D.
- Bergo R.
- Berto P.
- Berwanger O.
- Berwanger O.
- Bigolin R.
- Bitencourt W.
- Blattner C.
- Boldo R.
- Boniatti M.
- Borges M.
- Bozi G.
- Brand\ue3o A.
- Brilenger C.
- Brilhante Y.
- Broilo F.
- Burigo A.
- Cacau L.
- Caixeta C.
- Caldeira M.
- Canavessi H.
- Canzi R.
- Cappi S.
- Carbonell R.
- Cardoso L.
- Carmona C.
- Carneiro M.
- Carneiro S.
- Carvalho A.
- Carvalho C.
- Carvalho C.
- Carvalho F.
- Carvalho F.
- Carvalho F.
- Carvalho V.
- Carvalho W.
- Caser E.
- Cavalcante E.
- Cavalcanti A.
- Cavalcanti R.
- Cerantola R.
- Chamy G.
- Chiasso T.
- Coelho A.
- Coelho M.
- Conde K.
- Cordeiro R.
- Corr\ueaa V.
- Correa F.
- Correa T.
- Correia E.
- Cortegiani A.
- Costa A.
- Costa M.
- Costa R.
- Couto W.
- Cramer A.
- Cunha A.
- D\uedaz Quijano F.
- Dadam M.
- Damasceno B.
- de Oliveira Filho W.
- Decio J.
- Demarzo S.
- Dias A.
- Dias F.
- Dias P.
- Diaz Quijano F.
- Domingues S.
- Dragosavak D.
- Duarte J.
- Duarte P.
- Duarte R.
- Dutra V.
- Falc\ue3o A.
- Falc\ue3o J.
- Farran J.
- Felizardo L.
- Ferguson N.
- Ferraz \ucd.
- Ferreira A.
- Ferreira A.
- Ferreira C.
- Ferreira C.
- Ferreira E.
- Ferreira E.
- Ferreira F.
- Ferreira R.
- Festti J.
- Feto J.
- Fialkow L.
- Figueiredo A.
- Figueiredo L.
- Filho A.
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- Foernges R.
- Fran\ue7a G.
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- G\uf3is A.
- Galassi M.
- Gallego R.
- Galv\ue3o E.
- Garcez M.
- Gatti C.
- Geha N.
- Germano A.
- Germiniani B.
- Giacomassi I.
- Giannini F.
- Gil F.
- Gimenez F.
- Giuberti A.
- Giuberti J.
- Gomes B.
- Gomes T.
- Gon\ue7alves F.
- Gon\ue7alves I.
- Gorski A.
- Grion C.
- Grion C.
- Guadalupe E.
- Guerra A.
- Guerreiro M.
- Guimar\ue3es D.
- Guimar\ue3es H.
- Guimar\ue3es H.
- Guimar\ue3es H.
- Gurgel S.
- Guyatt G.
- Hajjar L.
- Heirel C.
- Henriques L.
- Herek A.
- Hinestrosa A.
- Hirota A.
- Holanda M.
- Hopf J.
- Horner M.
- Inagaki A.
- Infantini R.
- Jesus K.
- Kauss I.
- Kawaguchi I.
- Kazue P.
- Kleber W.
- Kleber W.
- Kodama A.
- Kretzer L.
- Kuroda C.
- Lago R.
- Laprovita M.
- Larangeira A.
- Laube G.
- Le\ue3o R.
- Leite P.
- Lima C.
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- Lovato W.
- Lucena D.
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- Maccari J.
- Macedo P.
- Machado F.
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- Maia I.
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- Martinez A.
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- Martins M.
- Martins M.
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- Matsubara R.
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- Miranda W.
- Miura C.
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- Moreira C.
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- Morong A.
- Morsch R.
- Nascimento F.
- Nassar A.
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- Nedel W.
- Neto E.
- Neto F.
- Neto G.
- Neto J.
- Neto J.
- Neto J.
- Nienstedt E.
- Nobrega M.
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- Nomoto S.
- Nunes A.
- Odir I.
- Oliveira A.
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- Oliveira G.
- Oliveira I.
- Oliveira K.
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- Passos D.
- Patrocinio A.
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- Pellegrini J.
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- Rabelo L.
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- Rahal L.
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- Ray A.
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- Regenga M.
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- Reis A.
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- Rezende A.
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- Rezende V.
- Ribeiro G.
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- Rieder M.
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- Romano E.
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- Sandri P.
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- Schaich F.
- Schettino G.
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- Schievano F.
- Schulz L.
- Schwarz P.
- Schwarz P.
- Seeger G.
- Segundo V.
- Severino M.
- Silva A.
- Silva A.
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- Silva D.
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- Silva N.
- Silva P.
- Silva R.
- Silva R.
- Silva S.
- Silva S.
- Silva S.
- Smith T.
- Sousa M.
- Souza A.
- Souza M.
- Souza M.
- Starling C.
- Suguitani E.
- Suzuki V.
- Suzumura \uc9.
- Tagliari L.
- Taino B.
- Taira E.
- Takahashi L.
- Takahashi L.
- Takatani R.
- Tallo F.
- Tamazato E.
- Taniguchi L.
- Tarkieltaub E.
- Tavares D.
- Tavares D.
- Tavares M.
- Tavares R.
- Tcherniakovisk L.
- Teixeira C.
- Teixeira C.
- Teixeira C.
- Teixeira L.
- Telles M.
- Thompson M.
- Toledo D.
- Tomizuka C.
- Torres F.
- Toufen C.
- Tozo T.
- Trindade R.
- Tucci M.
- Uratani C.
- Vanzuita R.
- Vasconcelos M.
- Vasconcelos P.
- Vassallo P.
- Vendrame L.
- Verdeal J.
- Vianna A.
- Vieira D.
- Vieira S.
- Vieira V.
- Vieira V.
- Walter S.
- Wawrzeniak I.
- Werneck V.
- Westphal G.
- Westphal G.
- Winveler G.
- Wysocki N.
- Xavier P.
- Yamada S.
- Zanta C.
- Zoghbi K.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
BACKGROUND:
Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART).
METHODS/DESIGN:
ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH2O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure 6430 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle.
DISCUSSION:
If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration metho
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial
- Author
- Abreu Matheus O.
- Acerbi Paulo S. C.
- Albuquerque Regis B.
- Aldrighi Jose R.
- Alencastro Andre
- Almeida Marilia S.
- Almeida Patricia S.
- Almeida Samara D.
- Almeida Samara D.
- Alves Janine D.
- Amaral Karine A. E. H.
- Amaro Andreson F.
- Amato Marcelo B. P.
- Amato Marcelo B. P.
- Amorim Denise S.
- Amorim Fabio F.
- Andrade Ana H. V.
- Andrade Isaac G.
- Andrade Lucia C.
- Andrade Luciana A. S.
- Andrade Wandalvo
- Apoena Pablo
- Araujo Neto Jose A.
- Araujo Arthur C.
- Araujo Jose F.
- Araujo Marcelo E. U.
- Araujo Mario F. A.
- Arduini Rodrigo G.
- Assef Maria G. P. L.
- Azevedo Luciano C. P.
- Azevedo Luciano C. P.
- Backes Fabiane
- Bainy Marina P.
- Baptista Filho Mario L. A.
- Barbosa Pierry O.
- Barra Williams F.
- Barros Dalton
- Baruzzi Claudio
- Bastos Ana C. A. G.
- Bastos Rafael S.
- Batista Roseane A.
- Becker Daniel A.
- Bergo Ricardo R.
- Berto Paula
- Berwanger Otavio
- Berwanger Otavio
- Bigolin Rodrigo
- Bitencourt Wesley S.
- Bitencourt Wesley S.
- Blattner Clarissa
- Boldo Rodrigo
- Boniatti Marcio M.
- Borges Marcos C.
- Bozi Giovana G.
- Brandao Andre L. S. B.
- Brilenger Caroline O.
- Brilhante Yuzeth Nobrega
- Broilo Fabiano P.
- Burigo Ana C.
- Cacau Lucas A. P.
- Caixeta Carlos R.
- Caldeira Milton
- Caldeira Milton
- Canavessi Hugo Schlebinger
- Canzi Regina A.
- Cappi Sylas B.
- Carbonell Roberto C. C.
- Cardoso Lucienne T. Q.
- Carmona Cesar V.
- Carneiro Mauricio
- Carneiro Saul R.
- Carvalho Alexandre G. R.
- Carvalho Carlos R. R.
- Carvalho Carlos R. R.
- Carvalho Fabricio R. T.
- Carvalho Fernanda L. G.
- Carvalho Frederico B.
- Carvalho Frederico B.
- Carvalho Ivana L. V.
- Carvalho Vitor O.
- Carvalho Waneska L. N.
- Caser Eliana
- Castanelo Carlos
- Cavalcante Eulalia
- Cavalcanti Alexandre B.
- Cavalcanti Alexandre B.
- Cavalcanti Raphael Ali
- Cerantola Rodrigo B.
- Chagas Filho Aldir
- Chamy Gauco
- Chaves Filho Francisco G.
- Chiasso Tatiana M.
- Coelho Adalberto M.
- Coelho Edward, Jr.
- Coelho Milena P. P. M.
- Conde Katia A. P.
- Cordeiro Rodrigo B.
- Correa Fabiano G.
- Correa Tiago A.
- Correa Viviane M.
- Correia Emmanuel I. S.
- Cortegiani Andrea
- Costa Andre F.
- Costa Maristela C.
- Costa Ramon T.
- Couto Wivian A. D.
- Cramer Amanda S.
- Cunha Adenard F. C.
- Dadam Michelli M.
- Damasceno Bruna
- de Oliveira Filho Wilson
- de Oliveira Filho Wilson
- Decio Janaina C.
- Demarzo Sergio E.
- Dias Alysson P.
- Dias Fernando S.
- Dias Polyana P. L. C.
- Diaz S. Edgard
- Diaz-Quijano Fredi A.
- Diaz-Quijano Fredi A.
- Domingues Sergio M., Jr.
- Dragosavak Desanka
- Duarte Juliana N.
- Duarte Pericles A. D.
- Duarte Robson
- Dutra Victor G.
- Eberhart Neto Ervin
- Falcao Antonio
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- Farran Jorge
- Felizardo Livia R. S. M.
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- Ferreira Neto Fleury
- Ferreira Ana P.
- Ferreira Cassia M.
- Ferreira Claiton S.
- Ferreira Denise M.
- Ferreira Edgard V.
- Ferreira Elaine M.
- Ferreira Firmino H., Jr.
- Ferreira Reinaldo
- Festti Josiane
- Fialkow Lea
- Figueiredo Adelaide C.
- Figueiredo Luciana C.
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- Flores Dimitri G.
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- Goncalves Neto Graciliano J. L.
- Goncalves Fernanda A. F.
- Goncalves Iran, Jr.
- Gonzalez C. Octavio
- Gorski Anthony G.
- Grion Cintia M. C.
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- Guadalupe Erika G. L.
- Guerra Andre
- Guerreiro Marcio O.
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- Gurgel Sanderland J. T.
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- Heirel Debora C. B.
- Henriques Lilian A.
- Herek Andrea
- Hinestrosa Alfredo
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- Holanda Marcelo A.
- Hopf Joao L. S.
- Horner Marina B. W.
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- Infantini Rodrigo M.
- Isola Alexandre
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- Kleber Wladimy
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- Kodama Alessandra A.
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- Ray Alexandre
- Rech Tatiana H.
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- Reis Andrezza T. J. B.
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- Rosso Deorgelis
- Sa Alexandre
- Sala Andrea D.
- Sales Joao A. L., Jr.
- Salgado Diamantino R.
- Salomao Maria C.
- Sandri Priscila
- Santana Hericalizandra S. R.
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- Santos Grazielle O.
- Santos Jose R. P.
- Santos Lucio S.
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- Santos Patricia L.
- Santos Priscila J. C. D.
- Santos Thiago M.
- Sarat Saturnino Campo, Jr.
- Savi Augusto
- Scaglia Nris C.
- Schaich Felipe
- Schettino Guilherme P. P.
- Schiavetto Paulo M.
- Schievano Fabiana R.
- Schulz Luis F.
- Schwarz Patricia
- Schwarz Patricia
- Seeger Gabriela M.
- Segundo Valerio J.
- Severino Marta A.
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- Souza Ana R.
- Souza Marcia L. V. D.
- Souza Marcia M. F.
- Starling Claudia M.
- Suguitani Edmundo O.
- Suzuki Vivian C.
- Suzumura Erica A.
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- Tagliari Luciana
- Taino Bruno
- Taira Elisabete E.
- Takahashi Luzia
- Takahashi Luzia N.
- Takatani Rodrigo R.
- Tallo Fernando S.
- Tamazato Edys Y.
- Taniguchi Leandro
- Tarkieltaub Elcio
- Tavares Daniele
- Tavares Daniele C. C.
- Tavares Marcel V.
- Tavares Roberta C.
- Tcherniakovisk Leo
- Teixeira Cassiano
- Teixeira Cassiano
- Teixeira Cassiano
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- Teixeira Luciano O.
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- Toledo Diogo
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- Trindade Renata S.
- Tucci Mauro
- Uratani Cristiana C. S.
- Vanzuita Raquel
- Vasconcelos Marcia O. M.
- Vasconcelos Paula T.
- Vassallo Paula F.
- Vendrame Leticia S.
- Verdeal Juan C.
- Vianna Arthur
- Vieira Debora F. V. B.
- Vieira Silvia R. R.
- Vieira Vitor M.
- Vieira Vitor M.
- Viera Filho Edesio
- Walter Stephen
- Wawrzeniak Iuri C.
- Werneck Vinicius
- Westphal Glauco
- Westphal Glauco
- Winveler Georgia F. P.
- Wysocki Natacha
- Xavier Patricia A.
- Yamada Sergio S.
- Zanta Camila C.
- Zoghbi Karina K.
- Publication venue
- LONDON
- Publication date
- 28/08/2012
- Field of study
Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt
Delayed admission to the ICU increases mortality in septic shock
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
Microalbuminuria evaluated as a biomarker in patients with septic shock
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2010
- Field of study
Serial evaluation of SOFA score in a Brazilian teaching hospital
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
Parenteral colistin for the treatment of severe infections by multidrug-resistant Gram-negative bacteria
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Polymyxin for treatment of ventilator-associated pneumonia in a setting of high carbapenem resistance
- Author
- A Kandilov
- AC Kalil
- AM Sandri
- B Kim
- BT Tsuji
- Camila Ribeiro Lopes
- Centers for Disease Control and Prevention
- Cintia Magalhães Carvalho Grion
- Clinical and Laboratory Standards Institute
- Cláudia Maria Dantas de Maio Carrilho
- Eduardo Alexandrino Medeiros
- EY Klein
- F da Silveira
- FR Machado
- IA Braga
- Isabella Patruceli de Azevedo
- Ivanil Aparecida Moro Kauss
- J Garnacho-Montero
- JCF Quintanilha
- JM Pogue
- Josiane Festti
- JP Lynch
- Karine Maria Boll
- KPH Mattos
- Késia Paes
- Leticia Maria Alves da Silva
- LF Queiroz
- Lucienne Tibery Queiroz Cardoso
- LY Hsu
- M Singer
- Marcos Toshiyuki Tanita
- Martina Crivellari
- MC Padoveze
- O Zusman
- Padoveze MC Fortaleza CMCB
- RA Quintano Neira
- RL Nation
- RM Ruggiero
- SH Loss
- Thalita Bento Talizin
- The European Committee on Antimicrobial Susceptibility Testing
- Y Yu
- ZP Bulman
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Effect of lung recruitment and titrated Positive End-Expiratory Pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome - A randomized clinical trial
- Author
- Abdalla G.
- Abrahao Hajjar L.
- Abrantes Saraiva S.
- Abrunhosa A.
- Adler Maccagnan Pinheiro Besen B.
- Adrieno Westphal G.
- Afiq Syahmi Ramli M.
- Aires de Araujo Neto J.
- Akemi Higo M.
- Alberti da Silva G.
- Almeida Delfino Duarte P.
- Almeida Victorino J.
- Alves Ferreira Goncalves F.
- Amado Rabelo L.
- Amador Correia T.
- Amarante Costa A.
- Amato M. B. P.
- Andrade A. H. V.
- Andrioli de Araujo P.
- Anibal Leite Barros Agostinho T.
- Antoniazzi R.
- Aparecida Leite M.
- Aparecida Pereira J.
- Aparecida Pessoa Conde K.
- Azevedo L.
- Azzi Barbosa N.
- Baccaro Rossetti Santana H.
- Balzi A. P.
- Baptista Filho M. L. A.
- Barberena Moraes R.
- Barbosa Cerantola R.
- Barbosa Gomes Galas F. R.
- Barbosa P. G.
- Barboza Carnevalli Bueno T.
- Barros de Oliveira M. E.
- Barros Duarte I. J.
- Barroso A.
- Bassi E.
- Bastos de Moura E.
- Bastos Vieira P. C.
- Bautista-Rincon D. F.
- Belacho Azeredo Coutinho J.
- Belda F. J.
- Bermudez W. F.
- Bernadete Caser E.
- Berto P.
- Berwanger O.
- Bezerra Lima Z.
- Bin da Silva S. R.
- Blattner C.
- Bolognese D.
- Bonaccorsi Fernandino B.
- Bonin Campos L.
- Borba Pereira T.
- Botelho Foernges R.
- Braga Hagreaves Ribeiro de Freitas R.
- Breckenfeld Heirel D. C.
- Brocco Magnan G.
- Bruinje Cosentino M. F.
- Buarque Souza de Lima M. H.
- Burigo Grumann A. C.
- Buss E. K.
- Buttignol M.
- Cadavid Gutierrez C.
- Caldeira Filho M.
- Calderon L. E.
- Camargo Narciso R.
- Camassola A. P.
- Campos N. M. P.
- Campos Tonussi R. L.
- Carbonell J. A.
- Carolina Salomao M.
- Caser E. B.
- Castaneda J. A.
- Castro Escobar Furlan F.
- Cattelan Bonorino K.
- Cavalcante Lola Biazzoto E. P.
- Cavalcanti A. B.
- Chagas C. E. R. C.
- Charro F. A.
- Christmann Wawrzeniak I.
- Cisari G.
- Coelho M.
- Colozza Mecatti G.
- Conceicao Andrade L.
- Conti Ramos R.
- Cordeiro de Abreu Filho C. A.
- Cordioli R.
- Correia Santos Bonomo D.
- Cortegiani A.
- Costa Carvalho L. F.
- Costa G.
- Costa Lisboa T.
- Costa M.
- Cruz Carbonell R. C.
- da Cunha S.
- da Graca Pasquotto de Lima Assef M.
- da Silva Bettega F.
- da Silva Franco R. S.
- da Silva Guimaraes B. L.
- da Silva K. S.
- da Silva M. S.
- da Silva Marques L.
- da Silva Motta J.
- da Silva P. N.
- Dadam M.
- Dal-Pizzol F.
- Damiani L. P.
- De Alencar Filho M. S.
- de Almeida M. M. M. F.
- de Andrade K. M.
- De Aquino Martins P.
- de Araujo Macedo Pinto W.
- de Araujo Nazare M.
- de Assuncao Melo L.
- de Azevedo Naves S.
- de Brito Cordeiro R.
- de Brito Sobrinho E.
- de Campos Balzano P.
- de Carvalho A.
- De Carvalho Borges M.
- De Carvalho C. R. R.
- de Carvalho Fonseca Assuncao N. S.
- de Carvalho M. A.
- de Carvalho-Filho M. A.
- de Faria Cordeiro H.
- De Lima Assef M. D. G. P.
- de Linhares J. M.
- de Lucca F. C.
- de Marchi Benfica A. F.
- de Menezes Ferreira C.
- De Moraes Paisani D.
- De Moraes Regenga M.
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- De Oliveira Filho W.
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- De Oliveira R. P.
- de Oliveira Teixeira L.
- de Paiva A. P.
- de Pinho J. C.
- de Souza Andrade Neto J.
- de Souza G. F.
- de Souza Machado Y. L.
- de Souza Nobrega M.
- de Souza Oliveira Garcia T.
- de Souza R. R.
- de Souza Trindade R.
- de Vasconcellos Baldisserotto S.
- Deczka Morsch R.
- Delascio Lopes R.
- Deucher R. A. O.
- Dias Alves J.
- Dias Brugugnolli I.
- Dias Chiavegato L.
- Dias da Silva F.
- Dias de Almeida S.
- Dias E Santos J. A.
- Diaz-Quijano F. A.
- Diogo Sala A.
- Do Espirito Santo J. A.
- Do Val Tavares P. E.
- Domingos Correa T.
- Dos Anjos Sad F. C.
- Dos Santos Francisco R.
- Dos Santos Ramos N. C.
- Dragosavac D.
- Eberhart Neto E.
- Elias Aquim E.
- Elias de Oliveira N.
- Esneda Rocha Gaona M.
- Espitia Hernandez A. M.
- Fadhil Hadi Bin Jamaluddin M.
- Falcao J. G.
- Farran J.
- Favretto J.
- Fernandes Machado L.
- Ferrando C.
- Ferreira da Silva S. D.
- Ferreira de Souza M. M.
- Ferreira Sousa M.
- Festti J.
- Fialkow L.
- Flavio Costa Filho F.
- Florizel Almeida de Araujo M.
- Fonseca de Sousa J.
- Fonseca Silva T.
- Fontoura Prado K.
- Fornazari J. C.
- Franca de Oliveira M. C.
- Franci D.
- Franco M. R.
- Franke C.
- Franz da Costa A.
- Freitas I.
- Frizera Vassallo P.
- Furtado Lamego L.
- Gacel A.
- Gallego D. A.
- Garay M.
- Gasparetto Maccari J.
- Gatelli Noronha C.
- Gatti Cirillo C.
- Gaudin A.
- Genelhu G.
- Germano A.
- Gessolo Lins P.
- Giancursi T. S.
- Giarratano A.
- Giraldo Ramirez N.
- Giraldo-Ramirez N. D.
- Girardelli Baptista W. C.
- Girotto F.
- Giuberti J.
- Gomez Ravetti C.
- Goncalves Libanio P.
- Gontijo-Coutinho C. M.
- Gonzalez H. H.
- Gorka J.
- Goulart R.
- Griebler M.
- Guerra de Almeida A.
- Guimaraes Dantas B.
- Guimaraes de Carvalho F. L.
- Guimaraes H. P.
- Guimaraes Leal Guadalupe E.
- Gut A. L.
- Hadrich M.
- Hasan M. S.
- Helenditi Fernandes Camurca Martins R.
- Henn Moura R.
- Herek A.
- Hirata F.
- Hirota A. S.
- Hoher J.
- Hurtado J.
- Ishiwaki S.
- Isola A.
- Iwamoto T.
- Jorge A. C.
- Junqueira Ribeiro L.
- Kohl Pinheiro E.
- Kretzer L. P.
- Lacerda V.
- Ladeira J. P.
- Lage de Assis Rocha D.
- Lameira Verissimo A.
- Laranjeira L. N.
- Lessa Soares F.
- Lesti Esteves A. R.
- Lima de Andrade A.
- Lima Silva M. M.
- Lisboa de Souza R.
- Lobo S.
- Locks Stahlhofer L.
- Longhi Simoes de Almeida S.
- Loureiro Sebold M.
- Lovato W. J.
- Luzzi S.
- Macedo Araujo L.
- Machado F. R.
- Machado J. A.
- Magalhaes Carvalho Grion C.
- Maia I. S.
- Maia R.
- Manozzo Boniatti M.
- Mara Gomes T.
- Marcal de Vasconcelos M. O.
- Marco R.
- Marques Andrade G.
- Marques Barroso C.
- Marques Ferreira Mendez V.
- Martines Moralez G.
- Martins Arruda J.
- Martins de Lima G.
- Martins De Stefano L.
- Martins Dzivielevski B.
- Martins G. A.
- Martins Lima Silva M.
- Martins Santos T.
- Massariol T. C.
- Matheus Cadamuro F.
- Matos Brito Coelho C.
- Matsui M.
- Mayumi Higa R.
- Mazza B. F.
- Medina Matos A.
- Melo Silva R.
- Mendes Filho S. P.
- Menezes de Rezende C.
- Metran Nascente A. P.
- Mezzaroba A. L.
- Milioli Ferreira D.
- Miranda Barreto Mourao L.
- Miranda Mafra Oliveira M.
- Miura M. C.
- Morais M. O.
- Morales D.
- Morales M.
- Moreira de Sousa M.
- Moreira R.
- Mousinho Gomes R. L.
- Muniz R.
- Murilo Domingues S.
- Naia A.
- Nakad Orsatti V.
- Naranjo Sierra S.
- Nardela R.
- Nascimento Loureiro N.
- Nazareno Conceicao C.
- Nedel W.
- Nery P.
- Nin N.
- Nobre V.
- Nogueira de Paula L.
- Nogueira Filho W.
- Nomoto S.
- Nowak I.
- Nunes M.
- Oliveira C.
- Oliveira de Paula A. E.
- Oliveira Lage J.
- Orozco Levi M.
- Ortiz G.
- Ortiz M.
- Osaku E. F.
- Osni Machado F.
- Osorio Guerreiro M.
- Ospina-Tascon G. A.
- Paiva de Souza A.
- Paiva T. K. B.
- Pantaleao S. L.
- Papacidero C. H.
- Parolo E.
- Passos Amato M. B.
- Pastore L.
- Paulino C.
- Peixoto E.
- Peliser P.
- Penna Guimaraes H.
- Pereira da Silva E.
- Pereira Santos J. R.
- Peres Bainy M.
- Peres I.
- Peretti Torelly A.
- Pfuetzenreiter F.
- Pimentel Alvim S. H.
- Pincelli M.
- Pinheiro de Almeida J.
- Pinheiro de Oliveira R.
- Pinto Goncalves C. H.
- Piras C.
- Pires Barrientto L. C.
- Pizarro C.
- Plata Valdivieso R.
- Povoa P.
- Puig J.
- Quinones E.
- Rai Hakumat Rai V.
- Raineri S. M.
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- Ramos Mello M.
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- Rebello de Jesus K.
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- Reis H.
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- Resende E.
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- Ribas Rosa de Oliveira A. M.
- Ribeiro Campos D.
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- Ribeiro de Santis Santiago R.
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- Riccio P.
- Rios F.
- Rios Vieira S. R.
- Ritter C.
- Rocha Rodrigues da Silva F.
- Rodrigues da Cruz M.
- Rodrigues M.
- Rodrigues Torres de Carvalho F.
- Romano E. R.
- Romano M.
- Rossi Peras Americo V.
- Rosso Verdeal J. C.
- Rubini P.
- Russotto V.
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- Ryoji Takatani R.
- Sa Malbouisson L. M.
- Saldanha Dos Santos R.
- Samartino Zavanelli G.
- Sanches Laranjeira A.
- Sande L.
- Santa Maria Lucin G.
- Santa Rosa Santana H.
- Santos Pellegrini J. A.
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- Satoshi Inagaki A.
- Scalzo A. C.
- Schmitz de Figueiredo F.
- Schwan Filho F.
- Schwarz P.
- Seczynska B.
- Sega A.
- Seiji Ueno Gil F.
- Semboloni Bitencourt W.
- Serpa Neto A.
- Shahnaz Hasan M.
- Silva Cavallaro Torres K.
- Silva de Almeida P.
- Silva de Araujo A.
- Silva de Souza A.
- Silva J. M.
- Silva M.
- Silva Maia I.
- Silva Sales B.
- Simoes da Silva F.
- Simoes Giancursi T.
- Siqueira da Silva A.
- Sisconetto L.
- Soares Nasrala M. L.
- Soro M.
- Souza Amorim D.
- Souza da Silva R.
- Souza Dos Santos L.
- Souza Marques A.
- Souza Ribeiro M.
- Spegiorin Moreno M.
- Sperotto G.
- Staffa Gonzaga da Silva L.
- Steponovicius Piedade Cruz F.
- Stucchi E. M.
- Suzumura E. A.
- Szczeklik W.
- Tadahiro Ikeoka D.
- Tagliari L.
- Taniguchi L. N. T.
- Tavares Gurgel S. J.
- Teixeira C.
- Teixeira de Gois A. F.
- Teixeira Pinheiro T.
- Thompson M. M.
- Tibery Queiroz Cardoso L.
- Tierno P.
- Torres D.
- Torres P.
- Toshiyuki Tanita M.
- Toufen C.
- Tozo T. C.
- Tucci M. R.
- Valente Barbas C. S.
- Valiatti J. L.
- Vantini Capasso Palamim C.
- Vargas M.
- Vasconcelos de Sousa G.
- Vasconcelos R.
- Veiga de Oliveira A. L.
- Vendrame L. S.
- Verissimo A.
- Vieda E.
- Vieira de Lacerda N. M.
- Vieira Do Nascimento Martins E.
- Vieira S. R. R.
- Vilela Costa Pinto B.
- Vilela Siqueira H.
- Villasante Troncoso E. M.
- Vinicius Pereira M.
- Vitor Fera J.
- Werneck V.
- Yen Ju C.
- Yudi Horikawa F.
- Zampieri F.
- Zandonai C. L.
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/01/2017
- Field of study
IMPORTANCE: The effects of recruitment maneuvers and positive end-expiratory pressure (PEEP) titration on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) remain uncertain. OBJECTIVE: To determine if lung recruitment associated with PEEP titration according to the best respiratory-system compliance decreases 28-day mortality of patients with moderate to severe ARDS compared with a conventional low-PEEP strategy. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, randomized trial conducted at 120 intensive care units (ICUs) from 9 countries from November 17, 2011, through April 25, 2017, enrolling adults with moderate to severe ARDS. INTERVENTIONS: An experimental strategy with a lung recruitment maneuver and PEEP titration according to the best respiratory-system compliance (n = 501; experimental group) or a control strategy of low PEEP (n = 509). All patients received volume-assist control mode until weaning. MAIN OUTCOMES AND MEASURES: The primary outcome was all-cause mortality until 28 days. Secondary outcomes were length of ICU and hospital stay; ventilator-free days through day 28; pneumothorax requiring drainage within 7 days; barotrauma within 7 days; and ICU, in-hospital, and 6-month mortality. RESULTS: A total of 1010 patients (37.5% female; mean [SD] age, 50.9 [17.4] years) were enrolled and followed up. At 28 days, 277 of 501 patients (55.3%) in the experimental group and 251 of 509 patients (49.3%) in the control group had died (hazard ratio [HR], 1.20; 95% CI, 1.01 to 1.42; P = .041). Compared with the control group, the experimental group strategy increased 6-month mortality (65.3% vs 59.9%; HR, 1.18; 95% CI, 1.01 to 1.38; P = .04), decreased the number of mean ventilator-free days (5.3 vs 6.4; difference, −1.1; 95% CI, −2.1 to −0.1; P = .03), increased the risk of pneumothorax requiring drainage (3.2% vs 1.2%; difference, 2.0%; 95% CI, 0.0% to 4.0%; P = .03), and the risk of barotrauma (5.6% vs 1.6%; difference, 4.0%; 95% CI, 1.5% to 6.5%; P = .001). There were no significant differences in the length of ICU stay, length of hospital stay, ICU mortality, and in-hospital mortality. CONCLUSIONS AND RELEVANCE: In patients with moderate to severe ARDS, a strategy with lung recruitment and titrated PEEP compared with low PEEP increased 28-day all-cause mortality. These findings do not support the routine use of lung recruitment maneuver and PEEP titration in these patients. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01374022
[The effect of low-dose hydrocortisone on requirement of norepinephrine and lactate clearance in patients with refractory septic shock].
- Author
- Abbey Ianthe
- Abdel Rehim Marwa
- Abdel Rehim Marwa
- Abdul Rahman A
- Abduljawwad Emad
- Abduljawwad Emad
- Abe Emuri
- Abe Ryuzo
- Aboab Jerome
- Aboab Jerome
- Acevedo Juan
- Acharya Anand
- Acquarolo Annamaria
- Acquarolo Annamaria
- Adamzik Michael
- Adamzik Michael
- Adembri Chiara
- Adrie Christophe
- Adrie Christophe
- Afessa Bekele
- Ainoda Yusuke
- Aiyar S
- Al Dabbagh Tarek
- Al Dabbagh Tarek
- Al Knawy Bandar A
- Al Knawy Bandar A
- Al-Abdulkareem Abdulmajeed
- Al-Abdulkareem Abdulmajeed
- Al-Abdulkareem Abdulmajeed
- Al-Abdulkareem Abdulmajeed
- Al-Arabi Rida
- Al-Dorzi Hasan M
- Al-Dorzi Hasan M
- Al-Muhamadi Ali
- Al-Naeeb Yasseen
- Al-Naeeb Yasseen
- Al-Shaer Mohammad
- Al-Shaer Mohammad
- Al-Tamimi Waleed
- Al-Tamimi Waleed
- Alaniz Cesar
- Alevizaki Maria
- Alevizaki Maria
- Alinejad Faranak
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- Allolio Bruno
- AlNajjar Taghreed
- AlNajjar Taghreed
- Altintas M A
- Alvarez Jean-Claude Claude
- Alvarez Jean-Claude Claude
- Alvarez Jean-Claude Claude
- Amano Kosaku
- Amano Kosaku
- Amathieu Roland
- Amathieu Roland
- Amathieu Roland
- Amathieu Roland
- Ambriz-Plascencia Ana Rosa
- Ameen Abdelbadee
- Ameen Abdelbadee
- Amini Amir
- Amini Amir
- Amini Amir
- Amos Taryn
- Amour Julien
- Anderegg Brent A
- Anderegg Brent A
- Andersson Liane
- Andersson Liane
- Andrade Bertha Coelho
- Androulakis Ioannis P
- Aneja Rajesh
- Angus Derek C
- Angus Derek C
- Anjum Aisha
- Anjum Aisha
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annetta M
- Antonelli M
- Antonopoulou Anastasia N
- Antonopoulou Anastasia N
- Antonucci E
- Apollonatou Sofia
- Apollonatou Sofia
- Apostolidou Efterpi N
- Apostolidou Efterpi N
- Apostolou K
- Apostolou K
- Arabi Yaseen M
- Arabi Yaseen M
- Arabi Yaseen M
- Arabi Yaseen M
- Arabi Yaseen M
- Arabi Yaseen M
- Araujo Leonardo V
- Aravinthan Aloysious
- Aravinthan Aloysious
- Arbor Ann
- Arlt Wiebke
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- Armaganidis Apostolos
- Armaganidis Apostolos
- Armaganidis Apostolos
- Armaganidis Apostolos
- Aronowitz Paul
- Arriagada S Daniela
- Arroyo Vicente
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- Asahata Sayaka
- Asehnoune Karim
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- Asfar Pierre
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- Ashby Deborah
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- Atay Suleyman
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- Belkouchi Abdelkader
- Bellissant Eric
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- Bellissant Eric
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- Bellomo Rinaldo
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- Ibrahim Fidaa
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- Ikka Leon
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- Kim Young-Kug
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- Kleine-Borgmann Julian
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- Kluge Stefan
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- Knaup Reymond Marlies
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- Knawy Bandar Al
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- Knippschild Uwe
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- Kotsaki Antigone
- Kox Matthijs
- Kraemer Dale F
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- Kreth Simone
- Kruger Peter
- Kubo Osami
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- Kubo Toshio
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- Kwon O Jung
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- Lavenu A
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- Ledderose Carola
- Lee Chih-Hsin
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- Lee Sang D O
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- Yu Xuezhong
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- Yu Zhui
- Yu Zhui
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- Zakynthinos Spyros
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- Zampieri Fernando Godinho
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- Zandstra Durk F
- Zaritsky Arno
- Zeni Fabrice
- Zervou Maria
- Zhang Fengmin
- Zhang Fengmin
- Zhang Haibo
- Zhang Haibo
- Zhang Qian
- Zhang Qian
- Zhang Yang
- Zhang Yang
- Zhang Zhong
- Zhang Zhong
- Zhao Xin
- Zhao Xin
- Zheng Juanjuan
- Zheng Juanjuan
- Zheng Liangliang
- Zhou Qing
- Zhou Qing
- Zhu Huadong
- Ziegenfuss Marc
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- Zijlstra J G
- Zimmerman Jerry J
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- Zuckerberg Aaron
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/10/2007
- Field of study
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial
- Author
- Abreu Matheus O.
- Acerbi Paulo S. C.
- Albuquerque Regis B.
- Aldrighi Jose R.
- Alencastro Andre
- Almeida Marilia S.
- Almeida Patricia S.
- Almeida Samara D.
- Almeida Samara D.
- Alves Janine D.
- Amaral Karine A. E. H.
- Amaro Andreson F.
- Amato Marcelo B. P.
- Amato Marcelo B. P.
- Amorim Denise S.
- Amorim Fabio F.
- Andrade Ana H. V.
- Andrade Isaac G.
- Andrade Lucia C.
- Andrade Luciana A. S.
- Andrade Wandalvo
- Apoena Pablo
- Araujo Neto Jose A.
- Araujo Arthur C.
- Araujo Jose F.
- Araujo Marcelo E. U.
- Araujo Mario F. A.
- Arduini Rodrigo G.
- Assef Maria G. P. L.
- Azevedo Luciano C. P.
- Azevedo Luciano C. P.
- Backes Fabiane
- Bainy Marina P.
- Baptista Filho Mario L. A.
- Barbosa Pierry O.
- Barra Williams F.
- Barros Dalton
- Baruzzi Claudio
- Bastos Ana C. A. G.
- Bastos Rafael S.
- Batista Roseane A.
- Becker Daniel A.
- Bergo Ricardo R.
- Berto Paula
- Berwanger Otavio
- Berwanger Otavio
- Bigolin Rodrigo
- Bitencourt Wesley S.
- Bitencourt Wesley S.
- Blattner Clarissa
- Boldo Rodrigo
- Boniatti Marcio M.
- Borges Marcos C.
- Bozi Giovana G.
- Brandao Andre L. S. B.
- Brilenger Caroline O.
- Brilhante Yuzeth Nobrega
- Broilo Fabiano P.
- Burigo Ana C.
- Cacau Lucas A. P.
- Caixeta Carlos R.
- Caldeira Milton
- Caldeira Milton
- Canavessi Hugo Schlebinger
- Canzi Regina A.
- Cappi Sylas B.
- Carbonell Roberto C. C.
- Cardoso Lucienne T. Q.
- Carmona Cesar V.
- Carneiro Mauricio
- Carneiro Saul R.
- Carvalho Alexandre G. R.
- Carvalho Carlos R. R.
- Carvalho Carlos R. R.
- Carvalho Fabricio R. T.
- Carvalho Fernanda L. G.
- Carvalho Frederico B.
- Carvalho Frederico B.
- Carvalho Ivana L. V.
- Carvalho Vitor O.
- Carvalho Waneska L. N.
- Caser Eliana
- Castanelo Carlos
- Cavalcante Eulalia
- Cavalcanti Alexandre B.
- Cavalcanti Alexandre B.
- Cavalcanti Raphael Ali
- Cerantola Rodrigo B.
- Chagas Filho Aldir
- Chamy Gauco
- Chaves Filho Francisco G.
- Chiasso Tatiana M.
- Coelho Adalberto M.
- Coelho Edward, Jr.
- Coelho Milena P. P. M.
- Conde Katia A. P.
- Cordeiro Rodrigo B.
- Correa Fabiano G.
- Correa Tiago A.
- Correa Viviane M.
- Correia Emmanuel I. S.
- Cortegiani Andrea
- Costa Andre F.
- Costa Maristela C.
- Costa Ramon T.
- Couto Wivian A. D.
- Cramer Amanda S.
- Cunha Adenard F. C.
- Dadam Michelli M.
- Damasceno Bruna
- de Oliveira Filho Wilson
- de Oliveira Filho Wilson
- Decio Janaina C.
- Demarzo Sergio E.
- Dias Alysson P.
- Dias Fernando S.
- Dias Polyana P. L. C.
- Diaz S. Edgard
- Diaz-Quijano Fredi A.
- Diaz-Quijano Fredi A.
- Domingues Sergio M., Jr.
- Dragosavak Desanka
- Duarte Juliana N.
- Duarte Pericles A. D.
- Duarte Robson
- Dutra Victor G.
- Eberhart Neto Ervin
- Falcao Antonio
- Falcao Jansen G.
- Farran Jorge
- Felizardo Livia R. S. M.
- Ferguson Niall
- Ferraz Iris L.
- Ferreira Neto Fleury
- Ferreira Ana P.
- Ferreira Cassia M.
- Ferreira Claiton S.
- Ferreira Denise M.
- Ferreira Edgard V.
- Ferreira Elaine M.
- Ferreira Firmino H., Jr.
- Ferreira Reinaldo
- Festti Josiane
- Fialkow Lea
- Figueiredo Adelaide C.
- Figueiredo Luciana C.
- Filgueira Feto Jose E.
- Flores Dimitri G.
- Flores Dimitri G.
- Foernges Rafael B.
- Franca Gustavo G. P.
- Francisco Renata S.
- Franke Cristiano
- Galassi Marcela S.
- Gallego Raquel C. N.
- Galvao Endi L.
- Garcez Melissa C. M.
- Garcia L. Sandra M. C.
- Gatti Ciro
- Geha Nadia N.
- Germano Almir
- Germiniani Bruno C.
- Giacomassi Ivens W. S.
- Giancursi Thiago S.
- Giannini Fabio
- Gil Fernando S. U.
- Gimenez Francielli M. P.
- Giuberti Adriana F. T.
- Giuberti Jonas, Jr.
- Gois Aecio
- Gomes Bruno C.
- Gomes Tania M.
- Goncalves Neto Graciliano J. L.
- Goncalves Fernanda A. F.
- Goncalves Iran, Jr.
- Gonzalez C. Octavio
- Gorski Anthony G.
- Grion Cintia M. C.
- Grion Cintia M. C.
- Guadalupe Erika G. L.
- Guerra Andre
- Guerreiro Marcio O.
- Guimaraes Daniela M. Q. S.
- Guimaraes Helio P.
- Guimaraes Helio P.
- Guimaraes Helio P.
- Gurgel Sanderland J. T.
- Guyatt Gordon
- Hajjar Ludhmila A.
- Heirel Debora C. B.
- Henriques Lilian A.
- Herek Andrea
- Hinestrosa Alfredo
- Hirota Adriana S.
- Holanda Marcelo A.
- Hopf Joao L. S.
- Horner Marina B. W.
- Inagaki Alexandre S.
- Infantini Rodrigo M.
- Isola Alexandre
- Jesus Karinne R.
- Kauss Ivanil A. M.
- Kawaguchi Ines A. L.
- Kazue Priscila
- Kleber Wladimy
- Kleber Wladmy
- Kodama Alessandra A.
- Kretzer Lara
- Kuroda Cristina M.
- Lago Roberto
- Laprovita Maria P.
- Larangeira Alexandre S.
- Laube Gilberto, Jr.
- Leao Rosangela M.
- Leite Petronio A.
- Lima Cyntia M. L. S.
- Lima Fernando B.
- Lima Maria H. B. S.
- Lima Zildamara B.
- Lira Jose A.
- Lopes Renato D.
- Lovato Wilson
- Lucena Debora N. L.
- Lunardi Maria C.
- Luzzi Sergio
- Maccari Juara G.
- Macedo Pedro L.
- Machado Fernando O.
- Machado Flavia R.
- Machado Luis A. M. W.
- Machado Nelma J. N.
- Magalhaes Nascimento Francine J.
- Maia Israel S.
- Maia Marcelo O.
- Malbouison Luiz M.
- Marcilino Antonielen
- Margalho Silviano B.
- Margarida Kathia
- Marino Nathalia F.
- Marques Leonardo S.
- Marraccini Thiago
- Martinez Amadeu
- Martins Edna T. J.
- Martins Eliauria R.
- Martins Eliauria R.
- Martins Gloria A.
- Martins Marcele F.
- Martins Marcio A.
- Martins Marcio A.
- Martins Mariana L.
- Matsubara Rosely R.
- Matsui Mirna
- Mazza Bruno F.
- Mecatti Giovana C.
- Medeiros Luciana G.
- Mendez Vanessa M. F.
- Mendonca Angela
- Menescal Brena
- Merluzzi Thalita
- Mezzaroba Ana L.
- Miranda Whiniton
- Miura Claudia
- Monteiro Livia L.
- Moraes Ana P. P.
- Moraes Rafael B.
- Morais Jussara E. P.
- Morais Mirene O.
- Morales Daniela
- Moreira Cora L. C. B.
- Moreira Fabiana B. R.
- Moreira Monique A.
- Moreno Marcelo S.
- Morong Aline S.
- Morsch Rafaela D.
- Nassar Antonio P., Jr.
- Naves Sergio A.
- Nedel Wagner
- Neto Jeronimo C. B.
- Nienstedt Esteban C.
- Nobrega Marciano S.
- Nogueira Filho Wilson
- Nogueira Eduardo E. F.
- Nomoto Silmara H.
- Nunes Andre L.
- Odir Isaura
- Oliveira Aline E.
- Oliveira Andre L. V.
- Oliveira Clezio S.
- Oliveira Glauce L.
- Oliveira Ivonaldo M.
- Oliveira Katia R.
- Oliveira Luiz R. C.
- Oliveira Marcelo E.
- Oliveira Roselaine P.
- Oliveira Roselaine P.
- Oliveira Roselaine P.
- Oliveira Tatiana A.
- Oliveira Vanessa M.
- Oliver Wilson R.
- Ornellas Izadora B.
- Orsatti Vinicius N.
- Park Marcelo
- Passos Denise B. V. G.
- Patrocinio Ana C. L.
- Paula Ludmila N.
- Pavia Caio L. P.
- Pedro A.
- Peixoto Daniela C.
- Peliser Priscila
- Pellegrini Jose A. S.
- Pellegrini Jose A. S.
- Pena Felipe M.
- Pereira Antonio J.
- Pereira Cesar A.
- Pereira Sheila A.
- Pincelli Mariangela
- Pinheiro Filho Gilvan R.
- Pinheiro Filho Gilvan R.
- Pinto Walkyria A. M.
- Piovesan Maysa Z. R.
- Piras Claudio
- Pizarro Camilo
- Pompilio Carlos E.
- Poquiriqui Rodolfo M. B.
- Potratz Jorge L.
- Prado Karen F.
- Prado Luiz F. A.
- Rabelo Livia A.
- Rabelo Melina V.
- Rahal Luciana
- Raineri Santi M.
- Ramos Joroastro E., Jr.
- Rangel Vivian P. L.
- Ray Alexandre
- Rech Tatiana H.
- Regenga Marisa M.
- Regenga Marisa M.
- Rego Leila R. M.
- Reis Andrezza T. J. B.
- Reis Diego L.
- Reis Diego L.
- Reis Helder
- Rezende Claudnei M.
- Rezende Ederlon
- Rezende Ederlon A. C.
- Rezende Valeria M. C.
- Ribeiro Gisele F. M.
- Ribeiro Rubens A. B.
- Ribeiro Wagner
- Rieder Marcelo M.
- Rocha Edson P.
- Rodrigues Ricardo G.
- Romano Edson
- Romano Edson
- Romano Marcelo
- Rossetti Santana Heloisa B.
- Rosso Deorgelis
- Sa Alexandre
- Sala Andrea D.
- Sales Joao A. L., Jr.
- Salgado Diamantino R.
- Salomao Maria C.
- Sandri Priscila
- Santana Hericalizandra S. R.
- Santiago Roberta R. S.
- Santos Gheisa D.
- Santos Grazielle O.
- Santos Jose R. P.
- Santos Lucio S.
- Santos Moreno C.
- Santos Patricia L.
- Santos Priscila J. C. D.
- Santos Thiago M.
- Sarat Saturnino Campo, Jr.
- Savi Augusto
- Scaglia Nris C.
- Schaich Felipe
- Schettino Guilherme P. P.
- Schiavetto Paulo M.
- Schievano Fabiana R.
- Schulz Luis F.
- Schwarz Patricia
- Schwarz Patricia
- Seeger Gabriela M.
- Segundo Valerio J.
- Severino Marta A.
- Silva Albano S.
- Silva Aline C. F.
- Silva Alline O.
- Silva Anselmo C.
- Silva Dafne C. B.
- Silva Fabiano D.
- Silva Nelson B.
- Silva Patricia N.
- Silva Rosicley S.
- Silva Rozangela R.
- Silva Sabrina F.
- Silva Sandra R. B.
- Silva Silvangela G. A.
- Smith Thiago C.
- Sousa Neto Jefferson A.
- Sousa Marcelo F.
- Souza Ana R.
- Souza Marcia L. V. D.
- Souza Marcia M. F.
- Starling Claudia M.
- Suguitani Edmundo O.
- Suzuki Vivian C.
- Suzumura Erica A.
- Suzumura Erica A.
- Tagliari Luciana
- Taino Bruno
- Taira Elisabete E.
- Takahashi Luzia
- Takahashi Luzia N.
- Takatani Rodrigo R.
- Tallo Fernando S.
- Tamazato Edys Y.
- Taniguchi Leandro
- Tarkieltaub Elcio
- Tavares Daniele
- Tavares Daniele C. C.
- Tavares Marcel V.
- Tavares Roberta C.
- Tcherniakovisk Leo
- Teixeira Cassiano
- Teixeira Cassiano
- Teixeira Cassiano
- Teixeira Cristina
- Teixeira Luciano O.
- Telles Jose M. M.
- Thompson Marlus M.
- Toledo Diogo
- Tomizuka Carlos I.
- Torres Franciele C. C.
- Toufen Carlos, Jr.
- Tozo Tatiane C.
- Trindade Renata S.
- Tucci Mauro
- Uratani Cristiana C. S.
- Vanzuita Raquel
- Vasconcelos Marcia O. M.
- Vasconcelos Paula T.
- Vassallo Paula F.
- Vendrame Leticia S.
- Verdeal Juan C.
- Vianna Arthur
- Vieira Debora F. V. B.
- Vieira Silvia R. R.
- Vieira Vitor M.
- Vieira Vitor M.
- Viera Filho Edesio
- Walter Stephen
- Wawrzeniak Iuri C.
- Werneck Vinicius
- Westphal Glauco
- Westphal Glauco
- Winveler Georgia F. P.
- Wysocki Natacha
- Xavier Patricia A.
- Yamada Sergio S.
- Zanta Camila C.
- Zoghbi Karina K.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/07/2016
- Field of study
Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.13Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt