3,722 research outputs found
The EEE Project
The new experiment ``Extreme Energy Events'' (EEE) to detect extensive air
showers through muon detection is starting in Italy. The use of particle
detectors based on Multigap Resistive Plate Chambers (MRPC) will allow to
determine with a very high accuracy the direction of the axis of cosmic ray
showers initiated by primaries of ultra-high energy, together with a high
temporal resolution. The installation of many of such 'telescopes' in numerous
High Schools scattered all over the Italian territory will also allow to
investigate coincidences between multiple primaries producing distant showers.
Here we present the experimental apparatus and its tasks.Comment: 4 pages, 29th ICRC 2005, Pune, Indi
First Ex-Vivo Validation of a Radioguided Surgery Technique with beta- Radiation
Purpose: A radio-guided surgery technique with beta- -emitting radio-tracers
was suggested to overcome the effect of the large penetration of gamma
radiation. The feasibility studies in the case of brain tumors and abdominal
neuro-endocrine tumors were based on simulations starting from PET images with
several underlying assumptions. This paper reports, as proof-of-principle of
this technique, an ex-vivo test on a meningioma patient. This test allowed to
validate the whole chain, from the evaluation of the SUV of the tumor, to the
assumptions on the bio-distribution and the signal detection.
Methods: A patient affected by meningioma was administered 300 MBq of
90Y-DOTATOC. Several samples extracted from the meningioma and the nearby Dura
Mater were analyzed with a beta- probe designed specifically for this
radio-guided surgery technique. The observed signals were compared both with
the evaluation from the histology and with the Monte Carlo simulation.
Results: we obtained a large signal on the bulk tumor (105 cps) and a
significant signal on residuals of 0.2 ml (28 cps). We also show that
simulations predict correctly the observed yields and this allows us to
estimate that the healthy tissues would return negligible signals (~1 cps).
This test also demonstrated that the exposure of the medical staff is
negligible and that among the biological wastes only urine has a significant
activity.
Conclusions: This proof-of-principle test on a patient assessed that the
technique is feasible with negligible background to medical personnel and
confirmed that the expectations obtained with Monte Carlo simulations starting
from diagnostic PET images are correct.Comment: 17 pages, 4 Figs, Accepted by Physica Medic
Dilepton production in nucleus-nucleus collisions at top SPS energy within the Parton-Hadron-String Dynamics (PHSD) transport approach
Dilepton production in In+In collisions at 158 AGeV is studied within the
microscopic parton-hadron-string dynamics (PHSD) transport approach that
incorporates explicit partonic degrees-of-freedom, dynamical hadronization as
well as the more familiar hadronic dynamics in the final reaction stages. A
comparison to the data of the NA60 Collaboration shows that the measured
dilepton yield is well described by including the collisional broadening of
vector mesons, while simultaneously accounting for the electromagnetic
radiation of the strongly coupled quark-gluon plasma (sQGP) via off-shell
quark-antiquark annihilation, quark annihilation with additional gluon
Bremsstrahlung and the gluon-Compton scattering mechanisms. In particular, the
spectra in the intermediate mass range (1 GeV < M < 2.5 GeV) are dominated by
quark-antiquark annihilation in the nonperturbative QGP. Also, the observed
softening of the transverse mass spectra at intermediate masses (1 GeV < M <
2.5 GeV) is approximately reproduced. Furthermore, for dileptons of low masses
(M < 0.6 GeV), we find a sizable contribution from the quark annihilation with
additional gluon bremsstrahlung, thus providing another possible window for
probing the properties of the sQGP.Comment: 16 pages, 14 figure
A model to explain angular distributions of and decays into and
BESIII data show a particular angular distribution for the decay of the
and mesons into the hyperons
and . More in details the angular distribution of
the decay exhibits an opposite trend
with respect to that of the other three channels: , and
. We define a model to explain the
origin of this phenomenon.Comment: 6 pages, 7 figures, to be published in Chinese Physics
Surgical outcome and indicators of postoperative worsening in intra-axial thalamic and posterior fossa pediatric tumors: Preliminary results from a single tertiary referral center cohort
Background: Shared indications about the best management of intra-axial thalamic (IAT) and posterior fossa (PF) pediatric tumors are still lacking. The aim of this study was to analyze neurosurgical outcome in these tumors and to investigate factors associated with postoperative worsening. Methods: A retrospective single-center study on IAT and PF pediatric tumor patients treated surgically over a 7-year period was conducted. The Lansky Scale (LS) was used to assess patients' functional status. Surgical complexity was graded with the Milan Complexity Scale (MCS). The following analyses were performed: a longitudinal analysis of the preoperative, discharge, and 3 months' follow-up (FU) LS, a comparison between improved/unchanged and worsened patients, and an analysis of the predictive value of single MCS items. Results: 37 cases were collected: 20 PF and 17 thalamic. Mean MCS score was 6 ± 1.7. Mean preoperative, discharge and FU LS were 80.8, 74.6 and 80.3 respectively. Surgical mortality was 0%.The longitudinal analysis showed a neurological worsening at discharge compared to preoperative status (p = 0.011) and an improvement at FU compared to discharge (p < 0.004), both statistically significant. None of the variables analyzed showed a significant predictive value of early postoperative change; however, higher MCS scores were associated with a greater risk of worsening. Conclusions: The surgical management of IAT and PF pediatric brain tumors remains challenging; early postoperative worsening is possible, but most deficits tend to improve at FU. The MCS seems to be a valuable tool to estimate the risk of early postoperative worsening and to facilitate parents' informed consent
Test beam results with prototypes for the new Cylindrical GEM Inner Tracker of the BESIII experiment
A cylindrical GEM tracker is under construction in order to replace and improve the inner tracking system of the BESIII experiment. Tests with planar chamber prototypes were carried out on the H4 beam line of SPS (CERN) with
muons of 150 GeV/c momentum, to evaluate the efficiency and resolution under different working conditions. The obtained efficiency was in the 96â98% range. Two complementary algorithms for the position determination were developed: the charge centroid and the ÎŒ-TPC methods. With the former, resolutions < 100 ÎŒm and < 200 ÎŒm were achieved without and with magnetic field, respectively. The ÎŒTPC improved these results. By the end of 2016, the first cylindrical prototype was tested on the same beam line. It showed optimal stability under different settings. The comparison of its performance with respect to the planar chambers is ongoing. Here, the results of the planar prototype tests will be addressed
On relativization of the Sommerfeld-Gamow-Sakharov factor
The Sommerfeld-Gamow-Sakharov factor is considered for the general case of
arbitrary masses and energies. It is shown that the scalar triangular one-loop
diagram gives the Coulomb singularity in radiative corrections at the
threshold. The singular part of the correction is factorized at the complete
Born cross section regardless of its partial wave decomposition. Different
approaches to generalize the factor are discussed.Comment: 9 pages, 4 figures; references and discussion are extende
A simulation tool for MRPC telescopes of the EEE project
The Extreme Energy Events (EEE) Project is mainly devoted to the study of the
secondary cosmic ray radiation by using muon tracker telescopes made of three
Multigap Resistive Plate Chambers (MRPC) each. The experiment consists of a
telescope network mainly distributed across Italy, hosted in different building
structures pertaining to high schools, universities and research centers.
Therefore, the possibility to take into account the effects of these structures
on collected data is important for the large physics programme of the project.
A simulation tool, based on GEANT4 and using GEMC framework, has been
implemented to take into account the muon interaction with EEE telescopes and
to estimate the effects on data of the structures surrounding the experimental
apparata.A dedicated event generator producing realistic muon distributions,
detailed geometry and microscopic behavior of MRPCs have been included to
produce experimental-like data. The comparison between simulated and
experimental data, and the estimation of detector resolutions is here presented
and discussed
Long and very-long-chain ceramides correlate with a more aggressive behavior in skull base chordoma patients
Background: Skull base chordomas are rare tumors arising from notochord. Sphingolipids analysis is a promising approach in molecular oncology, and it has never been applied in chordomas. Our aim is to investigate chordoma behavior and the role of ceramides. Methods: Ceramides were extracted and evaluated by liquid chromatography and mass spectrometry in a cohort of patients with a skull base chordoma. Clinical data were also collected and correlated with ceramide levels. Linear regression and correlation analyses were conducted. Results: Analyzing the association between ceramides level and MIB-1, total ceramides and dihydroceramides showed a strong association (r = 0.7257 and r = 0.6733, respectively) with MIB-1 staining (p = 0.0033 and p = 0.0083, respectively). Among the single ceramide species, Cer C24:1 (r = 0.8814, p <= 0.0001), DHCer C24:1 (r = 0.8429, p = 0.0002) and DHCer C18:0 (r = 0.9426, p <= 0.0001) showed a significant correlation with MIB-1. Conclusion: Our lipid analysis showed ceramides to be promising tumoral biomarkers in skull base chordomas. Long- and very-long-chain ceramides, such as Cer C24:1 and DHCer C24:1, may be related to a prolonged tumor survival and aggressiveness, and the understanding of their effective biological role will hopefully shed light on the mechanisms of chordoma radio-resistance, tendency to recur, and use of agents targeting ceramide metabolism
The Extreme Energy Events HECR array: status and perspectives
The Extreme Energy Events Project is a synchronous sparse array of 52
tracking detectors for studying High Energy Cosmic Rays (HECR) and Cosmic
Rays-related phenomena. The observatory is also meant to address Long Distance
Correlation (LDC) phenomena: the network is deployed over a broad area covering
10 degrees in latitude and 11 in longitude. An overview of a set of preliminary
results is given, extending from the study of local muon flux dependance on
solar activity to the investigation of the upward-going component of muon flux
traversing the EEE stations; from the search for anisotropies at the sub-TeV
scale to the hints for observations of km-scale Extensive Air Shower (EAS).Comment: XXV ECRS 2016 Proceedings - eConf C16-09-04.
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