306 research outputs found
SDCBP (syndecan binding protein (syntenin))
Review on SDCBP (syndecan binding protein (syntenin)), with data on DNA, on the protein encoded, and where the gene is implicated
Continuous-variable sampling from photon-added or photon-subtracted squeezed states
We introduce a new family of quantum circuits in Continuous Variables and we
show that, relying on the widely accepted conjecture that the polynomial
hierarchy of complexity classes does not collapse, their output probability
distribution cannot be efficiently simulated by a classical computer. These
circuits are composed of input photon-subtracted (or photon-added) squeezed
states, passive linear optics evolution, and eight-port homodyne detection. We
address the proof of hardness for the exact probability distribution of these
quantum circuits by exploiting mappings onto different architectures of
sub-universal quantum computers. We obtain both a worst-case and an
average-case hardness result. Hardness of Boson Sampling with eight-port
homodyne detection is obtained as the zero squeezing limit of our model. We
conclude with a discussion on the relevance and interest of the present model
in connection to experimental applications and classical simulations.Comment: 11 pages, 6 figure
Highly purified extracellular vesicles from human cardiomyocytes demonstrate preferential uptake by human endothelial cells
Extracellular vesicles (EVs) represent a promising cell-free alternative for treatment of cardiovascular diseases. Nevertheless, the lack of standardised and reproducible isolation methods capable of recovering pure, intact EVs presents a significant obstacle. Additionally, there is significant interest in investigating the interactions of EVs with different cardiac cell types. Here we established a robust technique for the production and isolation of EVs harvested from an enriched (>97% purity) population of human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) with size exclusion chromatography. Utilizing an advanced fluorescence labelling strategy, we then investigated the interplay of the CM-EVs with the three major cellular components of the myocardium (fibroblasts, cardiomyocytes and endothelial cells) and identified that cardiac endothelial cells show preferential uptake of these EVs. Overall, our findings provide a great opportunity to overcome the translational hurdles associated with the isolation of intact, non-aggregated human iPSC-CM EVs at high purity. Furthermore, understanding in detail the interaction of the secreted EVs with their surrounding cells in the heart may open promising new avenues in the field of EV engineering for targeted delivery in cardiac regeneration
Highly purified extracellular vesicles from human cardiomyocytes demonstrate preferential uptake by human endothelial cells
Extracellular vesicles (EVs) represent a promising cell-free alternative for treatment of cardiovascular diseases. Nevertheless, the lack of standardised and reproducible isolation methods capable of recovering pure, intact EVs presents a significant obstacle. Additionally, there is significant interest in investigating the interactions of EVs with different cardiac cell types. Here we established a robust technique for the production and isolation of EVs harvested from an enriched (>97% purity) population of human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) with size exclusion chromatography. Utilizing an advanced fluorescence labelling strategy, we then investigated the interplay of the CM-EVs with the three major cellular components of the myocardium (fibroblasts, cardiomyocytes and endothelial cells) and identified that cardiac endothelial cells show preferential uptake of these EVs. Overall, our findings provide a great opportunity to overcome the translational hurdles associated with the isolation of intact, non-aggregated human iPSC-CM EVs at high purity. Furthermore, understanding in detail the interaction of the secreted EVs with their surrounding cells in the heart may open promising new avenues in the field of EV engineering for targeted delivery in cardiac regeneration
Optimal control of quantum superpositions in a bosonic Josephson junction
We show how to optimally control the creation of quantum superpositions in a
bosonic Josephson junction within the two-site Bose-Hubbard model framework.
Both geometric and purely numerical optimal control approaches are used, the
former providing a generalization of the proposal of Micheli et al [Phys. Rev.
A 67, 013607 (2003)]. While this method is shown not to lead to significant
improvements in terms of time of formation and fidelity of the superposition, a
numerical optimal control approach appears more promising, as it allows to
create an almost perfect superposition, within a time short compared to other
existing protocols. We analyze the robustness of the optimal solution against
atom number variations. Finally, we discuss to which extent these optimal
solutions could be implemented with the state of art technology.Comment: Several comments added, structure re-organize
Continuous-Variable Instantaneous Quantum Computing is Hard to Sample
Instantaneous quantum computing is a sub-universal quantum complexity class,
whose circuits have proven to be hard to simulate classically in the
Discrete-Variable (DV) realm. We extend this proof to the Continuous-Variable
(CV) domain by using squeezed states and homodyne detection, and by exploring
the properties of post-selected circuits. In order to treat post-selection in
CVs we consider finitely-resolved homodyne detectors, corresponding to a
realistic scheme based on discrete probability distributions of the measurement
outcomes. The unavoidable errors stemming from the use of finitely squeezed
states are suppressed through a qubit-into-oscillator GKP encoding of quantum
information, which was previously shown to enable fault-tolerant CV quantum
computation. Finally, we show that, in order to render post-selected
computational classes in CVs meaningful, a logarithmic scaling of the squeezing
parameter with the circuit size is necessary, translating into a polynomial
scaling of the input energy.Comment: Published versio
Macroscopic superposition states of ultracold bosons in a double-well potential
We present a thorough description of the physical regimes for ultracold
bosons in double wells, with special attention paid to macroscopic
superpositions (MSs). We use a generalization of the Lipkin-Meshkov-Glick
Hamiltonian of up to eight single particle modes to study these MSs, solving
the Hamiltonian with a combination of numerical exact diagonalization and
high-order perturbation theory. The MS is between left and right potential
wells; the extreme case with all atoms simultaneously located in both wells and
in only two modes is the famous NOON state, but our approach encompasses much
more general MSs. Use of more single particle modes brings dimensionality into
the problem, allows us to set hard limits on the use of the original two-mode
LMG model commonly treated in the literature, and also introduces a new mixed
Josephson-Fock regime. Higher modes introduce angular degrees of freedom and MS
states with different angular properties.Comment: 15 pages, 8 figures, 1 table. Mini-review prepared for the special
issue of Frontiers of Physics "Recent Progresses on Quantum Dynamics of
Ultracold Atoms and Future Quantum Technologies", edited by Profs. Lee, Ueda,
and Drummon
Performance of a Large-Area GEM Detector Prototype for the Upgrade of the CMS Muon Endcap System
Gas Electron Multiplier (GEM) technology is being considered for the forward
muon upgrade of the CMS experiment in Phase 2 of the CERN LHC. Its first
implementation is planned for the GE1/1 system in the region of the muon endcap mainly to control muon level-1 trigger rates
after the second long LHC shutdown. A GE1/1 triple-GEM detector is read out by
3,072 radial strips with 455 rad pitch arranged in eight -sectors.
We assembled a full-size GE1/1 prototype of 1m length at Florida Tech and
tested it in 20-120 GeV hadron beams at Fermilab using Ar/CO 70:30 and
the RD51 scalable readout system. Four small GEM detectors with 2-D readout and
an average measured azimuthal resolution of 36 rad provided precise
reference tracks. Construction of this largest GEM detector built to-date is
described. Strip cluster parameters, detection efficiency, and spatial
resolution are studied with position and high voltage scans. The plateau
detection efficiency is [97.1 0.2 (stat)]\%. The azimuthal resolution is
found to be [123.5 1.6 (stat)] rad when operating in the center of
the efficiency plateau and using full pulse height information. The resolution
can be slightly improved by 10 rad when correcting for the bias due
to discrete readout strips. The CMS upgrade design calls for readout
electronics with binary hit output. When strip clusters are formed
correspondingly without charge-weighting and with fixed hit thresholds, a
position resolution of [136.8 2.5 stat] rad is measured, consistent
with the expected resolution of strip-pitch/ = 131.3 rad. Other
-sectors of the detector show similar response and performance.Comment: 8 pages, 32 figures, submitted to Proc. 2014 IEEE Nucl. Sci.
Symposium, Seattle, WA, reference adde
Quality control and beam test of GEM detectors for future upgrades of the CMS muon high rate region at the LHC
Gas Electron Multipliers (GEM) are a proven position sensitive gas detector technology which nowadays is becoming more widely used in High Energy Physics. GEMs offer an excellent spatial resolution and a high particle rate capability, with a close to 100% detection efficiency. In view of the high luminosity phase of the CERN Large Hadron Collider, these aforementioned features make GEMs suitable candidates for the future upgrades of the Compact Muon Solenoid (CMS) detector. In particular, the CMS GEM Collaboration proposes to cover the high-eta region of the muon system with large-area triple-GEM detectors, which have the ability to provide robust and redundant tracking and triggering functions. In this contribution, after a general introduction and overview of the project, the construction of full-size trapezoidal triple-GEM prototypes will be described in more detail. The procedures for the quality control of the GEM foils, including gain uniformity measurements with an x-ray source will be presented. In the past few years, several CMS triple-GEM prototype detectors were operated with test beams at the CERN SPS. The results of these test beam campaigns will be summarised
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