Modificaciones subcelulares en la parálisis cerebral humana

El objetivo del presente trabajo es describir las modificaciones subcelulares en la parálisis cerebral humana encontrada en una búsqueda bibliográfica de los genes implicados en la misma.Facultad de Ciencias Médica

A global experiment on motivating social distancing during the COVID-19 pandemic

Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This cross-country, preregistered experiment (n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared with the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly internalized form of motivation relying on one’s core values) or behavioral intentions. Results supported hypothesized associations between people’s existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing. Controlled motivation was associated with more defiance and less long-term behavioral intention to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges

Forma y significado en el espacio público. Teorías y prácticas en la ciudad contemporánea

Fil: Roibón, María José. Universidad Nacional del Nordeste. Facultad de Arquitectura y Urbanismo; Argentina.Fil: Valdés, Paula. Universidad Nacional del Nordeste. Facultad de Arquitectura y Urbanismo; Argentina.Fil: Mahave, Alberto Patricio. Universidad Nacional del Nordeste. Facultad de Arquitectura y Urbanismo; Argentina.Fil: Pérez, Malena. Universidad Nacional del Nordeste. Facultad de Arquitectura y Urbanismo; Argentina.Fil: Berent, Mario Rubén. Universidad Nacional del Nordeste. Facultad de Arquitectura y Urbanismo; Argentina.Fil: Cáceres, Marcos Antonio. Universidad Nacional del Nordeste. Facultad de Arquitectura y Urbanismo; Argentina.Fil: Romano, Delia Estela. Universidad Nacional del Nordeste. Facultad de Arquitectura y Urbanismo; Argentina.Fil: Valdés, Mariana. Universidad Nacional del Nordeste. Facultad de Arquitectura y Urbanismo; Argentina.Fil: Godoy, Lía Marina. Universidad Nacional del Nordeste. Facultad de Arquitectura y Urbanismo; Argentina.Fil: Gómez Riguetti, Juan C. Universidad Nacional del Nordeste. Facultad de Arquitectura y Urbanismo; Argentina.Fil: Albendaño, Natalia A. Universidad Nacional del Nordeste. Facultad de Arquitectura y Urbanismo; Argentina.Fil: Zorrilla, Mario. Universidad Nacional del Nordeste. Facultad de Arquitectura y Urbanismo; Argentina.Fil: Acosta, Iván Marcelo. Universidad Nacional del Nordeste. Facultad de Arquitectura y Urbanismo; Argentina.Fil: Merino, Mario José. Universidad Nacional del Nordeste. Facultad de Arquitectura y Urbanismo; Argentina.Fil: Ferreyra, Carlos V. Universidad Nacional del Nordeste. Facultad de Arquitectura y Urbanismo; Argentina.La presente publicación expone el PI 17C002, radicado en el Área de la Expresión y la Representación. Conjuga a docentes e investigadores de distintas áreas. Se toma como objeto de estudio la ciudad actual, la arquitectura y específicamente el espacio público, como reflejo de la sociedad y de las estrategias de diseño que se llevan adelante desde diferentes ámbitos académicos y profesionales. Son andamiajes conceptuales la forma y significado, desde las teorías sobre la ciudad y su imagen a partir de elementos que la debieran organizar coherentemente, contribuyendo a que su estructura tenga identidad y significación

Imputation performance in Latin American populations: improving rare variants representation with the inclusion of native American genomes

Current Genome-Wide Association Studies (GWAS) rely on genotype imputation to increase statistical power, improve fine-mapping of association signals, and facilitate meta-analyses. Due to the complex demographic history of Latin America and the lack of balanced representation of Native American genomes in current imputation panels, the discovery of locally relevant disease variants is likely to be missed, limiting the scope and impact of biomedical research in these populations. Therefore, the necessity of better diversity representation in genomic databases is a scientific imperative. Here, we expand the 1,000 Genomes reference panel (1KGP) with 134 Native American genomes (1KGP + NAT) to assess imputation performance in Latin American individuals of mixed ancestry. Our panel increased the number of SNPs above the GWAS quality threshold, thus improving statistical power for association studies in the region. It also increased imputation accuracy, particularly in low-frequency variants segregating in Native American ancestry tracts. The improvement is subtle but consistent across countries and proportional to the number of genomes added from local source populations. To project the potential improvement with a higher number of reference genomes, we performed simulations and found that at least 3,000 Native American genomes are needed to equal the imputation performance of variants in European ancestry tracts. This reflects the concerning imbalance of diversity in current references and highlights the contribution of our work to reducing it while complementing efforts to improve global equity in genomic research.Published versionThis work was supported by “The Mexican Biobank Project: Building Capacity for Big Data Science in Medical Genomics in Admixed Populations”, a binational initiative between Mexico and the UK co-funded by CONACYT (Grant number FONCICYT/50/ 2016), and The Newton Fund through The Medical Research Council (Grant number MR/N028937/1) awarded to AME and AVSH. It was also supported by the International Center for Genetic Engineering and Biotechnology (ICGEB, Italy) grant number CRP/MEX20-01. MS was partially supported by the Chicago Fellows program of the University of Chicago. DODV is supported by the UC MEXUS CONACYT collaborative program (Grant number CN-19-29), and the UNAM PAPIIT funding program (Grant number IA200620)

Design of an algorithm for the diagnostic approach of patients with joint pain

Background Rheumatic diseases are a reason for frequent consultation with primary care doctors. Unfortunately, there is a high percentage of misdiagnosis. Objective To design an algorithm to be used by primary care physicians to improve the diagnostic approach of the patient with joint pain, and thus improve the diagnostic capacity in four rheumatic diseases. Methods Based on the information obtained from a literature review, we identified the main symptoms, signs, and paraclinical tests related to the diagnosis of rheumatoid arthritis, spondyloarthritis with peripheral involvement, systemic lupus erythematosus with joint involvement, and osteoarthritis. We conducted 3 consultations with a group of expert rheumatologists, using the Delphi technique, to design a diagnostic algorithm that has as a starting point “joint pain” as a common symptom for the four diseases. Results Thirty-nine rheumatologists from 18 countries of Ibero-America participated in the Delphi exercise. In the first consultation, we presented 94 items to the experts (35 symptoms, 31 signs, and 28 paraclinical tests) candidates to be part of the algorithm; 74 items (25 symptoms, 27 signs, and 22 paraclinical tests) were chosen. In the second consultation, the decision nodes of the algorithm were chosen, and in the third, its final structure was defined. The Delphi exercise lasted 8 months; 100% of the experts participated in the three consultations. Conclusion We present an algorithm designed through an international consensus of experts, in which Delphi methodology was used, to support primary care physicians in the clinical approach to patients with joint pain