Fractional Branes and N=1 Gauge Theories

We discuss fractional D3-branes on the orbifold C^3/Z_2*Z_2. We study the open and the closed string spectrum on this orbifold. The corresponding N=1 theory on the brane has, generically, a U(N_1)*U(N_2)*U(N_3)*U(N_4) gauge group with matter in the bifundamental. In particular, when only one type of brane is present, one obtains pure N=1 Yang-Mills. We study the coupling of the branes to the bulk fields and present the corresponding supergravity solution, valid at large distances. By using a probe analysis, we are able to obtain the Wilsonian beta-function for those gauge theories that possess some chiral multiplet. Although, due to the lack of moduli, the probe technique is not directly applicable to the case of pure N=1 Yang-Mills, we point out that the same formula gives the correct result also for this case.Comment: 21 pages, AMS-LaTeX, v2: references added and typos correcte

Conformal Solutions Of Duality Invariant 2D Magnetohydrodynamic Turbulence

We consider possible conformal field theory (CFT) descriptions of the various inertial ranges that exist in $2d$ duality invariant Magnetohydrodynamics. Such models arise as effective theories of dyonic plasmas in 3 dimensions in which all fields are independent of the third coordinate. We find new constraints on the allowed CFT's compared to those that may describe turbulence in $2d$ plasmas of electric charges only. The predictions from CFT concerning equipartition of energy amongst the electric and magnetic fields are discussed, and quantities exhibiting universal scaling are derived.Comment: Latex, 8 page

Duality Invariant Magnetohydrodynamics And Dyons

The theory of magnetohydrodynamics is extended to the cases of a plasma of separate magnetic and electric charges, as well as to a plasma of dyons respectively. In both these cases the system possesses electric-magnetic duality symmetry. In the former case we find that because of the existence of two independent generalized Ohm's law equations, the limit of infinite electric and magnetic conductivity results in the vanishing of both electric and magnetic fields, as well as the corresponding currents. In the dyonic case, we find that the resulting duality-invariant system of equations are equivalent to those of ordinary MHD, after suitable field redefinitions.Comment: 11 pages, late

Chiral Extensions of the MSSM

We present a class of extensions of the MSSM characterized by a fully chiral field content (no mu-terms) and no baryon or lepton number violating term in the superpotential due to an extra U'(1) gauge symmetry. The minimal model consist of the usual matter sector with family dependent U'(1) charges, six Higgs weak doublets, and three singlets required to give masses to the Higgsinos and cancel anomalies. We discuss its main features such as the tree level mass spectrum and the constraints on flavor changing processes.Comment: 13 pages. V2: Superpotential and U'(1) charges changed. Analysis of the spectrum for the new model added. References update

Prospective study on nanoparticle albumin-bound paclitaxel in advanced breast cancer. Clinical results and biological observations in taxane-pretreated patients

Background: There is a deep need to improve the care of metastatic breast cancer (MBC) patients, since even today it remains an incurable disease. Taxanes are considered the most effective cytotoxic drugs for the treatment of MBC, both in monotherapy and in combined schedules, but the need for synthetic solvents contributes to the severe toxicities and may have a negative impact on the efficacy. Nanoparticle albumin-bound paclitaxel (Nab-paclitaxel) is a colloidal suspension of paclitaxel and human serum albumin initially developed to avoid the toxicities associated with conventional taxanes. Patients and methods: The aim of this prospective, single-center open-label, noncomparative study was to evaluate the efficacy and safety of nab-paclitaxel in MBC patients pretreated with taxanes. The patients were treated with nab-paclitaxel as a single agent, 260 mg/m2 on day 1 of each 3-week cycle or 125 mg/m2 weekly. The primary endpoint was the overall response rate (ORR). Secondary objectives were duration of response, clinical benefit rate, progression-free survival (PFS), overall survival, and safety. Results: A total of 42 patients (median age 48 years, median Eastern Cooperative Oncology Group performance status 0, triple-negative MBC 19%, all pretreated with a taxane-based therapy, mainly in advanced disease) were enrolled in the study. The ORR was 23.8%, including one complete response (2.4%) and nine partial responses (21.4%); the disease control rate was 50%. The median duration of response was 7.2 months. After a median follow-up of 9 months, the median PFS was 4.6 months. ORR and PFS were similar irrespective of the previous chemotherapy lines, metastatic sites, and biomolecular expression. Nab-paclitaxel was well tolerated, and the most frequent treatment-related toxicities were mild to moderate (grades 1–2). Conclusion: This real-life study shows that nab-paclitaxel has a significant antitumor activity and a manageable safety profile in patients pretreated with taxanes and experiencing a treatment failure after at least one line of chemotherapy

Combination of Persistent Scatterer Interferometry and Single-Baseline Polarimetric Coherence Optimisation to Estimate Deformation Rates with Application to Tehran Basin

This study reports on the monitoring of land subsidence in a rural area located in the southwest of the Tehran basin, Iran, by combining a persistent scatterer interferometry (PSI) method with a single-baseline polarimetric coherence optimisation. Owing to vegetation coverage in this rural area, coherence level experiences a decline and the performance and coverage of conventional interferometry to estimate deformation rate reduces concomitantly. Since the launch of satellites with polarimetric information, the polarimetric InSAR (PolInSAR) technique, which is vector interferometry with different polarimetric channels, has been introduced to optimise the coherence level. One of the most common criteria to select PS pixels is coherence and maximising the coherence can lead to an increased number of selected PS pixels and enhanced PSI performance. The single-baseline polarimetric coherence optimisation method assumes equal polarisation states at the end of each baseline. In order to apply this technique in our study, two different multi-look windows for coherence calculation and also two TerraSAR-X data sets with different numbers of images are used to assess their effect on the polarimetric PSI. Combination of the single-baseline coherence optimisation method with PSI shows significant improvements (more than 50%) in terms of the number of selected PS pixels in the case study even using a data set with a small number of images. A 15 × 15 multi-look window selects a greater number of PS pixels compared to a 9×9 multi-look window, although this entails reducing spatial resolution. The most effective PSI approach in terms of the density of the selected PS turned out to be polarimetric PSI using a data set with a large number of images and a selection of a 15 × 15 multi-look window. Validation of the PSI methods using a large number of images with 9×9 and 15 × 15 multi-look windows via levelling measurements confirms the accuracy and reliability of the results obtained

Comparative study of the phase transition of Li1+xMn2-xO4 by anelastic spectroscopy and differential scanning calorimetry

Li1+xMn2xO4 is one of the most promising candidates as high performance cathode for lithium ion batteries. The stoichiometric compound is known to undergo a phase transition around room temperature, which has been widely studied and attributed either to Jahn–Teller effect or to charge ordering. For the applications it is important to suppress this phase transition, which lowers the electrochemical performances of the material. DSC measurements, which have been largely used in the literature to study the occurrence of the transformation, can detect a phase transition accompanied by latent heat only for x < 0.04. This fact has been generally accepted as a proof that the transformation is suppressed by doping. However, by using a technique extremely sensitive to rearrangements of atoms in the lattice, such as anelastic spectroscopy, we show that the phase transition persists up to x = 0.08, is shifted to lower temperatures, and changes its nature from first to higher order. The implications for the mechanism driving the transition and the similarities and differences with doped Fe3O4, which is the prototype of charge order transitions, are discussed

Eccentricity signal in the nannofossil time-series across the Mid-Pleistocene Transition in the northwestern Pacific Ocean (ODP Site 1209)

The Mid-Pleistocene Transition (MPT; 1.25–0.6 million years ago, Ma) is one of the most important and still debated climate reorganizations during which the glacial/interglacial cycles switched from a 41-thousand years (kyr) cycle (i.e. obliquity) to a quasi-periodic 100-kyr cycle (associated with orbital eccentricity). Variations in the orbital geometry can affect the abundance and distribution of certain marine biota such as the coccolithophores, a group of unicellular calcifying phytoplankton, whose skeletal remains – called nannofossils – represent a valid tool within the geological archives to infer change in surface water conditions and/or coccolithophore productivity and how orbital variations may have impacted them. Here, we apply for the first time various time series analytical techniques to the nannofossil dataset from mid-latitudinal Ocean Drilling Program (ODP) Site 1209 in the northwest Pacific Ocean for the interval spanning the last 1.6 Myr. To better interpret the orbital signal recorded by different nannofossil species we used time series analyses (i.e. wavelet, autocorrelation and cross correlation) to identify the main periodicities by single nannofossil species during the MPT, and to investigate further their response timings to those orbital drivers. In addition, we investigated how the recorded periodicities can improve understanding of the paleoecological preferences of particular species. The combination of multiple time series analyses allowed identification of the 100-kyr periodicity as the main cyclicity recorded in most analyzed species at Site 1209, documenting the predominance of the eccentricity-related signal at mid-latitudes and a reduced or absent influence of the obliquity response. Thus, our data highlight how orbital influence varies by latitude impacting the nannofossil species. The lag between eccentricity and species abundance fluctuations was also investigated, identifying a fast response ranging between 20 and 40 kyr for the taxa Calcidiscus leptoporus subspecies leptoporus, Gephyrocapsa caribbeanica small, and Reticulofenestra spp. (&gt;5 μm). This study corroborates the potential of nannofossils to deepen understanding of the dynamics and effects of variations in orbital geometry through time. It also underlines the need to extend the study of the responses of specific species through the use of different time series analysis techniques in order to return complementary information and detect clearer orbital signals