O'Raifeartaigh models with spontaneous R-symmetry breaking

O'Raifeartaigh models with general R-charge assignments can have vacua where both supersymmetry and R-symmetry are spontaneously broken. Most of these vacua are metastable because the potential shows a runaway behaviour. We explain the relation between runaway directions and R-symmetry.Comment: Submitted for SUSY07 proceeding

Serpagli, celebrating his 44th Silurian-research birthday

The editors are pleased to dedicate this volume on the Silurian of Sardinia to Enrico Serpagli, an outstanding personality of Italian palaeontology, who devoted substantial part of his professional life to marine faunas and biostratigraphy of Ordovician and Silurian sedimentary formations mostly of southern Sardinia. Two of the editors are former doctoral students of Enrico Serpagli and PS has been collaborating with him since his first, early postgradual visit to Sardinia in 1982

The Induction of Bone Formation by the recombinant human transforming growth Factor-β3 : From preclinical studies in Papio ursinus to translational research in Homo sapiens

Skeletal bone defects of the axial or the craniomaxillofacial skeletons still present formidable challenges to skeletal reconstructionists, tissue biologists and modern medicine. In systematic research experiments in the Chacma baboon Papio ursinus our laboratories have shown the previously unreported osteoinductive activity of the three mammalian transforming growth factor-β (TGF-β) isoforms. This review discusses the induction of bone formation by the mammalian TGF-βs with particular reference to the substantial and rapid induction of bone by the recombinant hTGF-β3 from the laboratory benches, to pre-clinical studies in heterotopic and orthotopic mandibular sites of Papio ursinus to clinical translation in human patients. Design and MethodsA series of systematic research experiments in Papio ursinus using the hTGF-β3 together with earlier experiments using the -β1 and β2 isoforms are reviewed and re-analyzed molecularly nd morphologically to provide the basic research data for the reported clinical translation in human patients. Results The three mammalian hTGF-β isoforms and notably hTGF-β3 induce rapid and substantial induction of heterotopic bone in intramuscular sites of Papio ursinus. Relatively low doses of hTGF-β1or hTGF-β3 in binary application with hBMP-7 synergize to induce massive corticalized ossicles in the rectus abdominis muscle. In orthotopic mandibular sites, 125 and250 µg doses of hTGF-β3 induce bone formation across large mandibular defects in Papio ursinus with corticalized buccal and lingual plates by day 30, with modeling and maintenance of corticalized bone by 9 to 12 months after implantation of the 250 µg dose in 3 cm mandibular defects Papio ursinus. Discussion hTGF-β3 significantly up-regulates RUNX-2 and Osteocalcin expression on day 15 controlling the differentiation of progenitor stem cells into the osteoblastic lineage. The induction of bone by the hTGF-β3 is via the bone morphogenetic proteins pathway; hTGF-β3 controls theinduction of bone by regulating the expression of BMPs gene and gene products via Noggin expression, eliciting bone induction by up-regulating exogenous BMPs

Il ruolo della costruzione di scenari nella spiegazione dei disturbi macrolinguistici della schizofrenia

Riassunto: Al centro di questo articolo è l’analisi dei fondamenti neurocognitivi dei deficit macrolinguistici, discorsivo-narrativi nello specifico, osservabili nei pazienti affetti da schizofrenia. Tale analisi è condotta in riferimento alle ricerche svolte negli ultimi decenni nell’ambito della psicolinguistica e delle neuroscienze. I risultati di queste ricerche hanno mostrato che alcuni aspetti dei disturbi macroelaborativi che caratterizzano il profilo linguistico dei pazienti schizofrenici possono essere spiegati chiamando in causa i deficit di tre sistemi cognitivi: teoria della mente, funzioni esecutive, memoria semantica. In questo articolo si sostiene che un tale quadro esplicativo vada integrato attraverso il riferimento a un ulteriore processo cognitivo cruciale per l’elaborazione macrolinguistica: la costruzione di scenari. Tale processo è fondamentale per la comprensione e produzione discorsiva in quanto responsabile della costruzione della rappresentazione globale degli eventi del discorso narrativo. Alla luce di queste considerazioni, in questo lavoro si propone che un ruolo cruciale nella spiegazione di alcuni aspetti dei disturbi macrolinguistici nella schizofrenia sia svolto da una compromissione nel processo di costruzione di scenari mentali e si avanza l’ipotesi che tale compromissione sia determinata, a sua volta, da problematiche che agiscono sul piano del funzionamento delle aree cerebrali preposte alla percezione e all’assemblaggio multimodale delle rappresentazioni sensomotorie.Parole chiave: Abilità macrolinguistiche; Costruzione di scenari; Elaborazione discorsiva: Embodied Cognition; Narrazione; Schizofrenia; Percezione; Modelli mentaliThe role scenario building in the explanation of macrolinguistic disorders in schizophreniaAbstract: This article analyzes the neurocognitive foundations of macrolinguistic deficits, specifically narrative, observable in patients with schizophrenia. This analysis is conducted with reference to the investigations carried out in recent decades in the field of psycholinguistics and neuroscience. The results of these investigations showed that some aspects of macrolinguistic deficits of schizophrenics can be explained in terms of impairments of three cognitive systems: theory of mind, executive functions, and semantic memory. In this article, it is suggested that this explanatory framework has to be integrated with the reference to a further cognitive process: scenarios construction. Such process turns out to be critical for discourse comprehension and production as it is responsible for the building of the global representation of events of a narrative. In the light of these considerations, it is claimed that a crucial role in the explanation of some aspects of macrolinguistic disorders in schizophrenia is played by an impairment in the process of constructing mental scenarios. The hypothesis is that this impairment is, in turn, determined by problems affecting the brain areas responsible for the perception and multimodal assembly of sensorimotor representations.Keywords: Discourse Processing; Embodied Cognition; Macrolinguistic Skills; Scenario Building; Narrative; Schizophrenia; Perception; Mental Model

The Silurian of Sardinia

The present volume “The Silurian of Sardinia” is composed of two related components. The first part comprises seven contributions introduced by an historical overview on the studies already carried out on the Silurian faunas of Sardinia. It aims to delineate a comprehensive scenario of the Silurian of Sardinia within a proper geological setting. A global overview regarding the palaeoenvironment and palaeogeography is also provided. The second part of the volume consists of seven research papers that illustrate actual knowledge on major fossil groups encountered in the Silurian limestones and shales of southern Sardinia

Extra-articular tenodesis combined with an anterior cruciate ligament reconstruction in acute anterior cruciate ligament tear in elite female football players

PURPOSE: The growing popularity of elite soccer among female participants has led to increased incidents of anterior cruciate ligament (ACL) ruptures. Many authors underline a positive glide after ACL reconstruction (ACLR), especially in women. In fact, an isolated intra-articular ACLR may be inadequate to control rotational instability after a combined injury of the ACL and the peripheral structures of the knee. Extra-articular procedures are sometimes used in primary cases displaying excessive antero-lateral rotatory instability. The purpose of this case series was to report subjective and objective outcomes after combined ACL and lateral extra-articular tenodesis (LET) with a minimum 4-year follow-up in a selected high-risk population of elite female football players. METHODS: Between January 2007 and December 2010, 16 elite Italian female football players were included in the study. All patients underwent the same surgical technique: anatomical ACLR with autogenous semitendinosus and gracilis tendons. After the intra-articular reconstruction was performed, an additional extra-articular MacIntosh modified Coker-Arnold procedure was carried out. Patients were assessed pre- and post-operatively with the subjective and objective International Knee Documentation Committee (IKDC) evaluation form, Tegner activity scale (TAS) and Lysholm score. Joint laxity was assessed with KT-1000 by measuring the side-to-side (S/S) differences in displacement at manual maximum (mm) testing. RESULTS: At a mean follow-up of 72.6 ± 8.1 months, two independent examiners reviewed all players. All of the patients had a fully recovered range of motion. Lachman test was negative in all patients (100 %). The evaluation of joint laxity and clinical evaluation showed a statistically significant improvement. No patients experienced complication or a re-rupture. DISCUSSION: The rationale of combining extra-articular procedures with ACLR is to restrict the internal rotation of the reconstructed knee, taking advantage of its long lever arm and thus providing more stability in the rotational axis and preventing the ACL graft from undergoing further excessive strain. CONCLUSIONS: The combination of an LET with ACLR in elite female football players demonstrated excellent results in terms of subjective scales, post-operative residual laxity and re-rupture rate with no complication, and a complete return to sport activity

Chest pain caused by multiple exostoses of the ribs: A case report and a review of literature

Abstract The aim of this paper is to report an exceptional case of multiple internal exostoses of the ribs in a young patient affected by multiple hereditary exostoses (MHE) coming to our observation for chest pain as the only symptom of an intra-thoracic localization. A 16 years old patient with familiar history of MHE came to our observation complaining a left-sided chest pain. This pain had increased in the last months with no correlation to a traumatic event. The computed tomography (CT) scan revealed the presence of three exostoses located on the left third, fourth and sixth ribs, all protruding into the thoracic cavity, directly in contact with visceral pleura. Moreover, the apex of the one located on the sixth rib revealed to be only 12 mm away from pericardium. Patient underwent video-assisted thoracoscopy with an additional 4-cm mini toracotomy approach. At the last 1-year followup, patient was very satisfied and no signs of recurrence or major complication had occured. In conclusion, chest pain could be the only symptom of an intra-thoracic exostoses localization, possibly leading to serious complications. Thoracic localization in MHE must be suspected when patients complain chest pain. A chest CT scan is indicated to confirm exostoses and to clarify relationship with surrounding structures. Video-assisted thoracoscopic surgery can be considered a valuable option for exostoses removal, alone or in addiction to a mini-thoracotomy approach, in order to reduce thoracotomy morbidity

Long term follow-up of pediatric mandibular reconstruction with human transforming growth factor-β3

Translating bone regeneration induced by recombinant human bone morphogenetic proteins from animal models to human patients has proven inexplicably inconsistent. This prompted us to test in 5 pediatric patients, an alternative osteoinductive morphogen, recombinant human transforming growth factor β3 (hTGF-β3), to reconstruct mandibular defects of such a size to preclude reconstruction with autologous bone. An osteoinductive implant of human demineralized bone matrix (DBM) loaded with 125 μg hTGF-β3 per gram of DBM was implanted into one defect, and 250 μg hTGF-β3 per gram of DBM in another. Thereafter in 3 patients limited amounts of particulate cortico-cancellous bone graft harvested from the posterior iliac crest were combined with 250 μg hTGF-β3 per gram of DBM. Patients were followed up for 3 to 6 years. Three patients achieved clinically significant osteoinduction, 1 patient with hTGF-β3 only, and 2 by combining hTGF-β3 with a small supplement of autologous bone. One patient with hTGF-β3 only and followed up for 5 years retains a viable reconstruction but has had sub-optimal bone regeneration. One patient had osteoinductive failure due to sepsis although the plate reconstruction remains viable. Recombinant human TGF-β3 initiates osteoinduction in humans and potentiates autologous bone graft activity allowing the reconstruction of large mandibular defects in pediatric patients.The University of the Witwatersrand, Johannesburg and the National Research Foundation of South Africa.https://journals.lww.com/jcraniofacialsurgery/pages/default.aspxhj2021Maxillo-Facial and Oral Surger