Associated ZH production at hadron colliders: the fully differential NNLO QCD calculation

We consider Standard Model Higgs boson production in association with a Z boson in hadron collisions. We present a fully exclusive computation of QCD radiative corrections up to next-to-next-to-leading order (NNLO). Our calculation includes the Higgs boson decay to bottom quarks (b) in next-to-leading order QCD and the leptonic decay of the Z boson with finite-width effects and spin correlations. The computation is implemented in a parton level Monte Carlo program that makes possible to consider arbitrary kinematical cuts on the final-state leptons, the b jets and the associated QCD radiation, and to compute the corresponding distributions in the form of bin histograms. We assess the impact of QCD radiative effects in the boosted kinematics at the LHC and show that the inclusion of the NNLO corrections is crucial to control the pT spectrum of the Higgs boson candidate.Comment: 10 pages, 2 figure

Higher-order QCD effects for associated WH production and decay at the LHC

We consider Standard Model Higgs boson production in association with a W boson in hadron collisions. We supplement the fully exclusive perturbative computation of QCD radiative effects up to next-to-next-to-leading order (NNLO) with the computation of the decay of the Higgs boson into a bb pair at next-to-leading order (NLO). We consider the selection cuts that are typically applied in the LHC experimental analysis, and we compare our fixed-order predictions with the results obtained with the MC@NLO event generator. We find that NLO corrections to the H -> bb decay can be important to obtain a reliable pT spectrum of the Higgs boson, but that, in the cases of interest, their effect is well accounted for by the parton shower Monte Carlo. NNLO corrections to the production process typically decrease the cross section by an amount which depends on the detail of the applied cuts, but they have a mild effect on the shape of the Higgs pT spectrum. We also discuss the effect of QCD radiative corrections on the invariant mass distribution of the Higgs candidate.Comment: 18 pages, 7 figures. References and figure added. Version published on JHE

Associated production of a Higgs boson decaying into bottom quarks at the LHC in full NNLO QCD

We consider the production of a Standard Model Higgs boson decaying to bottom quarks in association with a vector boson W/Z in hadron collisions. We present a fully exclusive calculation of QCD radiative corrections both for the production cross section and for the Higgs boson decay rate up to next-to-next-to-leading order (NNLO) accuracy. Our calculation also includes the leptonic decay of the vector boson with finite-width effects and spin correlations. We consider typical kinematical cuts applied in the experimental analyses at the Large Hadron Collider (LHC) and we find that the full NNLO QCD corrections significantly decrease the accepted cross section and have a substantial impact on the shape of distributions. We point out that these additional effects are essential to obtain precise theoretical predictions to be compared with the LHC data.Comment: Additional quantitative information included in the figures, minor changes in the text, version published on PL

Hypofractionated postoperative helical tomotherapy in prostate cancer: a mono-institutional report of toxicity and clinical outcomes

Purpose: This is a mono-institutional study of acute and late toxicities and early biochemical control of a retrospective series of 75 prostate cancer patients treated with moderate postoperative hypofractionation delivered by helical tomotherapy (HT).Patients and methods: From April 2013 to June 2017, 75 patients received adjuvant (n=37) or salvage (n=38) treatment, delivering to prostate bed a total dose of 63.8 Gy (equivalent dose in 2-Gy fraction..67.4 Gy) using 2.2 Gy fractions. Whole-pelvis irradiation was performed in 63% of cases (median dose, 49.3 Gy; range, 48-55.1 Gy). Concurrent hormonal therapy was administered in 46% of cases. Common Terminology Criteria for Adverse Events (version 4.0) was adopted for acute and late genitourinary (GU) and gastrointestinal (GI) toxicity evaluations. Biochemical progression was defined as PSA level increase of >= 0.2 or more above the postoperative radiotherapy (RT) nadir.Results: Acute GU toxicities were as follows: G1 in 46% and G2 in 4%, detecting no G >= 3 events. For GI toxicity, we recorded G1 in 36% and G2 in 18%. With a median follow-up of 30 months (range, 12-58 months), we found late toxicity G2 GI in 6.6% and G >= 2 GU in 5.3%, including two patients who underwent surgical incontinence correction. Acute toxicity and diabetes were found to be predictive of late GI >= 2 toxicity (P=0.04 and P=0.0019). Actuarial 2- and 3-year biochemical recurrence-free survivals were 88% and 73%, respectively, for the entire population.Conclusion: In our experience, moderate hypofractionated postoperative RT with HT was feasible and safe, with reports of low incidence of toxicity and promising biochemical control rates

Experimental investigation of exotic clustering in 13B and 14C using the resonance scattering method

In order to investigate the existence of molecular and/or exotic cluster configurations in Boron and Carbon n-rich isotopes we undertook two experiments: the first experimental study of exotic 9Li+α cluster states in 13B using the resonance scattering method at TRIUMF (Canada), and, with the same technique, the measurement of 10Be+α scattering at LNS in Catania, where a 10Be radioactive beam was produced for the first time. In order to measure the excitation function in a wide energy range, the beams were stopped in a Helium-flooded chamber. In the case of 13B, the elastic excitation function shows the presence of various peaks in an excitation energy region never explored before. In the case of 14C, our exclusive measurement of elastic scattering data with a high intensity beam, sheds some light on the contradictory previously published results [1, 2]

Optical Response of CVD-Grown ML-WS2 Flakes on an Ultra-Dense Au NP Plasmonic Array

The combination of metallic nanostructures with two-dimensional transition metal dichalcogenides is an efficient way to make the optical properties of the latter more appealing for opto-electronic applications. In this work, we investigate the optical properties of monolayer WS2 flakes grown by chemical vapour deposition and transferred onto a densely-packed array of plasmonic Au nanoparticles (NPs). The optical response was measured as a function of the thickness of a dielectric spacer intercalated between the two materials and of the system temperature, in the 75–350 K range. We show that a weak interaction is established between WS2 and Au NPs, leading to temperature- and spacer-thickness-dependent coupling between the localized surface plasmon resonance of Au NPs and the WS2 exciton. We suggest that the closely-packed morphology of the plasmonic array promotes a high confinement of the electromagnetic field in regions inaccessible by the WS2 deposited on top. This allows the achievement of direct contact between WS2 and Au while preserving a strong connotation of the properties of the two materials also in the hybrid system

The PREdictor of MAlnutrition in Systemic Sclerosis (PREMASS) Score:A Combined Index to Predict 12 Months Onset of Malnutrition in Systemic Sclerosis

Objective: Malnutrition is a severe complication in Systemic Sclerosis (SSc) and it is associated with significant mortality. Notwithstanding, there is no defined screening or clinical pathway for patients, which is hampering effective management and limiting the opportunity for early intervention. Here we aim to identify a combined index predictive of malnutrition at 12 months using clinical data and specific serum adipokines. Methods: This was an international, multicentre observational study involving 159 SSc patients in two independent discovery (n = 98) and validation (n = 61) cohorts. Besides routine clinical and serum data at baseline and 12 months, Malnutrition Universal Screening Tool (MUST) score and serum concentration of leptin and adiponectin were measured for each participant at baseline. The endpoint of malnutrition was defined according to European Society of Clinical Nutrition and Metabolism (ESPEN) recommendation. Significant parameters from univariate analysis were tested in logistic regression analysis to identify the predictive index of malnutrition in the derivation cohort. Results: The onset of malnutrition at 12 months correlated with adiponectin, leptin and their ratio (A/L), MUST, clinical subset, disease duration, Scl70 and Forced Vital Capaciy (FVC). Logistic regression analysis defined the formula: −2.13 + (A/L*0.45) + (Scl70*0.28) as the best PREdictor of MAlnutrition in SSc (PREMASS) (AUC = 0.96; 95% CI 0.93, 0.99). PREMASS 62% and negative predictive value (NPV) > 97% for malnutrition at 12 months. Conclusion: PREMASS is a feasible index which has shown very good performance in two independent cohorts for predicting malnutrition at 12 months in SSc. The implementation of PREMASS could aid both in clinical management and clinical trial stratification/enrichment to target malnutrition in SSc

Residual tumor micro-foci and overwhelming regulatory T lymphocyte infiltration are the causes of bladder cancer recurrence

Bladder cancer has an unexplained, high recurrence rate. Causes of recurrence might include the presence of sporadic tumor micro-foci in the residual urothelial tissue after surgery associated with an inverted ratio between intratumoral effector and regulatory T cell subsets. Hence, surgical specimens of both tumors and autologous, macroscopically/histologically free-of-tumor tissues were collected from 28 and 20 patients affected by bladder or renal cancer, respectively. The frequencies of effector (IFN?+ and IL17+ T cells) and regulatory (CD4+CD25hiCD127lo and CD8+CD28-CD127loCD39+ Treg) T cell subpopulations among tumor infiltrating lymphocytes were analyzed by immunofluorescence, while the gene expression of MAGE-A1 and MAGE-A2 tumor-associated antigens was studied by RT-PCR. The results show that both the T cell infiltrate and the frequency of MAGE-A1/A2 gene expression were comparable in tumors and in autologous free-of-tumor tissues in bladder cancer, while the autologous free-of-tumor renal tissues showed reduced T cell infiltrate and frequency of MAGE gene expression as compared to the autologous tumors. Importantly, the intra-tumor T effector/Treg cell ratio was consistently <1 in bladder cancer patients (n. 7) who relapsed within two years, while it was always >1 in patients (n. 6) without recurrence (regardless of tumor stage) (P = 0.0006, Odds ratio = 195). These unprecedented findings clarify the pathogenic mechanism of bladder cancer recurrence and suggest that microscopically undetectable micro-foci of tumor may predispose to recurrence when associated with an inverted intratumoral T effector/Treg cell ratio