114 research outputs found
Coreceptor Usage by HIV-1 and HIV-2 Primary Isolates: The Relevance of CCR8 Chemokine Receptor as an Alternative Coreceptor
The human immunodeficiency virus replication cycle begins by sequential interactions between viral envelope glycoproteins with CD4 molecule and a member of the seven-transmembrane, G-protein-coupled, receptors' family (coreceptor). In this report we focused on the contribution of CCR8 as alternative coreceptor for HIV-1 and HIV-2 isolates. We found that this coreceptor was efficiently used not only by HIV-2 but particularly by HIV-1 isolates. We
demonstrate that CXCR4 usage, either alone or together with CCR5 and/or CCR8, was more frequently observed in HIV-1 than in HIV-2 isolates. Directly related to this is the finding that the non-usage of CXCR4 is
significantly more common in HIV-2 isolates; both features could be associated with the slower disease progression generally observed in HIV-2 infected patients.
The ability of some viral isolates to use alternative coreceptors besides CCR5 and CXCR4 could further impact on the efficacy of entry inhibitor therapy and possibly also in HIV pathogenesis
Caracterização morfológica do trato gastrointestinal de frangos de corte da linhagem Cobb 500®
Potencial cicatricial da Bixa orellana L. em feridas cutâneas: estudo em modelo experimental
Tipos de colheita e épocas de aplicação de glifosato na erradicação de soqueiras de cana-de-açúcar
Estrutura foliar de curauá em diferentes intensidades de radiação fotossinteticamente ativa
MATURATION STAGES OF FRUITS AND PHYSIOLOGICAL SEED QUALITY OF Physalis ixocarpa BROT. EX HORMEN
Desempenho per se e parâmetros genéticos de linhagens de trigo com expressão do caráter "stay‑green"
Efeito da adição de fontes de matéria orgânica como amenizantes do efeito tóxico de B, Zn, Cu, Mn e Pb no cultivo de Brassica juncea
Microbiological and chemical attributes of a Hapludalf soil with swine manure fertilization
Taxocenose de anuros (Amphibia: Anura) em uma área de Floresta Ombrófila Densa no Sul do Brasil
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