Mechanisms producing different precipitation patterns over north‐eastern Italy: insights from HyMeX‐SOP1 and previous events

During the first HyMeX Special Observation Period (SOP1) field campaign, the target site of north‐eastern Italy (NEI) experienced a large amount of precipitation, locally exceeding the climatological values and distributed among several heavy‐rainfall episodes. In particular, two events that occurred during the last period of the campaign drew our attention. These events had common large‐scale patterns and a similar mesoscale setting, characterised by southerly low‐level flow interacting with the Alpine orography, but the precipitation distribution was very different. During Intensive Observing Period IOP18 (31 October–1 November 2012), convective systems were responsible for intense rainfall mainly located over a flat area of the eastern Po Valley, well upstream of the orography. Conversely, during IOP19 (4/5 November 2012), heavy precipitation affected only the Alpine area. In addition to IOP18 and IOP19, the present study analyses other heavy‐precipitation episodes that display similar characteristics and which occurred over NEI during the autumn of recent years. A high‐resolution (2 km grid spacing) non‐hydrostatic NWP model and available observations are used for this purpose. The two different observed precipitation patterns are explained in terms of interaction between the impinging flow and the Alps. Depending on the thermodynamic profile, convection can be triggered when the impinging flow is forced to rise over a pre‐existing cold‐air layer at the base of the orography. In this situation a persistent blocked‐flow condition and upstream convergence are responsible for heavy rain localized over the plain. Conversely, if convection does not develop, flow‐over conditions are established and heavy rain affects the Alps. Numerical parameters proposed in the literature are used to support the analysis. Finally, the role of evaporative cooling beneath the convective systems is evaluated. It turns out that the stationarity of the systems upstream of the Alps is mainly attributable to persistent blocked‐flow conditions, while convective outflow slightly modifies the location of precipitation

No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age

Background : we investigated the association between 9 polymorphisms of genes encoding hemostasis factors and myocardial infarction in a large sample of young patients chosen because they have less coronary atherosclerosis than older patients, and thus their disease is more likely to be related to a genetic predisposition to a prothrombotic state Methods and Results : this nationwide case-control study involved 1210 patients who had survived a first myocardial infarction at an age of 45 years who underwent coronary arteriography in 125 coronary care units and 1210 healthy subjects matched for age, sex, and geographical origin. None of the 9 polymorphisms of genes encoding proteins involved in coagulation (G-455A -fibrinogen: OR, 1.0; CI, 0.8 to 1.2; G1691A factor V: OR, 1.1; CI, 0.6 to 2.1; G20210A factor II: OR, 1.0; CI, 0.5 to 1.9; and G10976A factor VII: OR, 1.0; CI, 0.8 to 1.3), platelet function (C807T glycoprotein Ia: OR, 1.1; CI, 0.9 to 1.3; and C1565T glycoprotein IIIa: OR, 0.9; CI, 0.8 to 1.2), fibrinolysis (G185T factor XIII: OR, 1.2; CI, 0.9 to 1.6; and 4G/5G plasminogen activator inhibitor type 1: OR, 0.9; CI, 0.7 to 1.2), or homocysteine metabolism (C677T methylenetetrahydrofolate reductase: OR, 0.9; CI, 0.8 to 1.1) were associated with an increased or decreased risk of myocardial infarction Conclusions : this study provides no evidence supporting an association between 9 polymorphisms of genes encoding proteins involved in hemostasis and the occurrence of premature myocardial infarction or protection against it

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

gaMS-1: a gametophytic male sterile mutant in maize

Several pollen-specific genes from different species have been isolated and characterized at the molecular level, but the precise role of most of them is unknown. Mutant analysis represents a direct approach to uncovering gene function, but the paucity of available mutants affecting pollen development and/or function and the poor characterization of the known mutants have so far limited the exploitation of this approach. Here we present the cytological characterization of gametophytic male sterile-1 (gaMS-1), a maize mutant that we identified in a program of transposon insertion mutagenesis for the production of mutations in gametophytically acting genes involved in microsporogenesis. gaMS-1 is expressed during or immediately after the first microspore division and leads to the production of immature, nonfunctional pollen grains. The mutation appears to affect the events leading to the developmental switch that follows the first microspore mitosis

High power test results of the SPARC C-band accelerating structures

The energy upgrade of the SPARC photo-injector at LNF-INFN (Italy) from 180 to more than 240 MeV will be carried out by replacing a low gradient S-Band accelerating structure with two C-band structures. The structures are Traveling Wave (TW) and Constant Impedance (CI), with symmetric axial input couplers and have been optimized to work with a SLED RF input pulse. In this paper we present the results of the low and high power RF tests on the two fabricated structures that shown the feasibility of the operation at accelerating gradients larger than 35 MV/m