3,354 research outputs found
Unmet needs and current and future approaches for osteoporotic patients at high risk of hip fracture.
Summary: This review provides a critical analysis of currently available approaches to increase bone mass, structure and strength through drug therapy and of possible direct intraosseous
interventions for the management of patients at imminent risk of hip fracture.
Purpose : Osteoporotic hip fractures represent a particularly high burden in morbidity-, mortality- and health care-related costs. There are challenges and unmet needs in the early prevention of hip fractures, opening the perspective of new developments for the management of osteoporotic patients at imminent and/or at very high risk of hip fracture. Amongst them, preventive surgical intervention needs to be considered.
Methods: A European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)/International Osteoporosis Foundation
(IOF) working group reviewed the presently available intervention modalities including preventive surgical options for hip fragility. This paper represents a summary of the
discussions.
Results: Prevention of hip fracture is currently based on regular physical activity; prevention of falls; correction of nutritional deficiencies, including vitamin D repletion; and pharmacological
intervention. However, efficacy of these various measures to reduce hip fractures is at most 50% and may need months or years before becoming effective. To face the challenges
of early prevention of hip fractures for osteoporotic patients at imminent and/or at very high risk of hip fracture, preventive surgical intervention needs further investigation.
Conclusion: Preventive surgical intervention needs to be appraised for osteoporotic patients at imminent and/or at very high risk of hip fracture
A Study of Wall-Crossing: Flavored Kinks in D=2 QED
We study spectrum of D=2 N=(2,2) QED with N+1 massive charged chiral
multiplets, with care given to precise supermultiplet countings. In the
infrared the theory flows to CP^N model with twisted masses, where we construct
generic flavored kink solitons for the large mass regime, and study their
quantum degeneracies. These kinks are qualitatively different and far more
numerous than those of small mass regime, with features reminiscent of
multi-pronged (p,q) string web, complete with the wall-crossing behavior. It
has been also conjectured that spectrum of this theory is equivalent to the
hypermultiplet spectrum of a certain D=4 Seiberg-Witten theory. We find that
the correspondence actually extends beyond hypermultiplets in D=4, and that
many of the relevant indices match. However, a D=2 BPS state is typically
mapped to several different kind of dyons whose individual supermultiplets are
rather complicated; the match of index comes about only after summing over
indices of these different dyons. We note general wall-crossing behavior of
flavored BPS kink states, and compare it to those of D=4 dyons.Comment: 47 pages, 5 figures; typos fixed; references adde
Ab initio study of magnetism at the TiO2/LaAlO3 interface
In this paper we study the possible relation between the electronic and
magnetic structure of the TiO2/LaAlO3 interface and the unexpected magnetism
found in undoped TiO2 films grown on LaAlO. We concentrate on the role
played by structural relaxation and interfacial oxygen vacancies.
LaAlO3 has a layered structure along the (001) direction with alternating LaO
and AlO2 planes, with nominal charges of +1 and -1, respectively. As a
consequence of that, an oxygen deficient TiO2 film with anatase structure will
grow preferently on the AlO2 surface layer. We have therefore performed
ab-initio calculations for superlattices with TiO2/AlO2 interfaces with
interfacial oxygen vacancies. Our main results are that vacancies lead to a
change in the valence state of neighbour Ti atoms but not necessarily to a
magnetic solution and that the appearance of magnetism depends also on
structural details, such as second neighbor positions. These results are
obtained using both the LSDA and LSDA+U approximations.Comment: Accepted for publication in Journal of Materials Scienc
Phylogeny, molecular dating and zoogeographic history of the titi monkeys (Callicebus, Pitheciidae) of eastern Brazil
The titi monkeys belong to a genus of New World primates endemic to South America, which were recently reclassified in three genera (Cheracebus, Plecturocebus and Callicebus). The genus Callicebus, which currently includes five species, is endemic to eastern Brazil, occurring in the Caatinga, Savanna, and Atlantic Forest biomes. In the present study, we investigated the validity of these species and inferred their phylogenetic relationships, divergence times, and biogeographic patterns based on the molecular analysis of a concatenated sequence of 11 mitochondrial and nuclear DNA markers, derived from 13 specimens. We ran Maximum Likelihood (ML) and Bayesian Inference (BI) analyses, and estimated genetic distances, divergence times. Ancestral areas were estimated on BioGeoBears. Our results suggest that at about twelve million years ago, the ancestor of all titi monkeys inhabited a wide area that extended from the Amazon forest to the South of the Atlantic forest. A first vicariant event originated Cheracebus in the West of the Amazon and the ancestor of Callicebus and Plectorocebus which, later were separated by a second one. The diversification of Callicebus occurred during the Plio-Pleistocene (beginning at 5 Ma) probably influenced by climatic fluctuations and geological events. Therefore, the results of the present work confirmed the existence of five species that currently inhabit forested areas under increasing threat from human activities. Thus, a reliable diagnosis of the taxonomic status of species living in endangered environments is extremely important for the development of conservation measures
Wall Crossing and Instantons in Compactified Gauge Theory
We calculate the leading weak-coupling instanton contribution to the
moduli-space metric of N=2 supersymmetric Yang-Mills theory with gauge group
SU(2) compactified on R^3 x S^1. The results are in precise agreement with the
semiclassical expansion of the exact metric recently conjectured by Gaiotto,
Moore and Neitzke based on considerations related to wall-crossing in the
corresponding four-dimensional theory.Comment: 24 pages, no figure
BPS States, Refined Indices, and Quiver Invariants
For D=4 BPS state construction, counting, and wall-crossing thereof, quiver
quantum mechanics offers two alternative approaches, the Coulomb phase and the
Higgs phase, which sometimes produce inequivalent counting. The authors have
proposed, in arXiv:1205.6511, two conjectures on the precise relationship
between the two, with some supporting evidences. Higgs phase ground states are
naturally divided into the Intrinsic Higgs sector, which is insensitive to
wall-crossings and thus an invariant of quiver, plus a pulled-back ambient
cohomology, conjectured to be an one-to-one image of Coulomb phase ground
states. In this note, we show that these conjectures hold for all cyclic
quivers with Abelian nodes, and further explore angular momentum and R-charge
content of individual states. Along the way, we clarify how the protected spin
character of BPS states should be computed in the Higgs phase, and further
determine the entire Hodge structure of the Higgs phase cohomology. This shows
that, while the Coulomb phase states are classified by angular momentum, the
Intrinsic Higgs states are classified by R-symmetry.Comment: 51 pages, 5 figure
Complete gene expression profiling of Saccharopolyspora erythraea using GeneChip DNA microarrays
The Saccharopolyspora erythraea genome sequence, recently published, presents considerable divergence from those of streptomycetes in gene organization and function, confirming the remarkable potential of S. erythraea for producing many other secondary metabolites in addition to erythromycin. In order to investigate, at whole transcriptome level, how S. erythraea genes are modulated, a DNA microarray was specifically designed and constructed on the S. erythraea strain NRRL 2338 genome sequence, and the expression profiles of 6494 ORFs were monitored during growth in complex liquid medium
- …