Krokodil: The drug that kills

Psychotropic substances use and abuse have become a real global problem. Up to now, heroin is still one of the most abused drugs, however its consumption is in sharp decline in favor of Krokodil, also called “the poor’s heroine”. Krokodil originates from codeine that is extracted from antitussive and analgesic drugs, in “improvised” rudimentary laboratories and through artisan synthetic routes. Its low cost and easy procurement have allowed its rapid and dangerous spread. The objective of this paper was to describe the epidemiology, chemistry, synthesis and toxicology of Krokodil

Cacao agroforestry systems do not increase pest and disease incidence compared with monocultures under good cultural management practices

Pests and diseases threaten cacao production worldwide. Agroforestry systems are traditionally seen by farmers as one of the causes of increased pest and disease incidence, in contrast with full-sun monocultures. Cultural management practices - e.g. regular tree pruning, frequent pod harvest, regular removal of infested pods, weed management - have been reported to be crucial for pest and disease management. We performed two experiments for the purpose of assessing the effect of (i) different cacao production systems, and (ii) the frequency of harvest and removal of infested pods on the incidence of pests and diseases and on the cacao yield. The first experiment was performed in a long-term system comparison trial in Bolivia, where data on pest and disease incidence were recorded for three years in five production systems: two monocultures and two agroforestry system under organic and conventional farming, and one successional agroforestry system, i.e. a high tree density multi-strata system. Pest and disease management did not differ between systems and relied on cultural management practices. Overall, the incidence of pests and diseases did not differ between production systems, which indicated they were not the driver of yield differences between them. Across production systems, only 14% of the pods were affected by pests and diseases; 70% of these were affected by frosty pod rot. More than 80% of the pods infected by frosty pod rot were removed before the sporulation phase. In the second experiment, the effects of the frequency of harvest and removal of infected pods - every 15 days versus every 25 days - on pest and disease incidence and yield were tested in four farmers’ fields. Fortnightly harvest and diseased pod removal significantly decreased disease incidence and increased cacao yield, by 25% and 46% respectively. Our results show that cacao agroforestry systems do not increase pest and disease incidence compared with monocultures when good cultural management practices are implemented, which, in turn, can increase the productivity of the cacao plantations

Different yawns, different functions? Testing social hypotheses on spontaneous yawning in Theropithecus gelada

Here, we tested hypotheses about the potential functions of yawning based on its intensity and social contexts. Due to their spectrum intensity of yawns (covered teeth/YW1; uncovered teeth/YW2; uncovered gums/YW3), geladas are a good model species for this purpose. We suggest that yawns of different intensity can bear different information according to the performer, the context and the behavioural pattern temporally associated to the yawn event. YW3, mainly performed by high ranking males during periods of high social tension, was frequently associated with an auditory component and often accompanied by scratching (a measure of anxiety). YW1 and YW2, preferentially performed by females, were frequently associated to lip smacking, an affiliative display. In conclusion, even though a clear-cut functional distinction of geladas\u27 yawn intensity is difficult, YW1 and YW2 seem to be more linked to affiliative social interactions; whereas, YW3 seems to be more linked to agonistic and tension situations

Formal or Informal? Analysis of the Potato Seed System in Rwanda

The aim of the study was to analyze the formal and informal potato seed supply system in Rwanda and their interactions (year 2016). Three instruments were applied during this research: formal and informal interviews and expert interviews. In order to supply Rwandan farmers with high quality seed, the formal and informal systems must be complementary and mutually dependent. It is suggested that the certified seed production must be combined with the development of strong and targeted linkages along with the informal seed sector. At the same time, the strengthening of the informal seed system must be improved to increase the seed quality produced by farmers. The promotion of the integrated participative approaches in breeding, seed production and distribution would help improve the complementary between the two systems. By doing this, the actual quantity of certified seed could have a major impact on the overall seed supply and increase the seed quantity in the country

“Digitally Oriented Materials”: Focus on Lithium Disilicate Ceramics

The present paper was aimed at reporting the state of the art about lithium disilicate ceramics. The physical, mechanical, and optical properties of this material were reviewed as well as the manufacturing processes, the results of in vitro and in vivo investigations related to survival and success rates over time, and hints for the clinical indications in the light of the latest literature data. Due to excellent optical properties, high mechanical resistance, restorative versatility, and different manufacturing techniques, lithium disilicate can be considered to date one of the most promising dental materials in Digital Dentistry

Area accuracy gradient and artificial markers: a three-dimensional analysis of the accuracy of IOS scans on the completely edentulous upper jaw

Aim The present paper aimed to assess the accuracy gradient of scans made using an intraoral scanner (IOS) on a totally edentulous maxilla and the effectiveness of artificial markers. Materials and methods A reference scan was made by scanning a fully edentulous upper jaw cast (RC) with a dedicated metrological machine. On the RC, an IOS was used to make 10 scans then superimposed to detect their area accuracy gradient. Artificial markers with a diameter of 2 mm were placed in the less accurate areas following two approaches. In the first one, semispherical resin composite markers were used. In the second approach, a dermographic pen was used to draw circular flat markers. Three experimental groups (n = 10) were obtained: “no markers” for the control group without markers, “embossed markers” for resin composite markers, and “flat markers” for ink-drawn ones. The scans were processed into a specialized software, where trueness and precision were measured in millimeters. Descriptive statistics (95% C.I.) were conducted, also, the Games-Howell and Kruskal-Wallis tests (α = .05) were used to investigate differences between groups. Results Mean values for trueness were: no markers 48.8 (39.2- 58.3); embossed markers 39.2 (37.5-40.8); flat markers 60.5 (47.7-73.4), with statistically significant differences between embossed and flat markers (p = .011). Mean values for precision were: no markers 46.7 (29.7-63.7); embossed markers 41.4 (34.7- 48); flat markers 99.8 (69.3-130.3), with significant differences between embossed markers and flat ones (p = .008) and between the latter and the control group (p = .005). Minor accuracy was detected at both tuberosities, palate, posterior aspect of the papilla, and flattened areas of the ridges. Conclusions To improve IOS scans accuracy on the totally edentulous upper jaw, it is suggested to place embossed markers, rather than flat ones, in the areas of minor accuracy

PORTUS LUPIAE. 3D MODELING AND VISUAL NARRATIVE FOR RECONSTRUCTING A LONG MARITIME HISTORY

[EN] The fast evolution of digital technologies and techniques of data recording have had a great impact on archaeological research. The first effect of this revolution was an increased number of strongly technologically oriented projects and applications. Among all available solutions, the use of 3D models is particularly relevant for the reconstruction of sites and monuments poorly preserved, often destroyed by natural causes or human action. These digital replicas are, at the same time, a virtual environment that can be used as a tool for the interpretative hypotheses of archaeologists and an effective medium for a visual description of the cultural heritage as it crosses linguistic barriers. In this paper, methodology, aims and outcomes of a virtual reconstruction of the ancient harbour at St. Cataldo (Lecce, south Italy) carried out by Portus Lupiae Project of the University of Salento, are offered as case study for a virtual reconstruction of a long maritime activity. The use of 3D technologies for teaching and research as well as the post-processing and implementation of data generate a new digital workflow for sharing local culture.Ferrari, I.; Quarta, A.; Sammarco, M.; Carpentieri, A.; Di Tondo, A.; Leone, R. (2016). PORTUS LUPIAE. 3D MODELING AND VISUAL NARRATIVE FOR RECONSTRUCTING A LONG MARITIME HISTORY. En 8th International congress on archaeology, computer graphics, cultural heritage and innovation. Editorial Universitat Politècnica de València. 452-456. https://doi.org/10.4995/arqueologica8.2015.4156OCS45245

Pharmacokinetics of sumatriptan in non-respondent and in adverse drug reaction reporting migraine patients

Sumatriptan is a selectiveagonist of 5HT1 (1B/1D) receptors,which has proved to be effectiveand safe for the acute treatment ofmigraine attacks. Nevertheless, itsuse by migraine sufferers is stilllimited and some patients consideradverse reactions related to sumatriptan,especially chest symptoms,unacceptable even if not serious.Moreover, in clinical trials, almostone third and one sixth of patients,respectively, fail to experienceheadache relief either after oral orafter subcutaneous sumatriptanadministration. Our aim was to verifywhether differencies in sumatriptanpharmacokinetics couldexplain non-response and/oradverse drug reactions. Sumatriptanlevels were determined by HPLCwith electrochemical detection.Pharmacokinetic parameters werecalculated using a computer program(PK Solutions 2.0; non compartmentalPharmacokinetics DataAnalysis). After oral administration,sumatriptan is rapidly absorbed andsometimes displays multiple peaksof plasma concentration. This “multiplepeaking” gives rise to considerableinter-subject variability inthe time of reaching maximumplasma concentration.Pharmacokinetic parameters ofsumatriptan, both after oral andsubcutaneous administration, weresimilar in the three patient groups.Blood pressure and heart rate didnot show any significant differencesbetween groups. Pharmacokineticparameters and bioavailability ofsumatriptan did not seem to be correlatedeither to the lack of efficacyor the appearance of side effects.These results could depend on thelimited number of patients studied

Building integrated solar thermal design: assessment of performances of a low cost solar wall in a typical Italian building

Present work deals with the topic of building integration of solar thermal collector (BIST) as a refurbishment measure. Such equipment, more than its main function as heating generator, plays a specific role as a building component (envelope finishes, thermal insulation layer, roof cover etc). Consequently, from a heat transfer point of view, an integrated component affects twice the global building balance: supporting the thermal plant (i.e. providing heat for final uses) and modifying the wall heat-transfer pattern (i.e. reducing thermal losses). In turn, the collector performance itself is influenced by the wall structure (back losses reduction). Present work proposes a method for evaluating the yearly performance of a low cost BIST by means of a Trnsys model on a reference building. This model arises from previous studies based on experimental validation of a FEM model that was implemented in order to describe the collector-wall system efficiency