Metaphysics and biology a critique of David Wiggins' account of personal identity

Over his philosophical career, David Wiggins has produced a body of work that, though varied and wide-ranging, stands as a coherent and carefully integrated whole. Its parts cannot be studied in isolation, and a central aim of this thesis is to examine how three vital elements of his systematic metaphysics interconnect: his conceptualist-realism, his sortal theory ‘D’, and his account of personal identity – his human being theory. Yet critics murder to dissect, and Wiggins’ project is often unfairly decomposed into its parts. Thus, this study aims both to introduce his thoughts without neglecting the relations between them, and to rectify the various misinterpretations of them by – among others – Paul Snowdon, Eric Olson and Lynne Rudder Baker. In clarifying and exploring these connections another sunken, yet central, vein is revealed. It is argued that Wiggins’ metaphysics bears on, and is borne upon, by various discussions in the philosophy of biology. This is a connection that he himself adverts to, but which commentators have rarely investigated. Attending to it, one finds in his analyses of natural substances a novel form of biological anti-reductionism, which stands as a productive alternative to emergentism. Closer attention to his construal of substances – specifically organisms – also reveals a worry. At the core of Wiggins’ account of personal identity is the consilience he sees between the concept of a person and the concept of a natural substance (a human being). It is argued below that organ transplantation disturbs the Aristotelian distinction between natural substance and biological artefact, and thus tests the heart-string of his human being theory

Reliability of functional outcome measures in adults with neurofibromatosis 1

Objectives: To determine intra-rater and inter-rater reliability of functional outcome measures in adults with neurofibromatosis 1 (NF1) and to ascertain how closely objective and subjective measures align. Methods: Forty-nine ambulant adults with NF1 aged 16 years and over were included in this observational study. Median age 31 years (range 16-66), 29 females, 20 males. Participants were video-recorded or photographed performing four functional outcome measures. Four raters from the Neurofibromatosis centre multi-disciplinary team independently scored the measures to determine inter-rater reliability. One rater scored the measures a second time on a separate occasion to determine intra-rater reliability. The measures evaluated were the functional reach, timed up and go, ten metre walk and a modified nine-hole peg tests. Participants also completed a disease specific quality of life questionnaire (INF1-QOL). Results: Inter-rater reliability and intra-rater reliability scores (intra-class coefficient, ICC) were similar for each outcome measure. Excellent rater agreement (ICC r ≥ 0.9) was found for the functional reach, timed up and go and the 10 metre walk tests. Rater agreement was good for the modified 9-hole peg test; ICC r= 0.75 for intra-rater reliability and 0.76 for inter-rater reliability. The timed up and go and the 10 metre walk tests correlated highly with perceived mobility challenges in the quality of life questionnaire (INF1-QOL). Conclusions: The functional reach, timed up and go and 10 metre walk tests are potentially useful outcome measures for monitoring NF1 treatment and will be assessed for validity and reliability in future multi-centre studies

Global games and general claims: locating the contribution of Kristensen and Zeitlin.

This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Socio-Economic Review following peer review. The definitive publisher-authenticated version Ferner, A.M. (2008) Global games and general claims: locating the contribution of Kristensen and Zeitlin. Socio-Economic Review, 6 (2) pp. 379-384. is available online at: http://dx.doi.org/doi:10.1093/ser/mwn00

Metaphysics and biology a critique of David Wiggins' account of personal identity

Over his philosophical career, David Wiggins has produced a body of work that, though varied and wide-ranging, stands as a coherent and carefully integrated whole. Its parts cannot be studied in isolation, and a central aim of this thesis is to examine how three vital elements of his systematic metaphysics interconnect: his conceptualist-realism, his sortal theory ‘D’, and his account of personal identity – his human being theory. Yet critics murder to dissect, and Wiggins’ project is often unfairly decomposed into its parts. Thus, this study aims both to introduce his thoughts without neglecting the relations between them, and to rectify the various misinterpretations of them by – among others – Paul Snowdon, Eric Olson and Lynne Rudder Baker. In clarifying and exploring these connections another sunken, yet central, vein is revealed. It is argued that Wiggins’ metaphysics bears on, and is borne upon, by various discussions in the philosophy of biology. This is a connection that he himself adverts to, but which commentators have rarely investigated. Attending to it, one finds in his analyses of natural substances a novel form of biological anti-reductionism, which stands as a productive alternative to emergentism. Closer attention to his construal of substances – specifically organisms – also reveals a worry. At the core of Wiggins’ account of personal identity is the consilience he sees between the concept of a person and the concept of a natural substance (a human being). It is argued below that organ transplantation disturbs the Aristotelian distinction between natural substance and biological artefact, and thus tests the heart-string of his human being theory

Human Resource Management of US multinationals in Germany and the UK.

This research examines human resource management (HRM) in subsidiaries of US multinational firms (MNCs) operating in the UK and Germany. Together with parallel studies in Ireland and Spain it explores the potential tensions resulting from a transfer of US-type human resource (HR) policies to Europe. Whilst we expected that the liberal market British economy would not provide a major challenge for the transfer of US practices, we foresaw that the more densely institutionalized German business system would constitute a more serious barrier to transfer. This report is based on case studies of four large US MNCs. In all four firms we conducted interviews in the British and German subsidiaries, as well as the US and/or European headquarters, with HR managers, line managers and non-managerial employees. For three substantive issues – diversity management, employee participation and pay – as well as for the processual issue of ‘centralization–decentralization’ this report analyses whether the four US MNCs studied have global policies, how these are transferred to Europe and the extent to which they have to be adapted to the British and German contexts. Our findings support previous research which suggests that HR policies in US MNCs are not only relatively standardised, but also build on US domestic policies. However, the mechanisms of transfer appear to have changed. Whereas in the past, written guidelines, the transfer of home-country employees and extensive reporting seem to have been the major mechanisms employed to ensure that global policies were applied, today HR information systems, regional European headquarters and international teams of HR managers seem to play a more important role. Over the last decade, national subsidiaries in both countries have lost autonomy in HR decision-making. However, this has not been primarily in the form of recentralization towards headquarters, but rather towards the regional level and/or business unit. Turning to substantive issues, as expected, the German institutional environment represents a stronger challenge for US MNCs than the British one. Of particular importance is codetermination which affects all four firms and which in at least three of them exerts pressure on local management to adjust global polices to local conditions. However, in most cases the observed deviations were only marginal. Similarly, the German system of multi-employer bargaining does not constitute a major hurdle for US MNCs seeking to apply global practices. Although in general German host-country pressures were stronger than those in the UK, we found that UK management was able to use its role of interpreter of the local environment to force some adaptation of global policies, particularly in the substantive area of diversity management, suggesting that the extent to which local adaptation occurs is not entirely dependent on the strength of employment-relations institutions in the host country. Regarding practical implications, our research points firmly to the limits of global policies. With their knowledge of the local context subsidiary-level managers can and should have some freedom to adapt global policies to the local context. At least in Germany they have an additional role, as they have to manage a complex institutional environment. The system of collective bargaining and codetermination fosters collective HR policies that are often incompatible with the more individualistic global policies pursued by US MNCs. Nevertheless, as the case studies show, US MNCs are able to manage these institutions in such a way that the need for adaptation is minimized. This process of institutional arbitrage tends to be performed by local managers with a deep knowledge of the hostenvironment

The dynamics of central control and subsidiary autonomy in the management of human resources: case study evidence from US MNCs in the UK

This article revisits a central question in the debates on the management of multinationals: the balance between centralized policy-making and subsidiary autonomy. It does so through data from a series of case studies on the management of human resources in American multinationals in the UK. Two strands of debate are confronted. The first is the literature on differences between multinationals of different national origins which has shown that US companies tend to be more centralized, standardized, and formalized in their management of human resources. It is argued that the literature has provided unconvincing explanations of this pattern, failing to link it to distinctive features of the American business system in which US multinationals are embedded. The second strand is the wider debate on the balance between centralization and decentralization in multinationals. It is argued that the literature neglects important features of this balance: the contingent oscillation between centralized and decentralized modes of operation and (relatedly) the way in which the balance is negotiated by organizational actors through micro-political processes whereby the external structural constraints on the company are defined and interpreted. In such negotiation, actors’ leverage often derives from exploiting differences between the national business systems in which the multinational operates

Immobilisation of glycosidases from commercial preparation on magnetic beads: Part 2: Aroma enhancement in wine using immobilised glycosidases

Most of the terpenes in wines are conjugated to various sugars, representing a significant reservoir of aromatic precursors. To promote the release of these terpenes, certain enzymes, such as β-glucosidase, α-arabinosidase and α-rhamnosidase, are necessary. A simple and cost-effective procedure for the immobilisation of multiple glycosidase activities (β-D-glucopyranosidase, α-L-arabinofuranosidase, α-L-rhamnopyranosidase and β-D-xylopyranosidase) from commercial Aspergillus niger preparation onto magnetic beads as carriers was developed as reported in Part 1 (Ferner et al. 2016).The aim of this work was to analyse a possible application of this immobilised biocatalyst due to its well-known advantages over soluble enzyme preparations – that is, control of the reaction process and preparation of enzyme-free products. Volatile compounds were analysed by gas chromatography (mass spectrometric detection). After the treatment of the model wine with different glycosides and white wine with immobilised glycosidases, the amount of free terpenes was significantly increased with respect to that of the control wine.The results of this study are of considerable interest for possible future applications of immobilised enzymes in the wine-making industry

On the alert: future priorities for alerts in clinical decision support for computerized physician order entry identified from a European workshop

Background: Clinical decision support (CDS) for electronic prescribing systems (computerized physician order entry) should help prescribers in the safe and rational use of medicines. However, the best ways to alert users to unsafe or irrational prescribing are uncertain. Specifically, CDS systems may generate too many alerts, producing unwelcome distractions for prescribers, or too few alerts running the risk of overlooking possible harms. Obtaining the right balance of alerting to adequately improve patient safety should be a priority. Methods: A workshop funded through the European Regional Development Fund was convened by the University Hospitals Birmingham NHS Foundation Trust to assess current knowledge on alerts in CDS and to reach a consensus on a future research agenda on this topic. Leading European researchers in CDS and alerts in electronic prescribing systems were invited to the workshop. Results: We identified important knowledge gaps and suggest research priorities including (1) the need to determine the optimal sensitivity and specificity of alerts; (2) whether adaptation to the environment or characteristics of the user may improve alerts; and (3) whether modifying the timing and number of alerts will lead to improvements. We have also discussed the challenges and benefits of using naturalistic or experimental studies in the evaluation of alerts and suggested appropriate outcome measures. Conclusions: We have identified critical problems in CDS, which should help to guide priorities in research to evaluate alerts. It is hoped that this will spark the next generation of novel research from which practical steps can be taken to implement changes to CDS systems that will ultimately reduce alert fatigue and improve the design of future systems

Species boundaries in Philippine montane forest skinks (Genus Sphenomorphus): three new species from the mountains of Luzon and clarification of the status of the poorly known S. beyeri, S. knollmanae, and S. laterimaculatus

Recent collections of Sphenomorphus beyeri Taylor 1915 from the type locality (Mt. Banahao, Luzon Isl., Philippines) serve as the basis for a thorough analysis of topotypic variation in external morphology within the species, and allow for detailed comparisons to other taxa. We clarify the taxonomic status of S. beyeri with respect to other, phenotypically similar species and evaluate species boundaries between allopatric populations referred to this taxon. The high elevation (1400–1700 m) population of Sphenomorphus (Brown et al., 1995a) from the Zambales Mountains and Bataan Peninsula of Luzon Island (previously referred by us to S. beyeri) is a new species that we describe here. We also describe two additional new species from the isolated, high elevation (1650–1750 m) forests of the Northern Cordillera and the Sierra Madre of Luzon, specimens of both of which had been previously identified as S. beyeri. All three new species differ from each other and all other Sphenomorphus species by scalation, body size, and coloration and all have non-overlapping distributions, associated with separate, isolated, geological components of Luzon Island. In this paper we also formally redescribe S. beyeri on the basis of a large series of specimens from the type locality (Mt. Banahao, southern Luzon Island) that we have accumulated over the last 15 years. We place S. knollmanae Brown, Ruedas, and Ferner 1995 in synonymy with S. laterimaculatus (Brown and Alcala, 1980) and redescribe the latter species on the basis of the holotype and 20 additional newly collected specimens from six localities on the Bicol Peninsula of Luzon Island and Marinduque Island. These and other data suggest that species boundaries in Philippine Sphenomorphus are poorly understood and that taxonomic diversity is substantially underestimated and in need of comprehensive taxonomic review