“La metodología 6 sigma y la calidad del servicio en la empresa Sol & Mar Sac Comas, 2018.”

Las empresa requiere satisfacer las necesidades del cliente para ello requiere implementar estrategias para garantizar los procesos administrativos eficientes y eficaces en el cumplimientos de los procesos de la atención es así que la metodología 6 Sigma es una herramienta que proporciona un valor agregado a la empresa y tiene la finalidad de fortalecer la calidad del servicio al usuario. El objetivo es determinar la relación de la metodología 6 Sigma y la Calidad del Servicio en la empresa SOL & MAR SAC Comas, 2018. El estudio fue descriptivo de corte transversal, no experimental. La población estuvo conformada por 35 clientes; Se utilizaron dos escalas: de metodología 6 Sigma y calidad del servicio los cuales fueron evaluados por expertos y validado por la prueba piloto, respetando las consideraciones éticas. Los resultados evidencian que existe correlación altamente significativa en ambas variables. En relación a las dimensiones de metodología 6 Sigma y la variable calidad de servicio encontramos una alta correlación significativa de esta relación. En conclusión, existe fuerte correlación; sin embargo las metodologías que se desarrollan en el área administrativa es implementar el sostenimiento de acciones que beneficie al cliente y a la empresa asimismo estas acciones tiene el objetivo de establecer oportunidades de mejora continua de los procesos, que se centra en reducir y eliminar los defectos o fallos en los procesos administrativo que se aplica en la empresa con el fin de asegurar la calidad de los servicios que se prestan al cliente en la empresa

Oral Azithromycin for Treatment of Intractable Rosacea

Rosacea is a common chronic cutaneous disorder that primarily occurs on the convex surfaces of the central face and is often characterized by exacerbations and remissions. A case of a 52-yr-old woman visited our clinic in February 2008 complaining typical features of rosacea including multiple pinhead to rice-sized erythematous papules. We applied various conventional treatments including topical benzoyl peroxide and metronidazole as well as oral metronidazole, isotretinoin, and doxycycline. The lesions were not controlled but were rather aggravated by complications from these treatments. Therefore, we prescribed oral azithromycin, which has anti-inflammatory effects and reduces reactive oxygen species. Ten weeks after the administration of oral azithromycin, 500 mg per day for 2 weeks, the lesions had mostly disappeared and no specific side effects related to the azithromycin were noted. Oral azithromycin dosing 500 mg/day for 2 weeks is effective for treatment of intractable rosacea

Inflammaging as a prodrome to Alzheimer's disease

Recently, the term "inflammaging" was coined by Franceshci and colleagues to characterize a widely accepted paradigm that ageing is accompanied by a low-grade chronic up-regulation of certain pro-inflammatory responses. Inflammaging differs significantly from the traditional five cardinal features of acute inflammation in that it is characterized by a relative decline in adaptive immunity and T-helper 2 responses and is associated with increased innate immunity by cells of the mononuclear phagocyte lineage. While the over-active innate immunity characteristic of inflammaging may remain subclinical in many elderly individuals, a portion of individuals (postulated to have a "high responder inflammatory genotype") may shift from a state of "normal" or "subclinical" inflammaging to one or more of a number of age-associated diseases. We and others have found that IFN-γ and other pro-inflammatory cytokines interact with processing and production of Aβ peptide, the pathological hallmark feature of Alzheimer's disease (AD), suggesting that inflammaging may be a "prodrome" to AD. Although conditions of enhanced innate immune response with overproduction of pro-inflammatory proteins are associated with both healthy aging and AD, it is suggested that those who age "well" demonstrate anti-inflammaging mechanisms and biomarkers that likely counteract the adverse immune response of inflammaging. Thus, opposing the features of inflammaging may prevent or treat the symptoms of AD. In this review, we fully characterize the aging immune system. In addition, we explain how three novel treatments, (1) human umbilical cord blood cells (HUCBC), (2) flavanoids, and (3) Aβ vaccination oppose the forces of inflammaging and AD-like pathology in various mouse models

Sistema de Gestión de Calidad ISO 9001 y satisfacción del cliente de una empresa consultora de construcción, Lima 2022

La presente investigación realizada tuvo como objetivo principal “Determinar la relación entre el sistema de gestión de calidad ISO 9001: 2015 con la satisfacción del cliente de la empresa consultora Hurtado - Hermoza Ingenieros Consultores S.A. Lima, 2022”, respecto a la metodología realizada en el estudio fue método cuantitativo, tipo aplicada, de diseño no experimental, correlación – transversal; la población estuvo conformada por colaboradores de la empresa consultora Hurtado- Hermoza Ingenieros Consultores S.A. y personal que labora en distintas entidades a quienes se brindan sus servicios la empresa consultora, haciendo un total de 100 personas, el muestreo fue no probabilístico con la técnica de encuestas, la muestra fue de 100 colaboradores, los instrumentos que se utilizaron fueron dos cuestionarios, los cuales tuvieron 30 y 19 ítems, cada uno. Respecto al resultado, se encuentra una significación bilateral asintótica de 0.000 < 0.05, por lo que se rechaza la hipótesis alterna, y se acepta la hipótesis general, con respecto al coeficiente de relación de Rho de Spearman, tiene un valor r=0,796, por lo que se concluye, que existe relación entre el sistema de gestión de calidad ISO 9001 con la satisfacción del cliente de la empresa consultora Hurtado - Hermoza Ingenieros Consultores S.A. Lima, 202

Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD)

Microglial dysfunction is associated with the pathogenesis and progression of a number of neurodegenerative disorders including HIV associated dementia (HAD). HIV promotion of an M1 antigen presenting cell (APC) - like microglial phenotype, through the promotion of CD40 activity, may impair endogenous mechanisms important for amyloid- beta (Aβ) protein clearance. Further, a chronic pro-inflammatory cycle is established in this manner. CD45 is a protein tyrosine phosphatase receptor which negatively regulates CD40L-CD40-induced microglial M1 activation; an effect leading to the promotion of an M2 phenotype better suited to phagocytose and clear Aβ. Moreover, this CD45 mediated activation state appears to dampen harmful cytokine production. As such, this property of microglial CD45 as a regulatory "off switch" for a CD40-promoted M1, APC-type microglia activation phenotype may represent a critical therapeutic target for the prevention and treatment of neurodegeneration, as well as microglial dysfunction, found in patients with HAD

Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: Implications for HIV-associated neurocognitive disorders

Up to 50% of long-term HIV infected patients, including those with systemically well-controlled infection, commonly experience memory problems and slowness, difficulties in concentration, planning, and multitasking. Deposition of Aβ plaques is also a common pathological feature of HIV infection. However, it is not clear whether this accumulation is due to AD-like processes, HIV-associated immunosuppression, Tat protein-induced Aβ elevations, and/or the effects of single highly active antiretroviral therapy (ART). Here we evaluated the effects of several ART medications (Zidovudine, Lamivudine, Indinavir, and Abacavir) alone and in combination on: 1) Aβ1-40, 42 generation in murine N2a cells transfected with the human "Swedish" mutant form of APP; 2) microglial phagocytosis of FITC-Aβ1-42 peptides in cultured murine N9 microglia. We report for the first time that these antiretroviral compounds (10 μM) generally increase Aβ generation (~50-200%) in SweAPP N2a cells and markedly inhibit microglial phagocytosis of FITC-Aβ1-42 peptides in murine microglia. The most significant amyloidogenic effects were observed with combined ART (p < 0.05); suggesting certain ART medications may have additive amyloidogenic effects when combined. As these antiretroviral compounds are capable of penetrating the blood brain barrier and reaching the concentrations employed in the in vitro studies, these findings raise the possibility that ART may play a casual role in the elevated Aβ found in the brains of those infected with HIV. Therefore these compounds may consequently contribute to cognitive decline observed in HIV associated neurocognitive disorders (HAND)

Stimulation of cannabinoid receptor 2 (CB(2)) suppresses microglial activation

BACKGROUND: Activated microglial cells have been implicated in a number of neurodegenerative disorders, including Alzheimer's disease (AD), multiple sclerosis (MS), and HIV dementia. It is well known that inflammatory mediators such as nitric oxide (NO), cytokines, and chemokines play an important role in microglial cell-associated neuron cell damage. Our previous studies have shown that CD40 signaling is involved in pathological activation of microglial cells. Many data reveal that cannabinoids mediate suppression of inflammation in vitro and in vivo through stimulation of cannabinoid receptor 2 (CB(2)). METHODS: In this study, we investigated the effects of a cannabinoid agonist on CD40 expression and function by cultured microglial cells activated by IFN-γ using RT-PCR, Western immunoblotting, flow cytometry, and anti-CB(2 )small interfering RNA (siRNA) analyses. Furthermore, we examined if the stimulation of CB(2 )could modulate the capacity of microglial cells to phagocytise Aβ(1–42 )peptide using a phagocytosis assay. RESULTS: We found that the selective stimulation of cannabinoid receptor CB(2 )by JWH-015 suppressed IFN-γ-induced CD40 expression. In addition, this CB(2 )agonist markedly inhibited IFN-γ-induced phosphorylation of JAK/STAT1. Further, this stimulation was also able to suppress microglial TNF-α and nitric oxide production induced either by IFN-γ or Aβ peptide challenge in the presence of CD40 ligation. Finally, we showed that CB(2 )activation by JWH-015 markedly attenuated CD40-mediated inhibition of microglial phagocytosis of Aβ(1–42 )peptide. Taken together, these results provide mechanistic insight into beneficial effects provided by cannabinoid receptor CB(2 )modulation in neurodegenerative diseases, particularly AD

Dime con qué te cubres y te diré quién eres: estrategias de educación no formal como herramienta de conservación

En el marco del proyecto "Conocer para conservar nuestra diversidad biológica", guías del área de Educación Ambiental de la Estación Biológica Corrientes (EBCO, CONICET) y docentes y alumnos/as de la Facultad de Ciencias Exactas y Naturales y Agrimensura (FaCENA, UNNE) realizaron actividades de taller en el aula y en el Parque Provincial San Cayetano para estudiantes de primer grado pertenecientes a la Escuela Primaria Nº 553 "San Cayetano" (San Cayetano, Corrientes). El objetivo de estas actividades fue la comprensión de los distintos tipos de coberturas que tienen los animales terrestres y acuáticos de la Región. La metodología empleada incluyó la articulación entre el contenido curricular trabajado por los docentes de la escuela y las actividades ofrecidas por el área de Educación ambiental, desde la identificación de estructuras, las especies animales que las poseen y los ambientes que habitan. Los conceptos desarrollados giraron en torno a las adaptaciones de los animales, los tipos de cobertura que poseen (pelos, escamas, plumas) y su formas corporales. Estos conceptos, repasados en aula con un fuerte componentede lecto-comprensión fueron puestos en práctica a partir de una visita guiada a un ambiente natural protegido, el Parque Provincial San Cayetano (San Cayetano, Corrientes). Tanto los conceptos teóricos como los prácticos fueron implementados a partir del juego, lo que impactó positivamente sobre la asimilación de los conceptos en los niños y niñas de entre 6 a 7 años. Por lo tanto, estas actividades permiten concluir que la exploración del conocimiento en espacios no formales en articulación con el curriculum refuerza significativamente el conocimiento de la naturaleza y promueve valores de conservación.Fil: Obregon, Cesar Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia". Estación Biológica de Usos Múltiples (Sede Corrientes); ArgentinaFil: Romero, Verónica Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia". Estación Biológica de Usos Múltiples (Sede Corrientes); ArgentinaFil: Godoy, Angelina M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia". Estación Biológica de Usos Múltiples (Sede Corrientes); ArgentinaFil: Romero, Barbara G.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia". Estación Biológica de Usos Múltiples (Sede Corrientes); ArgentinaFil: Fernandez, Patricia M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia". Estación Biológica de Usos Múltiples (Sede Corrientes); ArgentinaFil: Kowalewski, Miguel Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia". Estación Biológica de Usos Múltiples (Sede Corrientes); Argentin

Differential Release and Phagocytosis of Tegument Glycoconjugates in Neurocysticercosis: Implications for Immune Evasion Strategies

Neurocysticercosis (NCC) is an infection of the central nervous system (CNS) by the metacestode of the helminth Taenia solium. The severity of the symptoms is associated with the intensity of the immune response. First, there is a long asymptomatic period where host immunity seems incapable of resolving the infection, followed by a chronic hypersensitivity reaction. Since little is known about the initial response to this infection, a murine model using the cestode Mesocestoides corti (syn. Mesocestoides vogae) was employed to analyze morphological changes in the parasite early in the infection. It was found that M. corti material is released from the tegument making close contact with the nervous tissue. These results were confirmed by infecting murine CNS with ex vivo–labeled parasites. Because more than 95% of NCC patients exhibit humoral responses against carbohydrate-based antigens, and the tegument is known to be rich in glycoconjugates (GCs), the expression of these types of molecules was analyzed in human, porcine, and murine NCC specimens. To determine the GCs present in the tegument, fluorochrome-labeled hydrazides as well as fluorochrome-labeled lectins with specificity to different carbohydrates were used. All the lectins utilized labeled the tegument. GCs bound by isolectinB4 were shed in the first days of infection and not resynthesized by the parasite, whereas GCs bound by wheat germ agglutinin and concavalinA were continuously released throughout the infectious process. GCs bound by these three lectins were taken up by host cells. Peanut lectin-binding GCs, in contrast, remained on the parasite and were not detected in host cells. The parasitic origin of the lectin-binding GCs found in host cells was confirmed using antibodies against T. solium and M. corti. We propose that both the rapid and persistent release of tegumental GCs plays a key role in the well-known immunomodulatory effects of helminths, including immune evasion and life-long inflammatory sequelae seen in many NCC patients