Control de inventarios y su relación con el estado de resultados de las empresas textiles del Cercado de Lima, 2019

El presente trabajo de investigación tuvo como objetivo general Determinar la relación del control de inventarios con los estados de resultados de las empresas textiles del Cercado de Lima, 2019. Este trabajo basó su estudio en un diseño no experimental correlacional de corte transversal. La población fue conformada por trabajadores de las empresas textiles del área administrativa para que así puedan ellos mismos contarnos como llevan su control en la empresa que esta siendo tomada como objeto de estudio la cual es un numero de muestra de 19 trabajadores. El estudio de investigación utilizo como instrumento para la recolección de datos, un cuestionario para evaluar la relación existente entre el control de inventarios y los estado de resultados que se da en la empresa. A través de la aplicación del método estadístico Chi cuadrado, obteniendo el porcentaje de correlación a través de los resultados. Finalmente, se concluye la investigación logrando obtener resultados significativos que determinaron que el control de inventarios se relaciona con los estado de resultados de las empresas textiles del Cercado de Lima, 2019

A duchenne muscular dystrophy gene hot spot mutation in dystrophin-deficient Cavalier King Charles Spaniels is amenable to exon 51 skipping

BACKGROUND Duchenne muscular dystrophy (DMD), which afflicts 1 in 3500 boys, is one of the most common genetic disorders of children. This fatal degenerative condition is caused by an absence or deficiency of dystrophin in striated muscle. Most affected patients have inherited or spontaneous deletions in the dystrophin gene that disrupt the reading frame resulting in unstable truncated products. For these patients, restoration of the reading frame via antisense oligonucleotide-mediated exon skipping is a promising therapeutic approach. The major DMD deletion "hot spot" is found between exons 45 and 53, and skipping exon 51 in particular is predicted to ameliorate the dystrophic phenotype in the greatest number of patients. Currently the mdx mouse is the most widely used animal model of DMD, although its mild phenotype limits its suitability in clinical trials. The Golden Retriever muscular dystrophy (GRMD) model has a severe phenotype, but due to its large size, is expensive to use. Both these models have mutations in regions of the dystrophin gene distant from the commonly mutated DMD "hot spot". METHODOLOGY/PRINCIPAL FINDINGS Here we describe the severe phenotype, histopathological findings, and molecular analysis of Cavalier King Charles Spaniels with dystrophin-deficient muscular dystrophy (CKCS-MD). The dogs harbour a missense mutation in the 5' donor splice site of exon 50 that results in deletion of exon 50 in mRNA transcripts and a predicted premature truncation of the translated protein. Antisense oligonucleotide-mediated skipping of exon 51 in cultured myoblasts from an affected dog restored the reading frame and protein expression. CONCLUSIONS/SIGNIFICANCE Given the small size of the breed, the amiable temperament and the nature of the mutation, we propose that CKCS-MD is a valuable new model for clinical trials of antisense oligonucleotide-induced exon skipping and other therapeutic approaches for DMD

Differentiable Tree Operations Promote Compositional Generalization

In the context of structure-to-structure transformation tasks, learning sequences of discrete symbolic operations poses significant challenges due to their non-differentiability. To facilitate the learning of these symbolic sequences, we introduce a differentiable tree interpreter that compiles high-level symbolic tree operations into subsymbolic matrix operations on tensors. We present a novel Differentiable Tree Machine (DTM) architecture that integrates our interpreter with an external memory and an agent that learns to sequentially select tree operations to execute the target transformation in an end-to-end manner. With respect to out-of-distribution compositional generalization on synthetic semantic parsing and language generation tasks, DTM achieves 100% while existing baselines such as Transformer, Tree Transformer, LSTM, and Tree2Tree LSTM achieve less than 30%. DTM remains highly interpretable in addition to its perfect performance.Comment: ICML 2023. Code available at https://github.com/psoulos/dt

Far-field effects of impulsive noise on coastal bottlenose dolphins

ACKNOWLEDGMENTS We would like to thank Bill Ruck, Moray First Marine and colleagues from the University of Aberdeen for assistance with the data collection. We are also grateful to Drs. Nathan Merchant and Adrian Farcas (CEFAS) for the provision of the data on the noise modeling and their valuable comments during the development of this work. The project benefited at all stages from input provided by the scientific steering groups and stakeholder groups established by UK and Scottish Governments to support the work conducted around these regional oil and gas and renewables projects. FUNDING Financial support for this study was provided through a series of consortia funded projects that involved the UK Department of Energy and Climate Change (DECC), Scottish Government, Oil and Gas UK Ltd., COWRIE, NatureScot, The Crown Estate, Highlands and Islands Enterprise, Beatrice Offshore Wind Ltd., and Moray Offshore Wind Farm (East) Ltd. OFB was funded by the Fundación “la Caixa” (Becas Posgrado, 2015) and their support was greatly appreciated. The authors declare that this study received funding from three commercial developers: Oil and Gas UK Ltd., Beatrice Offshore Wind Ltd., and Moray Offshore Wind Farm (East) Ltd. However, these funding bodies had no input into the study design, data collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.Peer reviewedPublisher PD

Factores clave de éxito del proceso de inteligencia comercial en una empresa logística de comercio exterior de Trujillo, 2022

El presente estudio tiene como objetivo principal determinar los factores clave de éxito que influyeron principalmente en el desarrollo del proceso de inteligencia comercial por la empresa logística de comercio exterior de Trujillo en el año 2022. La metodología empleada en la presente investigación tiene un enfoque cualitativo y fenomenológico. Para este fin, la población para realizar este estudio estuvo conformada por los colaboradores de la empresa. La técnica utilizada de estudio fue entrevista, este instrumento contó con 11 preguntas y los resultados fueron analizados con el programa ATLAS TI, así mismo se realizó una lista de cotejo, este instrumento contó con 19 ítems, dichos instrumentos fueron validados por expertos. Los resultados encontrados fueron que los factores clave de éxito fueron principalmente la organización, planificación y determinación, los que llevaron a la empresa a desarrollar un proceso de inteligencia comercial con resultados favorables

Analysis of the rumen microbiome and metabolome to study the effect of an antimethanogenic treatment applied in early life of kid goats

This work aimed to gain insight into the transition from milk to solid feeding at weaning combining genomics and metabolomics on rumen contents from goat kids treated with a methanogenic inhibitor (bromochloromethane, BCM). Sixteen goats giving birth to two kids were used. Eight does were treated (D+) with BCM after giving birth and over 2 months. One kid per doe in both groups was treated with BCM (k+) for 3 months while the other was untreated (k–). Rumen samples were collected from kids at weaning (W) and 1 (W + 1) and 4 (W + 4) months after and from does at weaning and subjected to 16S pyrosequencing and metabolomics analyses combining GC/LC-MS. Results from pyrosequencing showed a clear effect of age of kids, with more diverse bacterial community as solid feed becomes more important after weaning. A number of specific OTUs were significantly different as a result of BCM treatment of the kid at W while at W + 1 and W + 4 less OTUs were significantly changed. At W + 1, Prevotella was increased and Butyrivibrio decreased in BCM treated kids. At W + 4 only the effect of treating mothers resulted in significant changes in the abundance of some OTUs: Ruminococcus, Butyrivibrio and Prevotella. The analysis of the OTUs shared by different treatments revealed that kids at weaning had the largest number of unique OTUs compared with kids at W + 1 (137), W + 4 (238), and does (D) (23). D + k+ kids consistently shared more OTUs with mothers than the other three groups at the three sampling times. The metalobomic study identified 473 different metabolites. In does, lipid super pathway included the highest number of metabolites that were modified by BCM, while in kids all super-pathways were evenly affected. The metabolomic profile of samples from kids at W was different in composition as compared to W + 1 and W + 4, which may be directly ascribed to the process of rumen maturation and changes in the solid diet. This study shows the complexity of the bacterial community and metabolome in the rumen before weaning, which clearly differ from that after weaning and highlight the importance of the dam in transmitting the primary bacterial community after birth.</p

An Antimethanogenic Nutritional Intervention in Early Life of Ruminants Modifies Ruminal Colonization by Archaea

The aim of this work was to study whether feeding a methanogen inhibitor from birth of goat kids and their does has an impact on the archaeal population colonizing the rumen and to what extent the impact persists later in life. Sixteen goats giving birth to two kids were used. Eight does were treated (D+) with bromochloromethane after giving birth and over 2 months. The other 8 goats were not treated (D−). One kid per doe in both groups was treated with bromochloromethane (k+) for 3 months while the other was untreated (k−), resulting in four experimental groups: D+/k+, D+/k−, D−/k+, and D−/k−. Rumen samples were collected from kids at weaning and 1 and 4 months after (3 and 6 months after birth) and from does at the end of the treating period (2 months). Pyrosequencing analyses showed a modified archaeal community composition colonizing the rumen of kids, although such effect did not persist entirely 4 months after; however, some less abundant groups remained different in treated and control animals. The different response on the archaeal community composition observed between offspring and adult goats suggests that the competition occurring in the developing rumen to occupy different niches offer potential for intervention