Modeling the input history of programs for improved instruction-memory performance

When a program is loaded into memory for execution, the relative position of its basic blocks is crucial, since loading basic blocks that are unlikely to be executed first places them high in the instruction-memory hierarchy only to be dislodged as the execution goes on. In this paper we study the use of Bayesian networks as models of the input history of a program. The main point is the creation of a probabilistic model that persists as the program is run on different inputs and at each new input refines its own parameters in order to reflect the program's input history more accurately. As the model is thus tuned, it causes basic blocks to be reordered so that, upon arrival of the next input for execution, loading the basic blocks into memory automatically takes into account the input history of the program. We report on extensive experiments, whose results demonstrate the efficacy of the overall approach in progressively lowering the execution times of a program on identical inputs placed randomly in a sequence of varied inputs. We provide results on selected SPEC CINT2000 programs and also evaluate our approach as compared to the gcc level-3 optimization and to Pettis-Hansen reordering

Collapse of the Cooper pair phase coherence length at a superconductor to insulator transition

We present investigations of the superconductor to insulator transition (SIT) of uniform a-Bi films using a technique sensitive to Cooper pair phase coherence. The films are perforated with a nanohoneycomb array of holes to form a multiply connected geometry and subjected to a perpendicular magnetic field. Film magnetoresistances on the superconducting side of the SIT oscillate with a period dictated by the superconducting flux quantum and the areal hole density. The oscillations disappear close to the SIT critical point to leave a monotonically rising magnetoresistance that persists in the insulating phase. These observations indicate that the Cooper pair phase coherence length, which is infinite in the superconducting phase, collapses to a value less than the interhole spacing at this SIT. This behavior is inconsistent with the gradual reduction of the phase coherence length expected for a bosonic, phase fluctuation driven SIT. This result starkly contrasts with previous observations of oscillations persisting in the insulating phase of other films implying that there must be at least two distinct classes of disorder tuned SITs

System and market failures: the unavailability of magnesium sulphate for the treatment of eclampsia and pre-eclampsia in Mozambique and Zimbabwe.

Low cost and effective drugs, such as magnesium sulphate, need to be included in initiatives to improve access to essential medicines in Afric

Probing the ejecta of evolved massive stars in transition: A VLT/SINFONI K-band survey

Massive evolved stars in transition phases, such as Luminous Blue Variables (LBVs), B[e] Supergiants (B[e]SGs), and Yellow Hypergiants (YHGs), are not well understood, and yet crucial steps in determining accurate stellar and galactic evolution models. The circumstellar environments of these stars reveal their mass-loss history, identifying clues to both their individual evolutionary status and the connection between objects of different phases. Here we present a survey of 25 such evolved massive stars (16 B[e]SGs, 6 LBVs, 2 YHGs, and 1 Peculiar Oe star), observed in the K-band with the Spectrograph for INtegral Field Observation in the Near-Infrared (SINFONI; R = 4500) on the ESO VLT UT4 8 m telescope. The sample can be split into two categories based on spectral morphology: one group includes all of the B[e]SGs, the Peculiar Oe star, and two of the LBVs, while the other includes the YHGs and the rest of the LBVs. The difference in LBV spectral appearance is due to some objects being in a quiescent phase and some objects being in an active or outburst phase. CO emission features are found in 13 of our targets, with first time detections for MWC 137, LHA 120-S 35, and LHA 115-S 65. From model fits to the CO band heads, the emitting regions appear to be detached from the stellar surface. Each star with ^12CO features also shows ^13CO emission, signaling an evolved nature. Based on the level of ^13C enrichment, we conclude that many of the B[e]SGs are likely in a pre-Red Supergiant phase of their evolution. There appears to be a lower luminosity limit of log L/L_solar = 5.0 below which CO is not detected. The lack of CO features in several high luminosity B[e]SGs and variability in others suggests that they may in fact be LBV candidates, strengthening the connection between these two very similar transition phases.Comment: 20 pages, 13 figures, 7 tables. Accepted for publication in A&

Impacts of in vivo and in vitro exposures to tamoxifen: comparative effects on human cells and marine organisms

Tamoxifen (TAM) is a first generation-SERM administered for hormone receptor-positive (HER+) breast cancer in both pre- and post-menopausal patients and may undergo metabolic activation in organisms that share similar receptors and thus face comparable mechanisms of response. The present study aimed to assess whether environmental trace concentrations of TAM are bioavailable to the filter feeder M. galloprovincialis (100 ng L-1) and to the deposit feeder N. diversicolor (0.5, 10, 25 and 100 ng L-1) after 14 days of exposure. Behavioural impairment (burrowing kinetic), neurotoxicity (AChE activity), endocrine disruption by alkali-labile phosphate (ALP) content, oxidative stress (SOD, CAT, GPXs activities), biotransformation (GST activity), oxidative damage (LPO) and genotoxicity (DNA damage) were assessed. Moreover, this study also pertained to compare TAM cytotoxicity effects to mussels and targeted human (i.e. immortalized retinal pigment epithelium - RPE; and human transformed endothelial cells - HeLa) cell lines, in a range of concentrations from 0.5 ng L-1 to 50 μg L-1. In polychaetes N. diversicolor, TAM exerted remarkable oxidative stress and damage at the lowest concentration (0.5 ng L-1), whereas significant genotoxicity was reported at the highest exposure level (100 ng L-1). In mussels M. galloprovincialis, 100 ng L-1 TAM caused endocrine disruption in males, neurotoxicity, and an induction in GST activity and LPO byproducts in gills, corroborating in genotoxicity over the exposure days. Although cytotoxicity assays conducted with mussel haemocytes following in vivo exposure was not effective, in vitro exposure showed to be a feasible alternative, with comparable sensitivity to human cell line (HeLa).info:eu-repo/semantics/publishedVersio

High coercivity induced by mechanical milling in cobalt ferrite powders

In this work we report a study of the magnetic behavior of ferrimagnetic oxide CoFe2O4 treated by mechanical milling with different grinding balls. The cobalt ferrite nanoparticles were prepared using a simple hydrothermal method and annealed at 500oC. The non-milled sample presented coercivity of about 1.9 kOe, saturation magnetization of 69.5 emu/g, and a remanence ratio of 0.42. After milling, two samples attained coercivity of 4.2 and 4.1 kOe, and saturation magnetization of 67.0 and 71.4 emu/g respectively. The remanence ratio MR/MS for these samples increase to 0.49 and 0.51, respectively. To investigate the influence of the microstructure on the magnetic behavior of these samples, we used X-ray powder diffraction (XPD), transmission electron microscopy (TEM), and vibrating sample magnetometry (VSM). The XPD analysis by the Williamson-Hall plot was used to estimate the average crystallite size and strain induced by mechanical milling in the samples