A geometric technique to generate lower estimates for the constants in the Bohnenblust--Hille inequalities

The Bohnenblust--Hille (polynomial and multilinear) inequalities were proved in 1931 in order to solve Bohr's absolute convergence problem on Dirichlet series. Since then these inequalities have found applications in various fields of analysis and analytic number theory. The control of the constants involved is crucial for applications, as it became evident in a recent outstanding paper of Defant, Frerick, Ortega-Cerd\'{a}, Ouna\"{\i}es and Seip published in 2011. The present work is devoted to obtain lower estimates for the constants appearing in the Bohnenblust--Hille polynomial inequality and some of its variants. The technique that we introduce for this task is a combination of the Krein--Milman Theorem with a description of the geometry of the unit ball of polynomial spaces on $\ell^2_\infty$.Comment: This preprint does no longer exist as a single manuscript. It is now part of the preprint entitled "The optimal asymptotic hypercontractivity constant of the real polynomial Bohnenblust-Hille inequality is 2" (arXiv reference 1209.4632

Influence of Phosphoramidites in Copper-Catalyzed Conjugate Borylation Reaction

Copper(I) has become the preferred metal to catalyze the β-boration of α,β-unsaturated carbonyl compounds, and now we demonstrate that easily accessible monodentate chiral ligands, such as phosphoramidites and phosphites, can be convenient alternative ligands to induce asymmetry in the enantioselective version of this reaction, particularly in the β-boration of α,β-unsaturated imines.

The Classification of Highly Supersymmetric Supergravity Solutions

The spinorial geometry method is an effective method for constructing systematic classifications of supersymmetric supergravity solutions. Recent work on analysing highly supersymmetric solutions in type IIB supergravity using this method is reviewed [arXiv:hep-th/0606049, arXiv:0710.1829]. It is shown that all supersymmetric solutions of IIB supergravity with more than 28 Killing spinors are locally maximally supersymmetric.Comment: 23 pages, latex. To appear in the proceedings of the Special Metrics and Supersymmetry conference at Universidad del Pais Vasco, May 2008. References correcte

Reconstrucción de la trayectoria del Instituto Municipal de la Mujer de León, Guanajuato, 1997-2006

Después de la Conferencia de Beijing en 1995, la incorporación de la perspectiva de género en las políticas públicas se convirtió en el eje del trabajo de los mecanismos públicos responsables del tema de la equidad. Esta afirmación es central para la presente tesis, pues se trata de potenciar los resultados positivos de las políticas, programas y acciones encaminadas a equilibrar las relaciones de género y al cumplimiento de los derechos humanos de las mujeres mediante la transversalización de la perspectiva de género en las políticas públicas. Los Institutos de las Mujeres en México se crean en este contexto internacional como resultado de la lucha de los grupos feministas y de una coyuntural voluntad política, con la intención de contar con una instancia que impulsara, desde el espacio público, la agenda feminista. En Guanajuato se creó el Instituto de la Mujer Guanajuatense, que posteriormente derivó en la creación de diversos institutos municipales para las mujeres. En León, Guanajuato, es fundamental la incidencia que el Instituto Municipal de la Mujer (IMM) podría lograr en la sociedad local para impulsar condiciones de vida sin discriminación para las mujeres así como su empoderamiento. Sin embargo, desde su fundación en 1997 hasta el 2006, periodo de análisis del presente trabajo, el IMM ha tenido una trayectoria que no ha sido registrada sistemáticamente y se observa que, a través de los años, la instancia muestra inconsistencias que provocan cuestionamientos sobre la congruencia del desempeño del instituto con las ideas y fines que le dieron origen, ya que hay visos que nos indican que se trata de una política pública alejada del fundamento de la teoría de género y de la plataforma de los derechos humanos. En este trabajo se hace una sistematización y análisis de la trayectoria de una institución creada para dar respuesta a los problemas específicos de las mujeres en León

Incidencia del género en los niveles de actividad física en las clases de educación física

The main objective of this paper is to describe physical activity levels in physical education classes among primary schoolchildren and to observe differences between genders. For these purposes 42 students were selected (22 boys and 20 girls) (10,5 ± 0,8 years of age; 40,5 ± 8,3 kg of mass; 143,8 ± 7,1 cm of heigth; 19,4 ± 3,2 kg/m2 of BMI). Their level of physical activity was assessed using a GT3X accelerometer (Actigraph, Pensacola, FL, USA) carried during five school days, attached at the right hip, with an epoch of 1s. Intensity was determined by cut-offs proposed by Evenson et al. (2008). The results show that students do moderate to vigorous intensity around 17% and 13% for boys and girls respectively. No significant differences were observed.El objetivo principal de este trabajo, es describir los niveles de actividad física en clases de Educación Física con escolares de Educación Primaria y, observar las posibles diferencias según el género. Se seleccionaron 42 estudiantes (22 chicos y 20 chicas) (10,5 ± 0,8 años de edad; 40,5 ± 8,3 kg de masa; 143,8 ± 7,1 cm de altura; 19,4 ± 3,2 kg/m2 de IMC) 4 y se evaluó el nivel de actividad física a través del acelerómetro GT3X (Actigraph, Pensacola, FL, USA) llevado durante los cinco días de la jornada escolar, en la cadera derecha, con un epoch de 1s. La intensidad de la actividad física se determinó mediante los puntos de corte de Evenson et al. (2008). Los resultados muestran que los alumnos realizan actividad física a intensidad moderada y vigorosa en torno a 17% y 13% para chicos y chicas respectivamente, no observándose diferencias significativas estadísticamente

Elastic scattering with weakly bound projectiles

Possible effects of the break-up channel on the elastic scattering threshold anomaly has been investigated. We used the weakly bound 6,7Li nuclei, which is known to undergo break-up, as projectiles in order to study the elastic scattering on a 27Al target. In this contribution we present preliminary results of these experiments, which were analyzed in terms of the Optical Model and compared with other elastic scattering data using weakly bound nuclei as projectile. © 2007 American Institute of Physics.Fil:Figueira, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Fernández Niello, J.O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Arazi, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Capurro, O.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Martí, G.V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Pacheco, A.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina

Catechol Polymers for pH-Responsive, Targeted Drug Delivery to Cancer Cells

A novel cell-targeting, pH-sensitive polymeric carrier was employed in this study for delivery of the anticancer drug bortezomib (BTZ) to cancer cells. Our strategy is based on facile conjugation of BTZ to catechol-containing polymeric carriers that are designed to be taken up selectively by cancer cells through cell surface receptor-mediated mechanisms. The polymer used as a building block in this study was poly(ethylene glycol), which was chosen for its ability to reduce nonspecific interactions with proteins and cells. The catechol moiety was exploited for its ability to bind and release borate-containing therapeutics such as BTZ in a pH-dependent manner. In acidic environments, such as in cancer tissue or the subcellular endosome, BTZ dissociates from the polymer-bound catechol groups to liberate the free drug, which inhibits proteasome function. A cancer-cell-targeting ligand, biotin, was presented on the polymer carriers to facilitate targeted entry of drug-loaded polymer carriers into cancer cells. Our study demonstrated that the cancer-targeting drug-polymer conjugates dramatically enhanced cellular uptake, proteasome inhibition, and cytotoxicity toward breast carcinoma cells in comparison with nontargeting drug-polymer conjugates. The pH-sensitive catechol-boronate binding mechanism provides a chemoselective approach for controlling the release of BTZ in targeted cancer cells, establishing a concept that may be applied in the future toward other boronic acid-containing therapeutics to treat a broad range of diseases

A collection and analysis of amphibians and reptiles from Nicaragua with new country and departmental records

Nicaragua is a biodiverse country, but documented herpetological specimens are underrepresented compared to neighboring countries. In 2018 we conducted a collaborative expedition between the University of Michigan Museum of Zoology and Nicaraguan biologists. We visited sites in the Pacific Low‑ lands, Caribbean Lowlands, and the Central Highlands, representing the three major biogeographic regions of Nicaragua. We collected specimens of 100 species from a total of 106 encountered. We provide acces‑ sion numbers and morphological, genetic, and ecological information for these specimens. We recorded 23 new departmental records and the first country record of Metlapilcoatlus indomitus (Smith & Ferrari‑Castro, 2008), filling gaps in the known distribution of the species within Nicaragua and across Central America. When available for each species, we provide range maps and comparative genetic trees including conspecific reference sequences from the region, making this work a significant addition to existing checklists of the herpetofauna in Nicaragua