Calculated energy loss of swift He, Li, B, and N ions in SiO2, Al2O3, and ZrO2

We have calculated the electronic stopping power and the energy-loss straggling parameter of swift He, Li, B, and N ions moving through several oxides, namely SiO2, Al2O3, and ZrO2. The evaluation of these stopping magnitudes was done in the framework of the dielectric formalism. The target properties are described by means of a combination of Mermin-type energy-loss functions that characterize the response of valence-band electrons, together with generalized oscillator strengths to take into account the ionization of inner-shell electrons. We have considered the different charge states that the projectile can have, as a result of electron capture and loss processes, during its motion through the target. The electron density for each charge state was described using the Brandt-Kitagawa statistical model and, for He and Li ions, also hydrogenic orbitals. This procedure provides a realistic representation of both the excitation properties of the target electrons and the projectile charge density, yielding stopping powers that compare reasonably well with available experimental data above a few tens of keV/amu.This work was supported by the Spanish Comisión Interministerial de Ciencia y Tecnología (BFM2003-04457-C02-01 and BFM2003-04457-C02-02). S.H.A. thanks the Fundación Cajamurcia for financial support and J.M.F.V. expresses his gratitute for a travel grant from the Universitat d’Alacant

Absorbed dose evaluation of Auger electron-emitting radionuclides: impact of input decay spectra on dose point kernels and S-values

The aim of this study was to investigate the impact of decay data provided by the newly developed stochastic atomic relaxation model BrIccEmis on dose point kernels (DPKs - radial dose distribution around a unit point source) and S-values (absorbed dose per unit cumulated activity) of 14 Auger electron (AE) emitting radionuclides, namely 67Ga, 80mBr, 89Zr, 90Nb, 99mTc, 111In, 117mSn, 119Sb, 123I, 124I, 125I, 135La, 195mPt and 201Tl. Radiation spectra were based on the nuclear decay data from the medical internal radiation dose (MIRD) RADTABS program and the BrIccEmis code, assuming both an isolated-atom and condensed-phase approach. DPKs were simulated with the PENELOPE Monte Carlo (MC) code using event-by-event electron and photon transport. S-values for concentric spherical cells of various sizes were derived from these DPKS using appropriate geometric reduction factors. The number of Auger and Coster-Kronig (CK) electrons and x-ray photons released per nuclear decay (yield) from MIRD-RADTABS were consistently higher than those calculated using BrIccEmis. DPKs for the electron spectra from BrIccEmis were considerably different from MIRD-RADTABS in the first few hundred nanometres from a point source where most of the Auger electrons are stopped. S-values were, however, not significantly impacted as the differences in DPKS in the sub-micrometre dimension were quickly diminished in larger dimensions. Overestimation in the total AE energy output by MIRD-RADTABS leads to higher predicted energy deposition by AE emitting radionuclides, especially in the immediate vicinity of the decaying radionuclides. This should be taken into account when MIRD-RADTABS data are used to simulate biological damage at nanoscale dimensions.Comment: 27 pages, 4 figures, 3 table

Experimental and theoretical L-subshell ionization cross sections for 83Bi by electron impact from the L3 threshold to 100 keV

We report experimental and theoretical Bi L1, L2, and L3 subshell ionization cross sections by the impact of electrons with energies from the Bi L3 ionization threshold to 100 keV. The x-ray spectra have been acquired with two Si drift detectors placed in vacuum, which allowed us to better evaluate the peak fit procedure in the L multiplet. The Lα, Lβ, Lγ, Lℓ, and Lη x-ray production cross sections, measured with relative uncertainties ranging from 5% to 9%, and two sets of atomic relaxation parameters have been used to derive the Bi L1, L2, and L3 ionization cross sections. Although the experimental uncertainties of the subshell ionization cross sections are smaller than those of the few previous measurements, they remain large due to the uncertainties associated with the relaxation parameters. Furthermore, ionization cross sections have been calculated for the three L subshells with the subconfiguration average distorted-wave (SCADW) formalism, which includes the full two-body retarded electromagnetic interaction between the projectile and target electrons. These theoretical cross sections are 15% to 30% lower than the measured values, but the agreement is reasonable given the aforementioned high uncertainties. We have also found that the simpler distorted-wave Born approximation yields subshell ionization cross sections that match those computed with the SCADW method

Lack of p62 Impairs Glycogen Aggregation and Exacerbates Pathology in a Mouse Model of Myoclonic Epilepsy of Lafora

Lafora disease (LD) is a fatal childhood-onset dementia characterized by the extensive accumulation of glycogen aggregates-the so-called Lafora Bodies (LBs)-in several organs. The accumulation of LBs in the brain underlies the neurological phenotype of the disease. LBs are composed of abnormal glycogen and various associated proteins, including p62, an autophagy adaptor that participates in the aggregation and clearance of misfolded proteins. To study the role of p62 in the formation of LBs and its participation in the pathology of LD, we generated a mouse model of the disease (malinKO) lacking p62. Deletion of p62 prevented LB accumulation in skeletal muscle and cardiac tissue. In the brain, the absence of p62 altered LB morphology and increased susceptibility to epilepsy. These results demonstrate that p62 participates in the formation of LBs and suggest that the sequestration of abnormal glycogen into LBs is a protective mechanism through which it reduces the deleterious consequences of its accumulation in the brain

Effectiveness of influenza vaccination programme in preventing hospital admissions, Valencia, 2014/15 early results

Preliminary results for the 2014/15 season indicate low to null effect of vaccination against influenza A(H3N2)-related disease. As of week 5 2015, there have been 1,136 hospital admissions, 210 were due to influenza and 98% of subtype A strains were H3. Adjusted influenza vaccine effectiveness was 33% (range: 6–53%) overall and 40% (range: 13% to 59%) in those 65 years and older. Vaccination reduced by 44% (28–68%) the probability of admission with influenza.The study was funded by a contract between FISABIO and Sanofi-Pasteur

Marco activo de recursos de innovación docente: Madrid

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Calculation of the energy loss of swift H and He ions in Ag using the dielectric formalism: the role of inner-shell ionization

The electronic energy loss of swift H and He ions in solid Ag is studied theoretically within the dielectric formalism, considering the different equilibrium charge states of the projectile inside the target. Excitation of the weakly-bound (outer) electrons is described by a superposition of Mermin-type energy-loss functions, whereas the contribution to the projectile energy loss due to the ionization of the K, L and M shells of the Ag atoms is included through hydrogenic or numerical generalized oscillator strengths. This method is used to evaluate the stopping power and the energy-loss straggling parameter of H and He ions in Ag as a function of the projectile energy, showing a good agreement with available experimental data. The contribution of the target inner-shells to the energy loss begins to be appreciable at projectile energies larger than a few hundred keV/u, being more important for the energy-loss straggling parameter than for the stopping cross section.This work has been financially supported by the Spanish Ministerio de Educación y Ciencia (projects BFM2003-04457-C02-01 and BFM2003-04457-C02-02). S.H.A. thanks the Fundación CajaMurcia for financial assistance and C.D.D. thanks the Spanish Ministerio de Educación y Ciencia for support under the Ramón y Cajal Program