Bayesian joint spatio-temporal analysis of multiple diseases

In this paper we propose a Bayesian hierarchical spatio-temporal model for the joint analysis of multiple diseases which includes specific and shared spatial and temporal effects. Dependence on shared terms is controlled by disease-specific weights so that their posterior distribution can be used to identify diseases with similar spatial and temporal patterns. The model proposed here has been used to study three different causes of death (oral cavity, esophagus and stomach cancer) in Spain at the province level. Shared and specific spatial and temporal effects have been estimated and mapped in order to study similarities and differences among these causes. Furthermore, estimates using Markov chain Monte Carlo and the integrated nested Laplace approximation are compared.Peer Reviewe

FGF2, but not EGF, Induces multiciliated ependymal cells to dedifferentiate and adopt radial glial features in vitro

Multiciliated ependymal cells form an epithelium lining most of the ventricular cavities of vertebrates brain. Although considered postmitotic and completely differentiated, ependymal cells maintain some phenotypic characteristics of neural stem cells. Thereby, under specific conditions they behave as neural stem cells, developing radial glia characteristics, and undergoing asymmetric division. Our group is searching for factors that promote dedifferentiation of ependymal cells in vitro. We developed a simple method to obtain pure cultures of non-adherent multiciliated ependymal cells from adult rats. These cultures were used to investigate the effect of FGF2 on the differentiation state and the aggregation of ependymal cells. Thus, FGF2 treated ependymal cells lose cilia and hence mobility, and after 7 days they aggregate to form irregular spheres (diameter ≥ 20-30 μm). Such changes were not observed when EFG was used instead of FGF2. To assess the specificity of FGF2 action on cell aggregation, the FGF receptor inhibitor PD166866 and an anti-FGF2 neutralizing antibody were used. In both conditions the aggregative effect of FGF2 was abolished. No cell proliferation was observed during sphere formation, at least in such experimental conditions. Spheres were analyzed by immunocytochemistry using radial glia markers. They were positive for GFAP, vimentin, BLBP and GLAST. These data suggest that FGF2 promotes the identity loss in multiciliated ependymal cells in vitro, which are transformed into cells with radial glia features.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Prior and acquired knowledge after a day of training on first aids in future teachers of Physical Education

[Resumen] Con esta investigación se pretendió indagar acerca de los conocimientos sobre primeros auxilios, y en especial de RCP, que poseía el alumnado del grado de maestro en Educación Primaria de la Facultad de Formación de Profesorado de Lugo, antes y después de recibir una jornada de formación teórico-práctica de 3 horas en tres fases (1- expositiva-demostrativa, 2- interactiva con resolución de problemas en pequeños grupos y 3- interactiva con resolución de problemas en gran grupo). La muestra (N=23) estuvo compuesta por 9 hombres (39,1%) y 14 mujeres (60,9%) matriculados en la mención de Educación Física. Para saber los conocimientos previos (CI) y adquiridos (CF) tras la jornada de formación, se administró un cuestionario Ad Hoc con 25 ítems. Los resultados descriptivos del CI revelaron una falta de conocimiento de los futuros docentes de Educación Física en relación a los primeros auxilios. Los datos arrojados por el CF, alcanzando una media del 90 % de preguntas correctamente contestadas, avalan la eficacia de la metodología y duración de la formación propuesta a corto plazo. La retención de los conocimientos se presenta como limitación del estudio y será evaluada más adelante. En conclusión, se destaca la importancia de que los futuros docentes de Educación Física se formen adecuadamente en la materia de primeros auxilios y se propone que forme parte de los contenidos del grado en Educación Primaria[Abstract]This research was intended to investigate (test) the knowledge of the students of master degree in Elementary Education from the Faculty of Teacher Training Lugo about their knowledge on first aid and C.P.R, before and after receiving a theoretical day training practice of three hours in three different ways (First(1)-exhibition-demonstration, Second(2)- solving a practical situation of the problem in small groups and third(3)- solving a practical situation of the problem with a large group). The sample (N = 23) consisted of 9 men (39.1%) and 14 women (60.9%) studying the degree of P.E. To find out the previous knowledge about the topic and at the end of the training session we created a test that was giving to them previous the training First test(FT) and after training day Second test(ST) to see the progress of the students after the training , a questionnaire with 25 items Ad Hoc was given. The descriptive results of the FC revealed a lack of knowledge of future teachers in the P.E topic of first aid. These procedures have been identified to make an improvement of the new teachers with appropriated training sessions. In data obtained from the ST, we reach on average more than a 90% of correct answers proving the efficacy of the methodology and duration of training given in short period of time. The retention of knowledge about this topic was shown as a limitation of the study and will be evaluated later on. In conclusion, the importance of the knowledge on the topic first aid and C.P.R in future teachers of P.E is proved after doing the test and is proposed as part of the topics to be teach on the degree

Sensorless unbalance correction as an ancillary service for LV 4-Wire/3-Phase power converters

IEEE Energy Conversion Congress and Exposition (9th. 2017. Cincinnati

Requisitos exigibles a los terrenos para aplicar la deducción por reinversión en el Impuesto sobre Sociedades

Traditionally the legislator of the Corporate Tax has come regulating a tax benefit to bring on corporate reinvestment, being that, also traditionally, has been a constant focus of conflict specify the required requirements, especially when it comes to terrains of real estate companies, where the barrier between the accounting concepts of stocks and immobilized is very diffuse. Hence in this paper we have dealt with to study in detail such requirements in the light of scientific and jurisprudential doctrines susceptible to bring to collation.Tradicionalmente el legislador del Impuesto sobre Sociedades ha venido regulando un beneficio fiscal para favorecer la reinversión empresarial, siendo que, también tradicionalmente, ha sido un constante foco de conflictos concretar los requisitos exigibles, máxime cuando se trata de terrenos de empresas inmobiliarias, donde la barrera entre los conceptos contables de existencias y de inmovilizado es muy difusa. De ahí que en el presente trabajo nos hayamos ocupado de estudiar de forma pormenorizada tales requisitos a la luz de las doctrinas científica y jurisprudencial susceptibles de traer a colación