Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis

Brown adipose tissue (BAT) thermogenesis affects energy balance, and thereby it has the potential to induce weight loss and to prevent obesity. Here, we document a macroautophagic/autophagic-dependent mechanism of peroxisome proliferator-activated receptor gamma (PPARG) activity regulation that induces brown adipose differentiation and thermogenesis and that is mediated by TP53INP2. Disruption of TP53INP2-dependent autophagy reduced brown adipogenesis in cultured cells. In vivo specific-tp53inp2 ablation in brown precursor cells or in adult mice decreased the expression of thermogenic and mature adipocyte genes in BAT. As a result, TP53INP2-deficient mice had reduced UCP1 content in BAT and impaired maximal thermogenic capacity, leading to lipid accumulation and to positive energy balance. Mechanistically, TP53INP2 stimulates PPARG activity and adipogenesis in brown adipose cells by promoting the autophagic degradation of NCOR1, a PPARG co-repressor. Moreover, the modulation of TP53INP2 expression in BAT and in human brown adipocytes suggests that this protein increases PPARG activity during metabolic activation of brown fat. In all, we have identified a novel molecular explanation for the contribution of autophagy to BAT energy metabolism that could facilitate the design of therapeutic strategies against obesity and its metabolic complications

FUTUR: Integración del CRIS y del Repositorio Institucional como portal de investigación de la Universitat Politècnica de Catalunya

Presentació del portal Futur realitzada a VI Jornadas de OS-Repositorios / XIV Workshop de REBIUN a CórdobaPreprin

FUTUR. Portal de la Producción Científica de los Investigadores de la Universitat Politècnica de Catalunya

Se presenta FUTUR, el Portal de la Producción Científica de los Investigadores de la UPC, desarrollado por el Servicio de Bibliotecas, Publicaciones y Archivos, con la colaboración de la Oficina Técnica de Investigación, Desarrollo e Innovación, que tiene por objetivo maximizar la visibilidad del currículum de los investigadores de la UPC y la producción científica de la Universidad en Internet.Postprint (author's final draft

FUTUR. Portal de la Producción Científica de los Investigadores de la Universitat Politècnica de Catalunya

Se presenta FUTUR, el Portal de la Producción Científica de los Investigadores de la UPC, desarrollado por el Servicio de Bibliotecas, Publicaciones y Archivos, con la colaboración de la Oficina Técnica de Investigación, Desarrollo e Innovación, que tiene por objetivo maximizar la visibilidad del currículum de los investigadores de la UPC y la producción científica de la Universidad en Internet

The HEV Ventilator: at the interface between particle physics and biomedical engineering.

A high-quality, low-cost ventilator, dubbed HEV, has been developed by the particle physics community working together with biomedical engineers and physicians around the world. The HEV design is suitable for use both in and out of hospital intensive care units, provides a variety of modes and is capable of supporting spontaneous breathing and supplying oxygen-enriched air. An external air supply can be combined with the unit for use in situations where compressed air is not readily available. HEV supports remote training and post market surveillance via a Web interface and data logging to complement standard touch screen operation, making it suitable for a wide range of geographical deployment. The HEV design places emphasis on the ventilation performance, especially the quality and accuracy of the pressure curves, reactivity of the trigger, measurement of delivered volume and control of oxygen mixing, delivering a global performance which will be applicable to ventilator needs beyond the COVID-19 pandemic. This article describes the conceptual design and presents the prototype units together with a performance evaluation